AutismKB 2.0

Annotation Detail for ATP2B4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ATP2B4 ( ATP2B2,DKFZp686G08106,DKFZp686M088,MXRA1,PMCA4,PMCA4b,PMCA4x )
Gene Full Name: ATPase, Ca++ transporting, plasma membrane 4
Band: 1q32.1
Quick LinksEntrez ID:493; OMIM: 108732; Uniprot ID:AT2B4_HUMAN; ENSEMBL ID: ENSG00000058668; HGNC ID: 817
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa04972Pancreatic secretion
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATP2B4 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of ATP2B4 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ATP2B4 mRNAdecreases expression 20064835
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of ATP2B4 mRNA]decreases reaction|increases expression 19228888
D002118 Calcium ATP2B4 protein results in increased export of Calciumincreases export 16452157
D002118 Calcium caloxin 1b1 inhibits the reaction [ATP2B4 protein results in increased export of Calcium]decreases reaction|increases export 16452157
C510327 caloxin 1b1 caloxin 1b1 inhibits the reaction [ATP2B4 protein results in increased export of Calcium]decreases reaction|increases export 16452157
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ATP2B4 mRNAaffects cotreatment|increases expression 18606552
D005419 Flavonoids Flavonoids results in decreased expression of ATP2B4 mRNAdecreases expression 18035473
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ATP2B4 mRNAaffects cotreatment|increases expression 18606552
C051890 irinotecan ATP2B4 protein results in decreased susceptibility to irinotecandecreases response to substance 16734730
D007657 Ketone Bodies Ketone Bodies results in decreased expression of ATP2B4 mRNAdecreases expression 16807920
C008493 methylselenic acid methylselenic acid results in increased expression of ATP2B4 mRNAincreases expression 18548127
D010656 Phenylephrine ATP2B4 protein results in increased susceptibility to Phenylephrineincreases response to substance 12933703
D010710 Phosphates Phosphates affects the expression of ATP2B4 mRNAaffects expression 16490722
C006253 pirinixic acid pirinixic acid results in increased expression of ATP2B4 mRNAincreases expression 12832660
D011374 Progesterone Progesterone results in decreased expression of ATP2B4 mRNAdecreases expression 18070364
D015237 Dinoprost ATP2B4 protein results in increased susceptibility to Dinoprostincreases response to substance 12933703
D012643 Selenium Selenium results in increased expression of ATP2B4 mRNAincreases expression 19244175
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of ATP2B4 mRNA]decreases reaction|increases expression 19228888
D014284 Triiodothyronine Triiodothyronine results in increased expression of ATP2B4 mRNAincreases expression 19228888
C024746 tobacco tar tobacco tar results in decreased expression of ATP2B4 mRNAdecreases expression 19559774
D014212 Tretinoin Tretinoin affects the expression of ATP2B4 mRNAaffects expression 18230668
D014635 Valproic Acid Valproic Acid results in increased expression of ATP2B4 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.368875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8119490988
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.586695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3516434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0817306315
MESH:D000505 Alopecia Tretinoin 3.5115955085
MESH:D000550 Amblyopia Valproic Acid 5.1017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.4717497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0017460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8312569548 16835338 16251483 18414634
MESH:D001169 Arthritis, Experimental Tretinoin 3.0016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D050197 Atherosclerosis Arsenic 3.1712928151 19371607
MESH:D001321 Autistic Disorder Valproic Acid 2.0218985861 18177632 18558336 18396377 17507914 18940202 17688650 19460635 18316065 19232924 17157402 15238991 20603192 18775368 16609825
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.5716206674 16197459
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.328888407
MESH:D001862 Bone Resorption bisphenol A 3.7411985600
MESH:D001919 Bradycardia Phenylephrine 4.4115306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2117868700
MESH:D001930 Brain Injuries Progesterone 4.1315665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9517474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 1.9517123778
MESH:D001943 Breast Neoplasms Progesterone 1.9517614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tretinoin 1.9516443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5215504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.1417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.141917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.8617123778
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.3318922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3320419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3316096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9618640142
MESH:D006332 Cardiomegaly Phenylephrine 3.4611754973 17287366 15728586 11179087 17124262 16170337
MESH:D009202 Cardiomyopathies Zalcitabine 4.6210591146
MESH:D002318 Cardiovascular Diseases Arsenic 3.3617938729 19152805 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.2018022660 16973168
MESH:D002386 Cataract Tretinoin 3.0217460283
MESH:D002471 Cell Transformation, Neoplastic Dinoprost 7.5616192471
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.5619559774
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6620734317
MESH:D002779 Cholestasis pirinixic acid 2.7319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002972 Cleft Palate Tretinoin 2.619407595
MESH:D003092 Colitis Selenium 9.0617936198
MESH:D003092 Colitis Tretinoin 9.0617035595
MESH:D003110 Colonic Neoplasms irinotecan 2.5717725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3618259882 16391804 18509181 16303861 17159606 15273666 17454858
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.6417551590 9224671 10589399 9211117 8800419 14991402 16925845 9664655 9125849 9142499
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.6417688650 8888407 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.3617187935
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8815131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.8819641884 1733752
MESH:D004362 Drug Toxicity Zalcitabine 4.757515130
MESH:D004421 Dystonia Valproic Acid 3.921851702
MESH:D004487 Edema pirinixic acid 2.3612083418
MESH:D004489 Edema, Cardiac Tretinoin 4.3418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.6517692515
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0216569247
MESH:D004715 Endometriosis Progesterone 3.6516134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.023659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.793922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.486426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.177750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.933659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9816530937
MESH:D005124 Eye Abnormalities Tretinoin 3.4816938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 12.6219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 12.6214986274 19224547
MESH:D005234 Fatty Liver Zalcitabine 12.6218299183
MESH:D005315 Fetal Diseases Valproic Acid 4.7616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0018558336 8888407
MESH:D005334 Fever Dinoprost 5.4011852909
MESH:D005355 Fibrosis Tretinoin 3.3817994277
MESH:D005534 Foot Diseases Arsenic 5.436392382
MESH:D005909 Glioblastoma Tretinoin 2.9217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4320471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.4314991402 9664655
MESH:D006333 Heart Failure pirinixic acid 6.6820558911
MESH:D006333 Heart Failure Selenium 6.6817162251
MESH:D006529 Hepatomegaly pirinixic acid 2.8719176532 18467677 19772884 16221962
MESH:D015658 HIV Infections Zalcitabine 4.2717457083
MESH:D006849 Hydrocephalus Valproic Acid 4.7417688650
MESH:D006930 Hyperalgesia Tretinoin 3.1116870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3417050553
MESH:D006973 Hypertension Arsenic 5.4916076760 11953799 9931084
MESH:D006973 Hypertension Phenylephrine 5.4912717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 4.4318502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.4316093927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2715869954
MESH:D007249 Inflammation Flavonoids 5.0417296493
MESH:D007249 Inflammation Progesterone 5.0415869954
MESH:D007251 Influenza, Human Selenium 4.0716624496
MESH:D007333 Insulin Resistance bisphenol A 7.0316393666
MESH:D007333 Insulin Resistance pirinixic acid 7.0316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6417994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.7817551590 15992940
MESH:D007642 Keratosis Arsenic 4.8612749816 16930632
MESH:D007676 Kidney Failure, Chronic Selenium 3.7616518626
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9216316344
MESH:D007938 Leukemia Tretinoin 2.7117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8016294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.4717339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.4717649720 16935935 17294898 12679006 16823087 16788101 19035177 17301526 17361223 16766008 19075265 17506722 9834237 16331271 16891316 19029980 17712046 15748426 17217047 19225113 17107899 17339181 16140955 19642359 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.219224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3015474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3016248980 18397230
MESH:D008107 Liver Diseases Arsenic 2.5111134558
MESH:D008113 Liver Neoplasms Arsenic 7.1516368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.1521137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.1515890375 20007298 16377806
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1317228818
MESH:D008175 Lung Neoplasms Arsenic 2.5019168569 17976673 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.506695378 17053015 20869020 18569708 20135361 18816296 18520028 20464547 20064080
MESH:D008223 Lymphoma Zalcitabine 4.5517941976 8764131 18798262 9205081 11980663 9488045 8840982
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.8511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.8515318939
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma Tretinoin 1.9316752155
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D001523 Mental Disorders Phosphates 4.8812686366
MESH:D008654 Mesothelioma Selenium 2.7415107826
MESH:D008881 Migraine Disorders Valproic Acid 3.1018803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D052016 Mucositis irinotecan 4.8817159606
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.918888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1517596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Arsenic 3.8815371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009362 Neoplasm Metastasis irinotecan 3.1218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 7.8211141357
MESH:D009369 Neoplasms pirinixic acid 7.8217405874
MESH:D009369 Neoplasms Tretinoin 7.8216594593 16946489
MESH:D009374 Neoplasms, Experimental Zalcitabine 4.979205081 9488045 8764131
MESH:D009421 Nervous System Malformations bisphenol A 9.3711399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 9.379125849
MESH:D009437 Neuralgia Zalcitabine 6.1917292584
MESH:D009436 Neural Tube Defects Arsenic 11.7116620997
MESH:D009436 Neural Tube Defects Tretinoin 11.719142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.718888407 16359493
MESH:D009447 Neuroblastoma irinotecan 3.418761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.608761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.2517056641
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D010024 Osteoporosis Calcium 3.7017882678
MESH:D010049 Ovarian Diseases bisphenol A 4.8611985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.7217306315
MESH:D010051 Ovarian Neoplasms Progesterone 7.7217393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7216936753
MESH:D010146 Pain Tretinoin 2.8016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4215976015
MESH:D010523 Peripheral Nervous System Diseases Arsenic 16.1916093927
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 16.1918606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 16.1918606552
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8616905509 6392382 15371236
MESH:D010954 Plasmacytoma Selenium 4.7615087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.3110548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.3120603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1416140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1416740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1416205645
MESH:D011507 Proteinuria Arsenic 8.8621343184
MESH:D011507 Proteinuria Tretinoin 8.8616636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.4112752131 11422049
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.6510548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.4516283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.4519155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8118045962
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures Valproic Acid 2.653137016 16876388 1511512 15475178 11044598 11738929 14763951 17978042
MESH:D012852 Sinusitis Phenylephrine 4.577327846
MESH:D012871 Skin Diseases Arsenic 2.7118709164 17938729 17050553 17548696 15952646 17453740 19834688 16702368 6392382 16353154 16759981
MESH:D012878 Skin Neoplasms Arsenic 9.1617976673 17029826 16251483 17050553 15504454 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1619755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 9.1616467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.1516503802 15862959
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3420155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 3.3415723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.3417261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.8516045194 16684133
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6716051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1017262798
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.393119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.0019429237 17306315 18640142 11144890 15987713 19322015 17976673
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0017053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.518888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5616129372
MESH:D014591 Uterine Diseases bisphenol A 4.8814652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.4816752155
MESH:D014652 Vascular Diseases Arsenic 4.6017056641
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
REACT:604 Hemostasis
KEGG:04972 Pancreatic secretion
KEGG:04970 Salivary secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25110
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved