AutismKB 2.0

Annotation Detail for GPX8


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Basic Information Top
Gene Symbol:GPX8 ( UNQ847 )
Gene Full Name: glutathione peroxidase 8 (putative)
Band: 5q11.2
Quick LinksEntrez ID:493869; OMIM: NA; Uniprot ID:GPX8_HUMAN; ENSEMBL ID: ENSG00000164294; HGNC ID: 33100
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4081glutathione redox reactions I
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GPX8 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GPX8 mRNAdecreases expression 17557909
C055122 orlistat orlistat results in increased expression of GPX8 mRNAincreases expression 18796435
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.8117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8914692618
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.1211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.9115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D019121 Burkholderia Infections orlistat 7.5117874328
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002779 Cholestasis Ethinyl Estradiol 3.2017681005 17333356 16105132 11677210 16919318 15861022 17110522
MESH:D002916 Chylothorax orlistat 7.5117003701
MESH:D048909 Diabetes Complications orlistat 6.7019207292
MESH:D003967 Diarrhea orlistat 5.3020002075
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6811834606 11529661 14725611 16393943 16081117 12392966 10915739 16485898 16177239 17562736 19923254 19420014 17906064 19370779 16109766 19164858 16781746 10663392 19739265 18713872 12958197 10774834 11287661 12594235 16227642 12153990 19085960 15619225 11421492 18071297 2444490 11739529 15968718 14550746 17522070 19416960 12705907 12540782 14986274 11461765 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.7712538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.2915345470
MESH:D005414 Flatulence orlistat 7.5120002075
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006949 Hyperlipidemias orlistat 5.6121332399
MESH:D007021 Hypospadias Ethinyl Estradiol 4.4616569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7617937319
MESH:D007333 Insulin Resistance orlistat 4.8417201808
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 7.5117185156
MESH:D008103 Liver Cirrhosis orlistat 4.5617404856
MESH:D008107 Liver Diseases Acetaminophen 1.7116611625 19784758 12587719 19460945 16610002 12969438 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008207 Lymphatic Metastasis orlistat 6.4718770866 20805790
MESH:D008545 Melanoma orlistat 3.4718770866 20805790
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009135 Muscular Diseases orlistat 6.1018430571
MESH:D009164 Mycobacterium Infections orlistat 6.3621442799
MESH:D009369 Neoplasms orlistat 4.0718710210
MESH:D009374 Neoplasms, Experimental orlistat 5.7119381703
MESH:D009389 Neovascularization, Pathologic orlistat 6.0817012255
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 6.0517404856
MESH:D009765 Obesity orlistat 3.8318773755 19207292 21438711 20002075 20540997 19046740 20599501 16938137 21442799 20065556 19461584 20518802
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010195 Pancreatitis orlistat 5.3716938137 20065556
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.2211578682
MESH:D011085 Polycystic Ovary Syndrome orlistat 5.7817201808
MESH:D011537 Pruritus Ethinyl Estradiol 4.0515861022 16919318
MESH:D012035 Refsum Disease orlistat 6.8120871815
MESH:D013088 Spermatocele Ethinyl Estradiol 4.8116709447
MESH:D013274 Stomach Neoplasms orlistat 3.2819381703
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.1511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5715669648
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 4.0214671159 15869587
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:00480 Glutathione metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00143 - BSS Plus Dietary supplement;Micronutrient
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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