AutismKB 2.0

Annotation Detail for PHOSPHO2


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Basic Information Top
Gene Symbol:PHOSPHO2 ( MGC111048,MGC22679 )
Gene Full Name: phosphatase, orphan 2
Band: 2q31.1
Quick LinksEntrez ID:493911; OMIM: NA; Uniprot ID:PHOP2_HUMAN; ENSEMBL ID: ENSG00000144362; HGNC ID: 28316
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00750Vitamin B6 metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PHOSPHO2 mRNAincreases expression 18648102
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of PHOSPHO2 mRNAincreases expression 16631469
D016572 Cyclosporine Cyclosporine results in decreased expression of PHOSPHO2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PHOSPHO2 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of PHOSPHO2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D001943 Breast Neoplasms Tamoxifen 2.1717440819 19142967 18821012 19103187 18997820 11161223 19288272 19084267 21138602 19011961 15565566 20135344 16873071 15668708 19487384 19115204 21152245 18351453 19244106 16202921 20544844 18984771 17893378 19155303 16273361 20005174 16818667 18629630 19221464 18855134 20065188 18425577 17261762 20390343 19410462 17242785 19289846 18815881 19066611 17049068 19189210 20859285 19059307 19200415 19189212
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.113581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.367505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3612371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.939022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.9319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.9317333356 16919318 17681005 11677210 16105132 15861022 17110522
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.288156756 18759878 11906362 2524372 12868966 14531868 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.039653073 18692083 6482804 9328219 6679447 1440618 18648102 18289764 11289319 7440962 9022650 16192314 8291058
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2619155303 17893378 20544844 16202921
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Cyclosporine 15.3219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.3215345470
MESH:D005234 Fatty Liver Tamoxifen 15.3219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.528314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.206582329
MESH:D007680 Kidney Neoplasms Cyclosporine 14.2012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 14.2018625569
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.731399818 598648 3712494 6587162
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8319196723 16827153 11731420 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.083581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.156582329 7505956 6587162 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.428074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.428653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00750 Vitamin B6 metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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