AutismKB 2.0

Annotation Detail for OAS3


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Basic Information Top
Gene Symbol:OAS3 ( MGC133260,p100 )
Gene Full Name: 2'-5'-oligoadenylate synthetase 3, 100kDa
Band: 12q24.13
Quick LinksEntrez ID:4940; OMIM: 603351; Uniprot ID:OAS3_HUMAN; ENSEMBL ID: ENSG00000111331; HGNC ID: 8088
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of OAS3 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of OAS3 mRNAdecreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of OAS3 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of OAS3 mRNAincreases expression 19619570
D013629 Tamoxifen Tamoxifen results in increased expression of OAS3 mRNAincreases expression 19155303
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of OAS3 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of OAS3 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of OAS3 mRNAincreases expression 20106945
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 14514962 15322242
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.249612607
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Estradiol 1.8119861407 14630087 17289903 16675129 17018787 12948864 18497071 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 1.8119059307 20544844 20859285 18855134 16273361 18815881 21138602 19011961 18425577 17893378 17242785 20135344 19103187 18351453 19410462 16818667 19084267 19066611 19487384 15565566 18984771 19189210 20005174 19155303 21152245 19244106 19200415 19221464 20390343 18997820 17261762 19115204 15668708 18821012 17440819 19142967 16873071 20065188 19288272 19189212 19289846 16202921 17049068 18629630 11161223
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1016924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 12621046 15668235 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.8119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8119279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 9.0111462148
MESH:D004362 Drug Toxicity Zidovudine 9.0115040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.9219031437
MESH:D016889 Endometrial Neoplasms Estradiol 8.0411473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0420544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Cyclosporine 15.1719224547
MESH:D005234 Fatty Liver Tamoxifen 15.1714986274 19224547
MESH:D005234 Fatty Liver Zidovudine 15.1718299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 9.9112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.9120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006402 Hematologic Diseases Zidovudine 5.0612579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D015658 HIV Infections Zidovudine 3.6320032539 11141242 11698656 17358032 11363243
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716354765 18606429 8697196 16959395 15340226
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818850075 18670907
MESH:D007249 Inflammation Tamoxifen 5.3719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3712878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1616627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.498314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.4915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 20.1012371664
MESH:D007680 Kidney Neoplasms Estradiol 20.1015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 20.1018625569
MESH:D007680 Kidney Neoplasms Zidovudine 20.1012579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7420370541
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5912878042
MESH:D008113 Liver Neoplasms Tamoxifen 4.7216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Tamoxifen 3.6218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6219555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 3.6218800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6116891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6111731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 14.4519453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.4519453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.3617358032
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 10.7711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7714600291
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.028532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0216192470
MESH:D013088 Spermatocele Tamoxifen 4.8116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4516712894 8653321 17572228
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1812579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
KEGG:05162 Measles
REACT:6900 Signaling in Immune system
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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