AutismKB 2.0

Annotation Detail for OAZ2


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Basic Information Top
Gene Symbol:OAZ2 ( AZ2 )
Gene Full Name: ornithine decarboxylase antizyme 2
Band: 15q22.31
Quick LinksEntrez ID:4947; OMIM: 604152; Uniprot ID:OAZ2_HUMAN; ENSEMBL ID: ENSG00000180304; HGNC ID: 8096
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of amino acids and derivatives
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of OAZ2 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in decreased expression of OAZ2 mRNAdecreases expression 20106945
D010634 Phenobarbital Phenobarbital results in increased expression of OAZ2 mRNAincreases expression 19270015
D012643 Selenium Selenium results in increased expression of OAZ2 mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of OAZ2 mRNAaffects expression 17440010
C025643 vinclozolin vinclozolin affects the expression of OAZ2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of OAZ2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.9820007298 17173139 20935162 6705139 1701930
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0114986274 10915739 19370779 10663392 19739265 12540782 16781746 12705907 16393943 15619225 12392966 18071297 16177239 11739529 12958197 17906064 16485898 18713872 19416960 19923254 14725611 19420014 11461765 12153990 15968718 14550746 16109766 10774834 11421492 11743745 17562736 12594235 11834606 19164858 16227642 11529661 17522070 11287661 19085960 2444490 16081117
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly Phenobarbital 3.8416109766
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1917440010
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.8612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.8618776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.8612488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 4.1319014921 16610002 12969438 16611625 19460945 11587558 19784758 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.3919812893 19073162 19482888 8742319 15975961 21047994
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.861399818 2563599 6150874 17172636 18308698
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011230 Precancerous Conditions Cyclosporine 9.8112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.812563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2919015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012640 Seizures Phenobarbital 2.873137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00129 - L-Ornithine Dietary supplement;Micronutrient;Non-Essential Amino Acids
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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