AutismKB 2.0

Annotation Detail for OGDH


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Basic Information Top
Gene Symbol:OGDH ( AKGDH,E1k,OGDC )
Gene Full Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Band: 7p13
Quick LinksEntrez ID:4967; OMIM: 613022; Uniprot ID:ODO1_HUMAN; ENSEMBL ID: ENSG00000105953; HGNC ID: 8124
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-50842-ketoglutarate dehydrogenase complex
PWY-5690TCA cycle variation III (eukaryotic)
Pathway IDPathway Name
hsa00310Lysine degradation
hsa00380Tryptophan metabolism
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
Pathway IDPathway Name
Pyruvate metabolism and Citric Acid (TCA) cycle
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P00051TCA cycle
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Alpha-ketoglutarate dehydrogenase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000171 Acrolein Acrolein results in decreased activity of OGDH proteindecreases activity 16725382
D000535 Aluminum Aluminum results in decreased expression of and results in decreased activity of OGDH proteindecreases activity|decreases expression 16906525
D000535 Aluminum Aluminum results in increased activity of OGDH proteinincreases activity 10806405
D000638 Amiodarone Amiodarone affects the expression of OGDH mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of OGDH mRNAaffects expression 19483382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OGDH mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]decreases activity|decreases reaction 12680778
D020122 tert-Butylhydroperoxide [GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]affects cotreatment|decreases activity|decreases reaction 12680778
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased activity of OGDH proteindecreases activity 12680778
D002994 Clofibrate Clofibrate affects the expression of OGDH mRNAaffects expression 19483382
D003958 Diamide Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein]decreases activity|increases reaction 12680778
D004229 Dithiothreitol Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]decreases activity|decreases reaction 12680778
D004229 Dithiothreitol Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]decreases activity|decreases reaction 12680778
D005001 Ethionine Ethionine affects the expression of OGDH mRNAaffects expression 19483382
D005978 Glutathione [GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]affects cotreatment|decreases activity|decreases reaction 12680778
D005978 Glutathione Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein]decreases activity|increases reaction 12680778
D006861 Hydrogen Peroxide Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]decreases activity|decreases reaction 12680778
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased activity of OGDH proteindecreases activity 12680778
D015741 Metribolone Metribolone affects the splicing of OGDH mRNAaffects splicing 17010196
D009853 Omeprazole Omeprazole affects the expression of OGDH mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of OGDH mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of OGDH mRNAaffects expression 19483382
C004648 testosterone enanthate testosterone enanthate affects the expression of OGDH mRNAaffects expression 17440010
D013853 Thioacetamide Thioacetamide affects the expression of OGDH mRNAaffects expression 19483382
D014212 Tretinoin Tretinoin results in increased expression of OGDH mRNAincreases expression 16054129
D014415 Tunicamycin Tunicamycin results in decreased expression of OGDH mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Acrolein 9.0120525806 21297076
MESH:D055371 Acute Lung Injury pirinixic acid 9.0118653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4016434500
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:C536582 Alpha-ketoglutarate dehydrogenase deficiency marker/mechanism
MESH:D000544 Alzheimer Disease Acrolein 5.0415207723 14715435 17570602
MESH:D000544 Alzheimer Disease Aluminum 5.0410721010 17662457
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7220041841 18218290 18057881
MESH:D001161 Arteriosclerosis Acrolein 4.9215014928
MESH:D001169 Arthritis, Experimental Tretinoin 3.0216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D050197 Atherosclerosis Acrolein 3.9216126721 17363696 16037261
MESH:D001281 Atrial Fibrillation Amiodarone 3.8418651412 19698954
MESH:D001321 Autistic Disorder Glutathione 3.0216917939 19267885 18929414 19056591
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 56.9219483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 56.9219483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 56.9219483382
MESH:D001778 Blood Coagulation Disorders Ethionine 56.9219483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 56.9219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 56.9219483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 56.9219483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 56.9219483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 56.9216206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2916443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.711701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.7117997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.711917145
MESH:D002294 Carcinoma, Squamous Cell Glutathione 4.9717015178
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9716096774 16051514
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8619225199 15710769
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4516936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0018974383
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7220889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.721399818
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D002637 Chest Pain Omeprazole 5.0315447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.2118291259
MESH:D002779 Cholestasis pirinixic acid 2.7619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tretinoin 2.639407595
MESH:D003092 Colitis Tretinoin 3.6217035595
MESH:D015179 Colorectal Neoplasms Acrolein 2.9217597105
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8116925845 14991402 17551590 9224671 9142499 9664655 10589399 9125849 9211117 8800419
MESH:D003550 Cystic Fibrosis Glutathione 4.4119747007
MESH:D003556 Cystitis Acrolein 5.3112161096
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 4.1812963478
MESH:D004381 Duodenal Ulcer Omeprazole 4.2416613094 17151854 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 4.0016707586
MESH:D004487 Edema pirinixic acid 2.4012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.3918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0516569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0520426865
MESH:D005124 Eye Abnormalities Tretinoin 3.5116938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.6416456712
MESH:D005234 Fatty Liver Amiodarone 12.7514986274
MESH:D005234 Fatty Liver Clofibrate 12.7519224547
MESH:D005234 Fatty Liver pirinixic acid 12.7520131406 19236843
MESH:D005355 Fibrosis Tretinoin 3.4317994277
MESH:D005909 Glioblastoma Tretinoin 2.9517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.859664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4915929193 17276928 18665440
MESH:D006505 Hepatitis Thioacetamide 4.1316456712
MESH:D006529 Hepatomegaly Amiodarone 8.2915265979
MESH:D006529 Hepatomegaly pirinixic acid 8.2919772884 16221962 18467677 19176532
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6717440010
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.798137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D007037 Hypothyroidism Amiodarone 11.3217991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.3218031379 8137927
MESH:D007249 Inflammation Aluminum 3.9416052892
MESH:D007333 Insulin Resistance pirinixic acid 2.5716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.8217551590 15992940
MESH:D007674 Kidney Diseases Acrolein 3.7912488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1916518626
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0219248655
MESH:D007938 Leukemia Tretinoin 2.7317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0617596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0915748426 17506722 17217047 16788101 19029980 17649720 16331271 16823087 17368321 17294898 17301526 12679006 16935935 19642359 9834237 17712046 16140955 17107899 19225113 17339181 16766008 16891316 19035177 19075265 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008064 Lipidoses Amiodarone 3.4515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.4917050028 10677585 15716488 15465738 15158331 12557150 12531686 16511523 11172339 18606216 17629604 14739098 15474484 18263696 18416461 18615449 16126171 12085344 11682029 15362042 15095483 18395095 18032466 15334695 15288472 12679928 16343077 16097051 18458672 16489207 15078482 12891558 11481614 16098781 18031379 12175628 15316131 17355460 16248980 17292413 15075984 18380797 18295389 15288473 17127702
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4918397230 16248980
MESH:D008107 Liver Diseases Thioacetamide 2.6818374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.2312479984 15313186 15633222 17276928
MESH:D008113 Liver Neoplasms pirinixic acid 1.7915890375 16377806 20007298
MESH:D008133 Long QT Syndrome Amiodarone 3.5115350150 17391786 11989578
MESH:D008171 Lung Diseases Acrolein 12.3611504702
MESH:D008171 Lung Diseases Aluminum 12.3616052892
MESH:D008171 Lung Diseases Amiodarone 12.3612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4018516814
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma Tretinoin 1.9316752155
MESH:D008546 Melanoma, Experimental Acrolein 5.1210803710
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 6.2917086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 6.2917086897
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009181 Mycoses Amiodarone 4.8217974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8816411023
MESH:D009369 Neoplasms Acrolein 8.1217329238
MESH:D009369 Neoplasms pirinixic acid 8.1217405874
MESH:D009369 Neoplasms Tretinoin 8.1216594593 16946489
MESH:D009393 Nephritis Acrolein 6.2112653641
MESH:D009421 Nervous System Malformations Tretinoin 3.699125849
MESH:D009436 Neural Tube Defects Tretinoin 3.009142499
MESH:D019636 Neurodegenerative Diseases Acrolein 4.4411342003
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.859802331
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3216936753
MESH:D010146 Pain Tretinoin 2.8316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4315976015
MESH:D010212 Papilloma Hydrogen Peroxide 4.0012065085
MESH:D010300 Parkinson Disease Acrolein 3.5617690948
MESH:D010787 Photosensitivity Disorders Acrolein 5.6611550810
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8211597910 12490602 12832656
MESH:D051437 Renal Insufficiency Acrolein 4.9212732208
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0216283617 16116481
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0018724381
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.3312065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.338532709
MESH:D012878 Skin Neoplasms Tretinoin 9.3316467112
MESH:D013272 Stomach Diseases Omeprazole 4.5318545984
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Amiodarone 7.3018087811
MESH:D013276 Stomach Ulcer Omeprazole 7.3016755016 11906479 18237397 15991576 10750652 17977527
MESH:D020521 Stroke Acrolein 4.4816269634
MESH:D013610 Tachycardia Amiodarone 4.2011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1019225199
MESH:D013959 Thyroid Diseases Amiodarone 4.6819731979
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.2015710170
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2016026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.7719584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D016171 Torsades de Pointes Amiodarone 4.1111989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
Pathway ID Pathway Name
KEGG:00020 Citrate cycle (TCA cycle)
KEGG:00310 Lysine degradation
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
KEGG:00380 Tryptophan metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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