AutismKB 2.0

Annotation Detail for OGN


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Basic Information Top
Gene Symbol:OGN ( DKFZp586P2421,OG,OIF,SLRR3A )
Gene Full Name: osteoglycin
Band: 9q22.31
Quick LinksEntrez ID:4969; OMIM: 602383; Uniprot ID:MIME_HUMAN; ENSEMBL ID: ENSG00000106809; HGNC ID: 8126
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of OGN mRNAdecreases expression 20713471
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of OGN mRNAaffects expression 21346803
C006780 bisphenol A bisphenol A results in decreased expression of OGN mRNAdecreases expression 20739668
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of OGN mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of OGN mRNAincreases expression 16239168
C030123 coumarin coumarin results in decreased expression of OGN mRNAdecreases expression 18480146
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of OGN mRNAaffects cotreatment|decreases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of OGN mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of OGN mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OGN mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of OGN mRNAaffects expression 17351261
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of OGN mRNAaffects cotreatment|decreases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of OGN mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of OGN mRNAdecreases expression 20713471
D010126 Ozone Ozone results in decreased expression of OGN mRNAdecreases expression 12763052
D010656 Phenylephrine Phenylephrine results in decreased expression of OGN mRNAdecreases expression 18158353
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of OGN mRNAaffects cotreatment|decreases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of OGN mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D017632 Asbestos, Serpentine Asbestos, Serpentine results in decreased expression of OGN mRNAdecreases expression 16251409
C017947 sodium arsenite sodium arsenite results in increased expression of OGN mRNAincreases expression 17879257
C017947 sodium arsenite sodium arsenite results in increased expression of OGN mRNAincreases expression 18812580
C017947 sodium arsenite sodium arsenite results in decreased expression of OGN mRNAdecreases expression 19072884
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OGN mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of OGN mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C025643 vinclozolin vinclozolin affects the expression of OGN mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D000236 Adenoma Methylcholanthrene 3.506695378 10545420
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9317306315 16712894
MESH:D000544 Alzheimer Disease Ozone 4.4915513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.4919621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1117460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.3817659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3815885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001195 Asbestosis Asbestos, Serpentine 5.6810751356
MESH:D001249 Asthma Ozone 2.6416373670 17854713
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4511922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D001919 Bradycardia Phenylephrine 4.5615306635
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0211921183
MESH:D001943 Breast Neoplasms bisphenol A 2.0217123778
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0217474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6818315731 19059883 18417511 17626835 16777450 14754758 15516495
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916124888 16192424 15673190 16227642 16011737 16050911 3786805 15721981 16097048 10355542 15700767 18705752
MESH:D002277 Carcinoma Methylcholanthrene 8.3410545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6016705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6018788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.6015276417 17306315 16507464
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3818572023
MESH:D006332 Cardiomegaly Phenylephrine 6.8915728586 17287366 17124262 16170337 11179087 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8918850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.326135515
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.3216192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.3219524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8815861022 16105132 11677210 17681005 17333356 17110522 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1012621046 8697196 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4915824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6217728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6210048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4212438553
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3017446233
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 7.3119647726
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.3112642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3117107852
MESH:D003967 Diarrhea Dexamethasone 3.717237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.1821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.183786805 15968718 19336974 21278145 9327722 10915739 6623471 16177239 7179309 2869522 6884620 19085960 15998439 17522070 16227642 15027814 10092053 7440962 7120509 3732212 4309450 11566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004485 Eczema Dexamethasone 4.4712438553
MESH:D004487 Edema Dexamethasone 11.6319703484
MESH:D004487 Edema rosiglitazone 11.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.2317595544 12795759 16239168 15959796 61145 12631006 16045604 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2315345470
MESH:D005234 Fatty Liver rosiglitazone 13.2319196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9614633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 8.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6420067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.077520565
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia rosiglitazone 3.9212083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006973 Hypertension Dexamethasone 8.7317042910
MESH:D006973 Hypertension Phenylephrine 8.7312717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D006984 Hypertrophy Phenylephrine 4.5618502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.4718306037
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.2217937319
MESH:D007248 Infertility, Male sodium arsenite 11.2212646999 15346721
MESH:D007248 Infertility, Male vinclozolin 11.2216467254
MESH:D007249 Inflammation Dexamethasone 8.4511099482 8960868
MESH:D007249 Inflammation rosiglitazone 8.4512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4512878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.7516393666
MESH:D007333 Insulin Resistance rosiglitazone 7.7516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.4718306037
MESH:D007674 Kidney Diseases sodium arsenite 2.8020008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9816705839
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8116943688 21278145 17157831 11408273 17174718 17334410 16239168 16221502 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0118429990 12898905 17869086 12632514 18481824 17766677 15057751 17805973 16116963 17922224 10355542 18412020 17900296 15338365 15052691 18376398 16033810 16638106 15893842 16192424 16097048 15818738 18006644 12586293 14716833 18210741 15370692 18187930 17721639 17631135 18472094 18277467 18395095 15931870 12649538 17714472 17698563 18395914 18705752 12632512 20821823 15730626 12741479 14716496 18156304 17708605 18420326 18472332 17976157 12546737 15959796 12666154 14620537 17823541 15996030 15123356 17944888 15673190 17481882 14748882 15925388 18251166 12958196 17761835 13678700 15362042 16011737 17557913 11481614 16015684 16027843 18339082 18054572 16248980 12445418 17640975 17565644 18166357 14724832 18263696 12389079 18317297 16136751 12445421 12667390 14512876 15650968 18205269 12609069 18418968 15876570 18279442 17525996
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.0116718785
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 5.0117347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0815720792 16964402 15830285 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6916899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.707678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.7019294768
MESH:D008113 Liver Neoplasms sodium arsenite 10.7015276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.156135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.1515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.15598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1512151625
MESH:D008171 Lung Diseases Asbestos, Serpentine 12.5417200189
MESH:D008171 Lung Diseases Ozone 12.548266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 12.5419095001
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 8.5811198217
MESH:D008175 Lung Neoplasms Dexamethasone 8.5811195469 15824018
MESH:D008175 Lung Neoplasms Methylcholanthrene 8.5815390079 9230183 20512841 20970405 17909032 16271038 21163286 1399818 11893704 7750092 6695378 16337739 10545420
MESH:D008175 Lung Neoplasms Ozone 8.587614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 8.5816712894 15276417 17306315 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.5819555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 6.6311921183
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.6316827153
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3817261469
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D009101 Multiple Myeloma Dexamethasone 3.5115744524 16118317 15867202
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.549809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.887678174 18551238
MESH:D009369 Neoplasms sodium arsenite 2.5011559025
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 9.5811704859
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.5820056578
MESH:D009421 Nervous System Malformations bisphenol A 9.6111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6114600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1412854658
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4316049721
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4317306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.7110923243
MESH:D011014 Pneumonia Ozone 4.4118007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5421297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.3910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.3911222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.3919015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3516740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3516039940
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.8318569384 15511213
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0211700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5418551238
MESH:D012852 Sinusitis Phenylephrine 4.727327846
MESH:D012878 Skin Neoplasms sodium arsenite 5.6019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D013272 Stomach Diseases Dexamethasone 4.3415472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.4915138204
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1016049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1011723127 16452187 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Dexamethasone 4.851336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D014689 Venous Insufficiency coumarin 5.8112708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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