AutismKB 2.0

Annotation Detail for OLR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:OLR1 ( CLEC8A,LOX1,LOXIN,SCARE1,SLOX1 )
Gene Full Name: oxidized low density lipoprotein (lectin-like) receptor 1
Band: 12p13.2
Quick LinksEntrez ID:4973; OMIM: 602601; Uniprot ID:OLR1_HUMAN; ENSEMBL ID: ENSG00000173391; HGNC ID: 8133
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
hsa04145Phagosome
Pathway IDPathway Name
Hemostasis
No data
No data
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
Related Diseases/Disorders Top
No data
No data
Desease Name
Atherosclerosis
atherosclerosis, coronary
CARDIOVASCULAR
myocardial infarct
Alzheimer's disease
Edema rosiglitazone or pioglitazone
PHARMACOGENOMIC
NEUROLOGICAL
Myocardial Infarction
C-reactive protein cardiovascular event lipids
No data
Desease Name
Myocardial infarction, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C400184 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of OLR1 mRNAincreases expression 16386258
C047368 3-methylquercetin 3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1]decreases reaction|increases expression 16891912
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of OLR1 mRNAincreases expression 17034753
C041819 4-oxoretinol 4-oxoretinol results in increased expression of OLR1 mRNAincreases expression 17034753
D000082 Acetaminophen Acetaminophen affects the expression of OLR1 mRNAaffects expression 17562736
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
C103303 alitretinoin alitretinoin results in increased expression of OLR1 mRNAincreases expression 17034753
C068073 Am 580 Am 580 results in increased expression of OLR1 mRNAincreases expression 16982809
D000643 Ammonium Chloride Ammonium Chloride affects the expression of OLR1 mRNAaffects expression 16483693
C004984 apocarotenal apocarotenal results in increased expression of OLR1 mRNAincreases expression 17034753
C006632 arsenic trioxide arsenic trioxide results in decreased expression of OLR1 mRNAdecreases expression 19128835
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of OLR1 mRNAaffects cotreatment|increases expression 17639512
D019207 beta Carotene beta Carotene results in increased expression of OLR1 mRNAincreases expression 17034753
C459604 candoxin candoxin results in decreased expression of OLR1 mRNAdecreases expression 16309724
C043211 carvedilol carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
C043211 carvedilol carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
C043211 carvedilol carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
C043211 carvedilol carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D002117 Calcitriol Calcitriol results in decreased expression of OLR1 mRNAdecreases expression 16002434
D004317 Doxorubicin Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D004317 Doxorubicin Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D004317 Doxorubicin carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D004317 Doxorubicin carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D004317 Doxorubicin Doxorubicin results in increased expression of OLR1 mRNAincreases expression 16055083
D004317 Doxorubicin Doxorubicin results in increased expression of OLR1 proteinincreases expression 16055083
D004317 Doxorubicin OLR1 protein results in increased susceptibility to Doxorubicinincreases response to substance 16055083
D004317 Doxorubicin Razoxane inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D004317 Doxorubicin Razoxane inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [Lipids results in increased expression of OLR1]decreases reaction|increases expression 16891912
D006861 Hydrogen Peroxide Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D006861 Hydrogen Peroxide Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D006861 Hydrogen Peroxide carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D006861 Hydrogen Peroxide carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of OLR1 mRNAincreases expression 16055083
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of OLR1 proteinincreases expression 16055083
D006861 Hydrogen Peroxide Razoxane inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D006861 Hydrogen Peroxide Razoxane inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D008055 Lipids 3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1]decreases reaction|increases expression 16891912
D008055 Lipids Drugs, Chinese Herbal inhibits the reaction [Lipids results in increased expression of OLR1]decreases reaction|increases expression 16891912
D008055 Lipids Quercetin inhibits the reaction [Lipids results in increased expression of OLR1]decreases reaction|increases expression 16891912
D010972 Platelet Activating Factor Platelet Activating Factor results in increased expression of OLR1 mRNAincreases expression 16386258
C025299 polyphenols polyphenols results in decreased expression of OLR1 mRNAdecreases expression 16293270
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of OLR1 mRNAaffects cotreatment|increases expression 17639512
D011794 Quercetin Quercetin inhibits the reaction [Lipids results in increased expression of OLR1]decreases reaction|increases expression 16891912
D011794 Quercetin Quercetin affects the expression of OLR1 mRNAaffects expression 18178720
D011929 Razoxane Razoxane inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D011929 Razoxane Razoxane inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
D011929 Razoxane Razoxane inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]decreases reaction|increases expression 16055083
D011929 Razoxane Razoxane inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein]decreases reaction|increases expression 16055083
C089730 rosiglitazone rosiglitazone results in increased expression of OLR1 mRNAincreases expression 16982809
D014212 Tretinoin Tretinoin results in increased expression of OLR1 mRNAincreases expression 17034753
D014801 Vitamin A Vitamin A results in increased expression of OLR1 mRNAincreases expression 17034753
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000015 Abnormalities, Multiple Vitamin A 4.6610992263
MESH:D000038 Abscess Drugs, Chinese Herbal 6.0815043669
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3719825857 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 4.3717418594
MESH:D000419 Albuminuria Doxorubicin 4.3221441931
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8019621015
MESH:D000740 Anemia Drugs, Chinese Herbal 8.9515504547 17963324
MESH:D000740 Anemia Vitamin A 8.9516960172
MESH:D000743 Anemia, Hemolytic Quercetin 4.0317084956
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6016960172
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 5.1911477813
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.7315043669
MESH:D001169 Arthritis, Experimental Tretinoin 2.9416412693
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.5319655406
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 4.9816456186
MESH:D001249 Asthma Vitamin A 4.9816732791
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7515336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.1819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.4916206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.4916197459 16206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4714601052
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 4.629881647
MESH:D002545 Brain Ischemia beta Carotene 4.8616157235
MESH:D001932 Brain Neoplasms Doxorubicin 3.6117150277
MESH:D001943 Breast Neoplasms alitretinoin 2.8616344269
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.8616443354
MESH:D001943 Breast Neoplasms Calcitriol 2.8611237771
MESH:D001943 Breast Neoplasms Doxorubicin 2.8615634643 18234424 16264153 15993339 15136595 15994142 16935488 17983394 18695136 15567936 16595493 18382427 19526202 16826403 15939500 18628466 16096432 16115903 11325840 17426702 15692762 15668708 16322301 17369602
MESH:D001943 Breast Neoplasms Quercetin 2.8618628248
MESH:D001943 Breast Neoplasms Tretinoin 2.8616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.2616813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.2617377406 17426644
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1211589617
MESH:D002105 Cadmium Poisoning Quercetin 5.3116962696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5816051944
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.473084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.4715553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.4717876044 16234567 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.4719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.471917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7317234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6419014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0516201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9212490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 10.3117015178
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.3111237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.316189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.3116051514 16096774
MESH:D006332 Cardiomegaly Quercetin 3.1919794523
MESH:D009202 Cardiomyopathies marker/mechanism 16055083
MESH:D009202 Cardiomyopathies carvedilol 12.6215476868
MESH:D009202 Cardiomyopathies Doxorubicin 12.6217974986 16364871 16612575 16269455 15811867 16731534 17519947 17131338 17382496 15505089 17308081 16651473 16455267 18627295 16242529 17329180 15476868 16952015 17007740 16109756 15792986 16278810 17351982 17924179 17928571
MESH:D009202 Cardiomyopathies Razoxane 12.6217519947
MESH:D002311 Cardiomyopathy, Dilated carvedilol 6.3219477965
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.3216243910 17334414
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3616936243
MESH:D002386 Cataract Acetaminophen 11.7110977129
MESH:D002386 Cataract Am 580 11.7117460283
MESH:D002386 Cataract Tretinoin 11.7117460283
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 3.7218226522
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.2416153327
MESH:D002779 Cholestasis Vitamin A 4.1316175620
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Tretinoin 6.039407595
MESH:D002972 Cleft Palate Vitamin A 6.0316054864
MESH:D003092 Colitis Am 580 9.1817035595
MESH:D003092 Colitis Tretinoin 9.1817035595
MESH:D003110 Colonic Neoplasms polyphenols 5.7916293270
MESH:D003110 Colonic Neoplasms Quercetin 5.7919056647 11134977 17148506 15741050 19440933 16640504 17191121
MESH:D003110 Colonic Neoplasms Vitamin A 5.7916267017 17219422
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3820501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.3818259882 18802399
MESH:D015179 Colorectal Neoplasms Quercetin 3.3818852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.2417323712
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8310525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.839664655 9211117 9125849 16925845 17551590 9142499 10589399 14991402 8800419 9224671
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.8310992263
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.1819747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8815213294
MESH:D003920 Diabetes Mellitus rosiglitazone 4.1117446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5519496084
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4416506275
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.8316506275
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.8312642470
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.3211461765 19164858 16227642 19370779 14725611 14550746 15968718 15619225 17906064 16485898 19416960 16109766 11421492 16393943 12705907 11739529 19085960 11743745 10915739 19420014 19739265 17562736 12958197 11529661 14986274 12392966 16177239 19923254 12153990 10774834 11834606 2444490 18713872 12594235 16781746 12540782 17522070 16081117 10663392 11287661 18071297
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 11.3211287661
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.3217416283
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 11.3215027814
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.3219370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Doxorubicin 3.5018602426
MESH:D015352 Dry Eye Syndromes Vitamin A 5.5716146918
MESH:C538011 Eales disease Ascorbic Acid 12.639068938
MESH:C538011 Eales disease Vitamin A 12.639068938
MESH:D004480 Ectromelia Vitamin A 5.5916054864
MESH:D004487 Edema rosiglitazone 3.4512083418
MESH:D004489 Edema, Cardiac Tretinoin 4.2418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.7215138306
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.1017359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1016569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9318037988
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2512903497
MESH:D005124 Eye Abnormalities Tretinoin 3.4116938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 7.4715073043
MESH:D005234 Fatty Liver rosiglitazone 7.4719196556
MESH:D005327 Fetal Resorption Vitamin A 5.1316054864
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3619069698
MESH:D005355 Fibrosis Quercetin 8.2219474275
MESH:D005355 Fibrosis Tretinoin 8.2217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0416904648
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005909 Glioblastoma Doxorubicin 11.1017150277
MESH:D005909 Glioblastoma Quercetin 11.1019804834
MESH:D005909 Glioblastoma Tretinoin 11.1017312396
MESH:D005910 Glioma Quercetin 2.9717643826
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.3415692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.7616080930
MESH:D006330 Heart Defects, Congenital Tretinoin 10.7614991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 10.7610992263 16080930
MESH:D006331 Heart Diseases Doxorubicin 7.8916707910 18006777 18674790 16244372 16330681 17875725 16244371 14766674 12587719 16495754 17888722 16879835 16144979
MESH:D006331 Heart Diseases Razoxane 7.8917875725
MESH:D006333 Heart Failure Doxorubicin 3.2017481944
MESH:D006390 Hemangioendothelioma Razoxane 6.1715380572
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7015692506
MESH:D006505 Hepatitis Drugs, Chinese Herbal 4.5918339527
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 6.1916863852 16490937
MESH:D006548 Hernia, Diaphragmatic Vitamin A 6.1915707848 16863852 16292552 17436238 16877224 16490937
MESH:D015658 HIV Infections beta Carotene 6.8916960176
MESH:D015658 HIV Infections Vitamin A 6.8916960176
MESH:D006679 HIV Seropositivity Vitamin A 5.3717209195
MESH:D006689 Hodgkin Disease Doxorubicin 3.2217606976 15147373 18501091
MESH:D006930 Hyperalgesia Acetaminophen 12.0616870215
MESH:D006930 Hyperalgesia rosiglitazone 12.0612083418
MESH:D006930 Hyperalgesia Tretinoin 12.0616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia Quercetin 3.8318262572 11834736
MESH:D006973 Hypertension carvedilol 5.8616640825
MESH:D006973 Hypertension Quercetin 5.8618356687
MESH:D006986 Hypervitaminosis A Vitamin A 5.9416054864
MESH:D007249 Inflammation polyphenols 5.2316366677
MESH:D007249 Inflammation rosiglitazone 5.2312083418
MESH:D007251 Influenza, Human Quercetin 4.2816624496
MESH:D007333 Insulin Resistance rosiglitazone 3.6516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.5915955940
MESH:D007569 Jaw Abnormalities Tretinoin 3.6917551590 15992940
MESH:D007627 Keloid Quercetin 4.7317086741
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.4116144296
MESH:D007674 Kidney Diseases Acetaminophen 9.3812587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 9.3816775033 15699352 15369732
MESH:D007674 Kidney Diseases Quercetin 9.3816962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.4416707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.4416518626
MESH:D007938 Leukemia arsenic trioxide 9.8615070760
MESH:D007938 Leukemia Quercetin 9.8617468513
MESH:D007938 Leukemia Tretinoin 9.8617143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.8315802533
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7916482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7417050201 19850784 16467208 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1419225113 16891316 16330433 16823087 15336539 11468182 11161223 19035177 12018890 19642359 16331271 16112521 17869043 19075265 17712046 17649720 15622746 17107899 16966277 15213294 9834237 17217047 15748426 12679006 12712474
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1419642359 17368321 16788101 16140955 17294898 17107899 17712046 19029980 19075265 15748426 16935935 12679006 16823087 16331271 16891316 17339181 19035177 19225113 9834237 16766008 17301526 17217047 17361223 17506722 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1316882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.979224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.9716054864
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 7.0317163593
MESH:D008103 Liver Cirrhosis Vitamin A 7.0316256175
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.3816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 8.3817629604 15864749 12632512 15763062 18567088 15744066 15383259 17036385 18606216 18237412 15754396 15818738 16610055 17348192 17666798 15339415 15641146 15849816 18371158 17881167
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.3812741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.3815980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3818397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 8.3816248980
MESH:D008107 Liver Diseases Acetaminophen 9.0019784758 16611625 19460945 12587719 19014921 11587558 16610002 12969438
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 9.0017207593
MESH:D008107 Liver Diseases polyphenols 9.0016698588
MESH:D008107 Liver Diseases Vitamin A 9.0016175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.9316762690
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 7.1914682389
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 7.1918339527
MESH:D008113 Liver Neoplasms Quercetin 7.1918980244
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 21.5720377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 21.5718544905
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 21.5717113696
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 21.5716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 21.5719519916
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 21.5717113696
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1815213294
MESH:D008171 Lung Diseases Acetylcysteine 11.8112815614
MESH:D008171 Lung Diseases Ascorbic Acid 11.8116863852
MESH:D008171 Lung Diseases Vitamin A 11.8116863852
MESH:D008175 Lung Neoplasms alitretinoin 10.2616413115
MESH:D008175 Lung Neoplasms arsenic trioxide 10.2611798837 19825857
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.2616401635
MESH:D008175 Lung Neoplasms beta Carotene 10.2616401635
MESH:D008175 Lung Neoplasms Doxorubicin 10.266189445 17418594
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 10.2618339527
MESH:D008175 Lung Neoplasms Quercetin 10.2616280456
MESH:D008223 Lymphoma Doxorubicin 3.3016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.4315458769
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 9.4314758024
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.4316827153
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Doxorubicin 3.3016827129
MESH:D008545 Melanoma Tretinoin 3.3016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008654 Mesothelioma Doxorubicin 2.9717638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1917261469
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2915792986
MESH:D052016 Mucositis Doxorubicin 4.5617415656
MESH:D009101 Multiple Myeloma arsenic trioxide 7.1019549372 19417148 11468182 14977855 15949261
MESH:D009101 Multiple Myeloma Vitamin A 7.1016374440
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9616105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9617596541
MESH:D009203 Myocardial Infarction marker/mechanism
MESH:D009203 Myocardial Infarction Doxorubicin 5.7119429709 15857846
MESH:D009203 Myocardial Infarction Quercetin 5.7119595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6219207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7416624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 5.9514720322
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9518259882
MESH:D009369 Neoplasms alitretinoin 11.0616946489
MESH:D009369 Neoplasms beta Carotene 11.0617051425
MESH:D009369 Neoplasms Quercetin 11.0615185748
MESH:D009369 Neoplasms Tretinoin 11.0616946489 16594593
MESH:D009401 Nephrosis Doxorubicin 4.5416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8116889571 15640375
MESH:D009421 Nervous System Malformations Tretinoin 3.569125849
MESH:D009436 Neural Tube Defects Acetylcysteine 16.2219446573
MESH:D009436 Neural Tube Defects arsenic trioxide 16.2210525206
MESH:D009436 Neural Tube Defects Tretinoin 16.229142499
MESH:D009436 Neural Tube Defects Vitamin A 16.2217400914
MESH:D009447 Neuroblastoma Doxorubicin 3.1515555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.1517929310
MESH:D009765 Obesity Ascorbic Acid 3.0917217161
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 9.7616548355
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.7619495926
MESH:D012516 Osteosarcoma Doxorubicin 3.9315930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5119769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Quercetin 7.5119005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5116936753
MESH:D010146 Pain Acetaminophen 5.9816870215
MESH:D010146 Pain Tretinoin 5.9816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.1915580305
MESH:D010190 Pancreatic Neoplasms Quercetin 8.1916965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1915976015
MESH:D010212 Papilloma Hydrogen Peroxide 3.8612065085
MESH:D010235 Paraganglioma arsenic trioxide 3.9519927285
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9317638057
MESH:D017499 Porokeratosis alitretinoin 5.7716144296
MESH:D011230 Precancerous Conditions Quercetin 3.7919056647
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5515572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1619131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1616289102 18247401 16644109 15754350 12479363
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1615897917 15749863 16868541 18437689 16888761 16729912
MESH:D011471 Prostatic Neoplasms Quercetin 2.1614715546 17292933
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.1014606601
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 3.6316987627
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.7315043669
MESH:D051437 Renal Insufficiency Doxorubicin 4.0017922066
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.3112210543
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.5716877224
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2516849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916283617 16116481
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 5.0415015336
MESH:D012509 Sarcoma Doxorubicin 3.7916767912 15675481 15625365 17710206 17203757 18313854
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.5516646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.5516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5617846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.3116862918
MESH:D012871 Skin Diseases Ascorbic Acid 5.3418709164
MESH:D012871 Skin Diseases Vitamin A 5.3418709164
MESH:D012878 Skin Neoplasms Doxorubicin 8.9815692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.9812065085
MESH:D012878 Skin Neoplasms Tretinoin 8.9816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3417203757 16767912 15625365
MESH:D013272 Stomach Diseases beta Carotene 4.8617638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4017007042
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 3.4018339527
MESH:D013274 Stomach Neoplasms Tretinoin 3.4017261132
MESH:D013276 Stomach Ulcer Acetylcysteine 11.2317918041
MESH:D013276 Stomach Ulcer Ascorbic Acid 11.2318726076
MESH:D013276 Stomach Ulcer beta Carotene 11.2312500499
MESH:D020521 Stroke Ascorbic Acid 4.1116517955 16403987
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.5317634840
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0217997062
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.0419014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.0417909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 11.0417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7315213294
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.9112845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.9117653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.9116720314
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0017334414 17638931 17678736 16364871
MESH:D014802 Vitamin A Deficiency Vitamin A 5.0616960172 16146918 16175781
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.3516313111
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04145 Phagosome
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31920
    • No data
    Releated disease ID Related disease Name
    PA443994Edema
    Releated drug ID Related drug Name
    PA452631thiazolidinediones
    PA450952phospholipids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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