AutismKB 2.0

Annotation Detail for OMG


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Basic Information Top
Gene Symbol:OMG ( OMGP )
Gene Full Name: oligodendrocyte myelin glycoprotein
Band: 17q11.2
Quick LinksEntrez ID:4974; OMIM: 164345; Uniprot ID:OMGP_HUMAN; ENSEMBL ID: ENSG00000126861; HGNC ID: 8135
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200103p75(NTR)-mediated signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006780 bisphenol A bisphenol A results in increased expression of OMG mRNAincreases expression 18180321
D002117 Calcitriol Calcitriol results in increased expression of OMG mRNAincreases expression 12875902
D011794 Quercetin Quercetin results in increased expression of OMG mRNAincreases expression 15309432
D013629 Tamoxifen Tamoxifen results in decreased expression of OMG mRNAdecreases expression 19457130
D014212 Tretinoin Tretinoin results in increased expression of OMG mRNAincreases expression 12875902
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000743 Anemia, Hemolytic Quercetin 4.6117084956
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001260 Ataxia Telangiectasia Quercetin 5.5215336622
MESH:D001327 Autoimmune Diseases Quercetin 4.8919761891
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001862 Bone Resorption bisphenol A 4.2411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4417123778
MESH:D001943 Breast Neoplasms Calcitriol 2.4411237771
MESH:D001943 Breast Neoplasms Quercetin 2.4418628248
MESH:D001943 Breast Neoplasms Tamoxifen 2.4419142967 18425577 19155303 20859285 18629630 19288272 19244106 19410462 11161223 19189212 20135344 19189210 20544844 19200415 18815881 20390343 17893378 21138602 18351453 17242785 19103187 16873071 19115204 21152245 15668708 19066611 16202921 16818667 18855134 19487384 19011961 17049068 15565566 18997820 18821012 20005174 19221464 19084267 17261762 18984771 17440819 20065188 19289846 19059307 16273361
MESH:D001943 Breast Neoplasms Tretinoin 2.4416443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002105 Cadmium Poisoning Quercetin 6.1616962696
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.9012508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.9016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.901917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.5317123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.4417234771
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0511237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D006332 Cardiomegaly Quercetin 3.4919794523
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D003110 Colonic Neoplasms Quercetin 2.4611134977 17191121 19056647 17148506 16640504 19440933 15741050
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839142499 16925845 9664655 10589399 9211117 17551590 14991402 8800419 9224671 9125849
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0419496084
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.7215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.7219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.1719155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 8.1716569247
MESH:D005124 Eye Abnormalities Tretinoin 3.8416938888 9664655
MESH:D005234 Fatty Liver Tamoxifen 3.5314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Quercetin 10.6319474275
MESH:D005355 Fibrosis Tretinoin 10.6317994277
MESH:D005909 Glioblastoma Quercetin 7.9819804834
MESH:D005909 Glioblastoma Tretinoin 7.9817312396
MESH:D005910 Glioma Quercetin 3.1717643826
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006943 Hyperglycemia Quercetin 4.3811834736 18262572
MESH:D006973 Hypertension Quercetin 2.9618356687
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007251 Influenza, Human Quercetin 5.1216624496
MESH:D007333 Insulin Resistance bisphenol A 3.5016393666
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007627 Keloid Quercetin 5.4417086741
MESH:D007674 Kidney Diseases Quercetin 3.2816962696
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3518625569
MESH:D007938 Leukemia Quercetin 6.9717468513
MESH:D007938 Leukemia Tretinoin 6.9717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3715748426 16788101 17217047 17506722 17107899 16140955 16823087 16935935 9834237 17301526 19642359 19029980 17294898 19225113 17339181 17368321 17649720 12679006 16891316 19075265 17712046 17361223 16766008 16331271 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008064 Lipidoses Tamoxifen 3.4017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.7512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7518397230 16248980
MESH:D008113 Liver Neoplasms Quercetin 5.1118980244
MESH:D008113 Liver Neoplasms Tamoxifen 5.1116684651
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.2619519916
MESH:D008175 Lung Neoplasms Quercetin 2.6816280456
MESH:D008175 Lung Neoplasms Tamoxifen 2.6818625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8311731420 16827153 19196723 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tamoxifen 3.4419393235 12393984
MESH:D008545 Melanoma Tretinoin 3.4416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009203 Myocardial Infarction Quercetin 3.1119595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.0719207477
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Quercetin 5.7315185748
MESH:D009369 Neoplasms Tretinoin 5.7316946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119200415 19189210 19196722
MESH:D009421 Nervous System Malformations bisphenol A 11.3016427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 11.309125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D020078 Neurogenic Inflammation Quercetin 4.7717929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.6219495926
MESH:D010049 Ovarian Diseases bisphenol A 5.5311985600
MESH:D010051 Ovarian Neoplasms Quercetin 5.2919005980
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2916936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Quercetin 5.7516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.7515976015
MESH:D011230 Precancerous Conditions Quercetin 4.3119056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.4910548101
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.3215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0716740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0716289102 15754350 16644109 18247401 12479363
MESH:D011471 Prostatic Neoplasms Quercetin 2.0717292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D011629 Puberty, Precocious bisphenol A 5.3310548101
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012554 Schistosomiasis japonica Quercetin 6.1616862918
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013088 Spermatocele Tamoxifen 4.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.5216045194 16684133
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.6116720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6117572228 16712894 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014591 Uterine Diseases bisphenol A 5.6214652134
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
Pathway ID Pathway Name
REACT:11061 Signalling by NGF
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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