AutismKB 2.0

Annotation Detail for SCAPER


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SCAPER ( FLJ31533,FLJ31953,FLJ46212,KIAA1454,ZNF291,Zfp291 )
Gene Full Name: S-phase cyclin A-associated protein in the ER
Band: 15q24.3
Quick LinksEntrez ID:49855; OMIM: 611611; Uniprot ID:SCAPE_HUMAN; ENSEMBL ID: ENSG00000140386; HGNC ID: 13081
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SCAPER mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SCAPER proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCAPER mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SCAPER mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of SCAPER mRNAincreases expression 20739668
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SCAPER mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SCAPER mRNAaffects cotreatment|decreases expression 20360939
D002117 Calcitriol Calcitriol results in increased expression of SCAPER mRNAincreases expression 16002434
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of SCAPER mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of SCAPER mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SCAPER mRNAdecreases expression 18175754
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of SCAPER mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of SCAPER mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.896695378
MESH:D000236 Adenoma Diethylnitrosamine 6.896695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0917162532 19061943 16434500 19052882 18056438 17620307
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 1.9917123778
MESH:D001943 Breast Neoplasms Calcitriol 1.9911237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9917474063
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7117138121 19701751 16328049 19539802 16540662 18978308 19383236 19394651 19052882 18785209 16830150 16807293 20727157 20524982 20514400 20935162 18506893 20084675 18788625 19822196 17978847 11831363 16569478 21159647 18056438 20007298 10672840 19519916 17162532 16698587 19418558 18393292 18665156 3581430 16935385 16779866 19919837 19335982 16288022 17428255 20432363 18971187 20101231 10737359 19208518 17761372 20512989 3084413 18691550 17173139 20214788 18494052 16878318 19107877 19171122 16681979 17055752 16502159 18210153
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8111237771
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.017505956 17174075 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3315131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3315131321
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3220387270 21071580
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9216080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance bisphenol A 7.8516393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.8514714311
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7210783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.7215369732
MESH:D007674 Kidney Diseases Vitamin E 6.7212488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0816766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918522880 19638242 18665156 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.117678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.112125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1120195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1119073162 19294768 9163691 20101389 19427195 18977376 19690152 19996281 10737359 19850985 20492335 19638242 21047994 18754104 21167192 18978307 16942905 19551842 19642983 20434301 19426721 20583210 19256749 12112319 21071580 20501860 2862719 18644402 19833225 19812893 20405173 12771043 20137499 19255062 15885732 2422723 19254457 20452335 15175105 19499222 18648771 19090486 20118626 21278145
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.362876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.368603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.363124819 19009564 18282651 19004024 18093689 19519916 9362446 21159647 16842330 16267830 19126423 18544905 18164116 18775883 17942915 17174075 18308698 17854601 18253720 18079962 19539802 2563599
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9718816296 18520028 20064080 17053015 20869020 20464547 6695378 18569708 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9720970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Vitamin E 4.9711062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009421 Nervous System Malformations bisphenol A 4.1311399458 16427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1410548101
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8616740699
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8616644109 16289102 15754350 12479363 18247401
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8618760546
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8615084515
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.362093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved