AutismKB 2.0

Annotation Detail for OPRL1


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Basic Information Top
Gene Symbol:OPRL1 ( KOR-3,MGC34578,NOCIR,OOR,ORL1 )
Gene Full Name: opiate receptor-like 1
Band: 20q13.33
Quick LinksEntrez ID:4987; OMIM: 602548; Uniprot ID:OPRX_HUMAN; ENSEMBL ID: ENSG00000125510; HGNC ID: 8155
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway IDPathway Name
500405Peptide ligand-binding receptors
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017487 2-mercaptoacetate OPRL1 exon affects the susceptibility to 2-mercaptoacetateaffects response to substance 10802031
D000082 Acetaminophen Acetaminophen affects the expression of OPRL1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of OPRL1 mRNAaffects expression 16483693
D001285 Atropine Atropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]affects binding|decreases reaction|increases activity 12007927
D002047 Buprenorphine Buprenorphine binds to and results in increased activity of OPRL1 proteinaffects binding|increases activity 10998549
D002211 Capsaicin OPRL1 protein promotes the reaction [nociceptin (1-13) amide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]decreases reaction|increases reaction|increases secretion 17640294
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of OPRL1 mRNAdecreases expression 15620428
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNAaffects cotreatment|increases expression 16931933
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of OPRL1 mRNAdecreases expression 15620428
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of OPRL1 mRNAincreases expression 12655037
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of OPRL1 geneincreases mutagenesis 16495775
C402921 J 113397 J 113397 binds to and affects the activity of OPRL1 proteinaffects activity|affects binding 12007927
C402921 J 113397 J 113397 inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]affects binding|decreases reaction|increases activity 12007927
D007657 Ketone Bodies Ketone Bodies results in decreased expression of OPRL1 mRNAdecreases expression 16807920
C439964 nociceptin (1-13) amide nociceptin (1-13) amide affects the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]affects binding|affects reaction|increases activity 12007927
C439964 nociceptin (1-13) amide OPRL1 protein promotes the reaction [nociceptin (1-13) amide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]decreases reaction|increases reaction|increases secretion 17640294
C025256 nonylphenol nonylphenol results in decreased expression of OPRL1 mRNAdecreases expression 15620428
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of OPRL1 mRNAdecreases expression 16221955
C025643 vinclozolin vinclozolin affects the expression of OPRL1 mRNAaffects expression 19015723
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 9.2118926900
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 9.216734493
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.799612607
MESH:D058186 Acute Kidney Injury Capsaicin 4.5018460982
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma Ethylnitrosourea 3.696695378
MESH:D000505 Alopecia Capsaicin 4.6917569567
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001919 Bradycardia Capsaicin 5.0218207255
MESH:D001927 Brain Diseases Ethylnitrosourea 4.8414991843
MESH:D002545 Brain Ischemia Capsaicin 4.9419211983
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.2516436596 16357521 18412241 15144691 16651633
MESH:D001943 Breast Neoplasms Atropine 4.0012762645
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.373084413
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.6916003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.9617160924
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8416105132 11677210 17681005 17110522 15861022 17333356 16919318
MESH:D003371 Cough Capsaicin 5.1510350223
MESH:D003456 Cryptorchidism Dibutyl Phthalate 11.5616037377
MESH:D003456 Cryptorchidism vinclozolin 11.5614966744
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.0316882537
MESH:D003967 Diarrhea Atropine 4.9110867622
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.5810915739 12705907 16227642 12594235 15619225 18713872 16081117 18071297 19739265 10663392 19923254 11743745 11421492 17906064 11287661 11739529 17522070 11529661 2444490 16393943 14986274 19420014 11834606 19370779 19416960 19164858 16781746 12540782 14725611 10774834 11461765 12153990 15968718 16485898 19085960 12392966 16109766 17562736 12958197 14550746 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Lamivudine 8.6815040536
MESH:D004362 Drug Toxicity Zidovudine 8.6815040536
MESH:D004381 Duodenal Ulcer Atropine 9.9511595415
MESH:D004381 Duodenal Ulcer Capsaicin 9.9511535926 10671773
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.9618357618
MESH:D004487 Edema perfluorooctanoic acid 3.5417259670 12083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004935 Esophageal Diseases Capsaicin 5.6719566590
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8315345470
MESH:D005234 Fatty Liver Zidovudine 7.8318299183
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D005909 Glioblastoma Capsaicin 7.7318405923
MESH:D005909 Glioblastoma Ethylnitrosourea 7.7316436596
MESH:D005910 Glioma Ethylnitrosourea 3.4716651633 18412241 16357521
MESH:D006356 Heartburn Capsaicin 5.6719566590
MESH:D006402 Hematologic Diseases Zidovudine 4.6712579204
MESH:D006509 Hepatitis B Lamivudine 5.0617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.0615274664 16476009 12044531 15631357 15309715
MESH:D006529 Hepatomegaly perfluorooctanoic acid 4.063609246
MESH:D006556 Heroin Dependence Buprenorphine 7.0612756210
MESH:D015658 HIV Infections Lamivudine 6.9817530837 20032539 11141242 9296927
MESH:D015658 HIV Infections Zidovudine 6.9811698656 11363243 20032539 11141242 17358032
MESH:D006930 Hyperalgesia Acetaminophen 13.0316870215
MESH:D006930 Hyperalgesia Capsaicin 13.0317434803 17043245
MESH:D006930 Hyperalgesia perfluorooctanoic acid 13.0312083418
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5617937319
MESH:D007248 Infertility, Male vinclozolin 6.5616467254
MESH:D007249 Inflammation Capsaicin 5.6916956363
MESH:D007249 Inflammation perfluorooctanoic acid 5.6912083418
MESH:D007674 Kidney Diseases Acetaminophen 2.1712587719 15629191
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 7.8917379185
MESH:D007680 Kidney Neoplasms Zidovudine 7.8912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3720370541
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 12.828812269
MESH:D007984 Leydig Cell Tumor vinclozolin 12.8216417039
MESH:D008107 Liver Diseases Acetaminophen 4.2916611625 11587558 12969438 16610002 19460945 12587719 19014921 19784758
MESH:D008107 Liver Diseases Capsaicin 4.2916956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 5.2311940454
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 5.2314757943 18709148
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.0217703301 16019985 6695378 16271038
MESH:D008175 Lung Neoplasms Zidovudine 3.0218800350
MESH:D008223 Lymphoma Ethylnitrosourea 3.9115790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.0115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.4818041768 10767621 10838139
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008579 Meningioma Ethylnitrosourea 5.9617943659
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8117358032
MESH:D009101 Multiple Myeloma Capsaicin 4.1217505005
MESH:D009216 Myopia Atropine 4.9612601066
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.3616707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.3817160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D020078 Neurogenic Inflammation Capsaicin 5.0517961222
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.919802331
MESH:D009765 Obesity Capsaicin 3.3819056576
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.9617160924
MESH:D010146 Pain Acetaminophen 6.8716870215
MESH:D010146 Pain Capsaicin 6.8718987195 16996476 17084039 17434803 17043245 19081190
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D011041 Poisoning Atropine 5.1118072136 17849254
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.8117132714
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8119015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D015427 Reperfusion Injury Capsaicin 3.9419211983 18460982
MESH:D012206 Rhabdomyolysis Lamivudine 5.509296927
MESH:D012640 Seizures Atropine 4.3517157343 11218047 12660363
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms Zidovudine 2.4717696246
MESH:D013276 Stomach Ulcer Atropine 4.7011595415
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.7017997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.1215790496
MESH:D014202 Tremor Atropine 5.7017594079
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.7212579204
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31944
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01497 agonist Etorphine Hypnotics and Sedatives;Narcotics;Analgesics, Opioid
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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