AutismKB 2.0

Annotation Detail for OPRM1


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Basic Information Top
Gene Symbol:OPRM1 ( KIAA0403,LMOR,MOR,MOR1,OPRM )
Gene Full Name: opioid receptor, mu 1
Band: 6q25.2
Quick LinksEntrez ID:4988; OMIM: 600018; Uniprot ID:OPRM_HUMAN; ENSEMBL ID: ENSG00000112038; HGNC ID: 8156
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
Opioid Signalling
Pathway IDPathway Name
200018IL4-mediated signaling events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway IDPathway Name
500833Opioid Signalling
Related Diseases/Disorders Top
No data
No data
Desease Name
alcohol dependence drug dependence
naltrexone response in alcohol-dependent patients
CHEMDEPENDENCY
pain response
alcohol craving
Heroin Dependence
epilepsy
cortisol response to opioid blockade
PHARMACOGENOMIC
alcoholism
Pain
pain tolerance, and opioid addiction
alcohol abuse
nicotine
NEUROLOGICAL
alcohol
pain intenity
alcohol dependency
METABOLIC
addiction to heroin
obesity
substance dependence
dyskinesias, levodopa-induced
substance abuse
diabetes, type 2
body mass smoking behavior
heroin abuse
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017487 2-mercaptoacetate OPRM1 exon affects the susceptibility to 2-mercaptoacetateaffects response to substance 10802031
C523979 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol binds to and results in increased activity of OPRM1 proteinaffects binding|increases activity 17656655
C523979 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol binds to OPRM1 proteinaffects binding 17656655
D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 proteinaffects binding 11991257
D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]affects reaction|decreases reaction|increases abundance 12031848
D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]affects reaction|decreases reaction|increases transport 12031848
D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]decreases reaction|increases transport 12031848
D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]decreases reaction|increases transport 12031848
D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 proteinaffects binding|increases activity 10988119
16954126
D000643 Ammonium Chloride Ammonium Chloride affects the expression of OPRM1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine affects the expression of OPRM1 mRNAaffects expression 12629526
D001464 Barium Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]affects reaction|decreases reaction|increases transport 12031848
D001464 Barium Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]decreases reaction|increases transport 12031848
D001464 Barium omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]decreases reaction|increases transport 12031848
D001464 Barium OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]affects reaction|increases transport 12031848
D001464 Barium OPRM1 protein affects the transport of Bariumaffects transport 12031848
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of OPRM1 mRNAdecreases expression 19428949
D002047 Buprenorphine Buprenorphine binds to and results in increased activity of OPRM1 proteinaffects binding|increases activity 16010532
D002047 Buprenorphine Buprenorphine binds to and results in increased activity of OPRM1 proteinaffects binding|increases activity 15966752
D020001 1-Butanol [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein]affects binding|affects reaction|decreases reaction|increases activity|increases chemical synthesis 14720217
D002395 Catecholamines Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]affects reaction|decreases reaction|increases abundance 12031848
D002395 Catecholamines OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]affects reaction|increases abundance 12031848
C009862 connective tissue-activating peptide connective tissue-activating peptide binds to and results in decreased activity of OPRM1 proteinaffects binding|decreases activity 16954126
C014347 decitabine decitabine affects the methylation of OPRM1 promoteraffects methylation 17452465
C014347 decitabine [decitabine affects the methylation of OPRM1 promoter] which affects the expression of OPRM1 mRNAaffects expression|affects methylation 17452465
D004041 Dietary Fats Dietary Fats results in increased expression of OPRM1 mRNAincreases expression 18721800
D004399 Dynorphins Dynorphins analog binds to OPRM1 proteinaffects binding 11270320
C105293 endomorphin 1 endomorphin 1 binds to and results in increased activity of OPRM1 proteinaffects binding|increases activity 10988119
C105294 endomorphin 2 endomorphin 2 binds to and results in increased activity of OPRM1 proteinaffects binding|increases activity 10988119
D000431 Ethanol OPRM1 protein affects the susceptibility to Ethanolaffects response to substance 17339526
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of OPRM1 geneincreases mutagenesis 16495775
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of OPRM1 mRNAincreases expression 18977430
D009020 Morphine Morphine binds to and results in increased activity of OPRM1 proteinaffects binding|increases activity 17656655
D009020 Morphine [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNAaffects cotreatment|increases expression 15979727
C034643 naloxonazine naloxonazine binds to and results in decreased activity of OPRM1 proteinaffects binding|decreases activity 10802031
D009270 Naloxone Naloxone binds to and results in decreased activity of OPRM1 proteinaffects binding|decreases activity 10988119
D009271 Naltrexone Naltrexone binds to and results in decreased activity of OPRM1 proteinaffects binding|decreases activity 19657356
C025256 nonylphenol nonylphenol results in increased expression of OPRM1 mRNAincreases expression 15620428
D020866 omega-Conotoxin GVIA omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]decreases reaction|increases transport 12031848
D010712 Phosphatidic Acids [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein]affects binding|affects reaction|decreases reaction|increases activity|increases chemical synthesis 14720217
D010852 Picrotoxin Picrotoxin results in increased expression of OPRM1 mRNAincreases expression 15170462
D011188 Potassium Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]affects reaction|decreases reaction|increases abundance 12031848
D011188 Potassium Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]affects reaction|decreases reaction|increases transport 12031848
D011188 Potassium OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]affects reaction|increases abundance 12031848
D011188 Potassium OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]affects reaction|increases transport 12031848
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of OPRM1 mRNAdecreases expression 19465110
C012589 trichostatin A trichostatin A affects the expression of OPRM1 mRNAaffects expression 17452465
D014635 Valproic Acid Valproic Acid affects the expression of OPRM1 mRNAaffects expression 17452465
D014801 Vitamin A Vitamin A affects the expression of OPRM1 mRNAaffects expression 17289162
D014801 Vitamin A Vitamin A affects the expression of OPRM1 proteinaffects expression 17289162
D015054 Zymosan Zymosan results in increased expression of OPRM1 mRNAincreases expression 18977430
D015054 Zymosan [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNAaffects cotreatment|increases expression 15979727
D015054 Zymosan Zymosan results in increased expression of OPRM1 mRNAincreases expression 15979727
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.3817676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.3815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 9.4119490988
MESH:D000015 Abnormalities, Multiple Vitamin A 9.4110992263
MESH:D000138 Acidosis Ammonium Chloride 9.3818287403
MESH:D000138 Acidosis Ethanol 9.3811192467
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.7311850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9020127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.326695378
MESH:D000236 Adenoma Ethylnitrosourea 6.326695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0516835633
MESH:D000303 Adrenal Cortex Diseases Catecholamines 6.996895166
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9915451040 15451039
MESH:D000437 Alcoholism Naltrexone 5.8018552399 18482155
MESH:D000550 Amblyopia Valproic Acid 4.9017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 13.4011748828
MESH:D000740 Anemia Vitamin A 13.4016960172
MESH:D000740 Anemia Zymosan 13.4018664788
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.5216960172
MESH:D000853 Anophthalmos Ethanol 4.5015513904
MESH:D001008 Anxiety Disorders Ethanol 8.1411141031
MESH:D001008 Anxiety Disorders Valproic Acid 8.1417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7619183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.5715238619
MESH:D001169 Arthritis, Experimental Zymosan 3.9216872482 15944321 15142272 17659584 15188379
MESH:D001249 Asthma Vitamin A 3.2516732791
MESH:D001259 Ataxia 1-Butanol 5.287820390
MESH:D001321 Autistic Disorder Naltrexone 2.958570775 9028057 19393386
MESH:D001321 Autistic Disorder Valproic Acid 2.9517507914 15238991 18316065 17688650 20603192 16609825 18396377 18775368 19232924 19460635 18177632 18940202 18985861 18558336 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 2.9120046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.338888407
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6014991843
MESH:D002545 Brain Ischemia Morphine 4.8219211983
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0118412241 16436596 16357521 16651633 15144691
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8920146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.8918320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 1.8920435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.2717377406 17426644
MESH:D002056 Burns Ethanol 4.3316374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.3615289165 18788625 15763234
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3420419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.3419215824
MESH:D006332 Cardiomegaly Ethanol 6.2419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.5116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.6517160924
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1416153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis Vitamin A 4.0616175620
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 9.1615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.1615340226 16354765 8697196 12621046 15668235
MESH:D002972 Cleft Palate Vitamin A 9.1616054864
MESH:D003110 Colonic Neoplasms decitabine 3.9417616700
MESH:D003110 Colonic Neoplasms Vitamin A 3.9417219422 16267017
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 5.1415513904 10194807 15451039 11873399 15451040 19302082 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.1416575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin A 5.1410992263
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4116506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D003967 Diarrhea Morphine 4.222540324
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.6811566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.6820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.6819641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.4816146918
MESH:D050171 Dyslipidemias Dietary Fats 3.2218367378
MESH:D004421 Dystonia Valproic Acid 3.751851702
MESH:C538011 Eales disease Vitamin A 5.299068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.6518357618
MESH:D004480 Ectromelia Vitamin A 5.4916054864
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1511000095 12711302
MESH:D004487 Edema Zymosan 6.157907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5715322242 18230668 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.9219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.9219294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7410568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0715821434 17637181 15328337
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.843659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7720417680 18234410
MESH:D004832 Epilepsy, Absence Naloxone 8.596254150
MESH:D004832 Epilepsy, Absence Valproic Acid 8.597562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.987750514
OMIM:600669 EPILEPSY, IDIOPATHIC GENERALIZED marker/mechanism
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.743659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3016530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.3016704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver Dietary Fats 11.5719004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver Ethanol 11.5716409862 19236843 18620774
MESH:D005234 Fatty Liver Valproic Acid 11.5714986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9715513904 10194807 15451040 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.828888407 18558336
MESH:D005327 Fetal Resorption Vitamin A 5.0316054864
MESH:D005334 Fever Lipopolysaccharides 3.739205823 11852909
MESH:D005355 Fibrosis Dietary Fats 7.5718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5720067830
MESH:D005756 Gastritis Ethanol 4.3615046732
MESH:D005909 Glioblastoma Ethylnitrosourea 7.0216436596
MESH:D005909 Glioblastoma trichostatin A 7.0218801729
MESH:D005910 Glioma Ethylnitrosourea 3.3618412241 16651633 16357521
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.2719215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.2220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2211294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin A 10.2216080930 10992263
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1016366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006501 Hepatic Encephalopathy marker/mechanism 11991257
MESH:D006505 Hepatitis Zymosan 4.3919110552
MESH:D006526 Hepatitis C marker/mechanism 17299060
MESH:D006526 Hepatitis C Enkephalin, Ala(2)-MePhe(4)-Gly(5)- 5.8617299060
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5815340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.5015707848 16863852 16490937 16877224 16292552 17436238
MESH:D006556 Heroin Dependence Buprenorphine 6.7612756210
MESH:D015658 HIV Infections Vitamin A 3.6516960176
MESH:D006679 HIV Seropositivity Vitamin A 5.2717209195
MESH:D006849 Hydrocephalus Valproic Acid 4.5417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116354765 16959395 15340226 18606429 8697196
MESH:D006930 Hyperalgesia Ethanol 3.4718783367
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3021332399
MESH:D006946 Hyperinsulinism Naltrexone 5.9616901484
MESH:D006949 Hyperlipidemias Dietary Fats 3.3221332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7818850075 18670907
MESH:D006986 Hypervitaminosis A Vitamin A 5.8416054864
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.5319822448
MESH:D007248 Infertility, Male decitabine 2.9917581917
MESH:D007249 Inflammation Dietary Fats 10.6020412841
MESH:D007249 Inflammation Lipopolysaccharides 10.6012878042 17255318 17237260 17963957 9205823
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.6012878042 12200463
MESH:D007249 Inflammation Zymosan 10.608014878 11289658
MESH:D007333 Insulin Resistance Dietary Fats 2.8911836018 18457598
MESH:D019586 Intracranial Hypertension Vitamin A 5.4915955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3317255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5117553498
MESH:D007569 Jaw Abnormalities Ethanol 9.1515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.6717379185
MESH:D007859 Learning Disorders Ethanol 3.8915451040
MESH:D007938 Leukemia decitabine 2.9119235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 3.7117236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.8719010910 19387464 17679729 18704418 18460780 18206229
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.8718206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.8717596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1318055864
MESH:D007970 Leukopenia Lipopolysaccharides 4.3715821434
MESH:D017880 Limb Deformities, Congenital Ethanol 7.9217676605
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.9216054864
MESH:D008103 Liver Cirrhosis Dietary Fats 10.1818296743
MESH:D008103 Liver Cirrhosis Ethanol 10.1815289165
MESH:D008103 Liver Cirrhosis Vitamin A 10.1816256175
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7718295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.6918166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.6912878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 4.6916248980
MESH:D008107 Liver Diseases Vitamin A 3.0716175620
MESH:D008108 Liver Diseases, Alcoholic Ethanol 10.4917347304 17207112
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 10.4916762690
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 3.9121137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 3.9116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4812151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 5.4817113696
MESH:D008171 Lung Diseases Vitamin A 3.8816863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9317228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.6921114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.2318569708 20869020 17053015 18520028 20464547 20135361 6695378 18816296 20064080
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.2317703301 16271038 6695378 16019985
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2311884234 19555203
MESH:D008223 Lymphoma decitabine 7.1419470736
MESH:D008223 Lymphoma Ethylnitrosourea 7.1415790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.7315375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.3110838139 18041768 10767621
MESH:D008545 Melanoma decitabine 3.5317785578 16505122
MESH:D008545 Melanoma trichostatin A 3.5316505122
MESH:D008569 Memory Disorders Ethanol 3.8815451040 18411066
MESH:D008579 Meningioma Ethylnitrosourea 5.6517943659
MESH:D008881 Migraine Disorders Valproic Acid 2.9618803445 18765137
MESH:D009041 Motion Sickness Dextroamphetamine 5.191613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9416381670
MESH:D009101 Multiple Myeloma decitabine 11.0318172295
MESH:D009101 Multiple Myeloma trichostatin A 11.0318172295
MESH:D009101 Multiple Myeloma Vitamin A 11.0316374440
MESH:D009102 Multiple Organ Failure Zymosan 4.9115241586 15213630 18160304 12879239 10479408 10890648 15259001 17724436 12130978 15834315
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.748888407
MESH:D009190 Myelodysplastic Syndromes decitabine 6.8818608210 19157545 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.8817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5611141357
MESH:D009369 Neoplasms decitabine 4.5619470736 19116145 17925555
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.0916707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9114600291
MESH:D009436 Neural Tube Defects Valproic Acid 6.9716359493 8888407
MESH:D009436 Neural Tube Defects Vitamin A 6.9717400914
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.0916003739 17160924 16651423
MESH:D009765 Obesity Dietary Fats 2.2120132043 17217161 20518802 21332399 11836018 16723640 18674790 18457598 19632207
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.6517160924
MESH:D010051 Ovarian Neoplasms decitabine 4.9119331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 4.9119331143
MESH:D010146 Pain 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol 7.4017656655
MESH:D010146 Pain Morphine 7.4016273134 15275824 15215642 18699797 6776300 20225289
MESH:D010190 Pancreatic Neoplasms decitabine 8.1119294695
MESH:D010190 Pancreatic Neoplasms Ethanol 8.1112384795
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.1119294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010538 Peritonitis Zymosan 4.5718557954 17826846 19088179 19641140 14761945 15259001 15979727 18977430 11985352 18760300 17371808
MESH:D011014 Pneumonia Lipopolysaccharides 4.2312224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3811399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.3820603192
MESH:D055728 Primary Myelofibrosis decitabine 11.3617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.3617616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5817292933
MESH:D011471 Prostatic Neoplasms trichostatin A 3.5818798265 19789329
MESH:D011537 Pruritus Naloxone 10.0115861022
MESH:D011537 Pruritus Naltrexone 10.0115861022 19657356
MESH:D019310 Pseudolymphoma Valproic Acid 4.2112752131 11422049
MESH:D015427 Reperfusion Injury Morphine 3.9719211983
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.4816877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012208 Rhabdomyosarcoma decitabine 9.9819155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.9819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012640 Seizures Ethanol 8.829754883
MESH:D012640 Seizures Picrotoxin 8.828635557 8954991
MESH:D012640 Seizures Valproic Acid 8.821511512 11738929 17978042 16876388 15475178 14763951 11044598 3137016
MESH:D018805 Sepsis Zymosan 4.3811441115
MESH:D012871 Skin Diseases Vitamin A 3.2718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.9519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.9516192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.252093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.2519037991
MESH:D013274 Stomach Neoplasms Ethanol 3.2518456281
MESH:D013276 Stomach Ulcer Ethanol 3.259562338 16755016 17189318 17918041 9211565 11906479
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.979754883
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8815821434
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.8315790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms decitabine 3.0917967635
MESH:D014178 Translocation, Genetic Valproic Acid 4.9017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.193119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.6917053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 4.6917616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.328888407
MESH:D014604 Uveal Neoplasms decitabine 4.5817785578
MESH:D014605 Uveitis Zymosan 5.0711006244
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D014802 Vitamin A Deficiency Vitamin A 4.9816175781 16146918 16960172
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D015430 Weight Gain Dietary Fats 3.4716723640
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31945
    • Releated gene ID Related gene Name
    PA31945OPRM1
    Releated disease ID Related disease Name
    PA445371Poisoning
    PA445208Pain
    PA443334Pain Insensitivity, Congenital
    PA445876Tobacco Use Disorder
    PA446879Alcohol-Related Disorders
    PA443309Alcoholism
    PA443355Anemia, Sickle Cell
    PA446876Substance-Related Disorders
    PA444460Heroin Dependence
    Releated drug ID Related drug Name
    PA450741oxycodone
    PA449088codeine
    PA448073ethanol
    PA450626nicotine
    PA450588naltrexone
    PA450401methadone
    PA450403methamphetamine
    PA450550morphine
    PA450586naloxone
    PA452618opioids
    PA452633morphine-6-glucoronide
    PA448084alfentanil
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00193 agonist Tramadol Narcotics;Analgesics;Analgesics, Opioid
    DB00295 agonist Paregorique Narcotics;Analgesics;Opiate Agonists;Analgesics, Opioid
    DB00318 partial agonist Co-codamol Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00327 agonist Hydromorphone Narcotics;Analgesics, Opioid
    DB00333 agonist Methadone Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00497 agonist Tylox Narcotics;Opiate Agonists;Antitussives;Analgesics, Opioid
    DB00504 partial agonist Levallorphan Analgesic Antagonists;Morphine Antidotes;Antinarcotic Agents;Narcotic Antagonists
    DB00611 partial antagonist Butorphanol Narcotics;Analgesics, Opioid;Antitussive Agents;Narcotic Antagonists
    DB00647 agonist Propoxyphene Narcotics;Analgesics;Antitussives;Analgesics, Opioid
    DB00652 antagonist Talwin Narcotics;Adjuvants, Anesthesia;Analgesics, Opioid;Narcotic Antagonists
    DB00704 antagonist Naltrexone Anti-craving Agents;Narcotic Antagonists;Depressants;Alcohol Antagonists;Opiate Antagonists
    DB00708 agonist Sufentanil Narcotics;Adjuvants, Anesthesia;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid
    DB00802 agonist Alfentanil Narcotics;Analgesics;Anesthetics;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid
    DB00813 agonist Innovar Injection Narcotics;Analgesics;Adjuvants, Anesthesia;Anesthetics;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB00836 agonist Loperamide Antidiarrheals
    DB00844 antagonist Nalbuphine Narcotics;Analgesics, Opioid;Narcotic Antagonists
    DB00854 agonist Levorphanol Narcotics;Analgesics, Opioid
    DB00899 agonist Remifentanil Hypnotics and Sedatives;Anesthetics, Intravenous;Analgesics, Opioid
    DB00904 other/unknown Ondansetron Anti-anxiety Agents;Antiemetics;Antipsychotics;Serotonin Antagonists;Antipruritics;Antipsychotic Agents
    DB00913 agonist Anileridine Narcotics;Analgesics;Opiate Agonists
    DB00921 partial agonist Buprenorphine Narcotics;Analgesics, Opioid;Narcotic Antagonists
    DB00956 agonist Tussaminic DH Pediatric Syrup Narcotics;Analgesics;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB01081 agonist Lomotil Narcotics;Analgesics, Opioid;Antidiarrheals;Antiperistaltic
    DB01183 antagonist Naloxone Antinarcotic Agents;Narcotic Antagonists;Depressants;Opiate Antagonists
    DB01192 agonist Oxymorphone Narcotics;Analgesics;Adjuvants, Anesthesia;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB01209 agonist Dezocine Analgesics, Opioid
    DB01227 agonist Levomethadyl Acetate Narcotics;Analgesics, Opioid
    DB01433 agonist Methadyl Acetate Narcotics;Analgesics, Opioid
    DB01439 agonist 3-Methylthiofentanyl Analgesics, Opioid
    DB01444 agonist Dimethylthiambutene Analgesics, Opioid
    DB01452 agonist Heroin Narcotics;Analgesics;Analgesics, Opioid
    DB01466 agonist Ethylmorphine Narcotics;Analgesics, Opioid;Antitussive Agents
    DB01497 agonist Etorphine Hypnotics and Sedatives;Narcotics;Analgesics, Opioid
    DB01535 agonist Carfentanil Analgesics, Opioid
    DB01548 antagonist Diprenorphine Narcotic Antagonists
    DB01565 agonist Dihydromorphine Narcotics;Analgesics, Opioid
    DB01571 agonist 3-Methylfentanyl Hypnotics and Sedatives;Analgesics
    DB06274 antagonist Alvimopan Opiate Antagonists
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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