AutismKB 2.0

Annotation Detail for SLC22A18


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Basic Information Top
Gene Symbol:SLC22A18 ( BWR1A,BWSCR1A,DKFZp667A184,HET,IMPT1,ITM,ORCTL2,SLC22A1L,TSSC5,p45-BWR1A )
Gene Full Name: solute carrier family 22, member 18
Band: 11p15.4
Quick LinksEntrez ID:5002; OMIM: 602631; Uniprot ID:S22AI_HUMAN; ENSEMBL ID: ENSG00000110628; HGNC ID: 10964
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500360Organic cation transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
1944Breast cancer
Desease Name
HEMATOLOGICAL
serum bilirubin levels
CHEMDEPENDENCY
alcohol dependence
Desease Name
Serum calcium
Serum bilirubin levels
Desease Name
Rhabdomyosarcoma
Lung cancer
Breast cancer
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in increased expression of SLC22A18 mRNAincreases expression 14583596
D000082 Acetaminophen Acetaminophen affects the expression of SLC22A18 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SLC22A18 mRNAdecreases expression 15725085
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SLC22A18 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC22A18 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SLC22A18 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine affects the expression of SLC22A18 mRNAaffects expression 20106945
D005047 Etoposide SLC22A18 protein affects the susceptibility to Etoposideaffects response to substance 16217747
C056933 fumonisin B1 fumonisin B1 results in increased expression of SLC22A18 mRNAincreases expression 16221962
D017239 Paclitaxel SLC22A18 protein results in decreased susceptibility to Paclitaxeldecreases response to substance 16734730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC22A18 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of SLC22A18 mRNAincreases expression 19244175
D014303 Trinitrotoluene Trinitrotoluene affects the expression of SLC22A18 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.307525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4111798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2719483382
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.3014601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.6515867366
MESH:D001943 Breast Neoplasms marker/mechanism
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0817474063 20146248
MESH:D001943 Breast Neoplasms Etoposide 2.0816322251
MESH:D001943 Breast Neoplasms Paclitaxel 2.0816115903 18323546 18234424 16273361 11325840 16244791 18223236 15136595
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7015073043 16217749 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.7016313753
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Trinitrotoluene 7.6614694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7412371664
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7320501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.7318802399
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.4715095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003490 Cyanosis Trinitrotoluene 5.0318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2514550746 16177239 11739529 19739265 18713872 12594235 12153990 11287661 12540782 12392966 10663392 11421492 19416960 12705907 10774834 16081117 11529661 17562736 16485898 17906064 16781746 17522070 14725611 16227642 11743745 11834606 11461765 19164858 16393943 2444490 12958197 14986274 18071297 16109766 15619225 19420014 10915739 19085960 15968718 19370779 19923254
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 9.2516221962
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2515131321
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.2518551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.5820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.5812903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.5816530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.5816481741
MESH:D005234 Fatty Liver arsenic trioxide 13.5515073043
MESH:D005234 Fatty Liver Cyclosporine 13.5519224547
MESH:D005234 Fatty Liver pirinixic acid 13.5519236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.2412168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6920471113
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006529 Hepatomegaly fumonisin B1 15.3016221962
MESH:D006529 Hepatomegaly pirinixic acid 15.3016221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Trinitrotoluene 15.3015817613
MESH:D006561 Herpes Simplex Etoposide 4.6810809021
MESH:D006689 Hodgkin Disease Etoposide 3.9418180244 16135485 16200630 17606976 15147373
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007248 Infertility, Male Trinitrotoluene 3.7312150543
MESH:D007251 Influenza, Human Selenium 4.3316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 18776723 10903974
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8012371664
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1520471514 16968895 17050201 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2619075265 11468182 12679006 15213294 15622746 17217047 17869043 9834237 19225113 17712046 11161223 12712474 15748426 15336539 16331271 12018890 16966277 16823087 19035177 17649720 17107899 19642359 16112521 16330433 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008080 Liposarcoma Paclitaxel 4.9117353645
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 12969438 19014921 16611625 12587719 19784758 11587558 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5621137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.5620007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.7820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms marker/mechanism
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4311798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4320064080 17053015 18816296 18569708 20869020 18520028 6695378 20464547 20135361
MESH:D008223 Lymphoma Etoposide 3.9812556972 12854902
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.1614749477
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008545 Melanoma Paclitaxel 2.6016342250 12040289 12025231
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009101 Multiple Myeloma arsenic trioxide 7.6914977855 11468182 15949261 19549372 19417148
MESH:D009101 Multiple Myeloma Paclitaxel 7.6914749477
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis Trinitrotoluene 4.8818551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.2815867366
MESH:D009369 Neoplasms 4-phenylbutyric acid 8.5919116145
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5911141357
MESH:D009369 Neoplasms pirinixic acid 8.5917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1710525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.4117852074 14694615 12819281
MESH:D010014 Osteolysis Paclitaxel 5.1015867366
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1916624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.1911161223
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6715580305
MESH:D010190 Pancreatic Neoplasms Etoposide 5.6719003803
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1217292933
MESH:D011471 Prostatic Neoplasms Etoposide 2.1217172428
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.1217172428 16356831 16729912 17136230
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D018233 Rhabdomyosarcoma, Embryonal marker/mechanism
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.7716646077
MESH:D012512 Sarcoma, Ewing's Etoposide 10.7714601052
MESH:D012640 Seizures Trinitrotoluene 3.4918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8310029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.838532709
MESH:D013163 Splenomegaly Trinitrotoluene 5.3015817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4720155912 2093021
MESH:D013274 Stomach Neoplasms Paclitaxel 3.4718506536 18396642
MESH:D024801 Tauopathies Paclitaxel 4.9316930453
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1519014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.1412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1417053015
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35846
    • Releated gene ID Related gene Name
    PA35846SLC22A18
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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