AutismKB 2.0

Annotation Detail for ORM1


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Basic Information Top
Gene Symbol:ORM1 ( AGP-A,AGP1,ORM )
Gene Full Name: orosomucoid 1
Band: 9q32
Quick LinksEntrez ID:5004; OMIM: 138600; Uniprot ID:A1AG1_HUMAN; ENSEMBL ID: ENSG00000229314; HGNC ID: 8498
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C054400 11-(dansylamino)undecanoic acid 11-(dansylamino)undecanoic acid binds to ORM1 proteinaffects binding 16461020
C027132 1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate binds to ORM1 proteinaffects binding 16461020
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ORM1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ORM1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of ORM1 mRNAincreases expression 15120968
15800402
D000082 Acetaminophen Acetaminophen results in increased expression of ORM1 proteinincreases expression 15800402
C430898 AGN 194204 AGN 194204 results in decreased expression of ORM1 mRNAdecreases expression 15302862
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ORM1 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in decreased expression of ORM1 mRNAdecreases expression 16648578
D019328 Buthionine Sulfoximine Buthionine Sulfoximine results in increased expression of ORM1 mRNAincreases expression 11841787
D019328 Buthionine Sulfoximine Buthionine Sulfoximine results in increased expression of ORM1 proteinincreases expression 11841787
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ORM1 mRNAincreases expression 16239168
15816358
D002251 Carbon Tetrachloride Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of ORM1 mRNA]decreases reaction|increases expression 15816358
D003345 Corticosterone Corticosterone results in increased expression of ORM1 mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine affects the expression of ORM1 mRNAaffects expression 20106945
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of ORM1 mRNAdecreases expression 16940010
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D004041 Dietary Fats Dietary Fats results in decreased expression of ORM1 mRNAdecreases expression 18042831
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of ORM1 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ORM1 mRNAdecreases expression 16940010
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ORM1 mRNAincreases expression 16926038
17108234
D005419 Flavonoids Flavonoids results in increased expression of ORM1 mRNAincreases expression 18035473
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of ORM1 mRNAincreases expression 15159207
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ORM1 mRNAincreases expression 11779202
D008727 Methotrexate Methotrexate results in increased expression of ORM1 mRNAincreases expression 15120968
D015741 Metribolone Metribolone results in increased expression of ORM1 mRNAincreases expression 16751804
D009582 Nitrofurantoin Nitrofurantoin results in increased expression of ORM1 mRNAincreases expression 11841787
D009582 Nitrofurantoin Nitrofurantoin results in increased expression of ORM1 proteinincreases expression 11841787
C042763 olive oil olive oil analog affects the expression of ORM1 mRNAaffects expression 17349074
D010126 Ozone Ozone results in increased expression of ORM1 mRNAincreases expression 17095637
C041786 palm oil palm oil results in decreased expression of ORM1 mRNAdecreases expression 18042831
C018637 phorone phorone results in increased expression of ORM1 mRNAincreases expression 11841787
C018637 phorone phorone results in increased expression of ORM1 proteinincreases expression 11841787
C006253 pirinixic acid pirinixic acid results in decreased expression of ORM1 mRNAdecreases expression 15302862
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ORM1 mRNA]decreases expression|increases reaction 20059764
D011374 Progesterone Progesterone binds to ORM1 proteinaffects binding 16901474
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of ORM1 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of ORM1 mRNAdecreases expression 17404688
D011374 Progesterone Progesterone affects the expression of ORM1 mRNAaffects expression 17251523
D015232 Dinoprostone Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of ORM1 mRNA]decreases reaction|increases expression 15816358
C488333 Ro 65-7199 Ro 65-7199 affects the expression of ORM1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of ORM1 mRNAaffects expression 14610520
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D012643 Selenium [Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of ORM1 mRNAaffects cotreatment|increases expression 11444866
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ORM1 mRNAincreases expression 17035482
16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ORM1 mRNAdecreases expression 11752688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ORM1 mRNAincreases expression 16960034
C423915 TO-901317 TO-901317 results in decreased expression of ORM1 mRNAdecreases expression 15302862
D014303 Trinitrotoluene Trinitrotoluene affects the expression of ORM1 mRNAaffects expression 21346803
D014425 Turpentine Turpentine results in increased expression of ORM1 mRNAincreases expression 11779202
D014638 Vanadates Vanadates results in increased expression of ORM1 proteinincreases expression 17874149
D014810 Vitamin E [Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of ORM1 mRNAaffects cotreatment|increases expression 11444866
D014812 Vitamin K Vitamin K affects the expression of ORM1 mRNAaffects expression 16636460
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 11.9112039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.9111752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 11.917525203
MESH:D000138 Acidosis Ammonium Chloride 3.1318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.7318653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.7318653653
MESH:D000210 Acute-Phase Reaction Turpentine 5.7416044259
MESH:D000230 Adenocarcinoma Estradiol 3.8011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.503712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.4716835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.6517942926
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.3417302879
MESH:D000544 Alzheimer Disease Ozone 4.1115513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.1119621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5811748828
MESH:D000799 Angioedema Acetaminophen 3.4010982225
MESH:D001014 Aortic Aneurysm Dinoprostone 5.2010231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 5.2110388637
MESH:D001161 Arteriosclerosis Dietary Fats 8.5115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.5111256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.4717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4715885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.5817286800
MESH:D001172 Arthritis, Rheumatoid Ozone 4.5815570426
MESH:D001249 Asthma Ozone 2.5017854713 16373670
MESH:D050197 Atherosclerosis olive oil 4.0816216721
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001477 Bartter Syndrome Dinoprostone 5.3215976003
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.581440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4815746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9017868700
MESH:D001930 Brain Injuries Progesterone 3.8415665606 15845082 15380490
MESH:D001943 Breast Neoplasms bexarotene 3.4416344269 16818667
MESH:D001943 Breast Neoplasms Dietary Fats 3.4420435547
MESH:D001943 Breast Neoplasms Estradiol 3.4418497071 14630087 19861407 17289903 12948864 17018787 16675129 17261762
MESH:D001943 Breast Neoplasms Hexachlorobenzene 3.4412709520 15061365
MESH:D001943 Breast Neoplasms Methotrexate 3.4416978400
MESH:D001943 Breast Neoplasms Progesterone 3.4417614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.4420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3418315731 16777450 15516495 14754758 18417511 19059883 17626835
MESH:D002100 Cachexia Ozone 4.3116183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.5416124888 16227642 16050911 16097048 15700767 15673190 16192424 3786805 10355542 18705752 15721981 16011737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.5416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.007296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.003084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.0018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.0016924424
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 8.0016328049
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0716247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.467296757
MESH:D002295 Carcinoma, Transitional Cell Nitrofurantoin 5.0815028437
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1218850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases olive oil 4.2416216721
MESH:D002386 Cataract Acetaminophen 6.6410977129
MESH:D002386 Cataract Trinitrotoluene 6.6415817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 13.617505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.6112371664
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 13.6116192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.6118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.5819486331 9022650
MESH:D002779 Cholestasis Cyclosporine 16.5819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.5817333356 17110522 17681005 15861022 16105132 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 16.5819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9116354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Selenium 3.3617936198
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4215824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.0714669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.0715095906
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.9817728286
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.989562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 4.9819769572
MESH:D003490 Cyanosis Trinitrotoluene 4.5018551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.8719747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.688156756 8970840 18759878 11298694 14531868 2524372 12868966 11906362
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 5.6812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.102952479 3621924
MESH:D003882 Dermatomyositis Methotrexate 4.7120191521
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9417446233
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.5516616286
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.0912642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0717187935
MESH:D003967 Diarrhea Dexamethasone 7.217237001
MESH:D003967 Diarrhea Dinoprostone 7.2111488427 7237001 10446763
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 16.426679447 9653073 9328219 18289764 18692083 6482804 1440618 11289319 16192314 9022650 18648102 8291058 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.4212392966 16081117 11529661 17562736 19739265 15968718 10774834 11421492 11287661 16485898 19923254 12594235 2444490 16227642 12540782 18071297 14550746 14725611 15619225 12705907 12153990 11834606 10663392 19085960 19420014 14986274 11739529 17906064 10915739 19370779 11743745 16109766 18713872 19164858 12958197 16393943 17522070 16177239 19416960 16781746 11461765
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.4210092053 7440962 6884620 21278145 6623471 4309450 7120509 15968718 15998439 10915739 16227642 7179309 3732212 19085960 3786805 2869522 19336974 16177239 11566570 15027814 9327722 17522070
MESH:D056486 Drug-Induced Liver Injury Nitrofurantoin 16.428373174 1551546 19789166 19214031
MESH:D056486 Drug-Induced Liver Injury Selenium 16.4215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.4220420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 16.4218551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1418367378
MESH:C538011 Eales disease Vitamin E 4.269068938
MESH:D004485 Eczema Dexamethasone 4.0512438553
MESH:D004487 Edema Dexamethasone 13.3419703484
MESH:D004487 Edema pirinixic acid 13.3412083418
MESH:D004487 Edema rosiglitazone 13.3412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.6817692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.7011473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 7.6916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.699294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.9715328337 17637181 15821434
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 1.993581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.7312631006 16239168 15959796 61145 12795759 19224547 16045604 17595544
MESH:D005234 Fatty Liver Cyclosporine 25.7319224547
MESH:D005234 Fatty Liver Dietary Fats 25.7317967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.7315345470
MESH:D005234 Fatty Liver pirinixic acid 25.7320131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 25.7319196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0411858732
MESH:D005334 Fever Dinoprostone 8.3916997862 11852909
MESH:D005334 Fever Lipopolysaccharides 8.399205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.586705139
MESH:D005355 Fibrosis Carbon Tetrachloride 17.6818705752
MESH:D005355 Fibrosis Cyclosporine 17.6812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 17.6818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.6820067830
MESH:D005756 Gastritis Acetaminophen 3.2416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.798708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.647505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.7316518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7810048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 5.7816080930
MESH:D006333 Heart Failure pirinixic acid 6.0420558911
MESH:D006333 Heart Failure Selenium 6.0417162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9915720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.876705139
MESH:D006505 Hepatitis Carbon Tetrachloride 7.8719900420 19110552
MESH:D006521 Hepatitis, Chronic Nitrofurantoin 5.5314986274
MESH:D006529 Hepatomegaly pirinixic acid 12.0519176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.0512621046 15340226 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 12.0515817613
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.427520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.4216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5915709030
MESH:D019584 Hot Flashes Estradiol 8.5917088409
MESH:D019584 Hot Flashes Vitamin E 8.5914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6118606429 16354765 15340226 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 11.3116870215
MESH:D006930 Hyperalgesia Dinoprostone 11.3116793879
MESH:D006930 Hyperalgesia rosiglitazone 11.3112083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2121332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2221332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5215034207
MESH:D006973 Hypertension Cyclosporine 7.5410903974
MESH:D006973 Hypertension Dexamethasone 7.5417042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.5418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6715338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916569931 16945680
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.0018306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9317937319
MESH:D007248 Infertility, Male Trinitrotoluene 5.9312150543
MESH:D007249 Inflammation Dexamethasone 20.628960868 11099482
MESH:D007249 Inflammation Dietary Fats 20.6220412841
MESH:D007249 Inflammation Flavonoids 20.6217296493
MESH:D007249 Inflammation Lipopolysaccharides 20.6212878042 17255318 17963957 9205823 17237260
MESH:D007249 Inflammation Progesterone 20.6215869954
MESH:D007249 Inflammation rosiglitazone 20.6212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.6212200463 12878042
MESH:D007251 Influenza, Human Selenium 9.5016624496
MESH:D007251 Influenza, Human Vitamin E 9.5016624496
MESH:D007333 Insulin Resistance Dietary Fats 15.3118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 15.3116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 15.3116306350
MESH:D007333 Insulin Resistance rosiglitazone 15.3116306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2317255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.589022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9516580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.0018306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0015604871
MESH:D007674 Kidney Diseases Acetaminophen 12.3012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.3018776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 12.3015618244
MESH:D007674 Kidney Diseases Vitamin E 12.3012488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.5016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.356582329
MESH:D007680 Kidney Neoplasms Cyclosporine 10.3512371664
MESH:D007680 Kidney Neoplasms Estradiol 10.3515610895
MESH:D007805 Language Development Disorders Methotrexate 4.709562676
MESH:D007970 Leukopenia Lipopolysaccharides 4.2715821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.7016239168 16943688 11408273 11903743 17334410 17174718 17157831 16221502 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 9.7018296743
MESH:D008103 Liver Cirrhosis Methotrexate 9.7014986274
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.3817976157 15931870 12667390 12546737 12666154 17922224 17525996 12632512 18429990 15362042 10355542 18395914 18481824 16248980 15057751 18376398 12586293 18412020 14716496 18210741 15650968 17714472 15893842 18251166 17721639 17631135 12958196 15338365 14716833 16136751 18277467 18006644 18205269 17869086 12445421 18187930 18472332 15818738 14724832 17766677 17944888 17481882 15876570 18054572 16033810 12649538 15052691 15925388 18317297 12898905 18420326 12632514 15996030 16638106 18263696 17708605 18418968 17805973 16097048 17557913 17823541 17698563 20821823 16192424 16011737 18472094 15959796 14620537 16116963 15673190 17640975 12389079 16015684 18339082 18166357 15123356 13678700 17761835 17565644 14512876 16027843 15370692 12609069 15730626 14748882 12445418 17900296 12741479 18395095 18156304 11481614 18279442 18705752
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.3816718785
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 14.3815816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.3814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 14.3812878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.3815474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 14.3815980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 14.3816169303
MESH:D008107 Liver Diseases Acetaminophen 8.4412587719 12969438 16611625 19014921 11587558 19784758 16610002 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.4416964402 15830285 16246199 17285989 15720792
MESH:D008107 Liver Diseases Dinoprostone 8.4415816358
MESH:D008107 Liver Diseases Nitrofurantoin 8.4414966256
MESH:D017093 Liver Failure therapeutic 18256743
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.1716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.2519294768
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 9.2518709148
MESH:D008113 Liver Neoplasms pirinixic acid 9.2515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.2516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.753712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.7512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 15.758603461
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 15.751423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.7512151625
MESH:D008171 Lung Diseases Nitrofurantoin 10.8914966256 9429087
MESH:D008171 Lung Diseases Ozone 10.8919066396 8266340
MESH:D008171 Lung Diseases Vitamin E 10.8916863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 10.6318516814
MESH:D017563 Lung Diseases, Interstitial Nitrofurantoin 10.6318516814
MESH:D055370 Lung Injury Lipopolysaccharides 13.0021114838
MESH:D055370 Lung Injury Nitrofurantoin 13.001313237
MESH:D055370 Lung Injury Ozone 13.0020417186
MESH:D008175 Lung Neoplasms bexarotene 5.9317849452
MESH:D008175 Lung Neoplasms Dexamethasone 5.9315824018 11195469
MESH:D008175 Lung Neoplasms Ozone 5.938597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.9319555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 5.9311062179
MESH:D008223 Lymphoma Methotrexate 3.6417352296
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 24.1715591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 24.1712807724
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 24.1716457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 24.1716891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 24.1711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 24.1716827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 24.1715318939
MESH:D020149 Manganese Poisoning Estradiol 4.0419453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1519513568
MESH:D008654 Mesothelioma Selenium 2.6115107826
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.0217261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3516801185
MESH:D008679 Metaplasia Ozone 4.6710496685
MESH:D020326 Migraine without Aura Dinoprostone 4.8511304026
MESH:D052016 Mucositis Methotrexate 4.8517488658
MESH:D009101 Multiple Myeloma Dexamethasone 3.2015867202 16118317 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.0916239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.299809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.9619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.1516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.1516411023
MESH:D009336 Necrosis Trinitrotoluene 4.3418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.293581430
MESH:D009369 Neoplasms pirinixic acid 1.7417405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3519196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3017289903
MESH:D009395 Nephritis, Interstitial Nitrofurantoin 5.3019214031
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9219348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.1111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.1114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.636679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5218514411
MESH:D009765 Obesity Dietary Fats 4.0217217161 19632207 21332399 18457598 20518802 18674790 11836018 20132043 16723640
MESH:D009765 Obesity pirinixic acid 4.0220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 7.984026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 7.9817852074 14694615 12819281
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.583988306
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.0318500342
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 4.6316397352
MESH:D010051 Ovarian Neoplasms Estradiol 4.3719401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.3716525653 17393432
MESH:D010146 Pain Acetaminophen 2.0616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.077296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010538 Peritonitis Ozone 3.7116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.036228378
MESH:D010954 Plasmacytoma Selenium 4.4515087411
MESH:D011014 Pneumonia Lipopolysaccharides 9.6711605937 12224865
MESH:D011014 Pneumonia Ozone 9.6718929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.749918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.7418163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.8612371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3021297632
MESH:D011248 Pregnancy Complications Nitrofurantoin 5.3819789166
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.7611399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5020887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.8516000583
MESH:D011471 Prostatic Neoplasms Estradiol 2.8516740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.8515084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.8916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 5.3616882103
MESH:D011565 Psoriasis Methotrexate 5.3617410198
MESH:D011654 Pulmonary Edema Nitrofurantoin 5.359429087
MESH:D011658 Pulmonary Fibrosis Nitrofurantoin 4.171551546
MESH:D051437 Renal Insufficiency Methotrexate 4.2917352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.1719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6218379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.053692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012640 Seizures Trinitrotoluene 3.1618551238
MESH:D012871 Skin Diseases Vitamin E 2.3218709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5016709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8515862959 16503802
MESH:D013163 Splenomegaly Trinitrotoluene 4.7815817613
MESH:D013272 Stomach Diseases Dexamethasone 3.8915472012
MESH:D013276 Stomach Ulcer Dexamethasone 6.6515138204
MESH:D013276 Stomach Ulcer olive oil 6.6516252198 12498302
MESH:D020521 Stroke Vitamin E 3.1816517955
MESH:D013576 Syndactyly Methotrexate 4.629562676
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.7915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.566582329 7505956 6587162 1399818 3712494
MESH:D013978 Tibial Fractures Estradiol 4.2519048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.108074119
MESH:D001749 Urinary Bladder Neoplasms Nitrofurantoin 5.1015028437
MESH:D014552 Urinary Tract Infections Nitrofurantoin 6.141551546
MESH:D014581 Urticaria Acetaminophen 2.5810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8914692618
MESH:D014605 Uveitis Cyclosporine 10.301336536
MESH:D014605 Uveitis Dexamethasone 10.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
MESH:D015430 Weight Gain Dietary Fats 3.3816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0017120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA260
    • No data
    Releated disease ID Related disease Name
    PA447230HIV
    Releated drug ID Related drug Name
    PA449373disopyramide
    PA449969imipramine
    PA451906warfarin
    PA449441efavirenz
    PA449977indinavir
    PA450264lopinavir
    PA450606nelfinavir
    PA451260ritonavir
    PA452621antineoplastic agents
    Drug Bank Top
    No data
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00280 other/unknown Disopyramide Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00321 - Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00334 - Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00454 - Meperidine Narcotics;Analgesics;Adjuvants, Anesthesia;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB00457 - Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
    DB00458 - Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00540 - Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00543 - Amoxapine Adrenergic Uptake Inhibitors;Dopamine Antagonists;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation;Neurotransmitter Uptake Inhibitors
    DB00571 - Propranolol Anti-anxiety Agents;Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00590 - Doxazosin Antineoplastic Agents;Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents;Antihyperplasia Agents
    DB00656 - Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00682 - Warfarin Anticoagulants;Rodenticides;Coumarin and Indandione Derivatives
    DB00706 - Tamsulosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB00802 - Alfentanil Narcotics;Analgesics;Anesthetics;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid
    DB00908 - Quinidine Enzyme Inhibitors;Antiarrhythmic Agents;Antimalarials;Muscarinic Antagonists;Adrenergic alpha-Antagonists;Anti-Arrhythmia Agents
    DB00934 - Maprotiline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00946 - Phenprocoumon Anticoagulants
    DB01142 other/unknown Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01151 - Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01156 - Bupropion Dopamine Uptake Inhibitors;Antidepressive Agents;Antidepressive Agents, Second-Generation
    DB01232 - Saquinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB01359 other/unknown Penbutolol Antihypertensive Agents;Adrenergic beta-Antagonists
    DB01418 - Acenocoumarol Anticoagulants;Coumarin and Indandione Derivatives
    DB01426 - Ajmaline Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB01429 - Aprindine Anti-Arrhythmia Agents
    DB04821 - Nomifensine Dopamine Uptake Inhibitors

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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