AutismKB 2.0

Annotation Detail for OSM


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:OSM ( MGC20461 )
Gene Full Name: oncostatin M
Band: 22q12.2
Quick LinksEntrez ID:5008; OMIM: 165095; Uniprot ID:ONCM_HUMAN; ENSEMBL ID: ENSG00000099985; HGNC ID: 8506
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200015GMCSF-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1781Rheumatoid arthritis
1831Prostate cancer
1997Dental plaque
2066Lung cancer
2087Bacterial infection
2097Hyperlipidemia
2132Kaposi sarcoma
2214Malignant glioma
2220Dermatitis
2230Alopecia
2231Arthritis
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of OSM mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of OSM mRNAincreases expression 12705907
D000082 Acetaminophen IL6 protein affects the reaction [Acetaminophen results in increased expression of OSM mRNA]affects reaction|increases expression 12705907
D001151 Arsenic Arsenic results in increased expression of OSM mRNAincreases expression 18039032
C053541 bicalutamide bicalutamide inhibits the reaction [OSM protein results in increased activity of AR protein]decreases reaction|increases activity 12114440
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of OSM mRNAincreases expression 14999682
D002251 Carbon Tetrachloride IL6 protein affects the reaction [Carbon Tetrachloride results in increased expression of OSM mRNA]affects reaction|increases expression 14999682
D002251 Carbon Tetrachloride OSM protein affects the reaction [IL6 protein affects the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]]affects reaction|increases expression 14999682
D002251 Carbon Tetrachloride OSM protein affects the reaction [IL6 protein affects the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]]affects reaction|increases expression 14999682
D002251 Carbon Tetrachloride OSM protein affects the reaction [IL6 protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]affects reaction|increases phosphorylation 14999682
D003520 Cyclophosphamide Cyclophosphamide affects the expression of OSM mRNAaffects expression 12624490
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of OSM mRNAincreases expression 18678246
15743783
C014290 hydroxyflutamide OSM protein promotes the reaction [hydroxyflutamide binds to and results in increased activity of AR protein]affects binding|increases activity|increases reaction 12114440
D009151 Mustard Gas Mustard Gas results in increased expression of OSM mRNAincreases expression 18955075
C093973 PD 98059 PD 98059 inhibits the reaction [OSM protein results in increased activity of AR protein]decreases reaction|increases activity 12114440
D014212 Tretinoin [Tretinoin co-treated with OSM protein] results in increased expression of MMP13 mRNAaffects cotreatment|increases expression 16467367
D014212 Tretinoin [Tretinoin co-treated with OSM protein] results in increased expression of TIMP1 mRNAaffects cotreatment|increases expression 16467367
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.8310737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.276705139
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9112569548 16251483 18414634 16835338
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.8115014928
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Mustard Gas 5.1310378619
MESH:D001249 Asthma Tretinoin 5.1316456186
MESH:D050197 Atherosclerosis Arsenic 3.3412928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7816206674 16197459
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.4416978400 11325840 17388661 17020986 15136595 12006526 18234424 15093573 18323546
MESH:D001943 Breast Neoplasms Tretinoin 2.4416873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916227642 16097048 16192424 16124888 15721981 18705752 15700767 16011737 16050911 10355542 15673190 3786805
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6817687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.733581430 17761372 10737359 3084413 6705139
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.733084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.7316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.7318788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 11.7319701751
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.731917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1316152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6116201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.9515504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4618022660 16973168
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8216925845 14991402 10589399 9664655 17551590 9125849 9142499 8800419 9224671 9211117
MESH:D003556 Cystitis Cyclophosphamide 5.2518710439 18093676 18295254 18372110 18483878 12388444 17010015 15276878 10700343 11948286 17979934 16614059 16989017 18433785 12161096 12913760 16651033 10498854 16413132 15643279
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2110990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2618772604
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8918071297 10774834 11287661 18713872 17522070 12392966 11421492 19420014 15968718 19164858 11461765 17562736 19416960 12153990 16109766 10663392 10915739 11743745 12705907 16177239 19739265 15619225 16781746 16227642 16081117 19923254 14725611 11739529 17906064 12594235 2444490 19370779 12540782 14550746 12958197 16393943 14986274 11529661 19085960 16485898 11834606
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.897440962 3732212 19085960 7120509 4309450 15027814 21278145 10092053 9327722 7179309 16177239 6884620 2869522 10915739 16227642 15998439 15968718 6623471 17522070 3786805 19336974 11566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema Mustard Gas 3.4811428647 11428631 11402378 9260866
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004802 Eosinophilia Cyclophosphamide 4.4311006010
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3419224547 12795759 16045604 15959796 17595544 16239168 61145 12631006
MESH:D005355 Fibrosis Carbon Tetrachloride 9.5318705752
MESH:D005355 Fibrosis Tretinoin 9.5317994277
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.7511389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2515172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.586705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.586705139
MESH:D006467 Hemophilia A Cyclophosphamide 5.5111918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8014986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.9317606976 16135485
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006973 Hypertension Arsenic 2.9216076760 9931084 11953799
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6016076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.7316517039 7193160
MESH:D007249 Inflammation Mustard Gas 2.8611402378 11428631 9357497 9260866 11428647 17524151 16001271 11428620 8975870
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007938 Leukemia Cyclophosphamide 6.8410602166
MESH:D007938 Leukemia Tretinoin 6.8417143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5617802794 17296974 17658394 18172266 17008537 18587576
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 5.4716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2110373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8719285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.1217339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.1217712046 17217047 16788101 16331271 19075265 15748426 17361223 16935935 17339181 16766008 17649720 17506722 17294898 12679006 16823087 9834237 19642359 19225113 16891316 19035177 17107899 17301526 17368321 16140955 19029980
MESH:D007970 Leukopenia Cyclophosphamide 5.2011830472 10052129
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8911408273 16239168 21278145 16221502 17174718 16943688 17334410 11903743 17157831
MESH:D008106 Liver Cirrhosis, Experimental therapeutic 17640959
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5412649538 17631135 15370692 12586293 12666154 13678700 15730626 15362042 15673190 18395914 17481882 18187930 18376398 18339082 17823541 18412020 16638106 17766677 14724832 17976157 15931870 18481824 15818738 18166357 12609069 15876570 17714472 18418968 17869086 15123356 17922224 18156304 17900296 18705752 11481614 18205269 18277467 12445421 12445418 12632514 17698563 17640975 14748882 17721639 18251166 18429990 20821823 18279442 15925388 16192424 14620537 18210741 14716833 12632512 16033810 16116963 16015684 12898905 17761835 15959796 14716496 15650968 17708605 15893842 14512876 17944888 18054572 18317297 18006644 12667390 16136751 16027843 18472094 15057751 18420326 16248980 16097048 17805973 18395095 12958196 18472332 17565644 17557913 15996030 12389079 10355542 12546737 12741479 15052691 18263696 16011737 15338365 17525996
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.7611587558 12969438 19460945 16611625 12587719 16610002 19014921 19784758
MESH:D008107 Liver Diseases Arsenic 6.7611134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7617285989 16964402 15830285 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 7.9814678523 16273603 10737359 18001218 11376686 10672840
MESH:D008113 Liver Neoplasms Arsenic 7.9816368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9819294768
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 6.626150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6215583823 12014681
MESH:D008171 Lung Diseases Mustard Gas 3.5618702808 18161513
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 3.7711376686
MESH:D008175 Lung Neoplasms Arsenic 3.7717306315 19168569 17976673
MESH:D008175 Lung Neoplasms Mustard Gas 3.778781369 3148597
MESH:D008223 Lymphoma Cyclophosphamide 3.9612854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.7816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.3111911406
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 11.5619513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 11.5616388313
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D017202 Myocardial Ischemia Arsenic 4.1215371236
MESH:D009369 Neoplasms Cyclophosphamide 5.6018854779
MESH:D009369 Neoplasms Tretinoin 5.6016946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Arsenic 7.7816620997
MESH:D009436 Neural Tube Defects Tretinoin 7.789142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.728761367 16115947 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.1312837982 8761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.5617056641
MESH:D009503 Neutropenia Cyclophosphamide 10.158291058
MESH:D009503 Neutropenia Mustard Gas 10.157688884 16761898
MESH:D009845 Oligospermia Cyclophosphamide 4.9516517039
MESH:D010051 Ovarian Neoplasms Arsenic 5.1517306315
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1516936753
MESH:D010146 Pain Acetaminophen 12.1516870215
MESH:D010146 Pain Cyclophosphamide 12.1512161096 18093676
MESH:D010146 Pain Tretinoin 12.1516870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.7111332152
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.7115976015
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2316905509 6392382 15371236
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8921297632
MESH:D011471 Prostatic Neoplasms Arsenic 2.8316140617
MESH:D011471 Prostatic Neoplasms bicalutamide 2.8319240160 17914592 15638997 19011039 18487222
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.8317136230
MESH:D011507 Proteinuria Arsenic 9.9021343184
MESH:D011507 Proteinuria Tretinoin 9.9016636307
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 6.2016636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 6.2017266442 17894541 17720292 10334151 17620002
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0116636934
MESH:D012871 Skin Diseases Arsenic 5.2719834688 16702368 15952646 16759981 16353154 17938729 17050553 17548696 18709164 17453740 6392382
MESH:D012871 Skin Diseases Mustard Gas 5.2715451306 12880345 16961503
MESH:D012878 Skin Neoplasms Arsenic 6.1616251483 15504454 17050553 17029826 17976673 19538983
MESH:D012878 Skin Neoplasms Tretinoin 6.1616467112
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.7516517039
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2912837982
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 8.951399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.9511144890 17306315 19322015 18640142 17976673 19429237 15987713
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.9514692829
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved