AutismKB 2.0

Annotation Detail for ALDH7A1


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Basic Information Top
Gene Symbol:ALDH7A1 ( ATQ1,EPD,FLJ11738,FLJ92814,PDE )
Gene Full Name: aldehyde dehydrogenase 7 family, member A1
Band: 5q23.2
Quick LinksEntrez ID:501; OMIM: 107323; Uniprot ID:AL7A1_HUMAN; ENSEMBL ID: ENSG00000164904; HGNC ID: 877
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LYSINE-DEG1-PWYlysine degradation II
PWY-2501fatty acid alpha-oxidation
PWY-5283lysine degradation V
Pathway IDPathway Name
hsa00561Glycerolipid metabolism
hsa00410beta-Alanine metabolism
hsa00310Lysine degradation
hsa00010Glycolysis / Gluconeogenesis
hsa00300Lysine biosynthesis
hsa00380Tryptophan metabolism
hsa00330Arginine and proline metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
hsa00053Ascorbate and aldarate metabolism
hsa00340Histidine metabolism
hsa00260Glycine, serine and threonine metabolism
hsa00620Pyruvate metabolism
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P043725-Hydroxytryptamine degredation
Pathway IDPathway Name
500781Lysine catabolism
Related Diseases/Disorders Top
No data
No data
No data
Desease Name
Osteoporosis
Desease Name
Epilepsy, pyridoxine-dependent
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ALDH7A1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ALDH7A1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ALDH7A1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ALDH7A1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of ALDH7A1 proteinincreases expression 16538041
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ALDH7A1 mRNAaffects expression 16483693
C004541 biochanin A biochanin A results in decreased expression of ALDH7A1 mRNAdecreases expression 12111696
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ALDH7A1 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of ALDH7A1 mRNAdecreases expression 20106945
D004317 Doxorubicin ALDH7A1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ALDH7A1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ALDH7A1 mRNAdecreases expression 17557909
D005480 Flurbiprofen Flurbiprofen results in decreased expression of ALDH7A1 mRNAdecreases expression 16949054
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ALDH7A1 promoteraffects acetylation|affects methylation 18448484
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH7A1 mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ALDH7A1 promoteraffects acetylation|affects methylation 18448484
D013629 Tamoxifen Tamoxifen affects the expression of ALDH7A1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH7A1 mRNAincreases expression 16267337
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH7A1 mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Doxorubicin 4.3917418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.753712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 5.0710680582
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9317306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.5521441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.051440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7314601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8117150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.8715136595 16595493 19526202 18695136 18628466 15634643 11325840 16322301 17369602 15993339 16096432 15994142 16115903 18382427 17983394 16264153 18234424 15692762 15668708 16826403 15567936 16935488 17426702 15939500
MESH:D001943 Breast Neoplasms Tamoxifen 1.8717893378 19289846 18815881 18629630 19221464 18351453 15668708 11161223 19189212 20005174 17440819 19103187 20544844 16202921 19189210 18855134 15565566 19115204 21152245 19155303 20859285 20135344 19011961 18984771 19084267 19142967 19200415 18425577 19244106 16818667 17242785 19059307 16873071 20390343 16273361 19410462 21138602 19487384 18997820 18821012 19288272 17049068 17261762 20065188 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.8416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.1216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.1216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 14.127296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.123084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 14.1217876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.1216507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.1216924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.557296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.551485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.826189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8218572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5316109756 17308081 17928571 18627295 17924179 16242529 16278810 17007740 16731534 17519947 15505089 16455267 16651473 17131338 16952015 17351982 15792986 16364871 17382496 16269455 16612575 15476868 17974986 17329180 15811867
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9416243910 17334414
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 21.146135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.147505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.1412371664
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 21.1419716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.1419524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.239022650 19486331
MESH:D002779 Cholestasis Cyclosporine 19.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.2317333356 17681005 17110522 16105132 15861022 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 19.2319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 12621046 15668235 15340226 8697196
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8211906362 18759878 12868966 14531868 8156756 8970840 11298694 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.503621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.2918289764 6679447 8291058 9328219 9653073 7440962 11289319 18692083 1440618 9022650 6482804 16192314 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2919923254 14986274 2444490 12392966 11529661 16485898 14550746 12705907 12540782 10774834 15619225 16081117 12594235 16227642 11739529 16109766 19164858 11421492 11743745 19085960 19420014 15968718 19416960 14725611 11287661 16781746 18071297 12958197 12153990 16393943 18713872 16177239 11461765 17522070 19739265 17562736 10915739 11834606 17906064 19370779 10663392
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.2917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Doxorubicin 8.1218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.1211462148
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.9819031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.5717359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.5716202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1918037988
OMIM:266100 EPILEPSY, PYRIDOXINE-DEPENDENT marker/mechanism
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.113581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 18.7819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.7815345470
MESH:D005234 Fatty Liver pirinixic acid 18.7819236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 18.7819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.056705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.5119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.5119069698
MESH:D005355 Fibrosis Cyclosporine 8.5312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma biochanin A 7.7816598420
MESH:D005909 Glioblastoma Doxorubicin 7.7817150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.047505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5315692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4816707910 17875725 18674790 16495754 16330681 16244372 16144979 16879835 14766674 12587719 16244371 18006777 17888722
MESH:D006333 Heart Failure Doxorubicin 7.0517481944
MESH:D006333 Heart Failure pirinixic acid 7.0520558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.526705139
MESH:D006529 Hepatomegaly pirinixic acid 8.3118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3116120746 12621046 15340226
MESH:D006689 Hodgkin Disease Doxorubicin 7.4917606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 7.4912676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9515034207
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6517937319
MESH:D007248 Infertility, Male sodium arsenite 6.6512646999 15346721
MESH:D007249 Inflammation Flurbiprofen 8.4711099482
MESH:D007249 Inflammation Tamoxifen 8.4719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.058074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 14.4515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 14.458314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 14.4515699352 16775033 15369732
MESH:D007674 Kidney Diseases sodium arsenite 14.4520008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1616707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.3716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.3716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 23.376582329
MESH:D007680 Kidney Neoplasms Cyclosporine 23.3712371664
MESH:D007680 Kidney Neoplasms Tamoxifen 23.3718625569
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1916085563
MESH:D008064 Lipidoses Tamoxifen 3.1615342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.209327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.9416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6312969438 12587719 19460945 16611625 19784758 11587558 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.257678174
MESH:D008113 Liver Neoplasms pirinixic acid 14.2516377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 14.2516712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 14.2516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.132876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.131399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.1317085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1312151625
MESH:D008171 Lung Diseases sodium arsenite 3.1719095001
MESH:D008175 Lung Neoplasms Doxorubicin 4.8617418594 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 4.8615276417 17077188 17306315 16712894 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 4.8618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8611884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.4616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5815621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.1515458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1519196722 19196723 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.5819453300
MESH:D008545 Melanoma Doxorubicin 5.1516827129
MESH:D008545 Melanoma sodium arsenite 5.1516487513 19082730
MESH:D008545 Melanoma Tamoxifen 5.1519393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008654 Mesothelioma Doxorubicin 3.0617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5015792986
MESH:D052016 Mucositis Doxorubicin 4.8117415656
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.7119429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.4118551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.523581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.5218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms pirinixic acid 4.9417405874
MESH:D009369 Neoplasms sodium arsenite 4.9411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319200415 19196722 19189210
MESH:D009401 Nephrosis Doxorubicin 4.7816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.3119348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.3115640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.276679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.2712854658
MESH:D009447 Neuroblastoma Doxorubicin 3.2615555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.0916049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.0916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.096482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.053988306
MESH:D012516 Osteosarcoma Doxorubicin 4.1115930896
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4317306315 15276417
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.507296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.506228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms biochanin A 1.9112111696
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9118437689 16729912 15749863 15897917 16868541 16888761
MESH:D011471 Prostatic Neoplasms Flurbiprofen 1.9117409433
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.2317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.383692021
MESH:D012509 Sarcoma Doxorubicin 3.9916767912 17203757 15625365 17710206 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8117846226
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8718551238
MESH:D012871 Skin Diseases monomethylarsonous acid 3.3817431481
MESH:D012878 Skin Neoplasms Doxorubicin 13.5915692506
MESH:D012878 Skin Neoplasms sodium arsenite 13.5919524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.598532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.5916192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5817203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.271399818 6587162 6582329 3712494 7505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.2716010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 24.1916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 24.1916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 24.198074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 24.1917653716
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 24.1920375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 24.1917306315 11723127 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 24.1916712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2317334414 17638931 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:00053 Ascorbate and aldarate metabolism
KEGG:00410 beta-Alanine metabolism
KEGG:00071 Fatty acid metabolism
KEGG:00561 Glycerolipid metabolism
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:00340 Histidine metabolism
KEGG:00300 Lysine biosynthesis
KEGG:00310 Lysine degradation
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00640 Propanoate metabolism
KEGG:00620 Pyruvate metabolism
KEGG:00380 Tryptophan metabolism
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24704
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00165 - Pyridoxine Essential Vitamin;Vitamins (Vitamin B Complex);Anti-inflammatory Agents;Vitamin B Complex
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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