AutismKB 2.0

Annotation Detail for OXT


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Basic Information Top
Gene Symbol:OXT ( MGC126890,MGC126892,OT,OT-NPI )
Gene Full Name: oxytocin, prepropeptide
Band: 20p13
Quick LinksEntrez ID:5020; OMIM: 167050; Uniprot ID:NEU1_HUMAN; ENSEMBL ID: ENSG00000101405; HGNC ID: 8528
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P04395Vasopressin synthesis
Pathway IDPathway Name
500408Vasopressin-like receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1907Depression
1916Pervasive development disorder
1934Cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C422565 13beta-methyl 19-nor-steroid 13beta-methyl 19-nor-steroid inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16797624
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [LHB protein results in increased secretion of OXT protein]increases reaction|increases secretion 16780177
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT proteinincreases secretion 16780177
16967098
C014024 2,4,5,2',4',5'-hexachlorobiphenyl Genistein inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
C014024 2,4,5,2',4',5'-hexachlorobiphenyl Mifepristone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl affects the reaction [LHB protein results in increased secretion of OXT protein]affects reaction|increases secretion 16780177
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT proteinincreases secretion 16967098
16780177
C028451 3,4,3',4'-tetrachlorobiphenyl Genistein inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
C028451 3,4,3',4'-tetrachlorobiphenyl Mifepristone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl affects the reaction [LHB protein results in increased secretion of OXT protein]affects reaction|increases secretion 16780177
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of OXT proteinincreases secretion 16780177
16967098
C023035 3,4,5,3',4'-pentachlorobiphenyl Genistein inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
D000255 Adenosine Triphosphate Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]increases reaction|increases secretion 11102496
D000255 Adenosine Triphosphate Adenosine Triphosphate results in increased secretion of OXT proteinincreases secretion 11102496
D000255 Adenosine Triphosphate pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]decreases reaction|increases secretion 11102496
D000255 Adenosine Triphosphate pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]affects cotreatment|decreases reaction|increases secretion 11102496
D000643 Ammonium Chloride Ammonium Chloride affects the expression of OXT mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid promotes the reaction [OXT protein results in increased secretion of Dinoprost]increases reaction|increases secretion 16254031
C028617 aroclor 1248 aroclor 1248 results in increased secretion of OXT proteinincreases secretion 16967098
C006780 bisphenol A bisphenol A results in increased expression of OXT mRNAincreases expression 17010207
D002118 Calcium OXT protein promotes the reaction [TRPC3 protein results in increased transport of Calcium]increases reaction|increases transport 12700192
D002118 Calcium OXT protein results in increased abundance of Calciumincreases abundance 16997130
D002118 Calcium Progesterone affects the reaction [OXT protein results in increased abundance of Calcium]affects reaction|increases abundance 16997130
D003024 Clozapine OXT protein affects the susceptibility to Clozapineaffects response to substance 20196918
D003375 Coumestrol Coumestrol results in increased secretion of OXT proteinincreases secretion 16967098
C004742 daidzein daidzein results in increased secretion of OXT proteinincreases secretion 16967098
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of OXT mRNAincreases expression 17010207
D004958 Estradiol [Estradiol co-treated with OXT protein] results in increased expression of SLC5A5 mRNAaffects cotreatment|increases expression 16954431
D004958 Estradiol Estradiol results in increased expression of OXT mRNAincreases expression 17010207
17400809
D004958 Estradiol Progesterone inhibits the reaction [Estradiol results in increased expression of OXT mRNA]decreases reaction|increases expression 17400809
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of OXT mRNAincreases expression 15834898
17351261
D005419 Flavonoids Flavonoids results in increased expression of OXT mRNAincreases expression 18035473
C070081 fulvestrant fulvestrant results in increased expression of OXT mRNAincreases expression 15842231
D019833 Genistein Genistein inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
D019833 Genistein Genistein inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
D019833 Genistein Genistein inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
D019833 Genistein Genistein results in increased secretion of OXT proteinincreases secretion 16967098
D012701 Serotonin OXT protein results in increased secretion of Serotoninincreases secretion 19228979
D015735 Mifepristone Mifepristone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
D015735 Mifepristone Mifepristone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased secretion of OXT protein]decreases reaction|increases secretion 16967098
D015735 Mifepristone Mifepristone inhibits the reaction [OXT protein binds to OXTR protein]affects binding|decreases reaction 16797624
D015735 Mifepristone Mifepristone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16797624
C025256 nonylphenol nonylphenol results in increased expression of OXT mRNAincreases expression 17010207
C474055 octylphenol octylphenol results in increased expression of OXT mRNAincreases expression 17010207
D017239 Paclitaxel Paclitaxel analog results in increased expression of OXT mRNAincreases expression 15585946
D017239 Paclitaxel Paclitaxel results in increased expression of OXT mRNAincreases expression 15585946
D010656 Phenylephrine Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]increases reaction|increases secretion 11102496
D010656 Phenylephrine Phenylephrine results in increased secretion of OXT proteinincreases secretion 15149956
D010656 Phenylephrine pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]affects cotreatment|decreases reaction|increases secretion 11102496
D010716 Phosphatidylinositols Progesterone inhibits the reaction [OXT protein results in increased abundance of Phosphatidylinositols]decreases reaction|increases abundance 16254031
D011374 Progesterone Progesterone inhibits the reaction [OXT protein binds to OXTR protein]affects binding|decreases reaction 17629525
16254031
D011374 Progesterone Progesterone inhibits the reaction [OXT protein results in increased abundance of Phosphatidylinositols]decreases reaction|increases abundance 16254031
D011374 Progesterone Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16254031
D011374 Progesterone Progesterone inhibits the reaction [Estradiol results in increased expression of OXT mRNA]decreases reaction|increases expression 17400809
D011374 Progesterone Progesterone affects the reaction [OXT protein results in increased abundance of Calcium]affects reaction|increases abundance 16997130
D011374 Progesterone Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16997130
D011374 Progesterone Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprostone]decreases reaction|increases secretion 16997130
D015232 Dinoprostone OXT protein results in increased secretion of Dinoprostoneincreases secretion 16997130
D015232 Dinoprostone Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprostone]decreases reaction|increases secretion 16997130
D015237 Dinoprost 13beta-methyl 19-nor-steroid inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16797624
D015237 Dinoprost Mifepristone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16797624
D015237 Dinoprost OXT protein results in increased secretion of Dinoprostincreases secretion 16797624
D015237 Dinoprost Arachidonic Acid promotes the reaction [OXT protein results in increased secretion of Dinoprost]increases reaction|increases secretion 16254031
D015237 Dinoprost Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16254031
D015237 Dinoprost OXT protein results in increased secretion of Dinoprostincreases secretion 16997130
D015237 Dinoprost Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]decreases reaction|increases secretion 16997130
C077792 pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]decreases reaction|increases secretion 11102496
C077792 pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]affects cotreatment|decreases reaction|increases secretion 11102496
D020849 Raloxifene Raloxifene results in increased expression of OXT mRNAincreases expression 15842231
D013629 Tamoxifen Tamoxifen results in increased expression of OXT mRNAincreases expression 15842231
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2314745880
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D000230 Adenocarcinoma daidzein 9.5211473722
MESH:D000230 Adenocarcinoma Estradiol 9.5211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.5214692618
MESH:D000230 Adenocarcinoma Genistein 9.5211473722
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 4.9216628245
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.7617942926
MESH:D000380 Agranulocytosis Clozapine 4.7512649775 14617031 16160616
MESH:D000419 Albuminuria Raloxifene 4.3017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4715800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1815469931
MESH:D001008 Anxiety Disorders therapeutic 19228979
MESH:D001014 Aortic Aneurysm Dinoprostone 5.3110231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 5.3310388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8517460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4715885639
MESH:D001284 Atrophy fulvestrant 4.5511514358
MESH:D001321 Autistic Disorder therapeutic 18775368
MESH:D001321 Autistic Disorder Arachidonic Acid 2.9818582451
MESH:D001321 Autistic Disorder Serotonin 2.9818361446 15132762 18062943 8570775 17157402 18405062 19221690
MESH:D001477 Bartter Syndrome Dinoprostone 5.4415976003
MESH:D001859 Bone Neoplasms Paclitaxel 4.2815867366
MESH:D001862 Bone Resorption bisphenol A 3.5911985600
MESH:D001919 Bradycardia Phenylephrine 10.0315306635
MESH:D001919 Bradycardia Serotonin 10.038112388
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0217868700
MESH:D001930 Brain Injuries Progesterone 9.9515845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 9.9516580743
MESH:D001943 Breast Neoplasms bisphenol A 5.5017123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.5015324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 5.5016675129 12948864 14630087 18497071 19861407 17018787 17289903 17261762
MESH:D001943 Breast Neoplasms fulvestrant 5.5018984771
MESH:D001943 Breast Neoplasms Genistein 5.5016541309 16873071 17200150
MESH:D001943 Breast Neoplasms Paclitaxel 5.5016273361 18223236 15136595 18234424 16244791 16115903 18323546 11325840
MESH:D001943 Breast Neoplasms Progesterone 5.5015562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 5.5017049068 15572757 15775269 16912660 17952589 16837676 15758505 17595753 17440819 17242785 17893378 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 5.5016873071 19189210 21152245 19084267 18997820 19288272 18821012 20859285 17261762 20544844 19410462 15565566 18425577 18629630 17242785 19011961 19487384 20135344 18984771 19221464 16273361 18815881 20390343 11161223 19142967 18351453 20065188 19115204 16818667 15668708 21138602 19155303 19066611 17893378 19244106 19189212 16202921 17049068 19289846 18855134 19103187 19200415 19059307 20005174 17440819
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.3016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.3016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.3016924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.3016313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.3016924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.6817123778
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6117572228
MESH:D006332 Cardiomegaly Phenylephrine 3.3617124262 11754973 15728586 17287366 11179087 16170337
MESH:D002318 Cardiovascular Diseases daidzein 11.1216332659
MESH:D002318 Cardiovascular Diseases Genistein 11.1216332659
MESH:D002318 Cardiovascular Diseases Raloxifene 11.1215775269
MESH:D002386 Cataract Adenosine Triphosphate 4.4315003327
MESH:D002471 Cell Transformation, Neoplastic Dinoprost 10.4216192471
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 10.4216192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4218566989
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.0521254450
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 4.7616628245
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6516105132 17110522 17681005 17333356 16919318 11677210 15861022
MESH:D021081 Chronobiology Disorders Serotonin 6.3717157402
MESH:D003072 Cognition Disorders Clozapine 10.6717123785
MESH:D003072 Cognition Disorders Raloxifene 10.6715800139
MESH:D003110 Colonic Neoplasms Genistein 2.2317182828
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 3.1017686920
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2616002989 12952375
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9017474826
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.9616402076
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 6.9616647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.9616647724
MESH:D003928 Diabetic Nephropathies Estradiol 13.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.5217308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.5219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1917187935
MESH:D003967 Diarrhea Dinoprostone 7.9711488427 10446763 7237001
MESH:D003967 Diarrhea Serotonin 7.9711488427 8112388 10446763
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2415331141
MESH:D050171 Dyslipidemias Clozapine 3.9616402076
MESH:D004487 Edema Arachidonic Acid 10.3311698051 9599246 16716910 9831321 15177302 7990266
MESH:D004487 Edema Raloxifene 10.3315860553
MESH:D004487 Edema Serotonin 10.3318841975
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 5.4417686920
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.5012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.5017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 19.5015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.5019031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.8616402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.8616402032
MESH:D016889 Endometrial Neoplasms daidzein 21.2211473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 21.2215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 21.2218566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 21.2211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 21.2219155303 16202921 17893378 20544844
MESH:D004715 Endometriosis Mifepristone 8.5316134523
MESH:D004715 Endometriosis Progesterone 8.5316134523
MESH:D007172 Erectile Dysfunction daidzein 4.7214972507
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.8116481741
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.5615345470
MESH:D005234 Fatty Liver Raloxifene 11.5617473493
MESH:D005234 Fatty Liver Tamoxifen 11.5619224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.5816534752 16611131 16513791 16002989 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.5816709447
MESH:D005334 Fever Arachidonic Acid 14.1611852909
MESH:D005334 Fever Dinoprost 14.1611852909
MESH:D005334 Fever Dinoprostone 14.1616997862 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8719069698
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6416452187
MESH:D005909 Glioblastoma Genistein 3.0616598420
MESH:D006330 Heart Defects, Congenital 3,4,3',4'-tetrachlorobiphenyl 7.3011294989
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 7.3017686920 20471113
MESH:D006331 Heart Diseases Raloxifene 3.3211110106
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006930 Hyperalgesia Dinoprostone 4.2916793879
MESH:D006948 Hyperkinesis Clozapine 4.6016046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1312960047 14722030
MESH:D006973 Hypertension daidzein 8.2417169123
MESH:D006973 Hypertension Phenylephrine 8.248949925 12717712
MESH:D006973 Hypertension Raloxifene 8.2415787275 17577099
MESH:D006984 Hypertrophy Phenylephrine 4.2818502941 12791704
MESH:D007021 Hypospadias Diethylstilbestrol 10.2316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.2316569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1015869954
MESH:D007246 Infertility Diethylstilbestrol 4.0615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Coumestrol 10.3516892005
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.3517937319
MESH:D007248 Infertility, Male fulvestrant 10.3511514358
MESH:D007249 Inflammation Arachidonic Acid 10.6915177302 17371808 9831321
MESH:D007249 Inflammation Flavonoids 10.6917296493
MESH:D007249 Inflammation Progesterone 10.6915869954
MESH:D007249 Inflammation Tamoxifen 10.6919457130
MESH:D007333 Insulin Resistance bisphenol A 6.7716393666
MESH:D007333 Insulin Resistance Estradiol 6.7716393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.4115618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.0314681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.0315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.0318625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7316316344
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7617184923
MESH:D007889 Leiomyoma Raloxifene 4.2116973256
MESH:D007938 Leukemia Genistein 2.8718980019 17468513
MESH:D008064 Lipidoses Clozapine 7.3517567588
MESH:D008064 Lipidoses Tamoxifen 7.3517567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.5317353645
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 4.7015816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.7017823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7018564211
MESH:D008107 Liver Diseases Dinoprostone 3.3815816358
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 6.9818644402 16835634
MESH:D008113 Liver Neoplasms Diethylstilbestrol 6.9815890375 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 6.9816684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7318625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2515700306
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8414749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2016002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.6411408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.6412929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.6411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.6411731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.5919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5919453300
MESH:D008545 Melanoma Paclitaxel 3.3312040289 12025231 16342250
MESH:D008545 Melanoma Tamoxifen 3.3312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8715990972
MESH:D001523 Mental Disorders Clozapine 3.6416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1619142101
MESH:D020326 Migraine without Aura Dinoprostone 4.9711304026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2415863610
MESH:D009101 Multiple Myeloma Paclitaxel 6.9014749477
MESH:D009101 Multiple Myeloma Raloxifene 6.9016497877
MESH:D009203 Myocardial Infarction Genistein 2.7317141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.7317141266
MESH:D009232 Myxoma Raloxifene 5.2416343187
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.5615867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 5.168820588
MESH:D009369 Neoplasms Diethylstilbestrol 5.1615313581
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009421 Nervous System Malformations bisphenol A 21.0611399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.0611399458
MESH:D009421 Nervous System Malformations Estradiol 21.0616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.0616427766
MESH:D009765 Obesity Clozapine 2.9419142110 18515891
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.1618500342
MESH:D010014 Osteolysis Paclitaxel 4.6715867366
MESH:D010024 Osteoporosis Calcium 10.9017882678
MESH:D010024 Osteoporosis Genistein 10.9019401787
MESH:D010024 Osteoporosis Raloxifene 10.9017882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.1916169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.1915758505 17823083 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.6811985600
MESH:D010051 Ovarian Neoplasms Estradiol 13.9019401270
MESH:D010051 Ovarian Neoplasms Genistein 13.9019005980
MESH:D010051 Ovarian Neoplasms Mifepristone 13.9016525653
MESH:D010051 Ovarian Neoplasms Paclitaxel 13.9011161223
MESH:D010051 Ovarian Neoplasms Progesterone 13.9017393432 16525653
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3716977796 15687265
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8110548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.8117184923
MESH:D011469 Prostatic Diseases marker/mechanism 17492653
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.6320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3816740699
MESH:D011471 Prostatic Neoplasms Coumestrol 2.3816921512
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.3816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.3815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.3817136230 16356831 17172428 16729912
MESH:D011471 Prostatic Neoplasms Raloxifene 2.3816536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.0016919318 15861022
MESH:D011618 Psychotic Disorders Clozapine 3.9615331141
MESH:D011629 Puberty, Precocious bisphenol A 4.4710548101
MESH:D011693 Purpura Raloxifene 5.2415770314
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012559 Schizophrenia Clozapine 2.7011151749 16141801 20521326 18855531 20521320 17726453 20452607 20107430 17123785 11763009 18806925 20580759 20168265 19369910 17667964
MESH:D012852 Sinusitis Phenylephrine 4.397327846
MESH:D013088 Spermatocele Diethylstilbestrol 18.3016709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 18.3016709447
MESH:D013088 Spermatocele Tamoxifen 18.3016709447
MESH:D013119 Spinal Cord Injuries Progesterone 16.9815862959 16503802
MESH:D013119 Spinal Cord Injuries pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid 16.9815258577
MESH:D013119 Spinal Cord Injuries Tamoxifen 16.9819457130
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418506536 18396642
MESH:D020521 Stroke Raloxifene 3.5816837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.6716684133 16045194
MESH:D024801 Tauopathies Paclitaxel 4.5016930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013978 Tibial Fractures Estradiol 12.6619048282
MESH:D013978 Tibial Fractures Raloxifene 12.6619048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.6917306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.6917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.6916712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.7716175088
MESH:D014591 Uterine Diseases bisphenol A 12.7614652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.7614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.4915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1316002989 16513791
MESH:D054556 Venous Thromboembolism Raloxifene 4.8916837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2416343187
MESH:D015430 Weight Gain Clozapine 4.2120107430 20521320 17502770 20564506 16402076 16141801
MESH:D015431 Weight Loss Clozapine 4.7717933447
Pathway ID Pathway Name
KEGG:00532 Glycosaminoglycan biosynthesis - chondroitin sulfate
KEGG:00534 Glycosaminoglycan biosynthesis - heparan sulfate
KEGG:01100 Metabolic pathways
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00107 binder Oxytocin Anti-tocolytic Agents;Labor Induction Agents;Oxytocics
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No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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