Annotation Detail for P2RX1
Basic Information
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| Pathway ID | Pathway Name |
|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04020 | Calcium signaling pathway |
| Pathway ID | Pathway Name |
|---|
| Hemostasis |
| Desease ID | Desease Name |
|---|
| 1995 | Varicosity |
| Desease Name |
|---|
| Bleeding disorder due to P2RX1 defect |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C041524 |
aluminum sulfate |
aluminum sulfate results in decreased expression of P2RX1 mRNA | decreases expression | 15961160
|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of P2RX1 mRNA | affects expression | 16483693
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in increased expression of P2RX1 mRNA | increases expression | 20504355
|
| D008294 |
Malathion |
Malathion results in increased expression of P2RX1 mRNA | increases expression | 19784758
|
| D008743 |
Methyl Parathion |
Methyl Parathion results in increased expression of P2RX1 mRNA | increases expression | 19784758
|
| D010278 |
Parathion |
Parathion results in increased expression of P2RX1 mRNA | increases expression | 19784758
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.02 | 18287403 |
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.04 | 20127859 20464547 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.82 | 6695378 |
| MESH:D000382 |
Agricultural Workers' Diseases |
|
Malathion |
11.24 | 17119214 11874814 |
| MESH:D000382 |
Agricultural Workers' Diseases |
|
Parathion |
11.24 | 17119214 11874814 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.49 | 19183758 |
| MESH:D025861 |
Blood Coagulation Disorders, Inherited |
marker/mechanism |
|
| |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
2.31 | 17474063 20146248 |
| MESH:D001943 |
Breast Neoplasms |
|
Malathion |
2.31 | 12762645 |
| MESH:D001943 |
Breast Neoplasms |
|
Parathion |
2.31 | 12762645 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.12 | 20419170 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
2.07 | 16530937 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.80 | 20471113 |
| MESH:D007248 |
Infertility, Male |
|
Parathion |
4.68 | 16029889 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
2.13 | 20195826 21137059 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 17053015 20464547 20064080 18816296 18520028 18569708 20135361 20869020 6695378 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.43 | 16381670 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.30 | 11141357 |
| MESH:D020258 |
Neurotoxicity Syndromes |
marker/mechanism |
|
| 19784758 |
| MESH:D020258 |
Neurotoxicity Syndromes |
|
Malathion |
9.73 | 15081274 |
| MESH:D020258 |
Neurotoxicity Syndromes |
|
Methyl Parathion |
9.73 | 19784758 |
| MESH:D011041 |
Poisoning |
|
Methyl Parathion |
5.38 | 17603234 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.92 | 17292933 |
| MESH:D012135 |
Respiratory Sounds |
|
Malathion |
12.06 | 11874814 17119214 |
| MESH:D012135 |
Respiratory Sounds |
|
Parathion |
12.06 | 17119214 11874814 |
| MESH:D012140 |
Respiratory Tract Diseases |
|
Malathion |
13.30 | 17119214 |
| MESH:D012140 |
Respiratory Tract Diseases |
|
Parathion |
13.30 | 17119214 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.49 | 10029692 19755658 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 20155912 2093021 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.28 | 17053015 |
PharmGKB Accession:PA32861
| Releated drug ID |
Related drug Name |
| PA449177 | cytarabine |
Drug Bank