AutismKB 2.0

Annotation Detail for P2RX4


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Basic Information Top
Gene Symbol:P2RX4 ( P2X4,P2X4R )
Gene Full Name: purinergic receptor P2X, ligand-gated ion channel, 4
Band: 12q24.31
Quick LinksEntrez ID:5025; OMIM: 600846; Uniprot ID:P2RX4_HUMAN; ENSEMBL ID: ENSG00000135124; HGNC ID: 8535
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of P2RX4 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of P2RX4 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of P2RX4 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of P2RX4 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of P2RX4 mRNA]decreases reaction|increases expression 17942915
D008701 Methapyrilene Methapyrilene results in decreased expression of P2RX4 mRNAdecreases expression 16393664
C041786 palm oil palm oil results in decreased expression of P2RX4 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of P2RX4 mRNAincreases expression 19270015
D018038 Sodium Selenite Sodium Selenite results in decreased expression of P2RX4 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of P2RX4 mRNA]decreases reaction|increases expression 15667827
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.266195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2615322242 11752688 14514962
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.046695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.0916434500 19061943 17620307 19052882 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.0917620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.0916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.797296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.793084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7919383236 18978308 20084675 16540662 20101231 18506893 18056438 16288022 16681979 16569478 16698587 19701751 19335982 16502159 11831363 20214788 18785209 18788625 18494052 16935385 20524982 16878318 18691550 17173139 3581430 20727157 18971187 16328049 17162532 19208518 19052882 10672840 19394651 17761372 20007298 17138121 21159647 19171122 19107877 20514400 17428255 17978847 18393292 19919837 19418558 17055752 20432363 16779866 3084413 19822196 20512989 16830150 19519916 20935162 18210153 10737359 16807293 18665156 19539802
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7917173139 20007298 6705139 1701930 20935162
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.157505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.157505956 17174075 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.309022650 19486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15340226 16354765 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.068970840 11906362 11298694 8156756 18759878 12868966 2524372 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.599653073 9328219 1440618 18692083 16192314 18648102 9022650 6679447 7440962 8291058 11289319 6482804 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5912153990 11461765 10774834 16177239 10663392 19370779 11529661 14725611 15619225 14986274 19923254 12705907 19420014 19164858 2444490 16781746 18713872 19416960 19739265 16109766 12392966 19085960 12540782 15968718 11287661 16485898 11739529 11834606 11743745 16081117 10915739 16393943 14550746 17562736 12958197 17522070 17906064 12594235 16227642 18071297 11421492
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.5919107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.5915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Dietary Fats 8.5518296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 8.5520387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Dietary Fats 9.5018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5020067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Phenobarbital 9.3216109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3216120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 18606429 8697196 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Dietary Fats 8.8520412841
MESH:D007249 Inflammation Diethylnitrosamine 8.8518785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8512200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.9118457598 11836018
MESH:D007333 Insulin Resistance Sodium Selenite 7.9114714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D008103 Liver Cirrhosis Dietary Fats 11.6418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.6418665156 18407596 18522880 20032147 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 11.6421047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 6.7619784758 16611625 12969438 11587558 19014921 12587719 19460945 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7617034775
MESH:D008107 Liver Diseases Phenobarbital 6.7619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.3221071580 18978307 18648771 15885732 19426721 9163691 19642983 19850985 21278145 19427195 19499222 19833225 20137499 20583210 15175105 21047994 19638242 2422723 12112319 19255062 21167192 20434301 19254457 20118626 18977376 19690152 19294768 20405173 20101389 19090486 12771043 20501860 2862719 18644402 19812893 16942905 20452335 19551842 18754104 19256749 19996281 20492335 19073162 10737359
MESH:D008113 Liver Neoplasms Methapyrilene 11.3215890375
MESH:D008113 Liver Neoplasms Phenobarbital 11.3219482888 19812893 19073162 8742319 15975961 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.13598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.1318093689 18775883 18164116 18079962 17854601 19539802 2563599 19519916 18282651 16842330 17942915 19009564 17174075 16267830 21159647 9362446 19126423 18308698 18253720 18544905 19004024 3124819
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.132563599 17172636 6150874 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.1312151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.316695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3119555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity Dietary Fats 2.3311836018 17217161 19632207 20518802 18674790 21332399 20132043 16723640 18457598
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.712563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.712563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3618760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012640 Seizures Phenobarbital 2.823137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.886582329 3712494 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.887505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.881399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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