AutismKB 2.0

Annotation Detail for P2RX5


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Basic Information Top
Gene Symbol:P2RX5 ( LRH-1,MGC47755,P2X5,P2X5R )
Gene Full Name: purinergic receptor P2X, ligand-gated ion channel, 5
Band: 17p13.2
Quick LinksEntrez ID:5026; OMIM: 602836; Uniprot ID:P2RX5_HUMAN; ENSEMBL ID: ENSG00000083454; HGNC ID: 8536
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of P2RX5 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of P2RX5 mRNAaffects expression 17562736
C061133 Am 80 Am 80 results in increased expression of P2RX5 mRNAincreases expression 17229644
D000643 Ammonium Chloride Ammonium Chloride affects the expression of P2RX5 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of P2RX5 mRNAincreases expression 20106945
D003314 Corn Oil Corn Oil affects the expression of P2RX5 mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in increased expression of P2RX5 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of P2RX5 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of P2RX5 mRNAincreases expression 19638242
C041786 palm oil palm oil results in increased expression of P2RX5 mRNAincreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of P2RX5 mRNAincreases expression 18158353
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.896695378
MESH:D000236 Adenoma Diethylnitrosamine 6.8910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0918056438 19061943 16434500 17162532 19052882 17620307
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1810965797
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2417460149
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001172 Arthritis, Rheumatoid Am 80 3.7816819260
MESH:D050197 Atherosclerosis Am 80 4.4116484594
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001919 Bradycardia Phenylephrine 4.7415306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.8820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9120101231 19822196 19383236 16569478 16540662 21159647 20935162 19919837 16830150 18506893 16698587 20214788 18691550 3581430 10672840 19171122 19418558 16328049 16681979 19335982 18665156 20007298 17055752 16779866 19519916 16288022 18971187 16935385 19394651 19052882 20084675 17138121 18494052 19208518 19107877 18393292 18785209 18210153 10737359 20727157 18978308 18788625 20432363 17978847 18056438 19701751 20512989 17761372 20514400 16878318 20524982 17173139 16807293 16502159 11831363 19539802 17428255 3084413 17162532
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Phenylephrine 3.6015728586 11754973 17124262 17287366 11179087 16170337
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.922727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8711421492 12540782 19416960 14550746 17906064 17562736 16781746 11834606 18071297 15619225 17522070 10774834 15968718 12958197 19085960 10663392 18713872 14986274 16177239 19164858 11743745 12153990 19739265 19370779 11287661 12594235 12705907 16227642 11739529 16081117 14725611 19923254 11461765 19420014 10915739 16485898 12392966 2444490 16109766 16393943 11529661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8719107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 5.2516819260
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Cyclosporine 13.9519224547
MESH:D005234 Fatty Liver Dietary Fats 13.9517967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 13.9521071580 20387270
MESH:D005355 Fibrosis Cyclosporine 9.2912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.2918296743
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006968 Hypersensitivity, Delayed Corn Oil 6.0311484837
MESH:D006973 Hypertension Cyclosporine 5.5310903974
MESH:D006973 Hypertension Phenylephrine 5.5312717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 4.6918502941 12791704
MESH:D007249 Inflammation Dietary Fats 5.3320412841
MESH:D007249 Inflammation Diethylnitrosamine 5.3318785209
MESH:D007333 Insulin Resistance Dietary Fats 3.1911836018 18457598
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.058314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.7316819260 16531727
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8818407596 18522880 19638242 20032147 18665156
MESH:D008107 Liver Diseases Acetaminophen 4.0112969438 16610002 16611625 19460945 12587719 19784758 11587558 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6820195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.6816942905 2422723 18977376 20434301 19638242 19256749 19499222 19090486 19073162 20405173 21047994 19255062 20101389 19996281 12771043 20492335 12112319 10737359 20137499 20118626 19254457 20583210 19833225 18978307 19294768 19850985 20452335 2862719 21278145 15885732 18648771 20501860 19427195 21167192 18754104 21071580 19426721 19551842 19690152 19642983 15175105 9163691 18644402 19812893
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7119004024 3124819 19519916 19539802 17174075 16267830 17854601 19126423 18282651 18544905 21159647 18775883 17942915 19009564 18093689 18079962 9362446 2563599 16842330 18253720 18164116 18308698
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4120064080 20135361 18520028 6695378 20869020 18569708 17053015 18816296 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.416695378 20970405 20512841 21163286
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma Am 80 4.6317229644
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity Dietary Fats 2.3119632207 21332399 17217161 11836018 18457598 20132043 20518802 16723640 18674790
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.7211550810
MESH:D011230 Precancerous Conditions Corn Oil 16.2114668109
MESH:D011230 Precancerous Conditions Cyclosporine 16.2112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.212563599
MESH:D011471 Prostatic Neoplasms Am 80 3.6716289102
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.6717292933
MESH:D011565 Psoriasis Am 80 6.2916819260
MESH:D011565 Psoriasis Cyclosporine 6.2916882103
MESH:D012852 Sinusitis Phenylephrine 4.907327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4310029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3620155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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