AutismKB 2.0

Annotation Detail for P2RY1


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Basic Information Top
Gene Symbol:P2RY1 ( P2Y1 )
Gene Full Name: purinergic receptor P2Y, G-protein coupled, 1
Band: 3q25.2
Quick LinksEntrez ID:5028; OMIM: 601167; Uniprot ID:P2RY1_HUMAN; ENSEMBL ID: ENSG00000169860; HGNC ID: 8539
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
No data
No data
Pathway IDPathway Name
500423P2Y receptors
500292ADP signalling through P2Y purinoceptor 1
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1854Alveolar bone loss
2029Tuberculosis
2129Thyroid cancer
1882Malaria
Desease Name
HEMATOLOGICAL
hematology indices
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16236484
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of P2RY1 mRNAaffects expression 21346803
C113043 2-methylthio-ADP [2-methylthio-ADP binds to and results in increased activity of P2RY1 protein] which results in increased uptake of Calciumaffects binding|increases activity|increases uptake 16973929
C008501 2-methylthio-ATP 2-methylthio-ATP results in increased activity of P2RY1 proteinincreases activity 14742736
D000082 Acetaminophen Acetaminophen affects the expression of P2RY1 mRNAaffects expression 17562736
C038699 acetophenone [acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY1] results in increased phosphorylation of MAPK1 proteinaffects cotreatment|increases phosphorylation 17472961
C038699 acetophenone [acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY1] results in increased phosphorylation of MAPK3 proteinaffects cotreatment|increases phosphorylation 17472961
C038699 acetophenone Pertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY1] results in increased phosphorylation of MAPK1 protein]affects cotreatment|decreases reaction|increases phosphorylation 17472961
C038699 acetophenone Pertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY1] results in increased phosphorylation of MAPK3 protein]affects cotreatment|decreases reaction|increases phosphorylation 17472961
D000244 Adenosine Diphosphate Adenosine Diphosphate results in increased activity of P2RY1 proteinincreases activity 14742736
D000255 Adenosine Triphosphate Adenosine Triphosphate affects the activity of P2RY1 proteinaffects activity 15243297
D000255 Adenosine Triphosphate [N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]affects binding|decreases activity|decreases reaction|increases uptake 16973929
C412373 AG 1879 AG 1879 inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16236484
D000643 Ammonium Chloride Ammonium Chloride affects the expression of P2RY1 mRNAaffects expression 16483693
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16236484
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
C467001 bisindolylmaleimide IX bisindolylmaleimide IX inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16236484
D020001 1-Butanol 1-Butanol inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16236484
D020001 1-Butanol 1-Butanol inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D020001 1-Butanol 1-Butanol inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D002118 Calcium Calcium affects the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]affects reaction|increases activity|increases phosphorylation 16236484
D002118 Calcium [2-methylthio-ADP binds to and results in increased activity of P2RY1 protein] which results in increased uptake of Calciumaffects binding|increases activity|increases uptake 16973929
D002118 Calcium [N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]affects binding|decreases activity|decreases reaction|increases uptake 16973929
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of P2RY1 mRNAaffects expression 12734012
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of P2RY1 mRNAdecreases expression 15620428
C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 proteinaffects binding|decreases activity 14742736
C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate [N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium]affects binding|decreases activity|decreases reaction|increases uptake 16973929
C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 proteinaffects binding|decreases activity 15235914
C025256 nonylphenol nonylphenol results in decreased expression of P2RY1 mRNAdecreases expression 15620428
D009711 Nucleotides 1-Butanol inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D009711 Nucleotides 1-Butanol inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D009711 Nucleotides bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D009711 Nucleotides bisindolylmaleimide I inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D009711 Nucleotides P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]affects reaction|increases activity|increases phosphorylation 17620283
D009711 Nucleotides P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]affects reaction|increases activity|increases phosphorylation 17620283
D009711 Nucleotides rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D009711 Nucleotides rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY1] results in increased phosphorylation of MAPK1 protein]affects cotreatment|decreases reaction|increases phosphorylation 17472961
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [[acetophenone co-treated with OLFR151 co-treated with P2RY1] results in increased phosphorylation of MAPK3 protein]affects cotreatment|decreases reaction|increases phosphorylation 17472961
D010622 Phencyclidine Phencyclidine results in increased expression of P2RY1 mRNAincreases expression 12105081
C006253 pirinixic acid pirinixic acid results in increased expression of P2RY1 mRNAincreases expression 18301758
C077792 pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid binds to and results in decreased activity of P2RY1 proteinaffects binding|decreases activity 14742736
C085746 rottlerin rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
C085746 rottlerin rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]affects reaction|decreases reaction|increases activity|increases phosphorylation 17620283
C447031 tyrphostin AG 1024 tyrphostin AG 1024 inhibits the reaction [P2RY1 protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 16236484
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.2916434500
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001259 Ataxia 1-Butanol 5.407820390
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9719483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5910355542 16124888 15721981 15673190 16050911 16227642 15700767 16011737 16097048 16192424 18705752 3786805
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.3416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.343084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.3418788625
MESH:D002386 Cataract Acetaminophen 7.4110977129
MESH:D002386 Cataract Adenosine Triphosphate 7.4115003327
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.646135515
MESH:D002779 Cholestasis pirinixic acid 2.6919176532
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.2616037377
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.8521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.8518713872 18071297 19164858 16109766 2444490 16081117 11529661 12705907 19923254 17522070 16393943 14986274 11287661 16227642 19370779 11421492 12153990 14725611 19739265 16781746 12594235 16177239 17562736 11834606 10915739 15968718 15619225 11461765 12540782 10774834 16485898 12392966 10663392 17906064 11743745 19085960 14550746 19416960 11739529 12958197 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.856884620 21278145 17522070 7440962 6623471 19085960 16227642 10915739 15998439 15968718 19336974 16177239 3786805 4309450 7120509 15027814 11566570 2869522 7179309 3732212 10092053 9327722
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004487 Edema bisindolylmaleimide I 6.728273558
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.1012795759 61145 15959796 17595544 12631006 16239168 16045604 19224547
MESH:D005234 Fatty Liver pirinixic acid 7.1019236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 3.2718705752
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 2.8119176532 16221962 19772884 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D007249 Inflammation bisindolylmaleimide I 3.808273558
MESH:D007333 Insulin Resistance pirinixic acid 2.5116306350
MESH:D007674 Kidney Diseases Acetaminophen 2.0915629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.8216705839
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.8516316344
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7016221502 17157831 11408273 16943688 16239168 17174718 17334410 11903743 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6815931870 15730626 16027843 17823541 17721639 18395914 12958196 12666154 18418968 18251166 17869086 18210741 18166357 14716496 12649538 17761835 18472094 16248980 16116963 17631135 18420326 18187930 12586293 16638106 17565644 15818738 12741479 17766677 15893842 17922224 11481614 14748882 14724832 18472332 20821823 12898905 18705752 12632514 12667390 12632512 12445421 16192424 14716833 18376398 15959796 17708605 16011737 17805973 18279442 17557913 17525996 15338365 18054572 15362042 15370692 18412020 15057751 15123356 18429990 18277467 15876570 17714472 15650968 16015684 18317297 15673190 17900296 18339082 17976157 12546737 17944888 14512876 12609069 18006644 16033810 16136751 17481882 15996030 12389079 16097048 10355542 18263696 18205269 17698563 17640975 18156304 15052691 13678700 14620537 12445418 15925388 18481824 18395095
MESH:D008106 Liver Cirrhosis, Experimental Nucleotides 3.6815465738
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6815474484
MESH:D008107 Liver Diseases Acetaminophen 3.7316610002 19460945 12587719 19014921 11587558 12969438 16611625 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7317285989 16964402 15830285 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 6.977678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.9719294768
MESH:D008113 Liver Neoplasms pirinixic acid 6.9715890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.532876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.5312014681 15583823
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6718551238 7678174
MESH:D009369 Neoplasms pirinixic acid 1.8617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2616049721
MESH:D010024 Osteoporosis Calcium 3.6617882678
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4118551238
MESH:D013119 Spinal Cord Injuries pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid 6.4615258577
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.2216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1310091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32868
    • Releated gene ID Related gene Name
    PA32868P2RY1
    No data
    Releated drug ID Related drug Name
    PA449053clopidogrel
    PA448497aspirin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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