Annotation Detail for P2RY11
Basic Information Top
| Gene Symbol: | P2RY11 ( P2Y11 ) |
|---|---|
| Gene Full Name: | purinergic receptor P2Y, G-protein coupled, 11 |
| Band: | 19p13.2 |
| Quick Links | Entrez ID:5032; OMIM: 602697; Uniprot ID:P2Y11_HUMAN; ENSEMBL ID: ENSG00000130810; HGNC ID: 8540 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Pathway ID | Pathway Name |
|---|---|
| Signaling by GPCR |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500423 | P2Y receptors |
| No data |
| No data |
| Desease Name |
|---|
| CARDIOVASCULAR |
| myocardial infarct |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C546599 | 4,4'-(carbonylbis(imino-3,1-phenylenecarbonylimino-3,1-(4-methylphenylene)carbonylimino))bis(1,3-xylene-alpha,alpha'-diphosphonic acid) | 4,4'-(carbonylbis(imino-3,1-phenylenecarbonylimino-3,1-(4-methylphenylene)carbonylimino))bis(1,3-xylene-alpha,alpha'-diphosphonic acid) binds to and results in increased activity of P2RY11 protein | affects binding|increases activity | 19815812 |
| C546599 | 4,4'-(carbonylbis(imino-3,1-phenylenecarbonylimino-3,1-(4-methylphenylene)carbonylimino))bis(1,3-xylene-alpha,alpha'-diphosphonic acid) | [4,4'-(carbonylbis(imino-3,1-phenylenecarbonylimino-3,1-(4-methylphenylene)carbonylimino))bis(1,3-xylene-alpha,alpha'-diphosphonic acid) binds to and results in increased activity of P2RY11 protein] which results in increased expression of IL8 protein | affects binding|increases activity|increases expression | 19815812 |
| C022571 | adenosine 5'-O-(3-thiotriphosphate) | adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein | affects binding|increases activity | 19815812 |
| C022571 | adenosine 5'-O-(3-thiotriphosphate) | [adenosine 5'-O-(3-thiotriphosphate) binds to and results in increased activity of P2RY11 protein] which results in increased expression of IL8 protein | affects binding|increases activity|increases expression | 19815812 |
| C017947 | sodium arsenite | sodium arsenite affects the expression of P2RY11 mRNA | affects expression | 19590694 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000310 | Adrenal Gland Neoplasms | sodium arsenite | 5.57 | 15276417 | |
| MESH:D018246 | Adrenocortical Adenoma | sodium arsenite | 5.77 | 16712894 17306315 | |
| MESH:D006528 | Carcinoma, Hepatocellular | sodium arsenite | 2.01 | 17306315 15276417 16507464 | |
| MESH:D002294 | Carcinoma, Squamous Cell | sodium arsenite | 2.47 | 18572023 | |
| MESH:D002471 | Cell Transformation, Neoplastic | sodium arsenite | 3.28 | 20056578 19524636 | |
| MESH:D005833 | Genital Neoplasms, Female | sodium arsenite | 5.42 | 16452187 | |
| MESH:D006689 | Hodgkin Disease | sodium arsenite | 3.56 | 12676792 | |
| MESH:D007248 | Infertility, Male | sodium arsenite | 3.26 | 15346721 12646999 | |
| MESH:D007674 | Kidney Diseases | sodium arsenite | 3.02 | 20008137 | |
| MESH:D008113 | Liver Neoplasms | sodium arsenite | 2.49 | 16712894 15276417 | |
| MESH:D008171 | Lung Diseases | sodium arsenite | 3.45 | 19095001 | |
| MESH:D008175 | Lung Neoplasms | sodium arsenite | 1.90 | 17306315 15276417 16712894 19931552 17077188 | |
| MESH:D008545 | Melanoma | sodium arsenite | 2.07 | 16487513 19082730 | |
| MESH:D009290 | Narcolepsy | marker/mechanism | 21170044 | ||
| MESH:D009369 | Neoplasms | sodium arsenite | 2.68 | 11559025 | |
| MESH:D009374 | Neoplasms, Experimental | sodium arsenite | 4.32 | 20056578 | |
| MESH:D009436 | Neural Tube Defects | sodium arsenite | 3.41 | 12854658 | |
| MESH:D010051 | Ovarian Neoplasms | sodium arsenite | 2.54 | 15276417 17306315 | |
| MESH:D011471 | Prostatic Neoplasms | sodium arsenite | 3.23 | 16039940 | |
| MESH:D012878 | Skin Neoplasms | sodium arsenite | 2.87 | 18572023 19524636 | |
| MESH:D016135 | Spinal Dysraphism | sodium arsenite | 4.14 | 12854658 | |
| MESH:D001749 | Urinary Bladder Neoplasms | sodium arsenite | 2.64 | 11723127 16712894 16452187 17306315 | |
| MESH:D002583 | Uterine Cervical Neoplasms | sodium arsenite | 4.21 | 11813266 | |
| MESH:D014652 | Vascular Diseases | sodium arsenite | 5.17 | 17056641 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04080 | Neuroactive ligand-receptor interaction |
| REACT:14797 | Signaling by GPCR |
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