AutismKB 2.0

Annotation Detail for P4HA1


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Basic Information Top
Gene Symbol:P4HA1 ( P4HA )
Gene Full Name: prolyl 4-hydroxylase, alpha polypeptide I
Band: 10q22.1
Quick LinksEntrez ID:5033; OMIM: 176710; Uniprot ID:P4HA1_HUMAN; ENSEMBL ID: ENSG00000122884; HGNC ID: 8546
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2025Polyarthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of P4HA1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of P4HA1 mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of P4HA1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of P4HA1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of P4HA1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of P4HA1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of P4HA1 mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in decreased expression of P4HA1 mRNAdecreases expression 15725085
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of P4HA1 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of P4HA1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of P4HA1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of P4HA1 mRNAincreases expression 19638242
D001556 Lindane Lindane results in decreased expression of P4HA1 mRNAdecreases expression 17785943
D008942 Mitoxantrone P4HA1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C030110 oxaliplatin oxaliplatin results in decreased expression of P4HA1 mRNAdecreases expression 17762391
C041786 palm oil palm oil results in decreased expression of P4HA1 mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of P4HA1 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of P4HA1 mRNAincreases expression 18301758
C002979 selenomethylselenocysteine selenomethylselenocysteine results in increased expression of P4HA1 mRNAincreases expression 18514395
C017947 sodium arsenite sodium arsenite affects the expression of P4HA1 mRNAaffects expression 19590694
D018038 Sodium Selenite Sodium Selenite results in increased expression of P4HA1 mRNAincreases expression 18514395
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of P4HA1 mRNAdecreases expression 16443690
18495758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of P4HA1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of P4HA1 mRNA]decreases reaction|increases expression 15667827
C066340 tolcapone tolcapone binds to P4HA1 proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7211752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2619825857 11798837
MESH:D000236 Adenoma Diethylnitrosamine 2.786695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.5217162532 19061943 17620307 19052882 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.5216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5715276417
MESH:D018246 Adrenocortical Adenoma Arsenic 13.3617306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 13.3617306315 16712894
MESH:D000382 Agricultural Workers' Diseases Lindane 4.2412661182
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.1611080934
MESH:D000544 Alzheimer Disease tolcapone 3.2520150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0017460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8318414634 12569548 16251483 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 3.7615238619
MESH:D050197 Atherosclerosis Arsenic 3.1719371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.5816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.5819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.5812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001919 Bradycardia Phenylephrine 4.4115306635
MESH:D001943 Breast Neoplasms Dietary Fats 2.3320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3317474063
MESH:D001943 Breast Neoplasms Lindane 2.3314688026
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 2.3318855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3320435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2011589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5217687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.5816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.5816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.583084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.5812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 16.5816507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.5814691202 15553829 16217749 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.5817138121 16807293 19383236 21159647 16569478 18785209 20101231 19519916 19107877 20007298 17978847 19539802 10737359 16540662 19919837 20935162 18691550 19822196 16502159 19701751 18788625 16779866 16328049 3084413 16878318 19394651 18506893 16830150 19208518 3581430 20512989 17428255 17055752 18210153 10672840 19335982 17173139 16698587 16681979 11831363 17162532 19418558 16288022 18978308 17761372 20084675 18056438 19052882 16935385 20524982 18665156 18971187 20432363 20214788 18494052 18393292 20514400 19171122 20727157
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.5817306315 16507464 15276417
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0012490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.7117687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7118572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9618640142
MESH:D006332 Cardiomegaly Phenylephrine 6.6411179087 15728586 11754973 17287366 17124262 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.3615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.2018022660 16973168
MESH:D002386 Cataract Acetaminophen 2.5110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.286135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.2812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.2821159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.2820056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002779 Cholestasis Cyclosporine 7.4319486331
MESH:D002779 Cholestasis pirinixic acid 7.4319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0516354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms oxaliplatin 3.1516510598 16004971 16024531
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8620501625
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.8618448328 18509181 17255274 17695437 17594712 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9517141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4320055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.4618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.4618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9715213294
MESH:D003866 Depressive Disorder tolcapone 4.2111224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.7910440460
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6616285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.0921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.0918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.0914725611 16177239 16485898 17906064 12705907 16227642 18713872 12594235 19370779 19739265 15619225 14986274 11529661 11421492 17562736 16081117 10663392 17522070 18071297 19085960 11461765 16109766 16393943 19923254 19420014 12958197 12392966 19164858 12540782 10915739 10774834 19416960 16781746 11287661 12153990 2444490 11739529 15968718 11743745 11834606 14550746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.0919107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 18.0915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.0920420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 18.0916604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.2711455177
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004487 Edema pirinixic acid 6.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2812903497
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.8219578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver arsenic trioxide 23.3615073043
MESH:D005234 Fatty Liver Cyclosporine 23.3619224547
MESH:D005234 Fatty Liver Dietary Fats 23.3618296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 23.3621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 23.3619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005355 Fibrosis Cyclosporine 13.9612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 13.9618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.9620067830
MESH:D005534 Foot Diseases Arsenic 5.436392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1316904648
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2611294989 10048152
MESH:D006331 Heart Diseases Mitoxantrone 4.0616019553
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006529 Hepatomegaly pirinixic acid 7.8316221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.8315340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.0412676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9218606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.7016870215
MESH:D006930 Hyperalgesia oxaliplatin 7.7017418472
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3417050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D006973 Hypertension Arsenic 11.9811953799 9931084 16076760
MESH:D006973 Hypertension Cyclosporine 11.9810903974
MESH:D006973 Hypertension Phenylephrine 11.9812717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.9818850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.4318502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.4316093927
MESH:D007248 Infertility, Male sodium arsenite 2.9015346721 12646999
MESH:D007249 Inflammation Dietary Fats 7.8820412841
MESH:D007249 Inflammation Diethylnitrosamine 7.8818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8812200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 11.8418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 11.8416306350
MESH:D007333 Insulin Resistance Sodium Selenite 11.8414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007642 Keratosis Arsenic 4.8612749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.5715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.5718776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 9.5720008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.7412371664
MESH:D007938 Leukemia arsenic trioxide 2.7715070760
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7318172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1216467208 17050201 19850784 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.5017339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.5019035177 19075265 9834237 11161223 12712474 16330433 19642359 16966277 16331271 15622746 17217047 17869043 16891316 12679006 15213294 19225113 12018890 15336539 17107899 16823087 17649720 16112521 15748426 11468182 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2216882451
MESH:D008103 Liver Cirrhosis Dietary Fats 6.4018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4018522880 18407596 20032147 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.0915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.0912878042
MESH:D008107 Liver Diseases Acetaminophen 9.1519014921 19460945 19784758 16610002 16611625 12587719 12969438 11587558
MESH:D008107 Liver Diseases Arsenic 9.1511134558
MESH:D008107 Liver Diseases Diethylnitrosamine 9.1517034775
MESH:D008107 Liver Diseases Lindane 9.151715830
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1216871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 25.127678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 25.1218177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Arsenic 25.1216368122
MESH:D008113 Liver Neoplasms arsenic trioxide 25.1214682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 25.1220452335 2862719 19850985 19996281 18648771 20492335 20501860 21071580 21278145 21047994 20118626 21167192 20101389 19090486 15885732 19427195 19254457 19551842 19812893 20583210 19499222 19642983 18978307 18644402 12771043 9163691 20434301 19256749 19638242 19690152 19294768 20405173 12112319 19073162 20137499 19255062 15175105 2422723 18977376 16942905 19426721 10737359 19833225 18754104
MESH:D008113 Liver Neoplasms pirinixic acid 25.1220007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 25.1216712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.1216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.782876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.788603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.7820377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.7818164116 17854601 17942915 19004024 16842330 19539802 18282651 19009564 18093689 16267830 18308698 18544905 3124819 17174075 9362446 18775883 19126423 2563599 18253720 18079962 19519916 21159647
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.7812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2515213294
MESH:D008171 Lung Diseases sodium arsenite 3.0819095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3514755239
MESH:D008175 Lung Neoplasms Arsenic 8.3517976673 17306315 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 8.3511798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3521163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 8.3516712894 17306315 15276417 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3511884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9314737004
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 4.1315318939
MESH:D008545 Melanoma sodium arsenite 2.0216487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0115949261 19417148 14977855 19549372 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0716105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Arsenic 8.6515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.917678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8316624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.523581430 9029167
MESH:D009369 Neoplasms Lindane 11.4212807735 16818664
MESH:D009369 Neoplasms Mitoxantrone 11.4216640825
MESH:D009369 Neoplasms pirinixic acid 11.4217405874
MESH:D009369 Neoplasms sodium arsenite 11.4211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5420056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D009436 Neural Tube Defects Arsenic 11.7216620997
MESH:D009436 Neural Tube Defects arsenic trioxide 11.7210525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.7212854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8220387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.2517056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009765 Obesity Dietary Fats 4.3211836018 20132043 19632207 21332399 16723640 17217161 20518802 18674790 18457598
MESH:D009765 Obesity pirinixic acid 4.3220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.5016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5016049721
MESH:D010051 Ovarian Neoplasms Arsenic 7.7117306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.7112452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.7117306315 15276417
MESH:D010146 Pain Acetaminophen 2.2916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.1215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.1216540662
MESH:D010235 Paraganglioma arsenic trioxide 4.0419927285
MESH:D010300 Parkinson Disease tolcapone 3.557566641 9591521 18328768 9708959 10651109 8635184 11746615 1977408 11586115 11432539 8739811 9305320 19783845 9333106 19578428 16758261 9754991 11793426 20334432 20216409 17089403
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0516093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.866392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.572563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 1.9016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9019131511
MESH:D011471 Prostatic Neoplasms Lindane 1.9012661182 14688026
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9016039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.9018760546
MESH:D011507 Proteinuria Arsenic 3.8821343184
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8316646077
MESH:D012640 Seizures 2,4-dinitrotoluene 9.4218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.4218551238
MESH:D012640 Seizures Lindane 9.4215475178 7539098 12842176
MESH:D012852 Sinusitis Phenylephrine 4.577327846
MESH:D012871 Skin Diseases Arsenic 2.7115952646 19834688 16702368 17938729 17548696 18709164 16353154 17453740 17050553 6392382 16759981
MESH:D012878 Skin Neoplasms Arsenic 13.0817029826 15504454 16251483 19538983 17050553 17976673
MESH:D012878 Skin Neoplasms sodium arsenite 13.0819524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.088532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.0816192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6912854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4117007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4118456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.8619014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.867505956
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8315213294
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.8219578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.2716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.2716049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.2711144890 18640142 19322015 17306315 17976673 19429237 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.2712845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.2717306315 16452187 16712894 11723127
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.5510091137
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6511813266
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D014652 Vascular Diseases Arsenic 11.4117056641
MESH:D014652 Vascular Diseases sodium arsenite 11.4117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D014820 Vitiligo tolcapone 5.0610573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00126 - Vitamin C Antioxidants;Essential Vitamins;Free Radical Scavengers;Vitamins (Vitamin C);Vitamins
DB00139 - Ubicoenzyme Anti-Ulcer Agents;Dietary supplement;Micronutrient;Radiation-Protective Agents
DB00172 - L-Proline Dietary supplement;Micronutrient;Non-Essential Amino Acids
DB01275 antagonist BiDil Antihypertensive Agents;Vasodilator Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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