AutismKB 2.0

Annotation Detail for PAEP


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Basic Information Top
Gene Symbol:PAEP ( GD,GdA,GdF,GdS,MGC138509,MGC142288,PAEG,PEP,PP14 )
Gene Full Name: progestagen-associated endometrial protein
Band: 9q34.3
Quick LinksEntrez ID:5047; OMIM: 173310; Uniprot ID:PAEP_HUMAN; ENSEMBL ID: ENSG00000122133; HGNC ID: 8573
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1721Female reproductive system disorder
1850Herpes
2241Infertility
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027132 1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate binds to PAEP proteinaffects binding 16461020
C057349 2,4-decadienal 2,4-decadienal affects the metabolism of PAEP proteinaffects metabolic processing 17226935
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal affects the metabolism of PAEP proteinaffects metabolic processing 17226935
C403894 4-oxo-2-nonenal 4-oxo-2-nonenal affects the metabolism of PAEP proteinaffects metabolic processing 17226935
D000171 Acrolein Acrolein affects the metabolism of PAEP proteinaffects metabolic processing 17226935
D002330 Carmustine Carmustine results in decreased expression of PAEP mRNAdecreases expression 15980968
D004958 Estradiol PAEP protein modified form results in increased metabolism of Estradiolincreases metabolic processing 17649829
D004958 Estradiol PAEP protein results in increased secretion of Estradiolincreases secretion 17649829
D004967 Estrogens PAEP protein modified form results in increased abundance of Estrogensincreases abundance 15852231
D004967 Estrogens PAEP protein results in increased abundance of Estrogensincreases abundance 15852231
D019791 Guanidine Guanidine results in decreased stability of PAEP protein modified formdecreases stability 12755705
D019791 Guanidine Trehalose inhibits the reaction [Guanidine results in decreased stability of PAEP protein modified form]decreases reaction|decreases stability 12755705
D006854 Hydrocortisone PAEP protein modified form results in increased metabolism of Hydrocortisoneincreases metabolic processing 17649829
D008315 Malondialdehyde Malondialdehyde affects the metabolism of PAEP proteinaffects metabolic processing 17226935
D017258 Medroxyprogesterone Acetate Medroxyprogesterone Acetate promotes the reaction [trichostatin A results in increased expression of PAEP mRNA]increases expression|increases reaction 17339403
D017258 Medroxyprogesterone Acetate Medroxyprogesterone Acetate results in increased expression of PAEP mRNAincreases expression 17339403
D010165 Palladium Palladium binds to PAEP proteinaffects binding 17097727
C023036 perfluorooctanoic acid perfluorooctanoic acid binds to and results in decreased folding of PAEP proteinaffects binding|decreases folding 16019014
D011374 Progesterone PAEP protein modified form results in increased abundance of Progesteroneincreases abundance 15852231
D011374 Progesterone PAEP protein modified form results in increased metabolism of Progesteroneincreases metabolic processing 17649829
D011374 Progesterone PAEP protein results in increased abundance of Progesteroneincreases abundance 15852231
D011374 Progesterone Progesterone results in decreased expression of PAEPdecreases expression 17510236
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PAEP mRNAincreases expression 15886252
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PAEP proteinincreases expression 15886252
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased secretion of PAEP proteinincreases secretion 15886252
D014199 Trehalose Trehalose inhibits the reaction [Guanidine results in decreased stability of PAEP protein modified form]decreases reaction|decreases stability 12755705
D014199 Trehalose Trehalose results in increased stability of PAEP protein modified formincreases stability 12755705
C012589 trichostatin A Medroxyprogesterone Acetate promotes the reaction [trichostatin A results in increased expression of PAEP mRNA]increases expression|increases reaction 17339403
C012589 trichostatin A trichostatin A results in increased expression of PAEP mRNAincreases expression 17339403
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8114514962 15322242 11752688
MESH:D055371 Acute Lung Injury Acrolein 4.6720525806 21297076
MESH:D000230 Adenocarcinoma Estradiol 2.0911473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000544 Alzheimer Disease Acrolein 3.2617570602 15207723 14715435
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0710965797
MESH:D000740 Anemia Malondialdehyde 9.2317278206
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D001161 Arteriosclerosis Acrolein 4.9715014928
MESH:D050197 Atherosclerosis Acrolein 3.9516037261 16126721 17363696
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3117868700
MESH:D001930 Brain Injuries Progesterone 4.2215665606 15845082 15380490
MESH:D001932 Brain Neoplasms Carmustine 4.3516187019
MESH:D001943 Breast Neoplasms Estradiol 1.8417261762 14630087 19861407 17018787 16675129 12948864 17289903 18497071
MESH:D001943 Breast Neoplasms Progesterone 1.8416175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.4816924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 3.4815341023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002972 Cleft Palate Hydrocortisone 6.2515826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2515668235 12621046 16354765 15340226 8697196
MESH:D015179 Colorectal Neoplasms Acrolein 2.9217597105
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 2.9817728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9810048152 15322242 20055451
MESH:D016638 Critical Illness Estrogens 5.9116670151
MESH:D003556 Cystitis Acrolein 5.3612161096
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4517187935
MESH:D003967 Diarrhea Hydrocortisone 4.687237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004487 Edema perfluorooctanoic acid 6.8117259670 12083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7417692515
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.6119294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.9511473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 8.8016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.809294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9120067830
MESH:D005909 Glioblastoma Carmustine 7.6616187019
MESH:D005909 Glioblastoma trichostatin A 7.6618801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D016481 Helicobacter Infections Malondialdehyde 5.9317278206
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 8.543609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5415340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.8112083418
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3615869954
MESH:D007249 Inflammation perfluorooctanoic acid 8.2612083418
MESH:D007249 Inflammation Progesterone 8.2615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.9416627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007674 Kidney Diseases Acrolein 6.4012488133
MESH:D007674 Kidney Diseases Estradiol 6.4015618244
MESH:D007676 Kidney Failure, Chronic Malondialdehyde 5.8216518626
MESH:D007680 Kidney Neoplasms Estradiol 2.9415610895
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Palladium 6.4717097727
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 2.9018206229
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.198812269
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2412878042
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 4.6018709148 14757943
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0812151625
MESH:D008171 Lung Diseases Acrolein 4.1811504702
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9617203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.9617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008545 Melanoma Carmustine 3.9312393984
MESH:D008545 Melanoma trichostatin A 3.9316505122
MESH:D008546 Melanoma, Experimental Acrolein 5.1710803710
MESH:D009101 Multiple Myeloma trichostatin A 3.8418172295
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2416810080
MESH:D009369 Neoplasms Acrolein 3.5217329238
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009393 Nephritis Acrolein 6.2612653641
MESH:D009421 Nervous System Malformations Estradiol 9.3311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3314600291
MESH:D019636 Neurodegenerative Diseases Acrolein 4.4711342003
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.919802331
MESH:D010051 Ovarian Neoplasms Estradiol 11.3019401270
MESH:D010051 Ovarian Neoplasms Medroxyprogesterone Acetate 11.3017393432
MESH:D010051 Ovarian Neoplasms Progesterone 11.3017393432 16525653
MESH:D010051 Ovarian Neoplasms trichostatin A 11.3019331143
MESH:D010190 Pancreatic Neoplasms trichostatin A 3.2719294695
MESH:D010300 Parkinson Disease Acrolein 3.5717690948
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 13.3711550810
MESH:D010787 Photosensitivity Disorders Acrolein 13.3711550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.5517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5511222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis trichostatin A 5.2117616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.5216740699
MESH:D011471 Prostatic Neoplasms trichostatin A 3.5219789329 18798265
MESH:D051437 Renal Insufficiency Acrolein 4.9712732208
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8418045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.2415862959 16503802
MESH:D020521 Stroke Acrolein 4.5216269634
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014947 Wounds and Injuries Estrogens 4.7011172683
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02405 - 12-Bromododecanoic Acid
DB03796 - Palmitic Acid Enzyme Inhibitors
DB04077 - Glycerol Solvents;Cryoprotective Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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