Annotation Detail for DUOX2
Basic Information
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| Desease Name |
|---|
| Thryoid dyshormonogenesis 6 |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D016604 |
Aflatoxin B1 |
Aflatoxin B1 affects the expression of DUOX2 protein | affects expression | 20106945
|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of DUOX2 mRNA | affects expression | 16483693
|
| C006632 |
arsenic trioxide |
arsenic trioxide results in increased expression of DUOX2 mRNA | increases expression | 20458559
|
| D019810 |
Sodium Azide |
Sodium Azide inhibits the reaction [IFNG protein results in increased activity of DUOX2 protein] | decreases reaction|increases activity | 16970942
|
| D013974 |
Thyroxine |
Thyroxine results in decreased expression of DUOX2 protein | decreases expression | 17332529
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.10 | 18287403 |
| MESH:D000230 |
Adenocarcinoma |
|
arsenic trioxide |
2.35 | 11798837 19825857 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
arsenic trioxide |
4.04 | 16206674 |
| MESH:D002051 |
Burkitt Lymphoma |
|
arsenic trioxide |
4.73 | 11589617 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Aflatoxin B1 |
3.23 | 21507988 12619106 12907637 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
arsenic trioxide |
3.23 | 11135700 14691202 15553829 16217749 15073043 |
| MESH:D002291 |
Carcinoma, Papillary |
|
arsenic trioxide |
5.49 | 19014326 |
| MESH:D018288 |
Carcinoma, Small Cell |
|
arsenic trioxide |
4.47 | 12490120 |
| MESH:D006332 |
Cardiomegaly |
|
Thyroxine |
4.27 | 18093424 |
| MESH:D015179 |
Colorectal Neoplasms |
|
arsenic trioxide |
1.86 | 20501625 |
| MESH:D003409 |
Congenital Hypothyroidism |
marker/mechanism |
|
| 16134168 16322276 |
| MESH:D023903 |
Coronary Restenosis |
|
arsenic trioxide |
4.63 | 12609071 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
arsenic trioxide |
1.89 | 10525206 |
| MESH:D016757 |
Death, Sudden, Cardiac |
|
arsenic trioxide |
4.50 | 15213294 |
| MESH:D004938 |
Esophageal Neoplasms |
|
arsenic trioxide |
2.38 | 12903497 |
| MESH:D005234 |
Fatty Liver |
|
arsenic trioxide |
3.66 | 15073043 |
| MESH:D005706 |
Gallbladder Neoplasms |
|
arsenic trioxide |
4.70 | 16904648 |
| MESH:D007938 |
Leukemia |
|
arsenic trioxide |
2.98 | 15070760 |
| MESH:D015459 |
Leukemia-Lymphoma, Adult T-Cell |
|
arsenic trioxide |
4.17 | 12560223 17077332 |
| MESH:D007948 |
Leukemia, Monocytic, Acute |
|
arsenic trioxide |
4.85 | 16972261 |
| MESH:D015464 |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
|
arsenic trioxide |
3.69 | 14633726 |
| MESH:D007951 |
Leukemia, Myeloid |
|
arsenic trioxide |
4.13 | 19077051 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
arsenic trioxide |
2.18 | 19850784 20471514 16467208 17050201 16968895 |
| MESH:D015473 |
Leukemia, Promyelocytic, Acute |
|
arsenic trioxide |
3.43 | 19075265 12018890 11161223 12712474 16330433 19642359 15748426 17217047 19225113 17107899 15336539 17712046 17869043 16112521 16966277 16823087 16331271 19035177 15622746 17649720 12679006 9834237 11468182 15213294 16891316 |
| MESH:D015458 |
Leukemia, T-Cell |
|
arsenic trioxide |
4.79 | 16882451 |
| MESH:D008113 |
Liver Neoplasms |
|
Aflatoxin B1 |
5.04 | 15890375 2125692 18177683 9163691 |
| MESH:D008113 |
Liver Neoplasms |
|
arsenic trioxide |
5.04 | 14682389 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Aflatoxin B1 |
6.72 | 8603461 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
arsenic trioxide |
6.72 | 20377131 |
| MESH:D008133 |
Long QT Syndrome |
|
arsenic trioxide |
3.62 | 15213294 |
| MESH:D008175 |
Lung Neoplasms |
|
Aflatoxin B1 |
2.61 | 14755239 |
| MESH:D008175 |
Lung Neoplasms |
|
arsenic trioxide |
2.61 | 19825857 11798837 |
| MESH:D009101 |
Multiple Myeloma |
|
arsenic trioxide |
3.35 | 11468182 19417148 19549372 14977855 15949261 |
| MESH:D009182 |
Mycosis Fungoides |
|
arsenic trioxide |
5.28 | 18349030 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
arsenic trioxide |
3.32 | 16105982 16882451 |
| MESH:D009361 |
Neoplasm Invasiveness |
|
arsenic trioxide |
4.40 | 16624393 |
| MESH:D009436 |
Neural Tube Defects |
|
arsenic trioxide |
3.33 | 10525206 |
| MESH:D010051 |
Ovarian Neoplasms |
|
arsenic trioxide |
2.49 | 16624393 19769630 12452020 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
arsenic trioxide |
2.62 | 15580305 |
| MESH:D010235 |
Paraganglioma |
|
arsenic trioxide |
4.57 | 19927285 |
| MESH:D011471 |
Prostatic Neoplasms |
|
arsenic trioxide |
3.22 | 19131511 |
| MESH:D012512 |
Sarcoma, Ewing's |
|
arsenic trioxide |
4.40 | 16646077 |
| MESH:D013274 |
Stomach Neoplasms |
|
arsenic trioxide |
1.86 | 17007042 |
| MESH:D013959 |
Thyroid Diseases |
|
Thyroxine |
6.25 | 19910387 |
| OMIM:607200 |
THYROID DYSHORMONOGENESIS 6 |
marker/mechanism |
|
| |
| MESH:D013964 |
Thyroid Neoplasms |
|
arsenic trioxide |
3.36 | 19014326 |
| MESH:D016171 |
Torsades de Pointes |
|
arsenic trioxide |
4.50 | 15213294 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
arsenic trioxide |
2.59 | 12845720 20435036 12973940 11780464 |
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