AutismKB 2.0

Annotation Detail for NOX4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NOX4 ( KOX,KOX-1,RENOX )
Gene Full Name: NADPH oxidase 4
Band: 11q14.3
Quick LinksEntrez ID:50507; OMIM: 605261; Uniprot ID:NOX4_HUMAN; ENSEMBL ID: ENSG00000086991; HGNC ID: 7891
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NOX4 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of NOX4 mRNAdecreases expression 17202762
15976192
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOX4 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of NOX4 mRNAdecreases expression 19654921
C032036 bromobenzene bromobenzene results in decreased expression of NOX4 mRNAdecreases expression 15976192
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of NOX4 mRNAdecreases expression 17854599
15976192
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of NOX4 proteindecreases expression 17854599
C057862 cyanoginosin LR cyanoginosin LR results in decreased expression of NOX4 mRNAdecreases expression 17654400
D004041 Dietary Fats Dietary Fats results in decreased expression of NOX4 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of NOX4 mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of NOX4 mRNAdecreases expression 15976192
D004317 Doxorubicin Doxorubicin promotes the reaction [tyrphostin AG 1478 results in increased expression of NOX4 mRNA]increases expression|increases reaction 18371937
D004317 Doxorubicin Doxorubicin results in increased expression of NOX4 mRNAincreases expression 18371937
D005419 Flavonoids Flavonoids results in decreased expression of NOX4 mRNAdecreases expression 18035473
D005632 Fructose Fructose results in increased expression of NOX4 mRNAincreases expression 17587757
C029424 hydrazine hydrazine results in decreased expression of NOX4 mRNAdecreases expression 15282401
D005996 Nitroglycerin Nitroglycerin results in decreased expression of NOX4 mRNAdecreases expression 17493633
C041786 palm oil palm oil results in decreased expression of NOX4 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of NOX4 mRNAincreases expression 19270015
C108475 pitavastatin pitavastatin results in decreased expression of NOX4 mRNAdecreases expression 15502390
D012643 Selenium Selenium deficiency results in increased expression of NOX4 mRNAincreases expression 16170372
D013853 Thioacetamide Thioacetamide results in decreased expression of NOX4 mRNAdecreases expression 15976192
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of NOX4 mRNAincreases expression 18087596
C101044 tyrphostin AG 1478 Doxorubicin promotes the reaction [tyrphostin AG 1478 results in increased expression of NOX4 mRNA]increases expression|increases reaction 18371937
C101044 tyrphostin AG 1478 tyrphostin AG 1478 results in increased expression of NOX4 mRNAincreases expression 18371937
D015032 Zinc Zinc results in increased expression of NOX4 mRNAincreases expression 16870260
C016837 zinc chloride zinc chloride results in increased expression of NOX4 mRNAincreases expression 16870260
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.276195326
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000169 Acrodermatitis Zinc 5.2317202136 17190629 16889938
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.6416033868
MESH:D000230 Adenocarcinoma Doxorubicin 4.6417418594
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.3615814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.683712494
MESH:D000236 Adenoma Diethylnitrosamine 10.686695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 10.6819555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.7019061943 17620307 18056438 19052882 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.7017620307
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0417306315
MESH:D000419 Albuminuria Doxorubicin 4.3821441931
MESH:D000544 Alzheimer Disease Zinc 2.7216580781 16325427 16410023 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 4.7316916123
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8212569548 18414634 16835338 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 3.7215238619
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1419898480
MESH:D001249 Asthma Zinc 2.9017085522
MESH:D050197 Atherosclerosis Arsenic 3.1519371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8511289319 1440618
MESH:D001778 Blood Coagulation Disorders Thioacetamide 4.0119483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5314601052
MESH:D001930 Brain Injuries Zinc 4.5217109824
MESH:D001932 Brain Neoplasms Doxorubicin 3.6617150277
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Doxorubicin 1.9615136595 18628466 18695136 15634643 16264153 15668708 19526202 17983394 16096432 18382427 16935488 16115903 17426702 11325840 15567936 16595493 15939500 16826403 16322301 18234424 15993339 15692762 17369602 15994142
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.7512794006
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6116097048 16227642 16192424 15700767 16124888 15673190 16011737 10355542 16050911 15721981 18705752 3786805
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6416051944
MESH:D002277 Carcinoma Dimethylnitrosamine 3.8919555203
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5017687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.457296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.453084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 16.4517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.4518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.4520524982 19335982 10737359 16569478 18665156 16878318 16328049 20514400 20007298 17761372 19107877 3084413 19383236 16288022 20101231 21159647 17162532 19052882 18691550 18506893 16681979 18788625 20727157 18210153 16502159 20214788 18494052 16935385 11831363 17173139 16830150 19701751 19208518 19822196 20084675 17138121 19394651 18393292 18971187 10672840 17428255 19539802 16698587 19919837 19519916 17055752 18978308 16779866 16540662 17978847 20935162 19171122 18785209 3581430 18056438 20512989 20432363 19418558 16807293
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.4518059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.4517173139 20007298 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 16.4517997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.3711212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.287296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.281485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 13.8417687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 13.8416033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.846189445
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 13.8411212258
MESH:D002294 Carcinoma, Squamous Cell Zinc 13.8416543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.9318640142
MESH:D009202 Cardiomyopathies Doxorubicin 3.4217382496 16269455 17924179 17329180 15792986 17351982 16612575 16651473 16952015 16731534 17007740 17308081 17131338 18627295 16278810 17928571 16242529 15476868 17519947 15505089 16364871 16109756 15811867 16455267 17974986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8916243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 7.2419152805 15738583 17938729
MESH:D002318 Cardiovascular Diseases Zinc 7.2416936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.1618022660 16973168
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.307505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.3021159647 7505956 2727394 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.084080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2519052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.2518291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.029022650 19486331
MESH:D003092 Colitis Selenium 3.6117936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003327 Coronary Disease Fructose 4.3718504504
MESH:D019465 Craniofacial Abnormalities Zinc 2.4219302082
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.648156756 14531868 18759878 8970840 11906362 12868966 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.332952479 3621924
MESH:D003920 Diabetes Mellitus Zinc 4.0616479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.3518603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.7120387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.7118603373
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 28.699328219 18692083 16192314 11289319 1440618 6482804 18648102 18289764 8291058 9022650 9653073 7440962 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 28.6915619225 11287661 12392966 11529661 16227642 16781746 19164858 10663392 12153990 14725611 18713872 14550746 17562736 12958197 12540782 12705907 19420014 10915739 16109766 17906064 16177239 19739265 14986274 18071297 16081117 11461765 11834606 11421492 11739529 15968718 12594235 19416960 19085960 17522070 19370779 2444490 11743745 16485898 16393943 19923254 10774834
MESH:D056486 Drug-Induced Liver Injury bromobenzene 28.6912628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 28.6917522070 7179309 3732212 10915739 19085960 10092053 15968718 3786805 2869522 11566570 16177239 15998439 4309450 15027814 21278145 19336974 9327722 6884620 16227642 6623471 7120509 7440962
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 28.6917654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 28.6919107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 28.698172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 28.6917416283
MESH:D056486 Drug-Induced Liver Injury Selenium 28.6915131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 28.6912963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Doxorubicin 3.5418602426
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D004421 Dystonia Phenobarbital 3.841851702
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3417359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9818037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.943659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.7011558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.406401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.853659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.153581430
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.1517016578
MESH:D004938 Esophageal Neoplasms Zinc 7.1516543248
MESH:D005218 Fat Necrosis Thioacetamide 5.5516456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.5615959796 16239168 12631006 16045604 12795759 17595544 61145 19224547
MESH:D005234 Fatty Liver Dietary Fats 17.5618296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 17.5621071580 20387270
MESH:D005234 Fatty Liver Fructose 17.5618395287 18641190 19196556
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.856705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.0118705752
MESH:D005355 Fibrosis Dietary Fats 14.0118296743
MESH:D005355 Fibrosis Fructose 14.0118504504
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D005756 Gastritis Acetaminophen 10.5916983495
MESH:D005756 Gastritis Zinc 10.5917241300
MESH:D005909 Glioblastoma Doxorubicin 3.2417150277
MESH:D018149 Glucose Intolerance Fructose 5.1619165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.887505956
MESH:D006130 Growth Disorders Zinc 3.8517217573
MESH:D006261 Headache Nitroglycerin 5.0211554966 11284996
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4115692506
MESH:D006331 Heart Diseases Doxorubicin 3.3716495754 16244371 16244372 16144979 18006777 18674790 16879835 12587719 17875725 17888722 16330681 16707910 14766674
MESH:D006333 Heart Failure Doxorubicin 16.1617481944
MESH:D006333 Heart Failure pitavastatin 16.1615502390
MESH:D006333 Heart Failure Selenium 16.1617162251
MESH:D006333 Heart Failure Zinc 16.1617162251
MESH:D006335 Heart Injuries Zinc 5.6017074742
MESH:D016481 Helicobacter Infections Zinc 4.3717241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7415692506
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4218665440 17276928 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 14.766705139
MESH:D006505 Hepatitis Carbon Tetrachloride 14.7619900420 19110552
MESH:D006505 Hepatitis Thioacetamide 14.7616456712
MESH:D006527 Hepatolenticular Degeneration Zinc 4.5217276780
MESH:D006529 Hepatomegaly Phenobarbital 3.3216109766
MESH:D006689 Hodgkin Disease Doxorubicin 3.2718501091 15147373 17606976
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4421332399
MESH:D006946 Hyperinsulinism Fructose 4.7514757778 18563319 18360027 15752949 19008412
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006949 Hyperlipidemias Dietary Fats 9.0221332399
MESH:D006949 Hyperlipidemias Fructose 9.0215752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7715034207
MESH:D006973 Hypertension Arsenic 5.6416076760 11953799 9931084
MESH:D006973 Hypertension Fructose 5.6414573337 19008412 14633139 14568997 16843071
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D015228 Hypertriglyceridemia Fructose 4.9319342510 19799862
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007249 Inflammation Dietary Fats 11.3020412841
MESH:D007249 Inflammation Diethylnitrosamine 11.3018785209
MESH:D007249 Inflammation Flavonoids 11.3017296493
MESH:D007249 Inflammation Tobacco Smoke Pollution 11.3018590791
MESH:D007251 Influenza, Human Selenium 4.0216624496
MESH:D007333 Insulin Resistance Dietary Fats 7.4711836018 18457598
MESH:D007333 Insulin Resistance Fructose 7.4719799862 19342510 18057795 17133782 19586609 14573337 18563319 19008412 18981581 14757778 14633139
MESH:D007511 Ischemia Zinc 4.4616584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.858074119 9022650
MESH:D007642 Keratosis Arsenic 4.8216930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 9.6012587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 9.6015699352 15369732 16775033
MESH:D007674 Kidney Diseases Zinc 9.6016960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 15.8616707910
MESH:D007676 Kidney Failure, Chronic Selenium 15.8616518626
MESH:D007676 Kidney Failure, Chronic Zinc 15.8616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.836582329
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9816085563
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4417339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.9916239168 17157831 16943688 17334410 11408273 17174718 16221502 11903743 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 14.9918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.9920032147 18522880 18665156 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 14.9921047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.099327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8812649538 17525996 15338365 17721639 18395095 18418968 15925388 16097048 17481882 18339082 18481824 15123356 16015684 17708605 18376398 17631135 14716833 15893842 16136751 12632512 12898905 17900296 18277467 18205269 18472094 13678700 17698563 18263696 14512876 10355542 12609069 15362042 18412020 15818738 20821823 15959796 17805973 15052691 16638106 12586293 14620537 18187930 18251166 17565644 15730626 15650968 18705752 18156304 12632514 18429990 15370692 15996030 18006644 12741479 12546737 18317297 15057751 17976157 17922224 17761835 12445418 16027843 18210741 17766677 18166357 16011737 18472332 15876570 17869086 16116963 14724832 18279442 18054572 12445421 12389079 17640975 16248980 12958196 17823541 16192424 15931870 12667390 12666154 16033810 17944888 18420326 18395914 14716496 11481614 17557913 14748882 17714472 15673190
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.8815383259 16042886 17198567 16270385 15571005 17666798 15504291 15339415 14709902 18095165 17724770 17640959 18629640 16570917 15369754 18237412 17534399 15942678 15577212 15086199 15798949 12925901 16627068 18364076 17201889 17432682 15067225 15763062 18567088 15723089 18672772 17465448 17348192 15298665 18239293 15591649 15744066 15842777 14726149 17036385 15864749 15081153 15793283 18210741 16169303 16603200 18637143 17719030 14568256 18371158 15161499 17203207 14643895 16544323 16009107 12918455 14659978 15366600 15733078 15479170 17196135 15138612 15492853 17881167 15099470
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.8818416461 12679928 16248980 16097051 12531686 16489207 15474484 16098781 15716488 14739098 16126171 17127702 18380797 15465738 17629604 18263696 18295389 17355460 18031379 15334695 15095483 10677585 15075984 18606216 11172339 16511523 18458672 16343077 18395095 15288472 15316131 12557150 15078482 17292413 11481614 18615449 15158331 15362042 18032466 12085344 11682029 12891558 17050028 15288473 12175628
MESH:D008107 Liver Diseases Acetaminophen 15.3012969438 19784758 12587719 19460945 16611625 19014921 16610002 11587558
MESH:D008107 Liver Diseases Arsenic 15.3011134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 15.3016246199 17285989 15830285 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 15.3017034775
MESH:D008107 Liver Diseases Phenobarbital 15.3019363144
MESH:D008107 Liver Diseases Thioacetamide 15.3018374380 16337175 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 22.0217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 22.0216899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 22.0217457977
MESH:D017114 Liver Failure, Acute Thioacetamide 22.0217276928 12479984 15633222 15313186
MESH:D008113 Liver Neoplasms Arsenic 13.5716368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.5719294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.5719638242 20434301 19833225 21167192 19812893 19254457 18644402 19427195 19690152 2862719 18977376 16942905 19073162 18978307 19499222 20118626 18754104 20501860 12771043 19996281 19426721 20101389 20452335 15885732 20137499 18648771 19294768 15175105 21278145 20583210 21047994 19256749 12112319 19090486 20405173 9163691 21071580 2422723 19642983 19551842 19255062 20492335 10737359 19850985
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 13.5715890375 3113478
MESH:D008113 Liver Neoplasms Phenobarbital 13.5719482888 19812893 15975961 19073162 8742319 21047994
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 22.006587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.0012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.0017854601 19539802 21159647 19009564 17174075 18775883 18308698 18079962 19004024 16267830 16842330 18093689 19519916 18544905 9362446 3124819 18253720 19126423 18164116 17942915 18282651 2563599
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.006150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 22.0016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.0017172636 6150874 1399818 18308698 2563599
MESH:D008175 Lung Neoplasms Arsenic 6.4117306315 17976673 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.4120970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 6.4116061637 19555203 11884234
MESH:D008175 Lung Neoplasms Doxorubicin 6.4117418594 6189445
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 6.413440675 16288123 12111688 11091918
MESH:D008223 Lymphoma Doxorubicin 3.3416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4015621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.4815458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.4815318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 9.4812773700
MESH:D008545 Melanoma Doxorubicin 2.2616827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008654 Mesothelioma Doxorubicin 6.0617638057
MESH:D008654 Mesothelioma Selenium 6.0615107826
MESH:D024821 Metabolic Syndrome X Fructose 4.6716815490 17261469 18497449 19165636 17098227
MESH:D008708 Methemoglobinemia Nitroglycerin 4.573537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.9614659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3415792986
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.2215006635
MESH:D052016 Mucositis Doxorubicin 4.6217415656
MESH:D009203 Myocardial Infarction Doxorubicin 6.0815857846 19429709
MESH:D009203 Myocardial Infarction Nitroglycerin 6.0814729435
MESH:D017202 Myocardial Ischemia Arsenic 3.8515371236
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3017484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.123581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.129029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.1218259882
MESH:D009401 Nephrosis Doxorubicin 4.6016899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8516889571 15640375
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.016679447
MESH:D009436 Neural Tube Defects Arsenic 7.0116620997
MESH:D009447 Neuroblastoma Doxorubicin 3.1815555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7120387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9420387270
MESH:D009765 Obesity Dietary Fats 4.8820132043 21332399 19632207 17217161 20518802 18674790 18457598 16723640 11836018
MESH:D009765 Obesity Fructose 4.8818585860 17707055
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.276482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.853988306
MESH:D010018 Osteomalacia Phenobarbital 4.1917016548
MESH:D012516 Osteosarcoma Doxorubicin 3.9815930896
MESH:D010051 Ovarian Neoplasms Arsenic 2.6917306315
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0616540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0616965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.317296757
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8216905509 6392382 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.306228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9817983394
MESH:D010954 Plasmacytoma Selenium 4.7215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9817638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.612563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.612563599
MESH:D011225 Pre-Eclampsia Zinc 4.0417114810
MESH:D011471 Prostatic Neoplasms Arsenic 2.7916140617
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7915749863 16729912 16868541 15897917 18437689 16888761
MESH:D011471 Prostatic Neoplasms Zinc 2.7916606632 16517595 16700911 12429649
MESH:D011507 Proteinuria Arsenic 3.8421343184
MESH:D019310 Pseudolymphoma Phenobarbital 4.3212752131
MESH:D051437 Renal Insufficiency Doxorubicin 4.0517922066
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.4518410779
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.583692021
MESH:D012162 Retinal Degeneration Zinc 8.5816584753
MESH:D012509 Sarcoma Doxorubicin 3.8416767912 17710206 15625365 15675481 18313854 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6217846226
MESH:D012640 Seizures Phenobarbital 2.5811442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.656407741
MESH:D012871 Skin Diseases Arsenic 2.7015952646 6392382 16702368 17548696 17938729 16759981 17453740 16353154 19834688 17050553 18709164
MESH:D012878 Skin Neoplasms Arsenic 9.2517976673 17050553 15504454 17029826 19538983 16251483
MESH:D012878 Skin Neoplasms Doxorubicin 9.2515692506
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 9.2518590791
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4015625365 16767912 17203757
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1012587719
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6218456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.6216033868
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 16.046587162 3712494 1399818 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.047505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.0417909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 16.041399818
MESH:D014062 Tongue Neoplasms Zinc 4.2516543248
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.458074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.4517976673 11144890 18640142 17306315 19429237 15987713 19322015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.4517653716
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 11.4512846360
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D014652 Vascular Diseases Arsenic 4.5617056641
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0517638931 17678736 16364871 17334414
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved