AutismKB 2.0

Annotation Detail for PAK1


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Basic Information Top
Gene Symbol:PAK1 ( MGC130000,MGC130001,PAKalpha )
Gene Full Name: p21 protein (Cdc42/Rac)-activated kinase 1
Band: 11q13.5-q14.1
Quick LinksEntrez ID:5058; OMIM: 602590; Uniprot ID:PAK1_HUMAN; ENSEMBL ID: ENSG00000149269; HGNC ID: 8590
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05211Renal cell carcinoma
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04660T cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Axon guidance
Signaling in Immune system
Pathway IDPathway Name
200181S1P2 pathway
200185EPHA2 forward signaling
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200083CXCR4-mediated signaling events
200085EGF receptor (ErbB1) signaling pathway
200087PLK1 signaling events
200066Angiopoietin receptor Tie2-mediated signaling
200074Netrin-mediated signaling
200166Aurora A signaling
200161Signaling events mediated by VEGFR1 and VEGFR2
200041EPHB forward signaling
200192Signaling events mediated by focal adhesion kinase
200190RAC1 signaling pathway
200057CDC42 signaling events
200054Regulation of p38-alpha and p38-beta
Pathway IDPathway Name
P00053T cell activation
P00005Angiogenesis
P00016Cytoskeletal regulation by Rho GTPase
P00007Axon guidance mediated by semaphorins
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
Pathway IDPathway Name
500100Signal transduction by L1
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1766Renal Cell cancer
1848Embryoma
1859Ovarian cancer
1944Breast cancer
1970Virus disease
1983Down syndrome
1997Dental plaque
2200Intraocular melanoma
Desease Name
CANCER
esophageal cancer
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C468114 1-palmitoyl-2-arachidonyl-3-phosphorylcholine 1-palmitoyl-2-arachidonyl-3-phosphorylcholine affects the localization of PAK1 proteinaffects localization 15472119
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PAK1 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PAK1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PAK1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PAK1 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of PAK1 proteinincreases expression 18991853
D003913 Dextroamphetamine Dextroamphetamine results in increased phosphorylation of PAK1 proteinincreases phosphorylation 18991853
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of PAK1 mRNAaffects cotreatment|decreases expression 18636392
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of PAK1 mRNAincreases expression 17654400
D003840 Deoxycholic Acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PAK1 mRNAaffects cotreatment|increases expression 16556975
D004041 Dietary Fats Dietary Fats results in increased expression of PAK1 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PAK1increases expression 17055752
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PAK1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PAK1 mRNAincreases expression 16174780
C030691 gluconic acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PAK1 mRNAaffects cotreatment|increases expression 16556975
D019812 Heparan Sulfate Proteoglycans Heparan Sulfate Proteoglycans promotes the reaction [CXCL1 protein results in increased activity of PAK1 protein]increases activity|increases reaction 12549928
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of PAK1 mRNAaffects cotreatment|decreases expression 18636392
C041786 palm oil palm oil results in increased expression of PAK1 mRNAincreases expression 18042831
D013629 Tamoxifen PAK1 affects the susceptibility to Tamoxifenaffects response to substance 20179234
D013629 Tamoxifen Tamoxifen affects the expression of PAK1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PAK1 mRNAdecreases expression 19465110
19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PAK1 mRNAincreases expression 16960034
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury Chlorine 4.2820601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma Diethylnitrosamine 2.826695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.9418056438 19061943 17162532 19052882 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9416835633
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D001161 Arteriosclerosis Dietary Fats 9.7815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6217854713 16373670
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms marker/mechanism 20179234
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9217474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.9215668708 16202921 19288272 18984771 18997820 18855134 19410462 19103187 21152245 18351453 16818667 11161223 20390343 20005174 19289846 19221464 16873071 20135344 19084267 19189212 18821012 18425577 17242785 20544844 19487384 19115204 17049068 19189210 19200415 18629630 21138602 18815881 19011961 19155303 19059307 17893378 19244106 15565566 16273361 19142967 17440819 19066611 20065188 17261762 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6418417511 17626835 18315731 16777450 15516495 14754758 19059883
MESH:D002100 Cachexia Ozone 4.7016183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5116705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.5116569478 18978308 19919837 18691550 19539802 21159647 20514400 16681979 20214788 19519916 16288022 16540662 10737359 20084675 19208518 18785209 18506893 17162532 18210153 18393292 18788625 18494052 19171122 20432363 10672840 3581430 16328049 19394651 16935385 19107877 17055752 19383236 18665156 20101231 3084413 17761372 16878318 20935162 18056438 16698587 19418558 19335982 17173139 17428255 16502159 20512989 19052882 20524982 17978847 19822196 19701751 20007298 18971187 16807293 17138121 11831363 20727157 16830150 16779866
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5116924424
MESH:D002292 Carcinoma, Renal Cell marker/mechanism 17621631
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.596135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.5921159647 17174075 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8416105132 17333356 17110522 16919318 15861022 17681005 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 8697196 15668235 16354765 12621046
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 3.5616213893
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.7618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.7618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.9021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.9018551238 21346803
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 11.9017654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.9019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004417 Dyspnea Chlorine 4.6020016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0217893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Dietary Fats 18.4419551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 18.4420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.4415345470
MESH:D005234 Fatty Liver Tamoxifen 18.4419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Dietary Fats 8.4918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4920067830
MESH:D005739 Gas Poisoning Chlorine 4.9820016425
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8512621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 18606429 15340226 16354765 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Dietary Fats 11.7620412841
MESH:D007249 Inflammation Diethylnitrosamine 11.7618785209
MESH:D007249 Inflammation Tamoxifen 11.7619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7612878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.0711836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.1916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.1916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 12.1918625569
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5518665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2712878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0917034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.557678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.5520452335 19294768 9163691 19426721 16942905 21278145 10737359 19690152 19427195 12771043 20583210 19254457 18644402 15175105 19256749 19090486 20118626 19642983 20492335 19638242 20501860 2862719 18978307 19499222 20434301 12112319 19255062 19551842 19850985 18648771 21047994 2422723 21167192 20101389 19812893 18977376 19833225 20137499 15885732 21071580 19073162 18754104 20405173 19996281
MESH:D008113 Liver Neoplasms Tamoxifen 10.5516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.952876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 13.956150874
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.959362446 19004024 19009564 16842330 2563599 18093689 16267830 18164116 19519916 18253720 19539802 3124819 18775883 17174075 19126423 21159647 17854601 17942915 18282651 18308698 18079962 18544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.9512151625
MESH:D008171 Lung Diseases Ozone 3.3519066396 8266340
MESH:D055370 Lung Injury Ozone 3.8120417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8020970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Ozone 4.807614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 4.8018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8011884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5914580682 19196722 19196723 16827153 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008545 Melanoma Tamoxifen 1.8719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008679 Metaplasia Ozone 5.0810496685
MESH:D009041 Motion Sickness Dextroamphetamine 5.491613127
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.2318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.679029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3020387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D009765 Obesity Dietary Fats 2.2820518802 18457598 11836018 17217161 19632207 16723640 20132043 21332399 18674790
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.7516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.7516049721
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010538 Peritonitis Ozone 4.0916369182
MESH:D011014 Pneumonia Ozone 4.3618007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.512563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D012120 Respiration Disorders Chlorine 5.1818579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.4716709447
MESH:D013088 Spermatocele Tamoxifen 11.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.957505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.1916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.1916049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.198653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.8710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.8710091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
KEGG:04062 Chemokine signaling pathway
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04012 ErbB signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32917
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448976choline
    PA448948chloroquine
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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