AutismKB 2.0

Annotation Detail for ATP5B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ATP5B ( ATPMB,ATPSB,MGC5231 )
Gene Full Name: ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Band: 12q13.3
Quick LinksEntrez ID:506; OMIM: 102910; Uniprot ID:ATPB_HUMAN; ENSEMBL ID: ENSG00000110955; HGNC ID: 830
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
Pathway IDPathway Name
P02721ATP synthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C403065 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide binds to ATP5B proteinaffects binding 19539807
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ATP5B mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ATP5B mRNAdecreases expression 12958071
D000171 Acrolein Acrolein affects the metabolism of ATP5B proteinaffects metabolic processing 17921335
D000638 Amiodarone Amiodarone results in increased expression of ATP5B mRNAincreases expression 17991464
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATP5B mRNAaffects expression 16483693
D001647 Bile Acids and Salts Bile Acids and Salts results in decreased expression of ATP5B mRNAdecreases expression 15883737
D001647 Bile Acids and Salts [Hydrochloric Acid co-treated with Bile Acids and Salts] results in decreased expression of ATP5B mRNAaffects cotreatment|decreases expression 15883737
C099555 CD 437 CD 437 results in decreased expression of ATP5B mRNAdecreases expression 12958071
D003024 Clozapine Clozapine results in decreased expression of ATP5B proteindecreases expression 19441803
D016572 Cyclosporine Cyclosporine results in decreased expression of ATP5B mRNAdecreases expression 20106945
C014347 decitabine [trichostatin A co-treated with decitabine] results in increased expression of ATP5B proteinaffects cotreatment|increases expression 19294695
C121718 dicyclanil dicyclanil results in increased expression of ATP5B mRNAincreases expression 15664270
D004958 Estradiol Estradiol results in increased expression of ATP5B mRNAincreases expression 20211987
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ATP5B mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATP5B mRNAincreases expression 19400957
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5B mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATP5B mRNAincreases expression 19400957
D005419 Flavonoids Flavonoids results in decreased expression of ATP5B mRNAdecreases expression 18035473
C070081 fulvestrant fulvestrant results in increased expression of ATP5B mRNAincreases expression 20211987
D006851 Hydrochloric Acid [Hydrochloric Acid co-treated with Bile Acids and Salts] results in decreased expression of ATP5B mRNAaffects cotreatment|decreases expression 15883737
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of ATP5B mRNAdecreases expression 15883737
D007657 Ketone Bodies Ketone Bodies results in increased expression of ATP5B mRNAincreases expression 15469884
D009255 Nafenopin Nafenopin affects the expression of ATP5B proteinaffects expression 10903494
C031721 naphthalene naphthalene metabolite binds to ATP5B proteinaffects binding 15892573
D011374 Progesterone Progesterone results in increased phosphorylation of ATP5B proteinincreases phosphorylation 17303654
C059514 resveratrol resveratrol binds to and results in decreased activity of [ATP5B protein binds to ATP5A1 protein binds to ATP5C1 protein]affects binding|decreases activity 17698806
D013629 Tamoxifen Tamoxifen results in increased expression of ATP5B mRNAincreases expression 20211987
D013629 Tamoxifen Tamoxifen affects the expression of ATP5B mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen results in increased expression of ATP5B mRNAincreases expression 19400957
D013629 Tamoxifen Tamoxifen results in increased expression of ATP5B mRNAincreases expression 19400957
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATP5B mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ATP5B mRNAdecreases expression 20399798
C066340 tolcapone tolcapone binds to ATP5B proteinaffects binding 19783845
C012589 trichostatin A trichostatin A affects the expression of ATP5B proteinaffects expression 19294695
C012589 trichostatin A [trichostatin A co-treated with decitabine] results in increased expression of ATP5B proteinaffects cotreatment|increases expression 19294695
D014810 Vitamin E Vitamin E results in increased expression of ATP5B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6211752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 9.9618287403
MESH:D000138 Acidosis Hydrochloric Acid 9.9611574821 16144966 12771618 19262391 15920416 20872349
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.5517183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.5820597076
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6516538975
MESH:D055371 Acute Lung Injury Acrolein 9.2020525806 21297076
MESH:D055371 Acute Lung Injury Hydrochloric Acid 9.2011953099 16759491 19094174 15970105 19060228 19760209 11850527
MESH:D000230 Adenocarcinoma Estradiol 4.0211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0214692618
MESH:D000236 Adenoma resveratrol 3.1915688382
MESH:D018248 Adenoma, Liver Cell dicyclanil 9.7317162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7316835633
MESH:D000380 Agranulocytosis Clozapine 4.8312649775 14617031 16160616
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.0611080934
MESH:D000544 Alzheimer Disease Acrolein 6.6117570602 15207723 14715435
MESH:D000544 Alzheimer Disease resveratrol 6.6116162502 16183991
MESH:D000544 Alzheimer Disease tolcapone 6.6120150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000860 Anoxia Hydrochloric Acid 5.0815090967
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6018057881 20041841 18218290
MESH:D001161 Arteriosclerosis Acrolein 9.5715014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9015885639
MESH:D001169 Arthritis, Experimental resveratrol 6.9017115116
MESH:D050197 Atherosclerosis Acrolein 6.7117363696 16037261 16126721
MESH:D050197 Atherosclerosis resveratrol 6.7116873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.7318651412 19698954
MESH:D001284 Atrophy fulvestrant 4.6311514358
MESH:D001778 Blood Coagulation Disorders Amiodarone 14.3519483382
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 14.3515920416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 4.0315845082 15380490 15665606
MESH:D002545 Brain Ischemia resveratrol 4.0617600658
MESH:D001943 Breast Neoplasms decitabine 3.6218320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 3.6217018787 17289903 19861407 16675129 18497071 12948864 14630087 17261762
MESH:D001943 Breast Neoplasms fulvestrant 3.6218984771
MESH:D001943 Breast Neoplasms Progesterone 3.6215562024 17614352 16175315
MESH:D001943 Breast Neoplasms resveratrol 3.6216393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 3.6220135344 19115204 17261762 19189212 19200415 19142967 16273361 19084267 11161223 20544844 18629630 16202921 18425577 19221464 20390343 18815881 16818667 17893378 20005174 18855134 18984771 19189210 18821012 15565566 19059307 18351453 19103187 21138602 20065188 20859285 19155303 19487384 18997820 19410462 19289846 17049068 17242785 19011961 19066611 15668708 21152245 19288272 19244106 16873071 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6220435547
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.4112378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.2415578804
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.4816705839
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 8.4817162532
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.4816924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.4816227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.4816924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3616675471
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7019215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.7016227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2416120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8215710769 19225199
MESH:D002318 Cardiovascular Diseases resveratrol 3.3215458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8518974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.246135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.2412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.2418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Cyclosporine 7.2219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2216919318 17333356 17681005 11677210 16105132 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0116354765 15668235 15340226 12621046 8697196
MESH:D003072 Cognition Disorders Clozapine 4.7417123785
MESH:D003092 Colitis resveratrol 3.9116474422
MESH:D003110 Colonic Neoplasms decitabine 3.8017616700
MESH:D003110 Colonic Neoplasms resveratrol 3.8016338953
MESH:D015179 Colorectal Neoplasms Acrolein 3.5317597105
MESH:D015179 Colorectal Neoplasms decitabine 3.5318981723
MESH:D015179 Colorectal Neoplasms resveratrol 3.5316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6116507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4119769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7918551238
MESH:D003556 Cystitis Acrolein 11.4912161096
MESH:D003556 Cystitis Hydrochloric Acid 11.4912853844 19279288 12599022 20719367
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.5817714534
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D003866 Depressive Disorder tolcapone 4.1511224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.7110440460
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5916873680
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.3116402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3117107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.9219279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.9216286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.9219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3215331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.4618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.4618218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4620420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 8.4616604736 19783845
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.1711455177
MESH:D050171 Dyslipidemias Clozapine 4.0216402076
MESH:C538011 Eales disease Vitamin E 4.479068938
MESH:D004487 Edema resveratrol 6.198985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.1312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.1317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 20.1317872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.1319031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.2619294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.2619294695
MESH:D016889 Endometrial Neoplasms Estradiol 6.9019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9016202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Progesterone 8.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.279294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6217923197
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.5619566590
MESH:D004941 Esophagitis Hydrochloric Acid 5.7712928072
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 13.9211346197
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 13.9220516732 11346197 14621274
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.7219578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Amiodarone 17.0814986274
MESH:D005234 Fatty Liver Cyclosporine 17.0819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.0815345470
MESH:D005234 Fatty Liver Tamoxifen 17.0819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005355 Fibrosis Cyclosporine 13.5812639820 12168785
MESH:D005355 Fibrosis Hydrochloric Acid 13.5818497604
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5820067830
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.2412378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.1119957777 20516732 20545468 12212954 19951613 20616304
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma trichostatin A 3.6918801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3419215824
MESH:D006356 Heartburn Hydrochloric Acid 5.5619566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1711294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.1716080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006529 Hepatomegaly Amiodarone 7.7915265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7916120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D006561 Herpes Simplex resveratrol 3.9516876885
MESH:D019584 Hot Flashes Estradiol 9.2817088409
MESH:D019584 Hot Flashes Vitamin E 9.2814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8118606429 15340226 16959395 8697196 16354765
MESH:D006937 Hypercholesterolemia Amiodarone 8.649751232 8137927
MESH:D006937 Hypercholesterolemia resveratrol 8.6417188708
MESH:D006940 Hyperemia Hydrochloric Acid 5.4212646421
MESH:D006948 Hyperkinesis Clozapine 4.6816046005
MESH:D006949 Hyperlipidemias resveratrol 3.8216873680
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.1216984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.2919262391
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1017488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816569931 16945680
MESH:D007022 Hypotension Hydrochloric Acid 4.5511574821
MESH:D007037 Hypothyroidism Amiodarone 4.2917991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.7415869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.7417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male decitabine 10.4617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.4617937319
MESH:D007248 Infertility, Male fulvestrant 10.4611514358
MESH:D007249 Inflammation Flavonoids 18.4417296493
MESH:D007249 Inflammation Hydrochloric Acid 18.4411574821
MESH:D007249 Inflammation Progesterone 18.4415869954
MESH:D007249 Inflammation resveratrol 18.4416366677
MESH:D007249 Inflammation Tamoxifen 18.4419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.4412200463 12878042
MESH:D007251 Influenza, Human resveratrol 10.3216624496
MESH:D007251 Influenza, Human Vitamin E 10.3216624496
MESH:D007333 Insulin Resistance Estradiol 2.8216627594 16393666
MESH:D007410 Intestinal Diseases Hydrochloric Acid 4.7511574821
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acrolein 13.4212488133
MESH:D007674 Kidney Diseases Cyclosporine 13.4210903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 13.4215618244
MESH:D007674 Kidney Diseases Vitamin E 13.4212488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.2316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.2312371664
MESH:D007680 Kidney Neoplasms Estradiol 16.2315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.2318625569
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.1316498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.1311510729
MESH:D007938 Leukemia decitabine 2.9618980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.8017236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1319010910 18206229 18704418 19387464 18460780 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.1318206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2318055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4316087638
MESH:D008064 Lipidoses Amiodarone 12.3017567588 15342952
MESH:D008064 Lipidoses Clozapine 12.3017567588
MESH:D008064 Lipidoses Tamoxifen 12.3017567588 15342952
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 3.9516984587
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.7016169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.337678174
MESH:D008113 Liver Neoplasms dicyclanil 13.3320118626
MESH:D008113 Liver Neoplasms resveratrol 13.3319812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 13.3316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.3316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.276135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.2712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4117391786 11989578 15350150
MESH:D008171 Lung Diseases Acrolein 16.4611504702
MESH:D008171 Lung Diseases Amiodarone 16.4612587719
MESH:D008171 Lung Diseases Hydrochloric Acid 16.4616784557
MESH:D008171 Lung Diseases Vitamin E 16.4616863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2518516814
MESH:D055370 Lung Injury Hydrochloric Acid 9.2019644408 15044056 18497604 11395602 18573544 21311175 21114838 19262391 17627322 18339021 20597076 15607125 15090967 16129981
MESH:D055370 Lung Injury naphthalene 9.206834280
MESH:D008175 Lung Neoplasms Tamoxifen 3.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.2411062179
MESH:D008223 Lymphoma decitabine 3.2619470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.0917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6914749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.2415688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.2419428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.0911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.0911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.0911606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.0914580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.8719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8719453300
MESH:D008545 Melanoma decitabine 7.0117785578 16505122
MESH:D008545 Melanoma resveratrol 7.0117992120
MESH:D008545 Melanoma Tamoxifen 7.0119393235 12393984
MESH:D008545 Melanoma trichostatin A 7.0116505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008546 Melanoma, Experimental Acrolein 4.9810803710
MESH:D001523 Mental Disorders Clozapine 3.7216856516
MESH:D008659 Metabolic Diseases resveratrol 4.1717112576
MESH:D024821 Metabolic Syndrome X Clozapine 4.2319142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D009101 Multiple Myeloma decitabine 11.3518172295
MESH:D009101 Multiple Myeloma resveratrol 11.3516267019 17935668 17164350 16490592 17049120 14749477
MESH:D009101 Multiple Myeloma trichostatin A 11.3518172295
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6417962980
MESH:D009181 Mycoses Amiodarone 4.6712754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2518608210 19157545 16882708 19010910
MESH:D009203 Myocardial Infarction Hydrochloric Acid 6.0418534312
MESH:D009203 Myocardial Infarction resveratrol 6.0416525036 17125593 17015251 16317513 16456233 17188708
MESH:D017202 Myocardial Ischemia resveratrol 8.4117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1116810080
MESH:D009205 Myocarditis resveratrol 4.5317322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.637678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Acrolein 5.2317329238
MESH:D009369 Neoplasms decitabine 5.2319116145 17925555 19470736
MESH:D009374 Neoplasms, Experimental resveratrol 3.788985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009393 Nephritis Acrolein 6.0612653641
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.7416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7414600291
MESH:D019636 Neurodegenerative Diseases Acrolein 8.3411342003
MESH:D019636 Neurodegenerative Diseases resveratrol 8.3417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1917929310
MESH:D009765 Obesity Clozapine 2.9618515891 19142110
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.7216049721
MESH:D009784 Occupational Diseases Hydrochloric Acid 8.7212378975
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0417513867
MESH:D010051 Ovarian Neoplasms CD 437 14.2317474084
MESH:D010051 Ovarian Neoplasms decitabine 14.2319259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 14.2319401270
MESH:D010051 Ovarian Neoplasms Progesterone 14.2316525653 17393432
MESH:D010051 Ovarian Neoplasms trichostatin A 14.2319331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.4119294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.4119294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010300 Parkinson Disease Acrolein 5.8117690948
MESH:D010300 Parkinson Disease tolcapone 5.819754991 8635184 16758261 20216409 11586115 1977408 8739811 9708959 9591521 19578428 7566641 11746615 19783845 20334432 11793426 18328768 9333106 17089403 11432539 10651109 9305320
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010787 Photosensitivity Disorders Acrolein 5.5111550810
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.1415607125 15970105 18497604 18573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0312371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.8316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8311399792 11118676 11222880 11896295
MESH:D055728 Primary Myelofibrosis decitabine 11.6817616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.6817616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms resveratrol 1.8915767336 17804756 17718901 17675339 16731767 17636462
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms trichostatin A 1.8918798265 19789329
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.0916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011618 Psychotic Disorders Clozapine 4.0215331141
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 5.7820597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 4.9815090967
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7712832656 12490602 11597910
MESH:D051437 Renal Insufficiency Acrolein 4.7812732208
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3516325855
MESH:D015427 Reperfusion Injury resveratrol 3.1617058453 16314181 16317513 17520802 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.5516784557 17627322 18549715 18339021 16129981
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.1311510729
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 4.9420516732
MESH:D012208 Rhabdomyosarcoma decitabine 4.1919155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012559 Schizophrenia Clozapine 2.7111763009 20107430 19369910 20452607 18806925 17726453 20521326 20168265 11151749 20580759 17123785 17667964 20521320 16141801 18855531
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3918551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8518724381
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms resveratrol 5.368985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7916709447
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.1116503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.1119457130
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013276 Stomach Ulcer Amiodarone 7.0718087811
MESH:D013276 Stomach Ulcer Hydrochloric Acid 7.0716755016 17189318 15309881
MESH:D020521 Stroke Acrolein 8.3916269634
MESH:D020521 Stroke Vitamin E 8.3916517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2816321402
MESH:D013610 Tachycardia Amiodarone 4.0711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Amiodarone 11.2819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2812697716
MESH:D013964 Thyroid Neoplasms decitabine 3.1617967635
MESH:D013971 Thyrotoxicosis Amiodarone 4.6318020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D014062 Tongue Neoplasms resveratrol 4.0116227395
MESH:D016171 Torsades de Pointes Amiodarone 3.9611989578 17467628
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.7219578428
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.2416049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 11.2416720286
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.2417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.248653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0910091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.9017473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7714692618
MESH:D014594 Uterine Neoplasms resveratrol 8.7717044934
MESH:D014604 Uveal Neoplasms decitabine 4.6817785578
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0817488730
MESH:D014820 Vitiligo tolcapone 4.9710573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Clozapine 4.2820107430 17502770 16141801 20564506 16402076 20521320
MESH:D015431 Weight Loss Clozapine 4.8517933447
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25122
    • No data
    No data
    Releated drug ID Related drug Name
    PA165291922doxorubicinol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04216 - Quercetin Antioxidants
    DB07384 - 1-ACETYL-2-CARBOXYPIPERIDINE
    DB07394 - AUROVERTIN B
    DB08399 - PICEATANNOL
    DB08629 - N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved