Annotation Detail for DEF6
Basic Information Top
| Gene Symbol: | DEF6 ( IBP,SLAT,SWAP70L ) |
|---|---|
| Gene Full Name: | differentially expressed in FDCP 6 homolog (mouse) |
| Band: | 6p21.31 |
| Quick Links | Entrez ID:50619; OMIM: 610094; Uniprot ID:DEFI6_HUMAN; ENSEMBL ID: ENSG00000023892; HGNC ID: 2760 |
| Relate to Another Database: | SFARIGene; denovo-db |
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| Pathway ID | Pathway Name |
|---|---|
| 200165 | Regulation of RAC1 activity |
| 200050 | Regulation of RhoA activity |
| No data |
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| Desease Name |
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| height |
| DEVELOPMENTAL |
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| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C472791 | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid | 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of DEF6 mRNA | increases expression | 16788091 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of DEF6 mRNA | affects expression | 17562736 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000799 | Angioedema | Acetaminophen | 4.91 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.83 | 10977129 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.68 | 11529661 19416960 12392966 11461765 16393943 18713872 19370779 18071297 17562736 12705907 19420014 12153990 14550746 16109766 10663392 14986274 16485898 14725611 19164858 19739265 11739529 12594235 12540782 16781746 10774834 17906064 11743745 16227642 10915739 19085960 11834606 16081117 11421492 12958197 15619225 17522070 11287661 16177239 15968718 19923254 2444490 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 5.17 | 19426721 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.74 | 16983495 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.11 | 16870215 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.44 | 15629191 12587719 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.71 | 19014921 12969438 19460945 16611625 12587719 19784758 16610002 11587558 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.74 | 17185352 16871587 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.33 | 19513568 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.31 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.82 | 16870215 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.58 | 10982225 |
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