AutismKB 2.0

Annotation Detail for ARHGEF4


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Basic Information Top
Gene Symbol:ARHGEF4 ( ASEF,ASEF1,GEF4,STM6 )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 4
Band: 2q21.1
Quick LinksEntrez ID:50649; OMIM: 605216; Uniprot ID:ARHG4_HUMAN; ENSEMBL ID: ENSG00000136002; HGNC ID: 684
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ARHGEF4 mRNAincreases expression 16788091
D008345 Manganese Manganese results in increased expression of ARHGEF4 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of ARHGEF4 mRNAincreases expression 17175027
D010100 Oxygen Oxygen deficiency results in increased expression of ARHGEF4 mRNAincreases expression 17175027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Oxygen 4.9916759491
MESH:D000756 Anemia, Sideroblastic Manganese 12.4816910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 12.4816910769
MESH:D000860 Anoxia Oxygen 5.6920872349
MESH:D050197 Atherosclerosis Oxygen 4.0116391483
MESH:D001943 Breast Neoplasms Oxygen 3.1817263869
MESH:D004417 Dyspnea Oxygen 5.5520016425
MESH:D005739 Gas Poisoning Oxygen 5.9420016425
MESH:D005909 Glioblastoma Manganese 4.1517043766
MESH:D055370 Lung Injury Oxygen 5.0718339021
MESH:D020149 Manganese Poisoning Manganese 6.2419453300 16551646 16568477
MESH:D009069 Movement Disorders Manganese 5.4716551646
MESH:D009410 Nerve Degeneration Manganese 4.5816551646
MESH:D010300 Parkinson Disease Manganese 3.4911181820
MESH:D020734 Parkinsonian Disorders Manganese 4.8616140633
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.9718339021 17627322
MESH:D013398 Sudden Infant Death Oxygen 6.1812563064
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24974
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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