AutismKB 2.0

Annotation Detail for ARHGEF3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARHGEF3 ( DKFZp434F2429,FLJ98126,GEF3,MGC118905,STA3,XPLN )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 3
Band: 3p14.3
Quick LinksEntrez ID:50650; OMIM: 612115; Uniprot ID:ARHG3_HUMAN; ENSEMBL ID: ENSG00000163947; HGNC ID: 683
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
mean platelet volume
Osteoporosis
METABOLIC
Desease Name
Mean platelet volume
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARHGEF3 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ARHGEF3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ARHGEF3 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ARHGEF3 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ARHGEF3 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of ARHGEF3 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of ARHGEF3 mRNAdecreases expression 16002434
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNAaffects cotreatment|increases expression 16996129
C006253 pirinixic acid pirinixic acid results in increased expression of ARHGEF3 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in increased expression of ARHGEF3 mRNAincreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARHGEF3 mRNAincreases expression 19933214
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 11752688 15322242
MESH:D058186 Acute Kidney Injury zoledronic acid 4.5719715164
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.6420200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001859 Bone Neoplasms zoledronic acid 5.0717312309 11697798 16778634 19442620 16121404 15867366
MESH:D001862 Bone Resorption zoledronic acid 4.8118404659 8053405 11869084 16769263 15845617 18496637
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015845082 15380490 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3817474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 2.3811237771
MESH:D001943 Breast Neoplasms Progesterone 2.3815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D001943 Breast Neoplasms zoledronic acid 2.3818695136 16096432
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6712907637 12619106 21507988
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5719233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.9018507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.7911237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.826135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 15668235 8697196 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D003327 Coronary Disease fluvastatin 4.8816142594
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.7415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.7417692515
MESH:D004715 Endometriosis Progesterone 9.2816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.2810568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005234 Fatty Liver pirinixic acid 7.9319236843 20131406
MESH:D005264 Femoral Fractures zoledronic acid 5.9816234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7319772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia zoledronic acid 4.3316769263
MESH:D006934 Hypercalcemia zoledronic acid 5.1619622757 18089816
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D006996 Hypocalcemia zoledronic acid 6.3712669777
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007249 Inflammation Progesterone 5.1515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.8818089816
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.647678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.642125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6420195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.6420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.196135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.198603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4220464547 20064080 18816296 18520028 6695378 20869020 20135361 17053015 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7117203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 6.7117312309
MESH:D008654 Mesothelioma zoledronic acid 3.7916675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma fluvastatin 8.4316996129
MESH:D009101 Multiple Myeloma zoledronic acid 8.4318089719 19621390 16996129
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009362 Neoplasm Metastasis zoledronic acid 3.6815867366 17312309 19139120
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010014 Osteolysis zoledronic acid 5.5215867366
MESH:D010024 Osteoporosis zoledronic acid 4.1017882678
MESH:D010051 Ovarian Neoplasms Progesterone 2.5517393432 16525653
MESH:D010146 Pain zoledronic acid 4.0316475674
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11118676 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9315572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6918247401 15754350 16289102 16644109 12479363
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.6919103299 12438248
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.0616121404
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.4315862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24973
    • No data
    Releated disease ID Related disease Name
    PA443670Cerebral Infarction
    PA444613Infarction
    PA445019Myocardial Infarction
    PA444222Fractures, Bone
    PA445190Osteoporosis
    PA446214Osteoporosis, Postmenopausal
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved