AutismKB 2.0

Annotation Detail for PAM


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Basic Information Top
Gene Symbol:PAM ( PAL,PHM )
Gene Full Name: peptidylglycine alpha-amidating monooxygenase
Band: 5q21.1
Quick LinksEntrez ID:5066; OMIM: 170270; Uniprot ID:AMD_HUMAN; ENSEMBL ID: ENSG00000145730; HGNC ID: 8596
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P04395Vasopressin synthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C025205 1,10-phenanthroline 1,10-phenanthroline results in decreased activity of PAM proteindecreases activity 16704972
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PAM mRNAdecreases expression 18648102
C066029 alpha-hydroxybenzoylglycine alpha-hydroxybenzoylglycine inhibits the reaction [Tetranitromethane results in decreased activity of PAM protein]decreases activity|decreases reaction 16704972
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PAM mRNAaffects expression 16483693
D001205 Ascorbic Acid Ascorbic Acid results in decreased activity of PAM proteindecreases activity 16704972
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PAM mRNAdecreases expression 15336504
D002118 Calcium Calcium binds to PAM proteinaffects binding 16704972
D003907 Dexamethasone Dexamethasone results in increased expression of and results in increased activity of PAM proteinincreases activity|increases expression 10347250
D003907 Dexamethasone Dexamethasone results in increased expression of PAM mRNAincreases expression 10347250
D004221 Disulfiram Disulfiram results in increased activity of PAM proteinincreases activity 8246921
10347250
D004227 Dithionite Dithionite results in decreased activity of PAM proteindecreases activity 16704972
D004492 Edetic Acid Edetic Acid results in decreased activity of PAM proteindecreases activity 16704972
D004533 Egtazic Acid Egtazic Acid results in decreased activity of PAM proteindecreases activity 16704972
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PAM mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PAM mRNAincreases expression 19619570
D000431 Ethanol Ethanol results in decreased expression of PAM mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PAM mRNAdecreases expression 15576828
17557909
C024555 ferric chloride ferric chloride binds to and results in decreased activity of PAM proteinaffects binding|decreases activity 16704972
C025302 ferric nitrate ferric nitrate binds to and results in decreased activity of PAM proteinaffects binding|decreases activity 16704972
C034163 gallium chloride gallium chloride binds to and results in decreased activity of PAM proteinaffects binding|decreases activity 16704972
C051890 irinotecan irinotecan analog results in decreased expression of PAM mRNAdecreases expression 18927307
D007501 Iron Iron binds to and affects the activity of PAM proteinaffects activity|affects binding 16704972
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of PAM mRNAincreases expression 12832660
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of PAM mRNAdecreases expression 12102619
C006253 pirinixic acid pirinixic acid results in decreased expression of PAM mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of PAM mRNAincreases expression 12832660
C025299 polyphenols polyphenols results in increased expression of PAM mRNAincreases expression 16293270
C031835 potassium ferrocyanide potassium ferrocyanide results in decreased activity of PAM proteindecreases activity 16704972
D012643 Selenium Selenium results in decreased expression of PAM mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PAM mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PAM mRNAincreases expression 19619570
D013774 Tetranitromethane alpha-hydroxybenzoylglycine inhibits the reaction [Tetranitromethane results in decreased activity of PAM protein]decreases activity|decreases reaction 16704972
D013774 Tetranitromethane Tetranitromethane results in increased acetylation of and results in decreased activity of PAM proteindecreases activity|increases acetylation 16704972
D014520 Urethane Urethane results in decreased expression of PAM mRNAdecreases expression 16289808
D014810 Vitamin E Vitamin E results in decreased expression of PAM mRNAdecreases expression 19244175
D015032 Zinc Zinc binds to PAM proteinaffects binding 16704972
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Disulfiram 12.7317676605
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.7318926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.7314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 9.4918287403
MESH:D000138 Acidosis Ethanol 9.4911192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D000163 Acquired Immunodeficiency Syndrome Disulfiram 5.269207937
MESH:D000169 Acrodermatitis Zinc 5.1117190629 16889938 17202136
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma Estradiol 6.7111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7114692618
MESH:D000230 Adenocarcinoma Urethane 6.7118316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.4115814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.523712494
MESH:D000236 Adenoma Urethane 6.5217093202 6695378 11497255 10822126 10530776 16926031 17195641
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9216835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0215451039 15451040
MESH:D000437 Alcoholism Disulfiram 4.7518968458 17079463 10841824
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.3616640825
MESH:D000544 Alzheimer Disease Iron 4.4216563566 16640825
MESH:D000544 Alzheimer Disease Zinc 4.4216410023 17119284 16325427 16580781
MESH:D000740 Anemia Iron 8.0816434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0811748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.3916569441 17163184 17162259 17375513 17147795
MESH:D000755 Anemia, Sickle Cell Zinc 4.6216916123
MESH:D000756 Anemia, Sideroblastic Iron 4.5516910769
MESH:D000853 Anophthalmos Ethanol 4.5315513904
MESH:D001008 Anxiety Disorders Ethanol 3.7711141031
MESH:D001145 Arrhythmias, Cardiac Iron 4.1216604332
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1811256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.7717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7715885639
MESH:D001249 Asthma Zinc 2.8617085522
MESH:D001260 Ataxia Telangiectasia Iron 5.1515336622
MESH:D050197 Atherosclerosis Iron 3.5416640825 16632123
MESH:D001321 Autistic Disorder Iron 2.8217352947
MESH:D001424 Bacterial Infections Iron 4.9016640825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7211289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001930 Brain Injuries Zinc 4.4017109824
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0016443354
MESH:D001943 Breast Neoplasms Disulfiram 2.0017026967
MESH:D001943 Breast Neoplasms Estradiol 2.0017018787 17261762 17289903 16675129 18497071 19861407 14630087 12948864
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D002056 Burns Ethanol 4.3616374292
MESH:D002177 Candidiasis Disulfiram 5.5615325261
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6416050911
MESH:D002277 Carcinoma Disulfiram 7.8617026967
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.357296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.3516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.3515289165 18788625 15763234
MESH:D002289 Carcinoma, Non-Small-Cell Lung Disulfiram 3.8117026967
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.547296757
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.8216543248
MESH:D006332 Cardiomegaly Ethanol 6.3019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3016120746 18670907 18850075
MESH:D009202 Cardiomyopathies Iron 3.8516640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.3616604332
MESH:D002318 Cardiovascular Diseases Zinc 3.4616936243
MESH:D002386 Cataract Disulfiram 4.3315003327 17936468
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 5.997505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.9012912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 17.5116629650 18164287 12927374 18590720 15500046 19486331 7624871 15913567
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.5119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 17.5117333356 17110522 11677210 15861022 16105132 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 17.5119176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.5519407337 10220858
MESH:D002971 Cleft Lip Ethanol 3.4315513904
MESH:D002972 Cleft Palate Ethanol 9.2615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.2615668235 8697196 16354765 12621046 15340226
MESH:D002972 Cleft Palate Urethane 9.2612810352
MESH:D019970 Cocaine-Related Disorders Disulfiram 5.4519462300
MESH:D003092 Colitis Selenium 3.4917936198
MESH:D003110 Colonic Neoplasms Dexamethasone 7.9015824018
MESH:D003110 Colonic Neoplasms irinotecan 7.9017287894 17725105
MESH:D003110 Colonic Neoplasms Iron 7.9016640825
MESH:D003110 Colonic Neoplasms polyphenols 7.9016293270
MESH:D015179 Colorectal Neoplasms irinotecan 2.3517159606 17454858 16391804 18509181 16303861 15273666 18259882
MESH:D003139 Common Cold Ascorbic Acid 5.1817323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8114669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.9617728286
MESH:D019465 Craniofacial Abnormalities Ethanol 6.9610194807 19302082 11198716 11873399 15513904 15451039 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9610048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 6.9619769572
MESH:D019465 Craniofacial Abnormalities Zinc 6.9619302082
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.1014531868 8156756 18759878 12868966 2524372 11298694 8970840 11906362
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.1012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.223621924 2952479
MESH:D003920 Diabetes Mellitus Iron 8.8216640825 16604332
MESH:D003920 Diabetes Mellitus Zinc 8.8216479319
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.2716506275
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.8516506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 6.8516506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D003967 Diarrhea Dexamethasone 3.427237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 14.0618289764 17522070 20133375 7624871
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.067440962 9328219 9022650 18692083 1440618 6679447 16192314 18289764 6482804 9653073 11289319 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Ethanol 14.0611566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 14.0619370779
MESH:D056486 Drug-Induced Liver Injury Selenium 14.0615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.0620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:C538011 Eales disease Ascorbic Acid 12.079068938
MESH:C538011 Eales disease Vitamin E 12.079068938
MESH:D004485 Eczema Dexamethasone 4.1812438553
MESH:D004487 Edema Dexamethasone 9.9319703484
MESH:D004487 Edema pirinixic acid 9.9312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.9311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6016714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9112538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.7911473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7710568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.913581430
MESH:D004938 Esophageal Neoplasms Ethanol 6.9116704527
MESH:D004938 Esophageal Neoplasms Zinc 6.9116543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver Ethanol 16.6616409862 18620774 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.6615345470
MESH:D005234 Fatty Liver Iron 16.6616640825
MESH:D005234 Fatty Liver pirinixic acid 16.6620131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0010194807 16946407 15513904 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.726705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.6620067830
MESH:D005621 Friedreich Ataxia Iron 5.1416640825 16604332
MESH:D005756 Gastritis Ethanol 10.5415046732
MESH:D005756 Gastritis Zinc 10.5417241300
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.767505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006130 Growth Disorders Zinc 3.7717217573
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.3416080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.3416080930
MESH:D006331 Heart Diseases Urethane 4.0416046796
MESH:D006333 Heart Failure pirinixic acid 10.7920558911
MESH:D006333 Heart Failure Selenium 10.7917162251
MESH:D006333 Heart Failure Zinc 10.7917162251
MESH:D006335 Heart Injuries Zinc 5.4717074742
MESH:D016481 Helicobacter Infections Zinc 4.2617241300
MESH:D006432 Hemochromatosis Iron 4.2816640825 16574947 17053826 17255318 16604332 17236123
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006486 Hemosiderosis Iron 4.9116604332
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 8.7018590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.706705139
MESH:D006525 Hepatitis, Viral, Human Iron 5.1716640825
MESH:D006527 Hepatolenticular Degeneration Iron 10.3317182432
MESH:D006527 Hepatolenticular Degeneration Zinc 10.3317276780
MESH:D006529 Hepatomegaly Iron 12.8216890145
MESH:D006529 Hepatomegaly pirinixic acid 12.8218467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.8215340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 9.0716863852 16490937
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 9.077520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 9.0716490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D015658 HIV Infections Iron 3.5216597321
MESH:D019584 Hot Flashes Estradiol 9.0517088409
MESH:D019584 Hot Flashes Vitamin E 9.0514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7515340226 8697196 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Ethanol 3.4918783367
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6515034207
MESH:D006973 Hypertension Dexamethasone 4.8717042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8718850075 18670907
MESH:D007006 Hypogonadism Iron 4.2016640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5216945680 16569931
MESH:D007037 Hypothyroidism Iron 4.7916640825
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2917937319
MESH:D007249 Inflammation Dexamethasone 7.5311099482 8960868
MESH:D007249 Inflammation polyphenols 7.5316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5312200463 12878042
MESH:D007251 Influenza, Human Selenium 9.9616624496
MESH:D007251 Influenza, Human Vitamin E 9.9616624496
MESH:D007333 Insulin Resistance Estradiol 6.5616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.5616306350
MESH:D019189 Iron Metabolism Disorders Iron 4.7617163184
MESH:D007511 Ischemia Zinc 4.3416584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.729022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 9.2415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2416580747
MESH:D007674 Kidney Diseases Estradiol 9.2015618244
MESH:D007674 Kidney Diseases Vitamin E 9.2012488133
MESH:D007674 Kidney Diseases Zinc 9.2016960431
MESH:D007676 Kidney Failure, Chronic Selenium 9.2016518626
MESH:D007676 Kidney Failure, Chronic Zinc 9.2016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.576582329
MESH:D007680 Kidney Neoplasms Estradiol 6.5715610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7516316344
MESH:D007859 Learning Disorders Ethanol 3.9215451040
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Disulfiram 4.0617026967
MESH:D020961 Lewy Body Disease Iron 5.1416563566
MESH:D017880 Limb Deformities, Congenital Disulfiram 8.1417676605
MESH:D017880 Limb Deformities, Congenital Ethanol 8.1417676605
MESH:D008103 Liver Cirrhosis Ethanol 6.6115289165
MESH:D008103 Liver Cirrhosis Iron 6.6116640825
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8018295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.019327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.2116718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.2118166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.2116169303
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 4.4617184895
MESH:D008107 Liver Diseases polyphenols 4.4616698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 10.5317207112 17347304
MESH:D008108 Liver Diseases, Alcoholic Iron 10.5317207112 16737972
MESH:D008113 Liver Neoplasms Iron 9.8116640825 20302851
MESH:D008113 Liver Neoplasms pirinixic acid 9.8116377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.8116984957
MESH:D008113 Liver Neoplasms Urethane 9.8117093202 17559639 16391232
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.843712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 8.8418544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.8412151625
MESH:D008171 Lung Diseases Ascorbic Acid 7.0716863852
MESH:D008171 Lung Diseases Vitamin E 7.0716863852
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.1016401635
MESH:D008175 Lung Neoplasms Dexamethasone 10.1015824018 11195469
MESH:D008175 Lung Neoplasms Iron 10.1016640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1019555203 11884234
MESH:D008175 Lung Neoplasms Tetranitromethane 10.109255578 14713543
MESH:D008175 Lung Neoplasms Urethane 10.1011074608 16391232 10997738 12765245 11497255 11544531 16337739 6695378 11552296 11246140 10779650 16289808 16204055 10822126 11307925 11893704 16007126 16926031 16788158 11992545 12117781 11323394 14587096 12466968 17093202 15166089 7750092 12957351 15136453 17255336 11062179 15902970 17195641 11807781 10530776
MESH:D008175 Lung Neoplasms Vitamin E 10.1011062179
MESH:D008268 Macular Degeneration Iron 3.8216640825
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.9511408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.9515318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 8.9512773700
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008545 Melanoma Disulfiram 3.3115367699
MESH:D008569 Memory Disorders Ethanol 3.9118411066 15451040
MESH:D008654 Mesothelioma Selenium 2.6715107826
MESH:D052016 Mucositis irinotecan 4.7117159606
MESH:D009101 Multiple Myeloma Dexamethasone 3.3015744524 15867202 16118317
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.3717086897
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009181 Mycoses Iron 5.1716640825
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.379809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Iron 8.4016604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.4012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.9616810080
MESH:D015428 Myocardial Reperfusion Injury Iron 12.9616604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.9616411023
MESH:D009361 Neoplasm Invasiveness Disulfiram 5.0318047805
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.033581430
MESH:D009362 Neoplasm Metastasis Disulfiram 9.0315367699
MESH:D009362 Neoplasm Metastasis irinotecan 9.0318259882
MESH:D009369 Neoplasms Disulfiram 7.7017079463
MESH:D009369 Neoplasms pirinixic acid 7.7017405874
MESH:D009369 Neoplasms Urethane 7.7015625555
MESH:D009374 Neoplasms, Experimental Urethane 4.3915582191
MESH:D009389 Neovascularization, Pathologic Disulfiram 9.4815367699
MESH:D009389 Neovascularization, Pathologic Estradiol 9.4817289903
MESH:D009404 Nephrotic Syndrome Iron 4.2717178036
MESH:D009421 Nervous System Malformations Estradiol 8.5311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.726679447
MESH:D009447 Neuroblastoma irinotecan 3.338761367
MESH:D019636 Neurodegenerative Diseases Iron 4.0116604332 17296847
MESH:D017599 Neuroectodermal Tumors irinotecan 4.438761367
MESH:D020258 Neurotoxicity Syndromes Disulfiram 4.4511005259
MESH:D009765 Obesity Ascorbic Acid 4.4917217161
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.174026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.723988306
MESH:D010003 Osteoarthritis Iron 3.7916640825
MESH:D010024 Osteoporosis Calcium 7.0917882678
MESH:D010024 Osteoporosis Iron 7.0916648989 16640825
MESH:D012516 Osteosarcoma Disulfiram 4.9418047805
MESH:D010051 Ovarian Neoplasms Disulfiram 7.6317026967
MESH:D010051 Ovarian Neoplasms Estradiol 7.6319401270
MESH:D010051 Ovarian Neoplasms Urethane 7.6316391232
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8612384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.507296757
MESH:D010212 Papilloma Iron 8.5012065085
MESH:D020447 Parasomnias Iron 5.7217352947
MESH:D010300 Parkinson Disease Iron 3.2116563566 16640825
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.7920133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.7912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.176228378
MESH:D010900 Pituitary Diseases Iron 5.3716604332
MESH:D010911 Pituitary Neoplasms Urethane 5.1216391232
MESH:D010954 Plasmacytoma Selenium 4.5915087411
MESH:D011041 Poisoning Iron 4.0216604332
MESH:D017119 Porphyria Cutanea Tarda Iron 10.0916640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.0918163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3821297632
MESH:D011225 Pre-Eclampsia Iron 8.7916640825
MESH:D011225 Pre-Eclampsia Zinc 8.7917114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9011222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Disulfiram 2.2219789329
MESH:D011471 Prostatic Neoplasms Estradiol 2.2216740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.2215084515
MESH:D011471 Prostatic Neoplasms Zinc 2.2216700911 12429649 16606632 16517595
MESH:D011528 Protozoan Infections Iron 5.7216640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.0215861022 16919318
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0314606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7511700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012148 Restless Legs Syndrome Iron 4.3316930377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.293692021
MESH:D012162 Retinal Degeneration Zinc 8.2916584753
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2316849425
MESH:D012640 Seizures Ethanol 6.309754883
MESH:D012640 Seizures ferric chloride 6.3012941455
MESH:D012871 Skin Diseases Ascorbic Acid 4.9418709164
MESH:D012871 Skin Diseases Vitamin E 4.9418709164
MESH:D012878 Skin Neoplasms Iron 12.4912065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.498532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.4916192470
MESH:D012878 Skin Neoplasms Urethane 12.4911807781
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6416709447
MESH:D013272 Stomach Diseases Dexamethasone 4.0315472012
MESH:D013274 Stomach Neoplasms Ethanol 2.7518456281
MESH:D013274 Stomach Neoplasms irinotecan 2.7515723263
MESH:D013276 Stomach Ulcer Ascorbic Acid 10.7318726076
MESH:D013276 Stomach Ulcer Dexamethasone 10.7315138204
MESH:D013276 Stomach Ulcer Ethanol 10.739211565 16755016 11906479 9562338 17918041 17189318
MESH:D020521 Stroke Ascorbic Acid 8.1216403987 16517955
MESH:D020521 Stroke Vitamin E 8.1216517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.009754883
MESH:D013398 Sudden Infant Death Iron 5.1516640825
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9517997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.5020133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.677505956 6582329 1399818 6587162 3712494
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D014062 Tongue Neoplasms Zinc 4.1416543248
MESH:D014376 Tuberculosis Iron 3.9016597321
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.178074119
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0214692618
MESH:D014605 Uveitis Dexamethasone 4.521336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D019043 Vascular Neoplasms Urethane 5.6110620525
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00126 - Vitamin C Antioxidants;Essential Vitamins;Free Radical Scavengers;Vitamins (Vitamin C);Vitamins
DB02598 - N-Alpha-Acetyl-3,5-Diiodotyrosylglycine
DB04150 - Threonine Derivative
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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