AutismKB 2.0

Annotation Detail for REG3A


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Basic Information Top
Gene Symbol:REG3A ( HIP,PAP,PAP-H,PAP1,PBCGF,REG-III,REG3 )
Gene Full Name: regenerating islet-derived 3 alpha
Band: 2p12
Quick LinksEntrez ID:5068; OMIM: 167805; Uniprot ID:REG3A_HUMAN; ENSEMBL ID: ENSG00000172016; HGNC ID: 8601
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of REG3A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of REG3A mRNAaffects expression 16483693
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA]decreases reaction|increases expression 18200517
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of REG3A mRNAincreases expression 15331540
D004041 Dietary Fats Dietary Fats results in decreased expression of REG3A mRNAdecreases expression 18457598
D005419 Flavonoids Flavonoids results in increased expression of REG3A mRNAincreases expression 18035473
C006253 pirinixic acid pirinixic acid results in increased expression of REG3A mRNAincreases expression 17426115
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNAincreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4617887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 11.3715014928
MESH:D001161 Arteriosclerosis Dietary Fats 11.3715238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7816807698
MESH:D050197 Atherosclerosis Curcumin 3.4518704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.8019761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D002545 Brain Ischemia Curcumin 4.6716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1617596214
MESH:D001943 Breast Neoplasms Curcumin 2.0719250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.0717388661 18323546 12006526 15093573 11325840 16978400 18234424 17020986 15136595
MESH:D001943 Breast Neoplasms Dietary Fats 2.0720435547
MESH:D002277 Carcinoma Curcumin 4.0318593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.223084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.2219701751
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.2316152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6316201981
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003092 Colitis Curcumin 10.9916804969 16782535 18200517
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.9916804969 17936198 16782535 18023891 11698051 17991707 16474422 16867261 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5117276891
MESH:D003103 Coloboma Curcumin 4.7918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.2018497527
MESH:D003556 Cystitis Cyclophosphamide 5.3617979934 16651033 18372110 16989017 18093676 11948286 15643279 12161096 10700343 15276878 18295254 17010015 18433785 18710439 18483878 10498854 16413132 16614059 12913760 12388444
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2710990075 11751995 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2818772604
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.2218204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6411529661 16781746 14550746 14725611 12540782 11421492 19923254 17906064 11739529 17522070 11743745 15968718 19164858 16109766 11461765 12392966 2444490 16177239 12153990 16393943 19416960 19085960 19420014 19370779 10663392 12705907 19739265 10915739 12594235 14986274 18713872 18071297 17562736 16485898 16081117 15619225 10774834 16227642 11287661 11834606 12958197
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004381 Duodenal Ulcer Curcumin 4.3317351913
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004802 Eosinophilia Cyclophosphamide 4.5211006010
MESH:D005234 Fatty Liver Curcumin 14.6319297423
MESH:D005234 Fatty Liver Dietary Fats 14.6319004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver pirinixic acid 14.6320131406 19236843
MESH:D005355 Fibrosis Curcumin 16.9018705752
MESH:D005355 Fibrosis Dietary Fats 16.9018296743
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 16.9017994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0018462866
MESH:D005909 Glioblastoma Curcumin 3.6217596214
MESH:D018316 Gliosarcoma Cyclophosphamide 5.8511389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.3415172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8118829502 18462866
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006467 Hemophilia A Cyclophosphamide 5.6011918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.9114986274
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 19772884 18467677
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3517701891
MESH:D006689 Hodgkin Disease Cyclophosphamide 4.0016135485 17606976
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Curcumin 10.0518704882
MESH:D006937 Hypercholesterolemia Dietary Fats 10.0521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D007154 Immune System Diseases Cyclophosphamide 5.7116076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.777193160 16517039
MESH:D007249 Inflammation Curcumin 9.1217151092 16956363 18403477
MESH:D007249 Inflammation Dietary Fats 9.1220412841
MESH:D007249 Inflammation Flavonoids 9.1217296493
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.9618596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.9618200517
MESH:D007333 Insulin Resistance Dietary Fats 7.7418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.9117994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.4510783313
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007889 Leiomyoma Curcumin 4.8318555241
MESH:D007938 Leukemia Curcumin 7.1118462866
MESH:D007938 Leukemia Cyclophosphamide 7.1110602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5818172266 18587576 17008537 17296974 17658394 17802794
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4516106398
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2610373061
MESH:D015458 Leukemia, T-Cell Curcumin 5.0416106398
MESH:D007970 Leukopenia Cyclophosphamide 5.3010052129 11830472
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5818006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5815474484
MESH:D008107 Liver Diseases Acetaminophen 4.2719014921 19784758 11587558 19460945 16611625 12969438 12587719 16610002
MESH:D008107 Liver Diseases Curcumin 4.2716956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8920007298 16377806 15890375
MESH:D008175 Lung Neoplasms Curcumin 2.2819359593 16243823 18462866
MESH:D008223 Lymphoma Curcumin 8.4918462866
MESH:D008223 Lymphoma Cyclophosphamide 8.4912854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.8616675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.3711911406
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0016173963
MESH:D008545 Melanoma Curcumin 2.4418462866 17885582
MESH:D008546 Melanoma, Experimental Acetaminophen 11.8819513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 11.8816388313
MESH:D008569 Memory Disorders Curcumin 4.4317263510
MESH:D009101 Multiple Myeloma Curcumin 3.6819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6518495463
MESH:D009369 Neoplasms Cyclophosphamide 5.5318854779
MESH:D009369 Neoplasms pirinixic acid 5.5317405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9112497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.0118462866
MESH:D009447 Neuroblastoma Cyclophosphamide 3.7516115947 15176712 8761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.238761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.588291058
MESH:D009765 Obesity Curcumin 7.7319297423
MESH:D009765 Obesity Dietary Fats 7.7317217161 20132043 16723640 20518802 18457598 11836018 18674790 21332399 19632207
MESH:D009765 Obesity pirinixic acid 7.7320558911
MESH:D009845 Oligospermia Cyclophosphamide 5.0516517039
MESH:D010024 Osteoporosis Curcumin 3.6118719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8819020741 18462866
MESH:D010146 Pain Acetaminophen 7.5316870215
MESH:D010146 Pain Cyclophosphamide 7.5318093676 12161096
MESH:D010190 Pancreatic Neoplasms Curcumin 5.9517440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.9511332152
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.4617698068
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9221297632
MESH:D011471 Prostatic Neoplasms Curcumin 3.6311398177 18769126 15129424 18226269 18156803 10851300 12497104
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.6317136230
MESH:D011656 Pulmonary Emphysema Curcumin 4.7619168576
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3616636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2818379247 10666014
MESH:D012509 Sarcoma Curcumin 4.3418462866
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0816636934
MESH:D018805 Sepsis Curcumin 4.2818389075
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.8516517039
MESH:D013276 Stomach Ulcer Curcumin 3.7316631530 19188055
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.3912837982
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.8218593936
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.8214692829
MESH:D014565 Urogenital Neoplasms Curcumin 5.6018462866
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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