AutismKB 2.0

Annotation Detail for PARK2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PARK2 ( AR-JP,LPRS2,PDJ,PRKN )
Gene Full Name: parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Band: 6q25.2-q27
Quick LinksEntrez ID:5071; OMIM: 602544; Uniprot ID:PRKN2_HUMAN; ENSEMBL ID: ENSG00000185345; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa05012Parkinson's disease
hsa04120Ubiquitin mediated proteolysis
No data
Pathway IDPathway Name
200187Alpha-synuclein signaling
Pathway IDPathway Name
P00049Parkinson disease
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00057Parkinson's disease
Desease IDDesease Name
1789Movement disorder
1832Congenital abnormality
1859Ovarian cancer
1944Breast cancer
2022Liver cancer
2029Tuberculosis
2051Leukemia
2067Primary tumor
2110Leprosy
2128CNS metastases
Desease Name
Parkinson's disease
Leprosy
NEUROLOGICAL
METABOLIC
INFECTION
serum metabolites
Desease Name
Serum metabolites
Pancreatic cancer
Desease Name
Leprosy, susceptibility to
Parkinson disease, juvenile, type 2
Adenocarcinoma of lung, somatic
Adenocarcinoma, ovarian, somatic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002385 3-morpholino-sydnonimine 3-morpholino-sydnonimine results in increased expression of PARK2 proteinincreases expression 12880480
C002385 3-morpholino-sydnonimine Selegiline inhibits the reaction [3-morpholino-sydnonimine results in increased expression of PARK2 protein]decreases reaction|increases expression 12880480
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PARK2 mRNAaffects expression 16483693
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PARK2 mRNAdecreases expression 18586549
C070053 carbonyl 3-chlorophenylhydrazone PARK2 gene mutant form results in increased susceptibility to carbonyl 3-chlorophenylhydrazoneincreases response to substance 16517603
C070053 carbonyl 3-chlorophenylhydrazone PARK2 protein results in decreased susceptibility to carbonyl 3-chlorophenylhydrazonedecreases response to substance 16517603
D002518 Ceramides epoxomicin inhibits the reaction [PARK2 protein results in decreased susceptibility to Ceramides]decreases reaction|decreases response to substance 12588799
D002518 Ceramides PARK2 protein inhibits the reaction [Ceramides affects the localization of CYCS protein]affects localization|decreases reaction 12588799
D002518 Ceramides PARK2 protein inhibits the reaction [Ceramides results in increased activity of CASP3 protein]decreases reaction|increases activity 12588799
D002518 Ceramides PARK2 protein results in decreased susceptibility to Ceramidesdecreases response to substance 12588799
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of PARK2 proteinincreases expression 16174552
D004298 Dopamine PARK2 protein inhibits the reaction [Dopamine results in increased abundance of Reactive Oxygen Species]decreases reaction|increases abundance 15198987
D004298 Dopamine PARK2 protein inhibits the reaction [Dopamine results in increased cleavage of CASP3 protein]decreases reaction|increases cleavage 15198987
D004298 Dopamine PARK2 protein inhibits the reaction [Dopamine results in increased cleavage of PARP1 protein]decreases reaction|increases cleavage 15198987
D004298 Dopamine PARK2 protein inhibits the reaction [Dopamine results in increased phosphorylation of JUN protein]decreases reaction|increases phosphorylation 15198987
C078846 epoxomicin epoxomicin results in decreased expression of PARK2 mRNAdecreases expression 18586549
C078846 epoxomicin epoxomicin inhibits the reaction [PARK2 protein results in decreased susceptibility to Ceramides]decreases reaction|decreases response to substance 12588799
C078846 epoxomicin epoxomicin results in decreased expression of PARK2 mRNAdecreases expression 18586549
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of PARK2 exonincreases mutagenesis 17156454
D016627 Oxidopamine PARK2 protein inhibits the reaction Oxidopaminedecreases reaction 15198987
D016627 Oxidopamine PARK2 protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]decreases expression|decreases reaction 16914382
D007213 Indomethacin Indomethacin promotes the reaction [PARK2 gene mutant form results in increased susceptibility to Rotenone]increases reaction|increases response to substance 16573651
D008911 Minocycline Minocycline inhibits the reaction [PARK2 gene mutant form results in increased susceptibility to Rotenone]decreases reaction|increases response to substance 16573651
D017382 Reactive Oxygen Species PARK2 protein inhibits the reaction [Dopamine results in increased abundance of Reactive Oxygen Species]decreases reaction|increases abundance 15198987
D017382 Reactive Oxygen Species PARK2 protein results in decreased abundance of Reactive Oxygen Speciesdecreases abundance 15198987
D012402 Rotenone PARK2 gene mutant form results in increased susceptibility to Rotenoneincreases response to substance 17687034
D012402 Rotenone PARK2 protein inhibits the reaction [LRRK2 gene polymorphism results in increased susceptibility to Rotenone]decreases reaction|increases response to substance 19741132
D012402 Rotenone PARK2 protein results in decreased susceptibility to Rotenonedecreases response to substance 19741132
17687034
D012402 Rotenone Indomethacin promotes the reaction [PARK2 gene mutant form results in increased susceptibility to Rotenone]increases reaction|increases response to substance 16573651
D012402 Rotenone Minocycline inhibits the reaction [PARK2 gene mutant form results in increased susceptibility to Rotenone]decreases reaction|increases response to substance 16573651
D012402 Rotenone PARK2 gene mutant form results in increased susceptibility to Rotenoneincreases response to substance 16573651
16517603
D012402 Rotenone PARK2 protein results in decreased susceptibility to Rotenonedecreases response to substance 16517603
D012642 Selegiline Selegiline inhibits the reaction [3-morpholino-sydnonimine results in increased expression of PARK2 protein]decreases reaction|increases expression 12880480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Indomethacin 2.7916537180
MESH:D000236 Adenoma Ethylnitrosourea 7.306695378
MESH:D000236 Adenoma Indomethacin 7.3011497255
MESH:D016301 Alveolar Bone Loss Indomethacin 5.4317225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7117627676 15579461
MESH:D001014 Aortic Aneurysm Indomethacin 4.8810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.9110388637
MESH:D018771 Arthralgia Indomethacin 5.232160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 5.5111248219
MESH:D001172 Arthritis, Rheumatoid Minocycline 5.5114528503
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.6714699433
MESH:D001321 Autistic Disorder marker/mechanism 19404257
MESH:D001477 Bartter Syndrome Indomethacin 5.0210684365
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9114991843
MESH:D001929 Brain Edema Indomethacin 5.0911481608
MESH:D002545 Brain Ischemia Indomethacin 4.4712524144
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3215144691 18412241 16651633 16436596 16357521
MESH:D001943 Breast Neoplasms Indomethacin 2.8317401462
OMIM:604370 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D002056 Burns Indomethacin 4.7510459503
MESH:D002100 Cachexia Indomethacin 5.0611239499 15141370 15625704 16537180
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 2.4516391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.7811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.4018791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3817341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8515482327 12636206
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.7416003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.0517160924
MESH:D002764 Cholecystitis Indomethacin 5.2311181007
MESH:D003110 Colonic Neoplasms marker/mechanism 19946270
MESH:D003110 Colonic Neoplasms Indomethacin 2.5915963497 15625704 11260862 15786552 15936596 15637740
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 11197048 18059344 17054584
MESH:D018352 Coronavirus Infections Indomethacin 5.7817302372
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 3.0515736158
MESH:D003967 Diarrhea Indomethacin 3.837237001 7907874
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 2.9617851650
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.2016133044 18043480 17190690 18446180 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.1717151854 11595431 17329845 16699067 11535926 10671773 17351913 17202747 17045617 11991626 11595415
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.0518357618
MESH:D004487 Edema Indomethacin 3.5316100529 10653021 7907874 8273558 19703484 7990266 8985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Minocycline 5.6011835378
MESH:D004715 Endometriosis Indomethacin 4.1715652904
MESH:D019446 Endotoxemia Indomethacin 4.5518509659
MESH:D004751 Enteritis Indomethacin 4.8116328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.0217980183
MESH:D004802 Eosinophilia Indomethacin 4.0911298111
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8111005569
MESH:D005334 Fever Indomethacin 4.1411852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.9410962813
MESH:D005355 Fibrosis Indomethacin 4.1117994277
MESH:D005499 Folliculitis Indomethacin 5.2311298111
MESH:D005600 Fragile X Syndrome Minocycline 6.8018835858
MESH:D005756 Gastritis Indomethacin 4.8115046732
MESH:D005909 Glioblastoma marker/mechanism 19946270
MESH:D005909 Glioblastoma Ethylnitrosourea 7.6816436596
MESH:D005909 Glioblastoma Indomethacin 7.6812870263
MESH:D005910 Glioma Ethylnitrosourea 6.5118412241 16651633 16357521
MESH:D005910 Glioma Indomethacin 6.5118371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.3111849393
MESH:D006073 Gout Indomethacin 5.4011248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7615482327
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.6015633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.7215135802
MESH:D006521 Hepatitis, Chronic Minocycline 6.2114986274
MESH:D006930 Hyperalgesia Indomethacin 3.7912727271
MESH:D034321 Hyperamylasemia Indomethacin 5.7817883296
MESH:D006940 Hyperemia Indomethacin 5.0612524144
MESH:D006949 Hyperlipidemias Indomethacin 4.1917546600
MESH:D007022 Hypotension Dopamine 5.056740701
MESH:D007077 Ileal Diseases Indomethacin 5.0918306037 10574470
MESH:D007079 Ileitis Indomethacin 5.4010647630 16133968 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.4316133044
MESH:D007249 Inflammation Indomethacin 2.993291741 12568917 7812673
MESH:D007410 Intestinal Diseases Indomethacin 4.3711855677 17329856 17994277 11713966 18236018 15831440 10210152 11686837 15610444
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.9619381132
MESH:D019586 Intracranial Hypertension Indomethacin 5.4315241188
MESH:D007579 Jejunal Diseases Indomethacin 5.0910574470 16133968 18306037
MESH:D007674 Kidney Diseases Indomethacin 3.2817190690
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.9517379185
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.9310320625 12228301 11703811
MESH:D007918 Leprosy marker/mechanism
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.9410785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6418360721
MESH:D007964 Leukocytosis Indomethacin 5.4316537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.7817980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.7811479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.3618194892
MESH:D008175 Lung Neoplasms marker/mechanism 19946270
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.9916271038 16019985 17703301 6695378
MESH:D008175 Lung Neoplasms Indomethacin 2.9911497255 11053908 16537180
MESH:D008223 Lymphoma Ethylnitrosourea 3.9615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.0915375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5310838139 10767621 18041768
MESH:D008545 Melanoma Reactive Oxygen Species 3.1717992120
MESH:D008579 Meningioma Ethylnitrosourea 6.0517943659
MESH:D008881 Migraine Disorders Indomethacin 3.6911903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.0112636206
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Minocycline 6.8311835378
MESH:D009362 Neoplasm Metastasis Indomethacin 3.1811053908 16537180 11239499
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 9.6916707424
MESH:D009374 Neoplasms, Experimental Indomethacin 9.6910663608 15625704
MESH:D009395 Nephritis, Interstitial Minocycline 5.98435818 444868
MESH:D009410 Nerve Degeneration marker/mechanism 17687034
MESH:D009410 Nerve Degeneration Rotenone 3.9018619942 15790535 17356569
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.4716003739 17160924 16651423
MESH:D019636 Neurodegenerative Diseases Indomethacin 9.1812349958
MESH:D019636 Neurodegenerative Diseases Oxidopamine 9.1818514411
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.236374098
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.0517160924
MESH:D010003 Osteoarthritis Indomethacin 3.687009135
MESH:D010146 Pain Indomethacin 3.4813679232 17627676 3291741 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.7412538197 18702446
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 3.7015580305
MESH:D010195 Pancreatitis Indomethacin 3.9515028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.7816537180
MESH:D010300 Parkinson Disease marker/mechanism 19946270 12588799 15198987 16573651
MESH:D010300 Parkinson Disease Rotenone 6.2919114014 16140633 11535288 18619942 15451049 16412576 18191903 19232380 11445065
MESH:D010300 Parkinson Disease Selegiline 6.2918328768
OMIM:600116 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE marker/mechanism|therapeutic 16914382
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.5011771942 15893579
MESH:D020734 Parkinsonian Disorders Indomethacin 9.4712349958
MESH:D020734 Parkinsonian Disorders Rotenone 9.4718197244 15927086 15795934 15574749
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.7811903285
MESH:D010437 Peptic Ulcer Indomethacin 5.2011148446
MESH:D010518 Periodontitis Indomethacin 4.9817225004
MESH:D047928 Premature Birth Indomethacin 5.1717000239
MESH:D011507 Proteinuria Indomethacin 4.1911849393
MESH:D013272 Stomach Diseases Indomethacin 4.4715472012 10486359 17160473 16113693 17207306 18209964 15038085 17638125 16184426 10192188 18545984 16280098 10215738
MESH:D013274 Stomach Neoplasms Indomethacin 2.3515609394
MESH:D013276 Stomach Ulcer Indomethacin 3.6118543354 14567935 11906479 11145282 18193104 11523592 17135157 12787963 10878458 12467913 17895592 16934674 15104355 16755016 17918041 12498302 16169175 16252198 17977527 18209962 17657623 16397915 10750652 18726076 18431645 17654042 10423059 15255614 1323529 12077510 16150113 18087811 17627676 11595415 11595431 11729361 16631530 18299717 18237397 12500499 15138204 18181030
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.2115790496
MESH:D013964 Thyroid Neoplasms Indomethacin 3.6014736730 11352223 18791128
MESH:D014456 Ulcer Indomethacin 4.9417380554 10574470
MESH:D014839 Vomiting Indomethacin 4.8111897121
Pathway ID Pathway Name
KEGG:05012 Parkinson's disease
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32942
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA444745Leprosy
    Releated drug ID Related drug Name
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved