AutismKB 2.0

Annotation Detail for PARN


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Basic Information Top
Gene Symbol:PARN ( DAN )
Gene Full Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Band: 16p13.12
Quick LinksEntrez ID:5073; OMIM: 604212; Uniprot ID:PARN_HUMAN; ENSEMBL ID: ENSG00000140694; HGNC ID: 8609
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03018RNA degradation
Pathway IDPathway Name
Metabolism of RNA
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PARN mRNAdecreases expression 20064835
20106945
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in decreased expression of PARN mRNAdecreases expression 19925653
D014810 Vitamin E Vitamin E results in increased expression of PARN mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.5816050911
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:C538011 Eales disease Vitamin E 5.579068938
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.3620471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.3616080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8216490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.8414716179
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.9517604070
MESH:D007251 Influenza, Human Vitamin E 5.0816624496
MESH:D007674 Kidney Diseases Vitamin E 3.0312488133
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9116169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.3720195826 21137059
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 5.3718177683
MESH:D008171 Lung Diseases Vitamin E 3.4516863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.796695378 20869020 20135361 20064080 18520028 18569708 17053015 18816296 20464547
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 3.7911696405 18597497 19925653 16337739 11246140 15390079 19359593
MESH:D008175 Lung Neoplasms Vitamin E 3.7911062179
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 4.011500032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.9011893704
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1015084515
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.8816517955
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3117053015
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03018 RNA degradation
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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