Annotation Detail for PAX4
Basic Information
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| Pathway ID | Pathway Name |
|---|
| hsa04950 | Maturity onset diabetes of the young |
| Pathway ID | Pathway Name |
|---|
| Regulation of beta-cell development |
| Pathway ID | Pathway Name |
|---|
| 500521 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
| Desease ID | Desease Name |
|---|
| 1904 | Diabetes mellitus |
| 2051 | Leukemia |
| Desease Name |
|---|
| diabetes, type 1 |
| IMMUNE |
| METABOLIC |
| diabetes, type 2 |
| Desease Name |
|---|
| Diabetes mellitus, type 2 |
| Diabetes mellitus, ketosis-prone |
| Maturity-onset diabetes of the young, type IX |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of PAX4 mRNA | affects expression | 16483693
|
| D001374 |
Azacitidine |
Azacitidine results in increased expression of PAX4 mRNA | increases expression | 18949370
|
| C002791 |
bismuth tripotassium dicitrate |
bismuth tripotassium dicitrate results in decreased expression of PAX4 mRNA | decreases expression | 15912405
|
| C014347 |
decitabine |
decitabine affects the expression of PAX4 mRNA | affects expression | 16701883
|
| D014810 |
Vitamin E |
Vitamin E results in decreased expression of PAX4 mRNA | decreases expression | 19244175
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.10 | 18287403 |
| MESH:D001943 |
Breast Neoplasms |
|
decitabine |
2.54 | 18320071 19208741 |
| MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Vitamin E |
4.41 | 16050911 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
decitabine |
2.67 | 19215824 |
| MESH:D003110 |
Colonic Neoplasms |
|
decitabine |
2.38 | 17616700 |
| MESH:D015179 |
Colorectal Neoplasms |
|
Azacitidine |
2.96 | 19934284 |
| MESH:D015179 |
Colorectal Neoplasms |
|
decitabine |
2.96 | 18981723 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Vitamin E |
1.92 | 19769572 |
| MESH:D003922 |
Diabetes Mellitus, Type 1 |
marker/mechanism |
|
| |
| MESH:D003924 |
Diabetes Mellitus, Type 2 |
marker/mechanism |
|
| |
| MESH:C538011 |
Eales disease |
|
Vitamin E |
5.32 | 9068938 |
| MESH:D004701 |
Endocrine Gland Neoplasms |
|
decitabine |
5.73 | 19294695 |
| MESH:D006258 |
Head and Neck Neoplasms |
|
decitabine |
3.71 | 19215824 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Vitamin E |
3.15 | 16080930 |
| MESH:D006548 |
Hernia, Diaphragmatic |
|
Vitamin E |
2.80 | 16490937 16863852 |
| MESH:D019584 |
Hot Flashes |
|
Vitamin E |
4.58 | 14716179 |
| MESH:D007248 |
Infertility, Male |
|
decitabine |
3.42 | 17581917 |
| MESH:D007251 |
Influenza, Human |
|
Vitamin E |
4.83 | 16624496 |
| MESH:D007674 |
Kidney Diseases |
|
Vitamin E |
2.98 | 12488133 |
| MESH:D007938 |
Leukemia |
|
Azacitidine |
7.28 | 19148494 |
| MESH:D007938 |
Leukemia |
|
decitabine |
7.28 | 19235587 18980019 |
| MESH:D007951 |
Leukemia, Myeloid |
|
Azacitidine |
11.17 | 19077051 |
| MESH:D007951 |
Leukemia, Myeloid |
|
decitabine |
11.17 | 17236224 19117987 18454857 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Azacitidine |
4.48 | 18720364 17596541 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
decitabine |
4.48 | 18206229 18704418 19010910 19387464 18460780 17679729 |
| MESH:D015477 |
Leukemia, Myelomonocytic, Chronic |
|
decitabine |
6.07 | 18055864 |
| MESH:D054429 |
Leukemia, Myelomonocytic, Juvenile |
|
Azacitidine |
5.60 | 19299654 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Vitamin E |
1.90 | 16169303 |
| MESH:D008171 |
Lung Diseases |
|
Vitamin E |
3.40 | 16863852 |
| MESH:D008175 |
Lung Neoplasms |
|
Azacitidine |
2.93 | 21224363 |
| MESH:D008175 |
Lung Neoplasms |
|
Vitamin E |
2.93 | 11062179 |
| MESH:D008223 |
Lymphoma |
|
decitabine |
3.66 | 19470736 |
| OMIM:612225 |
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 9 |
marker/mechanism |
|
| |
| MESH:D008545 |
Melanoma |
marker/mechanism |
|
| 18949370 |
| MESH:D008545 |
Melanoma |
|
decitabine |
2.28 | 16505122 17785578 |
| MESH:D009006 |
Monosomy |
|
Azacitidine |
6.69 | 19299654 |
| MESH:D009101 |
Multiple Myeloma |
|
Azacitidine |
8.52 | 18443271 19549372 |
| MESH:D009101 |
Multiple Myeloma |
|
decitabine |
8.52 | 18172295 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Azacitidine |
8.42 | 18720364 17596541 19805378 17611569 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
decitabine |
8.42 | 19010910 18608210 19157545 16882708 |
| MESH:D009369 |
Neoplasms |
|
decitabine |
2.86 | 19116145 17925555 19470736 |
| MESH:D010051 |
Ovarian Neoplasms |
|
decitabine |
2.73 | 19259094 19331143 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
decitabine |
2.86 | 19294695 |
| MESH:D055728 |
Primary Myelofibrosis |
|
decitabine |
5.21 | 17616702 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Azacitidine |
3.54 | 18324645 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Vitamin E |
3.54 | 15084515 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
decitabine |
4.81 | 19155313 |
| MESH:D012871 |
Skin Diseases |
|
Vitamin E |
2.51 | 18709164 |
| MESH:D013274 |
Stomach Neoplasms |
|
decitabine |
2.10 | 19037991 |
| MESH:D020521 |
Stroke |
|
Vitamin E |
3.81 | 16517955 |
| MESH:D013964 |
Thyroid Neoplasms |
|
decitabine |
3.60 | 17967635 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
decitabine |
2.83 | 17616700 19087683 |
| MESH:D014604 |
Uveal Neoplasms |
|
decitabine |
5.52 | 17785578 |
| Pathway ID |
Pathway Name |
|---|
| KEGG:04950 |
Maturity onset diabetes of the young |
| REACT:13641 |
Regulation of Beta-Cell Development |
| REACT:13698 |
Regulation of beta-cell development |
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