AutismKB 2.0

Annotation Detail for PAX5


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Basic Information Top
Gene Symbol:PAX5 ( BSAP )
Gene Full Name: paired box 5
Band: 9p13.2
Quick LinksEntrez ID:5079; OMIM: 167414; Uniprot ID:PAX5_HUMAN; ENSEMBL ID: ENSG00000196092; HGNC ID: 8619
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200130C-MYB transcription factor network
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00011Lymphoplasmacytic lymphoma
Cancers of haematopoietic and lymphoid tissues
Cancers
Desease IDDesease Name
1934Cancer
Desease Name
CANCER
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
No data
Desease Name
Lymphoplasmacytoid lymphoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of PAX5 mRNAincreases expression 20458559
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PAX5 mRNAaffects cotreatment|increases expression 17404688
C051890 irinotecan irinotecan analog results in decreased expression of PAX5 mRNAdecreases expression 18927307
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of and results in decreased activity of PAX5 proteindecreases activity|decreases expression 14600275
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of PAX5 mRNAdecreases expression 19675145
14600275
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PAX5 mRNAincreases expression 18483191
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PAX5 mRNA alternative formincreases expression 18483191
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PAX5 proteinincreases expression 18483191
D008070 Lipopolysaccharides Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of PAX5 protein]decreases activity|decreases expression|decreases reaction 14600275
D008070 Lipopolysaccharides Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 mRNA]decreases expression|decreases reaction 19675145
14600275
D008070 Lipopolysaccharides Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PAX5 mRNA]decreases reaction|increases expression 18483191
D008070 Lipopolysaccharides Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PAX5 mRNA alternative form]decreases reaction|increases expression 18483191
D008070 Lipopolysaccharides Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PAX5 protein]decreases reaction|increases expression 18483191
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PAX5 mRNAaffects cotreatment|increases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of PAX5 protein]decreases activity|decreases expression|decreases reaction 14600275
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in decreased expression of PAX5 mRNA]decreases expression|decreases reaction 19675145
14600275
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PAX5 mRNA]decreases reaction|increases expression 18483191
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PAX5 mRNA alternative form]decreases reaction|increases expression 18483191
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PAX5 protein]decreases reaction|increases expression 18483191
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [PRDM1 protein binds to PAX5 promoter]affects binding|decreases reaction 19237549
D014212 Tretinoin Tretinoin results in decreased expression of PAX5 mRNAdecreases expression 16093312
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 15322242 11752688
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3311850527 18653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5811798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.5811473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 17.0516206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.0512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.0516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Estradiol 1.9717261762 16675129 12948864 18497071 19861407 17018787 17289903 14630087
MESH:D001943 Breast Neoplasms Progesterone 1.9717614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9716443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8014691202 15553829 16217749 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.801917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0916354765 15340226 8697196 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 6.099407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D003110 Colonic Neoplasms irinotecan 2.6317287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7320501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.7316391804 18259882 17159606 17454858 18509181 16303861 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.899142499 10589399 9211117 17551590 14991402 9125849 16925845 9664655 9224671 8800419
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.4715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 13.4718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1117692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.9811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9816569247
MESH:D004715 Endometriosis Progesterone 9.8216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.8210568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7915328337 17637181 15821434
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.5211564622
MESH:D005124 Eye Abnormalities Tretinoin 9.5216938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 3.5715073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005334 Fever Lipopolysaccharides 4.289205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D005355 Fibrosis Tretinoin 9.8417994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.979664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007249 Inflammation Lipopolysaccharides 9.1317255318 12878042 17963957 17237260 9205823
MESH:D007249 Inflammation Progesterone 9.1315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.1312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9317255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8916580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.8915992940 17551590
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007938 Leukemia arsenic trioxide 6.7515070760
MESH:D007938 Leukemia Tretinoin 6.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.4319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.4316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0216467208 20471514 16968895 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2019075265 12712474 11161223 16891316 12018890 16823087 16330433 11468182 17869043 16112521 15622746 17712046 16966277 19642359 19225113 9834237 16331271 17649720 15748426 19035177 12679006 17107899 15336539 15213294 17217047
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2016788101 16935935 17294898 16766008 17712046 19029980 17361223 17301526 19075265 17368321 9834237 15748426 17107899 19225113 19642359 12679006 19035177 17506722 16140955 16891316 16823087 17217047 17339181 17649720 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D007970 Leukopenia Lipopolysaccharides 5.0915821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.1812878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.1818397230 16248980
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7314682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D055370 Lung Injury Lipopolysaccharides 4.3621114838
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3619825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3619555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6217203775 11408345 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.6211408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D052016 Mucositis irinotecan 5.4017159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919549372 14977855 11468182 15949261 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8716882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.2618259882
MESH:D009369 Neoplasms Tretinoin 2.5216946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 18.3411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.3414600291
MESH:D009421 Nervous System Malformations Tretinoin 18.349125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8710525206
MESH:D009436 Neural Tube Defects Tretinoin 7.879142499
MESH:D009447 Neuroblastoma irinotecan 3.608761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.128761367
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.9012452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 11.9019401270
MESH:D010051 Ovarian Neoplasms Progesterone 11.9017393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 11.9016936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5715976015
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.9512224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11399792 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1619131511
MESH:D011471 Prostatic Neoplasms Estradiol 3.1616740699
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.6815862959 16503802
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5617007042
MESH:D013274 Stomach Neoplasms irinotecan 3.5615723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.5617261132
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4315821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9219014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.9217045167 16026305
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5720435036 12973940 11780464 12845720
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32959
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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