AutismKB 2.0

Annotation Detail for PAX6


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Basic Information Top
Gene Symbol:PAX6 ( AN,AN2,D11S812E,MGC17209,MGDA,WAGR )
Gene Full Name: paired box 6
Band: 11p13
Quick LinksEntrez ID:5080; OMIM: 607108; Uniprot ID:PAX6_HUMAN; ENSEMBL ID: ENSG00000007372; HGNC ID: 8620
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04950Maturity onset diabetes of the young
No data
Pathway IDPathway Name
200057CDC42 signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1860Brain tumor
1865Hyperopia
2118Adenovirus infection
2125Bladder cancer
Desease Name
optic nerve malformation
DEVELOPMENTAL
No data
Desease Name
Aniridia
Morning glory disc anomaly
Optic nerve hypoplasia
Keratitis
Coloboma, ocular
Gillespie syndrome
Foveal hyperplasia
Peters anomaly
Cataract with late-onset corneal dystrophy
Coloboma of optic nerve
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PAX6 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PAX6 mRNAaffects expression 16483693
D001554 Benzene Benzene results in decreased expression of PAX6 mRNAdecreases expression 15120971
15122651
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PAX6 mRNAincreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of PAX6 mRNAincreases expression 17785945
C006780 bisphenol A bisphenol A results in decreased expression of PAX6 mRNAdecreases expression 17268083
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PAX6 mRNAdecreases expression 15336504
D002118 Calcium Calcium affects the expression of PAX6 mRNAaffects expression 15913539
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of PAX6 mRNAdecreases expression 16934159
D016572 Cyclosporine Cyclosporine results in increased expression of PAX6 mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of PAX6 mRNAincreases expression 16367923
D004317 Doxorubicin Doxorubicin results in increased expression of PAX6 mRNAincreases expression 16404146
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of PAX6 exonincreases mutagenesis 16303964
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of PAX6 geneincreases mutagenesis 16724327
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of PAX6 intronincreases mutagenesis 16303964
D017313 Fenretinide Fenretinide results in decreased expression of PAX6 proteindecreases expression 17110918
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PAX6 mRNAincreases expression 19465110
D014212 Tretinoin Tretinoin results in increased expression of PAX6 mRNAincreases expression 16604517
D014212 Tretinoin Tretinoin results in increased expression of PAX6 proteinincreases expression 15996115
D014212 Tretinoin [Tretinoin co-treated with SIX3 protein] results in increased expression of PAX6 mRNAaffects cotreatment|increases expression 16341014
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9014514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2820127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.2817418594
MESH:D000230 Adenocarcinoma Fenretinide 7.2810697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.343712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.346695378
MESH:D000236 Adenoma Ethylnitrosourea 11.346695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000419 Albuminuria Doxorubicin 4.5821441931
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000741 Anemia, Aplastic Benzene 4.3911369114 14761424 17661222
MESH:D015783 Aniridia marker/mechanism 18322702
MESH:C536370 Aniridia cerebellar ataxia mental deficiency marker/mechanism
MESH:C536372 Aniridia, type 2 marker/mechanism
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3516456186
MESH:D001321 Autistic Disorder marker/mechanism 18322702
OMIM:180500 AXENFELD-RIEGER SYNDROME, TYPE 1 marker/mechanism 14630904
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.081440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.0316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001855 Bone Marrow Diseases Benzene 5.2916183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7614601052
MESH:D001862 Bone Resorption bisphenol A 3.8911985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9114991843
MESH:D001932 Brain Neoplasms Doxorubicin 15.0017150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 15.0016651633 18412241 16357521 16436596 15144691
MESH:D001932 Brain Neoplasms Fenretinide 15.0016187019
MESH:D001943 Breast Neoplasms Benzene 4.7611921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.7620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 4.7617123778
MESH:D001943 Breast Neoplasms decitabine 4.7618320071 19208741
MESH:D001943 Breast Neoplasms Doxorubicin 4.7611325840 15567936 17983394 16096432 15993339 16264153 15994142 19526202 15692762 18628466 15634643 17426702 16935488 15939500 17369602 18382427 16595493 15136595 16322301 18695136 16826403 16115903 15668708 18234424
MESH:D001943 Breast Neoplasms Fenretinide 4.7616601279
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7620435547
MESH:D001943 Breast Neoplasms Tretinoin 4.7616443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002276 Carcinoid Tumor Doxorubicin 4.8716051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.687296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.6816234567 16023760 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 6.6816270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.681917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.0417123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.597296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.591485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.4520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 14.4519215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.456189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 14.4516274795
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.4516096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5516952015 16269455 17131338 17308081 16612575 16731534 16364871 16651473 16278810 15476868 16455267 17329180 17928571 17519947 17924179 17351982 15792986 17974986 17007740 15505089 16242529 17382496 15811867 18627295 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9517334414 16243910
MESH:D002386 Cataract Tretinoin 3.1117460283
OMIM:604219 CATARACT, AUTOSOMAL DOMINANT marker/mechanism
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.387505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3812371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 11.3816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.0517160924
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 13.1516154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 13.1516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.959022650 19486331
MESH:D002779 Cholestasis Cyclosporine 7.9519486331
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8015668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.809407595
MESH:D003092 Colitis Tretinoin 3.7517035595
MESH:D003103 Coloboma marker/mechanism
MESH:C535970 Coloboma of optic nerve marker/mechanism
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 3.6218981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6218259882 18802399
MESH:D015179 Colorectal Neoplasms Fenretinide 3.6217273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities marker/mechanism 7559133 9079035 9363853
MESH:D019465 Craniofacial Abnormalities Benzene 3.8515643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.859125849 10589399 8800419 16925845 9664655 17551590 14991402 9142499 9211117 9224671
MESH:D003872 Dermatitis Benzene 4.8115902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8418759878 2524372 12868966 14531868 11298694 11906362 8156756 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.1011289319 9022650 18648102 18289764 9328219 18692083 8291058 16192314 1440618 9653073 6679447 7440962 6482804
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.1017851650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.1017416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1020420201
MESH:D004362 Drug Toxicity Doxorubicin 8.1818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.1811462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.0518357618
MESH:C536185 Ectopia pupillae marker/mechanism
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.1618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.1618230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1819294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.6517359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2218037988
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.383581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 8.909664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 2.8819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 14.9812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.9820067830
MESH:D005355 Fibrosis Tretinoin 14.9817994277
OMIM:136520 FOVEAL HYPOPLASIA AND PRESENILE CATARACT SYNDROME marker/mechanism
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Doxorubicin 17.1817150277
MESH:D005909 Glioblastoma Ethylnitrosourea 17.1816436596
MESH:D005909 Glioblastoma Fenretinide 17.1816187019
MESH:D005909 Glioblastoma Tretinoin 17.1817312396
MESH:D005910 Glioma Ethylnitrosourea 3.5018412241 16651633 16357521
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms decitabine 13.1019215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 13.1015692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 13.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.179664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.5017875725 16144979 16879835 16244371 16495754 16707910 18006777 16330681 16244372 12587719 18674790 14766674 17888722
MESH:D006333 Heart Failure Doxorubicin 3.3617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9315692506
MESH:D006402 Hematologic Diseases Benzene 4.6916183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.4318501091 17606976 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 15340226 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Benzene 8.6717940673
MESH:D006973 Hypertension Cyclosporine 8.6710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6718670907 18850075
MESH:D007248 Infertility, Male decitabine 3.2217581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.3116393666
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.0316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.0315992940 17551590
MESH:C537022 Keratitis, hereditary marker/mechanism
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 8314463 10903974
MESH:D007674 Kidney Diseases Doxorubicin 6.1615699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1816707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.636582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 12.6317379185
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.1116316344
MESH:D007938 Leukemia Benzene 10.6618335105 14694614 17119257 15935818
MESH:D007938 Leukemia decitabine 10.6619235587 18980019
MESH:D007938 Leukemia Tretinoin 10.6617143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2216085563
MESH:D007951 Leukemia, Myeloid Benzene 16.2517506065
MESH:D007951 Leukemia, Myeloid decitabine 16.2518454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 16.2519285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Benzene 6.2619478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.2619387464 18460780 17679729 19010910 18704418 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.2616294345 19850784 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5218055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1716766008 17361223 16935935 16891316 17368321 16788101 9834237 17649720 12679006 17107899 17217047 17712046 16140955 17294898 17506722 19642359 15748426 17339181 19035177 19075265 19029980 19225113 16331271 16823087 17301526
MESH:D007972 Leukoplakia, Oral Fenretinide 6.1116707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.5216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5216248980 18397230
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.3620195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.30598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.3012562636
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.3016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.3012151625
MESH:D017563 Lung Diseases, Interstitial Benzene 4.8714698565
MESH:D008175 Lung Neoplasms Benzene 6.6512562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6520064080 6695378 20464547 18569708 17053015 18816296 18520028 20135361 20869020
MESH:D008175 Lung Neoplasms Doxorubicin 6.6517418594 6189445
MESH:D008175 Lung Neoplasms Ethylnitrosourea 6.6517703301 16271038 6695378 16019985
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6519555203 11884234
MESH:D008223 Lymphoma Benzene 18.1217584886 17119257
MESH:D008223 Lymphoma decitabine 18.1219470736
MESH:D008223 Lymphoma Doxorubicin 18.1216098063
MESH:D008223 Lymphoma Ethylnitrosourea 18.1215790496
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.8415621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 11.8415375218
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4912562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 14.5511921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 14.5515458769
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 14.5518041768 10767621 10838139
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 14.5510697514
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma marker/mechanism 16778180
MESH:D008545 Melanoma decitabine 7.4116505122 17785578
MESH:D008545 Melanoma Doxorubicin 7.4116827129
MESH:D008545 Melanoma Fenretinide 7.4116270382
MESH:D008545 Melanoma Tretinoin 7.4116752155
MESH:D008579 Meningioma Ethylnitrosourea 6.0517943659
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008607 Mental Retardation marker/mechanism 18322702
MESH:D008654 Mesothelioma Doxorubicin 3.0717638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5315792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8516381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.8516274795
MESH:D052016 Mucositis Doxorubicin 4.8417415656
MESH:D009101 Multiple Myeloma Benzene 7.6517119195
MESH:D009101 Multiple Myeloma decitabine 7.6518172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.5319157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5317596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.9619429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.883581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.8818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 12.0411141357
MESH:D009369 Neoplasms decitabine 12.0419116145 17925555 19470736
MESH:D009369 Neoplasms Fenretinide 12.0415958647 17353921
MESH:D009369 Neoplasms Tretinoin 12.0416594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.4416707424
MESH:D009401 Nephrosis Doxorubicin 4.8116899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.3819348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.3815640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 16.6011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.6014600291
MESH:D009421 Nervous System Malformations Tretinoin 16.609125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.316679447
MESH:D009436 Neural Tube Defects Benzene 12.3115643154
MESH:D009436 Neural Tube Defects Tretinoin 12.319142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.4716003739 17160924 16651423
MESH:D009447 Neuroblastoma Doxorubicin 3.2715555623
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.7316303764
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.254026338 6482804
MESH:D009784 Occupational Diseases Benzene 9.2516737584 15576619 15727169 15612468 15913788 17479406 15935809 17119257 17178637
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.0517160924
MESH:D009901 Optic Nerve Diseases marker/mechanism 12721955
OMIM:165550 OPTIC NERVE HYPOPLASIA, BILATERAL marker/mechanism
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010024 Osteoporosis Calcium 3.8017882678
MESH:D012516 Osteosarcoma Doxorubicin 4.1315930896
MESH:D010049 Ovarian Diseases bisphenol A 5.0411985600
MESH:D010051 Ovarian Neoplasms Benzene 11.4512562636
MESH:D010051 Ovarian Neoplasms decitabine 11.4519331143 19259094
MESH:D010051 Ovarian Neoplasms Fenretinide 11.4516133793
MESH:D010051 Ovarian Neoplasms Tretinoin 11.4516936753
MESH:D010146 Pain Tretinoin 2.9216870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.8319294695
MESH:D010190 Pancreatic Neoplasms Fenretinide 8.8315580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8315976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:C537884 Peters anomaly marker/mechanism
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2217638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.6810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6811118676 11896295 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.7717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1217292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1216740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1215749863 16868541 16888761 15897917 16729912 18437689
MESH:D011471 Prostatic Neoplasms Fenretinide 2.1217024972
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.8410548101
MESH:D051437 Renal Insufficiency Doxorubicin 4.2617922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.183692021
MESH:D012162 Retinal Degeneration Fenretinide 9.1816303925
MESH:D012208 Rhabdomyosarcoma decitabine 11.0619155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.0616116481 16283617
MESH:D012509 Sarcoma Doxorubicin 4.0115675481 15625365 17710206 18313854 17203757 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8417846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 22.6619755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 22.6615692506
MESH:D012878 Skin Neoplasms Fenretinide 22.6616467112
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 22.668532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 22.6616192470
MESH:D012878 Skin Neoplasms Tretinoin 22.6616467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6115625365 17203757 16767912
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms Benzene 4.7712562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.772093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.7719037991
MESH:D013274 Stomach Neoplasms Tretinoin 4.7717261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.0316045194 16684133
MESH:D013953 Thymus Neoplasms Benzene 12.3710850423
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 12.3715790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 17.313712494 6582329 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms decitabine 17.3117967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 17.3117909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 17.3116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014071 Tooth Abnormalities marker/mechanism 7559133 9363853
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.948074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.9417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.9417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.9417653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 15.9416720286
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 9.7916154183
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7916129372
MESH:D014591 Uterine Diseases bisphenol A 5.0714652134
MESH:D014594 Uterine Neoplasms Benzene 4.3712562636
MESH:D014604 Uveal Neoplasms decitabine 13.0417785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.0416752155
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2617678736 17638931 17334414 16364871
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04950 Maturity onset diabetes of the young
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32960
    • No data
    Releated disease ID Related disease Name
    PA443401Aphakia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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