AutismKB 2.0

Annotation Detail for IRX4


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Basic Information Top
Gene Symbol:IRX4 ( IRXA3,MGC131996 )
Gene Full Name: iroquois homeobox 4
Band: 5p15.33
Quick LinksEntrez ID:50805; OMIM: 606199; Uniprot ID:IRX4_HUMAN; ENSEMBL ID: ENSG00000113430; HGNC ID: 6129
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of IRX4 mRNAdecreases expression 18648102
C004984 apocarotenal apocarotenal results in decreased expression of IRX4 mRNAdecreases expression 17034753
D019207 beta Carotene beta Carotene results in decreased expression of IRX4 mRNAdecreases expression 17034753
C014347 decitabine decitabine affects the expression of IRX4 mRNAaffects expression 17194187
D002117 Calcitriol Calcitriol results in increased expression of IRX4 mRNAincreases expression 16002434
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of IRX4 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of IRX4 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of IRX4 mRNAincreases expression 17404688
C024746 tobacco tar tobacco tar results in decreased expression of IRX4 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615665606 15380490 15845082
MESH:D002545 Brain Ischemia beta Carotene 5.4316157235
MESH:D001943 Breast Neoplasms Calcitriol 2.0311237771
MESH:D001943 Breast Neoplasms decitabine 2.0319208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 2.0317289903 14630087 12948864 16675129 18497071 19861407 17261762 17018787
MESH:D001943 Breast Neoplasms Progesterone 2.0317614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.053581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0911237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.0919215824
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.287505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.2818566989
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 12.2819559774
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3219486331 9022650
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 18759878 14531868 12868966 11298694 8156756 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.019653073 18692083 1440618 18289764 6482804 11289319 9022650 8291058 6679447 16192314 18648102 9328219 7440962
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.2615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 10.2617692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D016889 Endometrial Neoplasms Estradiol 3.1311473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 3.9916134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D015658 HIV Infections beta Carotene 4.1516960176
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007249 Inflammation Progesterone 2.7015869954
MESH:D007333 Insulin Resistance Estradiol 3.1116393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007674 Kidney Diseases Estradiol 2.7115618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D007680 Kidney Neoplasms Estradiol 8.0415610895
MESH:D007938 Leukemia decitabine 3.1818980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2419117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118704418 18460780 18206229 17679729 19387464 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.86598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 6.8617113696
MESH:D008175 Lung Neoplasms beta Carotene 3.0416401635
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5511807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5517203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119010910 18608210 19157545 16882708
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms beta Carotene 6.0017051425
MESH:D009369 Neoplasms decitabine 6.0017925555 19116145 19470736
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 3.9311399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms decitabine 8.3019259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 8.3019401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.3017393432 16525653
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2616289102 15754350 18247401 16644109 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 3.2616740699
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D013119 Spinal Cord Injuries Progesterone 4.6216503802 15862959
MESH:D013272 Stomach Diseases beta Carotene 5.4317638125
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013276 Stomach Ulcer beta Carotene 4.5012500499
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.866582329 1399818 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms decitabine 7.8617967635
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.448074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4417616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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