Annotation Detail for PDCL
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of PDCL mRNA | affects expression | 16483693
|
| D004642 |
Emodin |
Emodin results in decreased expression of PDCL mRNA | decreases expression | 16045814
|
| D000431 |
Ethanol |
Ethanol results in increased expression of PDCL mRNA | increases expression | 16946407
|
| C011890 |
kojic acid |
kojic acid results in increased expression of PDCL mRNA | increases expression | 16595896
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDCL mRNA | affects binding|increases activity|increases expression | 19710929
|
| C006253 |
pirinixic acid |
pirinixic acid results in decreased expression of PDCL mRNA | decreases expression | 18445702
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Ethanol |
4.45 | 17676605 18926900 |
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
12.34 | 18287403 |
| MESH:D000138 |
Acidosis |
|
Ethanol |
12.34 | 11192467 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.52 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.02 | 16434500 |
| MESH:D020268 |
Alcohol-Induced Disorders, Nervous System |
|
Ethanol |
5.93 | 15451039 15451040 |
| MESH:D000853 |
Anophthalmos |
|
Ethanol |
5.30 | 15513904 |
| MESH:D001008 |
Anxiety Disorders |
|
Ethanol |
4.29 | 11141031 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.52 | 19483382 |
| MESH:D002056 |
Burns |
|
Ethanol |
5.14 | 16374292 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Ethanol |
2.42 | 15763234 18788625 15289165 |
| MESH:D006332 |
Cardiomegaly |
|
Ethanol |
3.61 | 19332462 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.08 | 19176532 |
| MESH:D002971 |
Cleft Lip |
|
Ethanol |
3.74 | 15513904 |
| MESH:D002972 |
Cleft Palate |
|
Ethanol |
3.29 | 15513904 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Ethanol |
2.34 | 19302082 10194807 15451039 15513904 11873399 15451040 11198716 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.56 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Ethanol |
2.68 | 11566570 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.85 | 12083418 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Ethanol |
2.82 | 16704527 |
| MESH:D005234 |
Fatty Liver |
|
Ethanol |
9.15 | 19236843 16409862 18620774 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
9.15 | 19236843 20131406 |
| MESH:D005235 |
Fatty Liver, Alcoholic |
|
Ethanol |
6.28 | 17920746 |
| MESH:D005310 |
Fetal Alcohol Syndrome |
|
Ethanol |
5.84 | 16946407 15513904 10194807 15451040 |
| MESH:D005355 |
Fibrosis |
|
Emodin |
5.28 | 19474275 |
| MESH:D005756 |
Gastritis |
|
Ethanol |
5.30 | 15046732 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.73 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.48 | 18467677 19176532 19772884 16221962 |
| MESH:D006930 |
Hyperalgesia |
|
Ethanol |
4.00 | 18783367 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.53 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.85 | 16306350 |
| MESH:D007569 |
Jaw Abnormalities |
|
Ethanol |
4.78 | 15513904 |
| MESH:D007859 |
Learning Disorders |
|
Ethanol |
4.69 | 15451040 |
| MESH:D015459 |
Leukemia-Lymphoma, Adult T-Cell |
|
Emodin |
5.40 | 17077332 |
| MESH:D017880 |
Limb Deformities, Congenital |
|
Ethanol |
4.06 | 17676605 |
| MESH:D008103 |
Liver Cirrhosis |
|
Ethanol |
3.54 | 15289165 |
| MESH:D008104 |
Liver Cirrhosis, Alcoholic |
|
Ethanol |
5.64 | 18295389 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Emodin |
3.89 | 15288473 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Ethanol |
3.89 | 18166357 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
3.89 | 15474484 |
| MESH:D008108 |
Liver Diseases, Alcoholic |
|
Ethanol |
5.14 | 17207112 17347304 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.92 | 16377806 15890375 20007298 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
kojic acid |
3.53 | 18544905 |
| MESH:D008569 |
Memory Disorders |
|
Ethanol |
4.63 | 18411066 15451040 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.99 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.26 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.22 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.09 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
Ethanol |
3.07 | 12384795 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.53 | 19058328 |
| MESH:D012640 |
Seizures |
|
Ethanol |
3.40 | 9754883 |
| MESH:D013274 |
Stomach Neoplasms |
|
Ethanol |
2.31 | 18456281 |
| MESH:D013276 |
Stomach Ulcer |
|
Ethanol |
3.90 | 9562338 17918041 9211565 11906479 16755016 17189318 |
| MESH:D013375 |
Substance Withdrawal Syndrome |
|
Ethanol |
4.60 | 9754883 |
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