AutismKB 2.0

Annotation Detail for PBX1


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Basic Information Top
Gene Symbol:PBX1 ( DKFZp686B09108,MGC126627 )
Gene Full Name: pre-B-cell leukemia homeobox 1
Band: 1q23.3
Quick LinksEntrez ID:5087; OMIM: 176310; Uniprot ID:PBX1_HUMAN; ENSEMBL ID: ENSG00000185630; HGNC ID: 8632
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200077Glucocorticoid receptor regulatory network
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00001Acute lymphoblastic leukemia (ALL) (Precursor B lymphoblastic leukemia)
Desease IDDesease Name
1831Prostate cancer
1856Obesity
1904Diabetes mellitus
1993Esophagus cancer
2051Leukemia
No data
No data
Desease Name
Leukemia, acute pre-B-cell
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PBX1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PBX1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PBX1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PBX1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in increased expression of PBX1 mRNAincreases expression 20678512
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PBX1 mRNAdecreases expression 15336504
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of PBX1 mRNAdecreases expression 16934159
D016572 Cyclosporine Cyclosporine results in decreased expression of PBX1 mRNAdecreases expression 20106945
D002945 Cisplatin PBX1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D002117 Calcitriol Calcitriol results in increased expression of PBX1 mRNAincreases expression 16002434
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PBX1 mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Estradiol results in decreased expression of PBX1 mRNAdecreases expression 20068009
C008493 methylselenic acid methylselenic acid results in increased expression of PBX1 mRNAincreases expression 18548127
D008942 Mitoxantrone PBX1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in increased expression of PBX1 mRNAincreases expression 15674844
C006253 pirinixic acid pirinixic acid results in increased expression of PBX1 mRNAincreases expression 17950772
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PBX1 mRNA]increases expression|increases reaction 17950772
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PBX1 mRNAaffects cotreatment|decreases expression 17404688
C045950 propiconazole propiconazole results in decreased expression of PBX1 mRNAdecreases expression 16730040
C017947 sodium arsenite sodium arsenite results in increased expression of PBX1 mRNAincreases expression 12760830
D002762 Cholecalciferol Cholecalciferol results in increased expression of PBX1 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 3.9015814532 12690470 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0320127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 7.0317638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.0311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4216434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8516712894 17306315
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001249 Asthma Mustard Gas 2.6910378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.9716142846
MESH:D001768 Blister Mustard Gas 5.1019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.0819483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8314601052
MESH:D001862 Bone Resorption bisphenol A 3.8011985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 4.1915845082 15665606 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9320146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.9317123778
MESH:D001943 Breast Neoplasms Calcitriol 2.9311237771
MESH:D001943 Breast Neoplasms Cisplatin 2.9318382427 19526202
MESH:D001943 Breast Neoplasms Estradiol 2.9317289903 17261762 16675129 19861407 12948864 14630087 18497071 17018787
MESH:D001943 Breast Neoplasms Progesterone 2.9316175315 17614352 15562024
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9210378619 17687719
MESH:D002051 Burkitt Lymphoma marker/mechanism 1967982 17244677
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.773084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.7721507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 8.7717982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7715276417 16507464 17306315
MESH:D002278 Carcinoma in Situ bisphenol A 4.9317123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0112023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.6720419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.6711237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.6717066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.6718572023
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.6320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.6312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.6318566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.6319524636 20056578
MESH:D002779 Cholestasis Cyclosporine 7.5919486331
MESH:D002779 Cholestasis pirinixic acid 7.5919176532
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0216227642 11461765 16485898 10663392 19923254 12958197 17522070 16781746 15619225 12705907 14986274 17906064 10774834 18071297 19420014 19085960 12153990 11287661 11529661 15968718 12540782 16081117 11743745 16177239 12594235 19739265 11739529 18713872 11421492 19416960 2444490 10915739 12392966 14725611 11834606 16109766 16393943 19164858 19370779 14550746 17562736
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 4.0217851650
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Cisplatin 3.8012231392 19839026 15033597 12649298
MESH:D004487 Edema Mustard Gas 6.689260866 11428647 11402378 11428631
MESH:D004487 Edema pirinixic acid 6.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.1015138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.1017692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.9419148513 11473722 18566989
MESH:D004715 Endometriosis Progesterone 3.7016134523
MESH:D004890 Erythema Mustard Gas 5.109357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1716530937
MESH:D004938 Esophageal Neoplasms Cisplatin 7.1715464296 16481741 15173087 17638652 16785472
MESH:D005234 Fatty Liver Cyclosporine 7.3619224547
MESH:D005234 Fatty Liver pirinixic acid 7.3619236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.0812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6715464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.2419898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3615464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6220471113
MESH:D006331 Heart Diseases Mitoxantrone 4.1016019553
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006529 Hepatomegaly pirinixic acid 8.6619772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly propiconazole 8.6617178689 17178688
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D006689 Hodgkin Disease Cisplatin 7.3516200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 7.3512676792
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006973 Hypertension Cyclosporine 2.0710903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3415869954
MESH:D007248 Infertility, Male sodium arsenite 2.9412646999 15346721
MESH:D007249 Inflammation Mustard Gas 5.2111428647 9357497 16001271 11402378 11428631 17524151 8975870 11428620 9260866
MESH:D007249 Inflammation Progesterone 5.2115869954
MESH:D007333 Insulin Resistance bisphenol A 12.0616393666
MESH:D007333 Insulin Resistance Estradiol 12.0616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.0616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0815464296
MESH:D007674 Kidney Diseases Acetaminophen 18.6515629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 18.6512649298 15190930 12231392 18289764 19839026
MESH:D007674 Kidney Diseases Cyclosporine 18.6518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 18.6515618244
MESH:D007674 Kidney Diseases sodium arsenite 18.6520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 7.0912371664
MESH:D007680 Kidney Neoplasms Estradiol 7.0915610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7411231351
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7618172266
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2815474484
MESH:D008107 Liver Diseases Acetaminophen 4.2612969438 11587558 16611625 19460945 16610002 19014921 19784758 12587719
MESH:D008107 Liver Diseases propiconazole 4.2619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1816871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.0015890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.0020195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms propiconazole 14.0019028983
MESH:D008113 Liver Neoplasms sodium arsenite 14.0016712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.288603461
MESH:D008114 Liver Neoplasms, Experimental propiconazole 6.2817178689
MESH:D008171 Lung Diseases Mustard Gas 7.3918702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 7.3919095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.5214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5220464547 20869020 6695378 17053015 18569708 18520028 18816296 20064080 20135361
MESH:D008175 Lung Neoplasms Cisplatin 6.5211798837 6189445 17225452
MESH:D008175 Lung Neoplasms Mustard Gas 6.523148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 6.5216712894 15276417 19931552 17306315 17077188
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9117203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.9117203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008545 Melanoma Cisplatin 3.5012393984 16432458 18176117 17023156 12374674 18505091 18332650 17761969 12883367 16809738 16248763 15577323 11135225
MESH:D008545 Melanoma sodium arsenite 3.5019082730 16487513
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.7115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Cisplatin 3.2217638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0816411023
MESH:D009369 Neoplasms Benzo(a)pyrene 15.4111141357
MESH:D009369 Neoplasms Cisplatin 15.4116773208
MESH:D009369 Neoplasms Mitoxantrone 15.4116640825
MESH:D009369 Neoplasms pirinixic acid 15.4117405874
MESH:D009369 Neoplasms sodium arsenite 15.4111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4415464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2319348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 9.5316427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 9.5311399458 16427766
MESH:D009436 Neural Tube Defects sodium arsenite 3.1012854658
MESH:D009447 Neuroblastoma Cisplatin 3.418761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.648761367
MESH:D009503 Neutropenia Mustard Gas 3.917688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D010049 Ovarian Diseases bisphenol A 4.9311985600
MESH:D010051 Ovarian Neoplasms Cisplatin 11.1517225452 6897625 15464296 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 11.1519401270
MESH:D010051 Ovarian Neoplasms Progesterone 11.1516525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.1517306315 15276417
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 2.9719003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.2917638057
MESH:D011041 Poisoning Mustard Gas 3.7315727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8910548101
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.3520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.3520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0916740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0918247401 16644109 16289102 12479363 15754350
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.0917024972
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0916205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0916039940
MESH:D011537 Pruritus Mustard Gas 4.0318058305
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7210548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9010334151 17620002 17894541 17266442 17720292
MESH:D051437 Renal Insufficiency Cisplatin 4.3415464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3614601052
MESH:D012871 Skin Diseases Mustard Gas 2.7016961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3110029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 9.3119524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.318532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2915464296
MESH:D013119 Spinal Cord Injuries Progesterone 4.2216503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.522093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 2.5217522103 15958060 18396642
MESH:D019966 Substance-Related Disorders bisphenol A 3.9216684133 16045194
MESH:D013736 Testicular Neoplasms Cisplatin 4.5715464296 17225452
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2317053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.2315464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.2316452187 11723127 17306315 16712894
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.4116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.4111813266
MESH:D014591 Uterine Diseases bisphenol A 4.9514652134
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5515577323
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D014839 Vomiting Cisplatin 4.6611897121
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32970
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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