AutismKB 2.0

Annotation Detail for PBX2


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Basic Information Top
Gene Symbol:PBX2 ( G17,HOX12,PBX2MHC )
Gene Full Name: pre-B-cell leukemia homeobox 2
Band: 6p21.32
Quick LinksEntrez ID:5089; OMIM: 176311; Uniprot ID:PBX2_HUMAN; ENSEMBL ID: ENSG00000204304; HGNC ID: 8633
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PBX2 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PBX2 mRNAincreases expression 15336504
D002330 Carmustine Carmustine results in decreased expression of PBX2 mRNAdecreases expression 15980968
D005419 Flavonoids Flavonoids results in increased expression of PBX2 mRNAincreases expression 15465739
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PBX2 mRNAaffects cotreatment|increases expression 17183730
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PBX2 mRNAincreases expression 12057914
D009151 Mustard Gas Mustard Gas results in decreased expression of PBX2 mRNAdecreases expression 15674843
D010936 Plant Extracts Plant Extracts results in increased expression of PBX2 mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of PBX2 mRNAincreases expression 15465739
D014212 Tretinoin Tretinoin results in increased expression of PBX2 mRNAincreases expression 16604517
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PBX2 mRNAaffects expression 21346803
D014415 Tunicamycin Tunicamycin results in increased expression of PBX2 mRNAincreases expression 17127020
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PBX2 mRNAaffects cotreatment|increases expression 17183730
D002762 Cholecalciferol Cholecalciferol results in increased expression of PBX2 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.087525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.088875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0911850527 18653653
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000544 Alzheimer Disease Plant Extracts 3.0216962711
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D001169 Arthritis, Experimental Plant Extracts 7.7814686799
MESH:D001169 Arthritis, Experimental Tretinoin 7.7816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Mustard Gas 5.0310378619
MESH:D001249 Asthma Tretinoin 5.0316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18177632 19232924 18940202 19460635 17157402 18985861 18396377 20603192 16609825 18316065 18775368 18558336 17507914 17688650
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.1016142846
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1020046352 17594078
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6616206674 16197459
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.438888407
MESH:D002545 Brain Ischemia Plant Extracts 4.8116041641
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D001943 Breast Neoplasms Tretinoin 2.2716166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002057 Burns, Chemical Plant Extracts 5.439625245
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 4.7018834353
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.701917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3016096774 16051514
MESH:D006332 Cardiomegaly Plant Extracts 3.8317645561
MESH:D002386 Cataract Acetaminophen 12.5910977129
MESH:D002386 Cataract Tretinoin 12.5917460283
MESH:D002386 Cataract Trinitrotoluene 12.5915817613 14694615
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tretinoin 2.699407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms polyphenols 2.6816293270
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.4515095906
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7014991402 9224671 9211117 17551590 8800419 10589399 9664655 16925845 9125849 9142499
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.708888407 17688650 16575769
MESH:D003490 Cyanosis Trinitrotoluene 4.9918551238
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.4519706694
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1819923254 17906064 2444490 16781746 12392966 11743745 12153990 11834606 17562736 19416960 16485898 14725611 19085960 12540782 16109766 19739265 15619225 14550746 19370779 11529661 12594235 10915739 16177239 11287661 19164858 14986274 18713872 12705907 16081117 11421492 15968718 11461765 16393943 11739529 19420014 16227642 10663392 12958197 10774834 17522070 18071297
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.1819370779
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.1818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.181733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004487 Edema Mustard Gas 7.559260866 11428631 11402378 11428647
MESH:D004487 Edema Plant Extracts 7.5512787963
MESH:D004489 Edema, Cardiac Tretinoin 4.5618230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.7815268973
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4817637181 15821434 15328337
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.013922381 16628512
MESH:D004827 Epilepsy Plant Extracts 7.0619439326 19700373
MESH:D004827 Epilepsy Valproic Acid 7.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D005124 Eye Abnormalities Tretinoin 3.629664655 16938888
MESH:D005234 Fatty Liver Plant Extracts 8.4015975614
MESH:D005234 Fatty Liver Valproic Acid 8.4014986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D005334 Fever Lipopolysaccharides 4.0611852909 9205823
MESH:D005355 Fibrosis Tretinoin 3.5817994277
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Carmustine 7.5716187019
MESH:D005909 Glioblastoma Tretinoin 7.5717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9214991402 9664655
MESH:D006333 Heart Failure Plant Extracts 3.9018097624
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4316366002
MESH:D006529 Hepatomegaly Trinitrotoluene 4.3015817613
MESH:D006561 Herpes Simplex Plant Extracts 4.7110715843
MESH:D015658 HIV Infections Plant Extracts 3.7112878215
MESH:D019584 Hot Flashes Plant Extracts 4.8414716179 16566672 17454163
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006930 Hyperalgesia Acetaminophen 7.7716870215
MESH:D006930 Hyperalgesia Tretinoin 7.7716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.5116484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.5315268973 15975614
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7016612254
MESH:D007248 Infertility, Male Trinitrotoluene 3.7112150543
MESH:D007249 Inflammation Flavonoids 16.2217296493
MESH:D007249 Inflammation Lipopolysaccharides 16.2212878042 17237260 17255318 17963957 9205823
MESH:D007249 Inflammation Mustard Gas 16.2211428620 8975870 17524151 9357497 9260866 11402378 11428631 16001271 11428647
MESH:D007249 Inflammation Plant Extracts 16.2212787963 16366677 19332304 15997105
MESH:D007249 Inflammation polyphenols 16.2216366677
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.6712628509 12351151 12584176
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007569 Jaw Abnormalities Tretinoin 3.9517551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9219850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9216294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1917339181 19075265 17368321 12679006 16140955 9834237 17217047 17294898 16935935 17361223 17107899 17506722 19035177 16823087 17301526 19225113 16331271 16891316 15748426 16788101 19642359 17712046 16766008 17649720 19029980
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008103 Liver Cirrhosis Plant Extracts 3.7617157831
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.7412878042
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 3.7415479170
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.7719014921 16611625 19784758 12587719 19460945 11587558 12969438 16610002
MESH:D008107 Liver Diseases Plant Extracts 6.7717034775
MESH:D008107 Liver Diseases polyphenols 6.7716698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms Plant Extracts 3.1719168119
MESH:D008171 Lung Diseases Mustard Gas 3.4818161513 18702808
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D055370 Lung Injury Lipopolysaccharides 4.0821114838
MESH:D008175 Lung Neoplasms Mustard Gas 2.953148597 8781369
MESH:D008175 Lung Neoplasms Plant Extracts 2.9520869020
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Carmustine 3.6712393984
MESH:D008545 Melanoma Tretinoin 3.6716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008881 Migraine Disorders Valproic Acid 3.2318803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4917596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4917596541
MESH:D009336 Necrosis Trinitrotoluene 4.8518551238
MESH:D009369 Neoplasms Tretinoin 2.4316594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.849125849
MESH:D009436 Neural Tube Defects Tretinoin 7.429142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.4216359493 8888407
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.2517168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009503 Neutropenia Mustard Gas 4.0316761898 7688884
MESH:D009765 Obesity Plant Extracts 3.1519056576 20132043
MESH:D009784 Occupational Diseases Trinitrotoluene 4.3914694615 17852074 12819281
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3616936753
MESH:D010146 Pain Acetaminophen 6.7416870215
MESH:D010146 Pain Tretinoin 6.7416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4815976015
MESH:D010212 Papilloma Plant Extracts 4.5615173996 16517061
MESH:D011014 Pneumonia Lipopolysaccharides 4.6411605937 12224865
MESH:D011041 Poisoning Mustard Gas 3.8515727166
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9120603192
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.9217024972
MESH:D011471 Prostatic Neoplasms Plant Extracts 3.9217804756 14666653
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011537 Pruritus Mustard Gas 4.1718058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.6411422049 12752131
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417266442 17620002 10334151 17720292 17894541
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.0616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.0619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures Trinitrotoluene 6.4018551238
MESH:D012640 Seizures Valproic Acid 6.4011044598 11738929 14763951 17978042 1511512 15475178 3137016 16876388
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 15451306 16961503
MESH:D012878 Skin Neoplasms Plant Extracts 9.7615173996 16517061
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.768532709
MESH:D012878 Skin Neoplasms Tretinoin 9.7616467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013163 Splenomegaly Trinitrotoluene 5.2715817613
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Plant Extracts 3.9518193104 17135157 15255614 12787963 18237397
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 13.6017997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 13.6017997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.8218097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.4018097624
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
MESH:D014947 Wounds and Injuries Plant Extracts 4.3019894650 20213670
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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