AutismKB 2.0

Annotation Detail for ATP5C1


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Basic Information Top
Gene Symbol:ATP5C1 ( ATP5C,ATP5CL1 )
Gene Full Name: ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Band: 10p14
Quick LinksEntrez ID:509; OMIM: 108729; Uniprot ID:ATPG_HUMAN; ENSEMBL ID: ENSG00000165629; HGNC ID: 833
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
Pathway IDPathway Name
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncou
No data
Pathway IDPathway Name
P02721ATP synthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ATP5C1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of ATP5C1 mRNAdecreases expression 15030884
D000082 Acetaminophen Acetaminophen results in increased expression of ATP5C1 proteinincreases expression 16538041
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATP5C1 mRNAaffects expression 16483693
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of ATP5C1 mRNAdecreases expression 17553608
C099555 CD 437 CD 437 results in decreased expression of ATP5C1 mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in decreased expression of ATP5C1 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5C1 mRNAaffects cotreatment|increases expression 18313992
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ATP5C1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ATP5C1 mRNAaffects expression 15212814
D005485 Flutamide Flutamide analog results in increased expression of ATP5C1 mRNAincreases expression 17702527
D005485 Flutamide Flutamide results in increased expression of ATP5C1 mRNAincreases expression 17702527
D007657 Ketone Bodies Ketone Bodies results in increased expression of ATP5C1 mRNAincreases expression 16807920
D010665 Phenylpropanolamine Phenylpropanolamine results in decreased expression of ATP5C1 mRNAdecreases expression 16465460
C059514 resveratrol resveratrol binds to and results in decreased activity of [ATP5B protein binds to ATP5A1 protein binds to ATP5C1 protein]affects binding|decreases activity 17698806
D012402 Rotenone Rotenone results in increased expression of ATP5C1 mRNAincreases expression 17702527
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATP5C1 mRNAincreases expression 18796159
C066340 tolcapone tolcapone binds to ATP5C1 proteinaffects binding 19783845
D014810 Vitamin E Vitamin E results in decreased expression of ATP5C1 mRNAdecreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5C1 mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.849612607
MESH:D058186 Acute Kidney Injury resveratrol 3.8516538975
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D000236 Adenoma resveratrol 3.3215688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.3211080934
MESH:D000544 Alzheimer Disease resveratrol 4.7016162502 16183991
MESH:D000544 Alzheimer Disease tolcapone 4.7020150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D000855 Anorexia Phenylpropanolamine 5.7317684035
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental resveratrol 7.3717115116
MESH:D050197 Atherosclerosis resveratrol 3.2716873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D002545 Brain Ischemia resveratrol 4.3017600658
MESH:D001943 Breast Neoplasms resveratrol 2.1416393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1420435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.0216227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6116675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7116227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.4715458977
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Cyclosporine 7.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7816919318 17333356 15861022 11677210 16105132 17110522 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1012621046 16354765 15340226 8697196 15668235
MESH:D003092 Colitis resveratrol 4.1416474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4616338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4819769572
MESH:D003866 Depressive Disorder tolcapone 4.3111224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.9010440460
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7716873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.9616286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2911739529 17906064 12392966 11421492 16393943 2444490 19370779 19739265 17562736 16227642 14550746 15619225 16485898 17522070 10663392 12958197 11743745 19085960 12540782 14986274 10774834 16109766 11529661 19923254 16781746 19164858 11461765 19420014 12153990 11287661 12705907 15968718 18713872 10915739 14725611 16081117 19416960 16177239 18071297 12594235 11834606
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2920420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 6.2916604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Lamivudine 13.8915040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.8911462148
MESH:D004362 Drug Toxicity Zidovudine 13.8915040536
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.4311455177
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004487 Edema resveratrol 6.888985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.1617872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8617923197
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.9819578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 13.1919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.1915345470
MESH:D005234 Fatty Liver Zidovudine 13.1918299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 8.5312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.5716080930
MESH:D006402 Hematologic Diseases Zidovudine 4.7212579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006509 Hepatitis B Lamivudine 5.1017703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1015274664 16476009 12044531 15631357 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016863852 16490937
MESH:D006561 Herpes Simplex resveratrol 4.2016876885
MESH:D015658 HIV Infections Lamivudine 7.069296927 11141242 20032539 17530837
MESH:D015658 HIV Infections Zidovudine 7.0617358032 11698656 11363243 20032539 11141242
MESH:D019584 Hot Flashes Vitamin E 4.0014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0818606429 15340226 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D017588 Hyperandrogenism Flutamide 5.4915356085
MESH:D006937 Hypercholesterolemia resveratrol 4.0117188708
MESH:D006949 Hyperlipidemias resveratrol 4.0316873680
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3117488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation resveratrol 5.0716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712200463 12878042
MESH:D007251 Influenza, Human resveratrol 11.1916624496
MESH:D007251 Influenza, Human Vitamin E 11.1916624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 10.0112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.018314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.0112488133
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007680 Kidney Neoplasms Zidovudine 7.5812579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4220370541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5816087638
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3416169303
MESH:D008107 Liver Diseases Acetaminophen 1.6312587719 12969438 19460945 19784758 11587558 16611625 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms resveratrol 4.5819073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1112151625
MESH:D008171 Lung Diseases Vitamin E 3.1816863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.4911062179
MESH:D008175 Lung Neoplasms Zidovudine 3.4918800350
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3117088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.2715688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.1111606380 8985016
MESH:D008545 Melanoma resveratrol 2.3717992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008659 Metabolic Diseases resveratrol 4.3817112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8717358032
MESH:D009101 Multiple Myeloma resveratrol 3.4717164350 17935668 16490592 16267019 14749477 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8917962980
MESH:D009203 Myocardial Infarction resveratrol 3.0316317513 16525036 17015251 17188708 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 9.0217015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0212213967
MESH:D009205 Myocarditis resveratrol 4.7817322642
MESH:D009374 Neoplasms, Experimental resveratrol 4.018985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.8817356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3618514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.3617652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.4117929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.2617513867
MESH:D010051 Ovarian Neoplasms CD 437 3.3217474084
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010300 Parkinson Disease Rotenone 5.8716140633 16412576 19114014 19232380 18191903 18619942 15451049 11445065 11535288
MESH:D010300 Parkinson Disease tolcapone 5.879305320 19578428 11432539 10651109 8739811 7566641 9708959 18328768 9591521 17089403 16758261 20334432 19783845 11793426 11586115 9333106 20216409 9754991 11746615 8635184 1977408
MESH:D020734 Parkinsonian Disorders Rotenone 4.0815927086 15574749 15795934 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D011085 Polycystic Ovary Syndrome Flutamide 5.0115356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.6616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6611896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Flutamide 2.803169114
MESH:D011471 Prostatic Neoplasms resveratrol 2.8015767336 17675339 17718901 17636462 16731767 17804756
MESH:D011471 Prostatic Neoplasms Vitamin E 2.8015084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6116325855
MESH:D015427 Reperfusion Injury resveratrol 3.2717058453 16314181 17520802 15827377 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.569296927
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms resveratrol 5.7215837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms Zidovudine 2.4717696246
MESH:D020521 Stroke Vitamin E 3.5216517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4816321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D014062 Tongue Neoplasms resveratrol 4.2116227395
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.9819578428
MESH:D001749 Urinary Bladder Neoplasms CD 437 3.3916720286
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.1017473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.5314692618
MESH:D014594 Uterine Neoplasms resveratrol 9.5317044934
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.7712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.3117488730
MESH:D014820 Vitiligo tolcapone 5.2010573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
KEGG:00190 Oxidative phosphorylation
KEGG:05012 Parkinson's disease
REACT:6305 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25125
    • No data
    No data
    Releated drug ID Related drug Name
    PA165291922doxorubicinol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04216 - Quercetin Antioxidants
    DB07384 - 1-ACETYL-2-CARBOXYPIPERIDINE
    DB07394 - AUROVERTIN B
    DB08399 - PICEATANNOL
    DB08629 - N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
    No data
    No data
    No data

    Simple Query:


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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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