AutismKB 2.0

Annotation Detail for PBX3


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Basic Information Top
Gene Symbol:PBX3 ( - )
Gene Full Name: pre-B-cell leukemia homeobox 3
Band: 9q33.3
Quick LinksEntrez ID:5090; OMIM: 176312; Uniprot ID:PBX3_HUMAN; ENSEMBL ID: ENSG00000167081; HGNC ID: 8634
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PBX3 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of PBX3 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PBX3 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of PBX3 mRNAdecreases expression 20106945
D005472 Fluorouracil PBX3 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C533894 LG 100815 LG 100815 results in decreased expression of PBX3 mRNAdecreases expression 16951191
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of PBX3 mRNAdecreases expression 16951191
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PBX3 mRNAaffects binding|decreases expression|increases activity 19710929
D014501 Uranium Uranium affects the expression of PBX3 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of PBX3 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4617638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000740 Anemia Fluorouracil 3.8717963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.4619217205 16595493 16557594 18608205 16110121 15136595 18357371
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.0116332177 17045692 16799960 17088986 17971768 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5317066447 16757204 16280240 18986760
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617016597 15001691 17172411 16510598 18772588 17725105 17287894 17169374 17018589 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 16303861 15289873 20501625 17016601 18448328 16331619 15148649 17401013 18509181 16391804 17454858 17255274 17695437 14970324 18383874 18949393 16524972 17094418 18802399 18288408 16282729
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6312540782 16227642 11743745 14725611 10663392 19085960 15619225 15968718 11287661 16781746 10774834 16177239 17562736 14986274 14550746 12594235 11529661 19416960 16485898 11461765 11739529 17522070 18071297 11421492 19370779 19739265 19923254 16109766 12392966 19420014 2444490 19164858 12153990 11834606 12705907 17906064 18713872 16081117 10915739 12958197 16393943
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4816785472 15173087 16481741 17638652 16337965
MESH:D005234 Fatty Liver Cyclosporine 8.1419224547
MESH:D005234 Fatty Liver pirinixic acid 8.1419236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015102660 15162350 18337622
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 19772884 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.8816985049
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 19014921 16611625 19460945 11587558 12969438 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 4.7217045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 4.7220007298 15890375 16377806
MESH:D008175 Lung Neoplasms Fluorouracil 2.0015246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7616757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms Fluorouracil 5.2416928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 5.2417405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7219003803 16929163 15113037 16500647
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3819082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1618722050 16160472 15538739 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.768532709
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 19084572 16424979 18567086 18396642 16951190 19015929 15786421 17172411 17498489
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32972
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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