AutismKB 2.0

Annotation Detail for PC


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PC ( PCB )
Gene Full Name: pyruvate carboxylase
Band: 11q13.2
Quick LinksEntrez ID:5091; OMIM: 608786; Uniprot ID:PYC_HUMAN; ENSEMBL ID: ENSG00000173599; HGNC ID: 8636
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
hsa00620Pyruvate metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
No data
Pathway IDPathway Name
P02772Pyruvate metabolism
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00073Pyruvate carboxylase deficiency
Inherited disorders of carbohydrate metabolism
Genetic disorders
No data
No data
No data
Desease Name
Pyruvate carboxylase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PC mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PC mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in increased expression of PC proteinincreases expression 16538041
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PC mRNAaffects expression 16483693
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of PC mRNAincreases expression 19737606
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of PC mRNAincreases expression 15912405
D002220 Carbamazepine Carbamazepine results in decreased expression of and results in decreased activity of PC proteindecreases activity|decreases expression 12840165
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PC mRNAaffects expression 16239168
D016572 Cyclosporine Cyclosporine results in decreased expression of PC mRNAdecreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of PC mRNAdecreases expression 17072980
C071192 entacapone entacapone binds to PC proteinaffects binding 19783845
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PC mRNAdecreases expression 17108234
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PC mRNAincreases expression 17557909
D019266 Iron, Dietary Iron, Dietary affects the expression of PC mRNAaffects expression 15637178
D008701 Methapyrilene Methapyrilene results in decreased expression of PC mRNAdecreases expression 16393664
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of PC mRNAincreases expression 16525678
D015735 Mifepristone Mifepristone results in decreased expression of PC mRNAdecreases expression 17584828
C045950 propiconazole propiconazole results in decreased expression of PC mRNAdecreases expression 19423681
D012643 Selenium Selenium results in increased expression of PC mRNAincreases expression 19244175
C009277 sodium arsenate sodium arsenate results in increased expression of PC mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite affects the expression of PC mRNAaffects expression 19590694
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PC mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PC mRNAdecreases expression 18465118
16054898
C066340 tolcapone tolcapone binds to PC proteinaffects binding 19783845
C032910 triadimefon triadimefon results in decreased expression of PC mRNAdecreases expression 19423681
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 8.198986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1915322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 7.0316033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0314692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 7.0315688392 15113128
MESH:D000236 Adenoma beta-Naphthoflavone 6.8519389873
MESH:D000236 Adenoma Dimethylnitrosamine 6.8519555203
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7516712894 17306315
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.1411080934
MESH:D000544 Alzheimer Disease entacapone 5.1020150427
MESH:D000544 Alzheimer Disease tolcapone 5.1020150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001714 Bipolar Disorder Carbamazepine 4.0620046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.3416253758 11306469 14633655
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316227642 16097048 18705752 16124888 3786805 15700767 16050911 15673190 16192424 10355542 15721981 16011737
MESH:D002277 Carcinoma Dimethylnitrosamine 7.9519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.603084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.6018788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.6017306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.7816033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7818572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.2610977129
MESH:D002386 Cataract Methylnitrosourea 7.2612484553
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.216135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.2112371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 15.212727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.2119524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis Cyclosporine 7.4019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4016919318 17110522 17333356 11677210 17681005 15861022 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9515340226 12621046 15668235 16354765 8697196
MESH:D002972 Cleft Palate triadimefon 5.9516781842
MESH:D003092 Colitis Selenium 3.6317936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D019465 Craniofacial Abnormalities Carbamazepine 5.419014606
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.4110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.4110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities triadimefon 5.4116875885 15834900
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3918551238
MESH:D003866 Depressive Disorder entacapone 8.417768276
MESH:D003866 Depressive Disorder tolcapone 8.4111224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 4.7710440460
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.2911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3216538176 16538175 20216337 15057820
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 32.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 32.7018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 32.7012594235 17906064 19420014 19370779 19416960 16081117 11739529 16781746 19739265 11421492 19923254 19085960 11461765 17522070 18713872 14725611 19164858 16393943 14550746 16485898 12153990 12392966 10663392 15968718 11529661 12705907 2444490 10915739 11743745 17562736 15619225 14986274 12540782 18071297 16177239 16109766 10774834 11287661 16227642 11834606 12958197
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 32.7017465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 32.7016177239 4309450 16227642 7120509 7440962 9327722 21278145 15027814 2869522 10092053 19085960 15998439 10915739 17522070 19336974 11566570 6623471 15968718 7179309 3786805 6884620 3732212
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 32.708172417
MESH:D056486 Drug-Induced Liver Injury entacapone 32.7019783845
MESH:D056486 Drug-Induced Liver Injury Selenium 32.7015131321
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 32.7018186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 32.7020420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 32.7019783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Carbamazepine 8.0320216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0311462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.2511455177
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 8.8917654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004715 Endometriosis Mifepristone 8.7116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.719294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1116415921 19915237 20485159 16538176 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.0617275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.8216628512 17116037 15008574
MESH:D004827 Epilepsy Carbamazepine 3.9219700373 17465707 7988514 9014606 17178248 18234410 19620853 20417680 19439326 821787
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.207750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 4.973659116 15276670
MESH:D004916 Erythromelalgia Carbamazepine 5.5719549232
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.8717016578
MESH:D005076 Exanthema Carbamazepine 5.3120485159
MESH:D054908 Extensively Drug-Resistant Tuberculosis entacapone 14.2019578428
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 14.2019578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.2516045604 16239168 15959796 61145 12631006 19224547 12795759 17595544
MESH:D005234 Fatty Liver Cyclosporine 12.2519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.2515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0811555667
MESH:D005355 Fibrosis Carbon Tetrachloride 13.8418705752
MESH:D005355 Fibrosis Cyclosporine 13.8412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8420067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005910 Glioma Methylnitrosourea 3.509825942
MESH:D018149 Glucose Intolerance sodium arsenate 4.9419446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2511294989 10048152
MESH:D006333 Heart Failure Selenium 2.9817162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519110552 19900420
MESH:D006529 Hepatomegaly propiconazole 13.8617178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8615340226 12621046 16120746
MESH:D006529 Hepatomegaly triadimefon 13.8617178688 17178689
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 16354765 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6010459572
MESH:D006965 Hyperplasia Carbamazepine 5.0618773962
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.7317937319
MESH:D007248 Infertility, Male Methylnitrosourea 10.737193160
MESH:D007248 Infertility, Male sodium arsenite 10.7312646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7812878042 12200463
MESH:D007251 Influenza, Human Selenium 4.0516624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8616580747
MESH:D007569 Jaw Abnormalities triadimefon 9.8615834900 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.5012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.508314463 18776723 10903974
MESH:D007674 Kidney Diseases sodium arsenite 9.5020008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.7516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.6416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.6416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6412371664
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.0915526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7311903743 16943688 17174718 11408273 16239168 17334410 16221502 21278145 17157831
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4418472332 14724832 12445421 17976157 15730626 14620537 17761835 16033810 17805973 18481824 17640975 13678700 18156304 12666154 12898905 18205269 18210741 15996030 15818738 17900296 12632512 16097048 12958196 12586293 14748882 15123356 15338365 17698563 15673190 10355542 18412020 15893842 18251166 15052691 12632514 17823541 16248980 15370692 17708605 11481614 17766677 14716496 18187930 17565644 18395914 18166357 17869086 16027843 18472094 15650968 17481882 18279442 12667390 17944888 16192424 15959796 15876570 18263696 17631135 14716833 17714472 12741479 16136751 18317297 18277467 18429990 12445418 15057751 16638106 20821823 17525996 12609069 15931870 18395095 16015684 12389079 18376398 18420326 17922224 18006644 12649538 18339082 17557913 15925388 12546737 16116963 18418968 18054572 18705752 17721639 14512876 15362042 16011737
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.4418371158 16009107 15733078 12925901 18672772 18629640 17036385 18637143 17432682 14659978 18210741 16570917 15479170 15161499 12918455 15744066 15942678 15798949 15081153 15138612 15492853 15504291 15383259 15577212 16042886 16627068 17666798 17203207 17348192 17534399 15763062 17724770 17719030 16603200 15339415 15793283 17196135 18239293 15366600 15723089 18364076 16169303 16544323 15571005 15067225 15591649 15099470 14643895 17465448 18567088 15864749 17881167 14568256 17198567 18237412 15842777 15298665 16270385 15086199 17640959 18095165 15369754 17201889 14709902 14726149
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008107 Liver Diseases Acetaminophen 9.1519784758 16611625 19460945 16610002 12969438 12587719 19014921 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.1515830285 16964402 17285989 16246199 15720792
MESH:D008107 Liver Diseases propiconazole 9.1519363144
MESH:D008107 Liver Diseases triadimefon 9.1519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.4917185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.4916899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 15.4917457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 29.087678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 29.0821295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.0819294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 29.083113478 15890375
MESH:D008113 Liver Neoplasms Methapyrilene 29.0815890375
MESH:D008113 Liver Neoplasms propiconazole 29.0819028983
MESH:D008113 Liver Neoplasms sodium arsenite 29.0815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.0816984957
MESH:D008113 Liver Neoplasms triadimefon 29.0819028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 26.852876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 26.8518164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.8515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 26.8515603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental propiconazole 26.8517178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.8512151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 26.8517178689
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.3116080182
MESH:D008171 Lung Diseases sodium arsenite 3.0719095001
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 4.7711884234 16061637 19555203
MESH:D008175 Lung Neoplasms Methylnitrosourea 4.7718062963
MESH:D008175 Lung Neoplasms sodium arsenite 4.7717077188 16712894 15276417 17306315 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7719555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5316628512
MESH:D008223 Lymphoma Methylnitrosourea 3.9011418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.6314633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.0815313902 10767621 19196723 16619500 16827153 16944150 15113128 15688392 10838139 11807958 14633655 16051031 17020996 11751437 12931682 17131329 14999141
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0815318939
MESH:D008545 Melanoma sodium arsenite 2.0116487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008607 Mental Retardation Carbamazepine 3.679014606
MESH:D008654 Mesothelioma Selenium 2.7315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.7218186108
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D009224 Myotonia Congenita Carbamazepine 5.3120399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.8418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.8418551238 7678174
MESH:D009369 Neoplasms Methylnitrosourea 5.2015533788
MESH:D009369 Neoplasms sodium arsenite 5.2011559025
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.9012696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.9020056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009421 Nervous System Malformations Carbamazepine 9.4416990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4414600291
MESH:D009436 Neural Tube Defects sodium arsenate 7.3219446573 10525206 18186108 11749123
MESH:D009436 Neural Tube Defects sodium arsenite 7.3212854658
MESH:D009442 Neurilemmoma Methylnitrosourea 5.3311555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.4412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.4416049721
MESH:D010018 Osteomalacia Carbamazepine 5.3117016548
MESH:D010051 Ovarian Neoplasms Mifepristone 5.0116525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0117306315 15276417
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Carbamazepine 6.5915215642
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.3116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010267 Parapsoriasis Carbamazepine 5.5516538176
MESH:D010300 Parkinson Disease entacapone 6.1720334432 11586115 17089403 19578428 19783845
MESH:D010300 Parkinson Disease tolcapone 6.1720334432 9754991 19783845 8635184 8739811 9305320 9333106 9591521 19578428 11793426 18328768 17089403 11432539 9708959 11746615 7566641 11586115 1977408 20216409 16758261 10651109
MESH:D020734 Parkinsonian Disorders entacapone 5.2618722529
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.7717145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010954 Plasmacytoma Selenium 4.7415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011248 Pregnancy Complications Carbamazepine 5.009014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 9.359014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3511118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.6615682402 12376480
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.6616039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 5.4512752131 9591791
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D015324 Pyruvate Carboxylase Deficiency Disease marker/mechanism
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.3018172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.3311555667
MESH:D012640 Seizures 2,4-dinitrotoluene 9.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.3618551238
MESH:D012640 Seizures Carbamazepine 9.369844417 19414003 9046859 16180713 16876388 15946322 16938433
MESH:D012878 Skin Neoplasms sodium arsenite 5.3619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3616192470
MESH:D012893 Sleep Disorders Carbamazepine 4.9719414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1212587719
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.0619915237 18855540 16538176 20485159 19694795 16415921 15057820
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.9716033868
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.9718593901 16257854 15930296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.0811418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 7.523078959 7505956
MESH:D013964 Thyroid Neoplasms triadimefon 7.5217178689
MESH:D018088 Tuberculosis, Multidrug-Resistant entacapone 14.2019578428
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 14.2019578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.9616049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.9611723127 16712894 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4810091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D014820 Vitiligo tolcapone 5.0410573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:00020 Citrate cycle (TCA cycle)
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32975
    • No data
    No data
    Releated drug ID Related drug Name
    PA448625biotin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00119 - Pyruvic acid Dietary supplement;Micronutrient
    DB00121 - Biotin Dietary supplement;Micronutrient;Vitamins (Vitamin B Complex);Vitamin B Complex
    DB07497 - 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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