AutismKB 2.0

Annotation Detail for CDON


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Basic Information Top
Gene Symbol:CDON ( CDO,MGC111524,ORCAM )
Gene Full Name: Cdon homolog (mouse)
Band: 11q24.2
Quick LinksEntrez ID:50937; OMIM: 608707; Uniprot ID:CDON_HUMAN; ENSEMBL ID: ENSG00000064309; HGNC ID: 17104
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Myogenesis
Pathway IDPathway Name
200144Signaling events mediated by the Hedgehog family
No data
Pathway IDPathway Name
500556CDO in myogenesis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CDON mRNAdecreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDON mRNAaffects expression 16483693
D004958 Estradiol Estradiol affects the expression of CDON mRNAaffects expression 14699072
D005419 Flavonoids Flavonoids results in increased expression of CDON mRNAincreases expression 18035473
C051890 irinotecan irinotecan analog results in decreased expression of CDON mRNAdecreases expression 18927307
C025299 polyphenols polyphenols results in decreased expression of CDON mRNAdecreases expression 16293270
D020849 Raloxifene Raloxifene affects the expression of CDON mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CDON mRNAdecreases expression 19933214
D014635 Valproic Acid Valproic Acid results in increased expression of CDON mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2814514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000419 Albuminuria Raloxifene 4.8317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918775368 17507914 19460635 18316065 18940202 15238991 17688650 18558336 19232924 20603192 18177632 18985861 17157402 18396377 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Estradiol 1.8716675129 17289903 12948864 17261762 18497071 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms Raloxifene 1.8715758505 15775269 17893378 17952589 17049068 17261762 15572757 17242785 17440819 16837676 16912660 17595753
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7816924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9118566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 8697196 12621046 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D003110 Colonic Neoplasms irinotecan 4.2317287894 17725105
MESH:D003110 Colonic Neoplasms polyphenols 4.2316293270
MESH:D015179 Colorectal Neoplasms irinotecan 2.3618259882 18509181 17159606 16303861 16391804 15273666 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5215322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5217688650 8888407 16575769
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.6219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6217451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.6119370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.6119641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema Raloxifene 7.5415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.2315845917
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.777562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Raloxifene 8.7317473493
MESH:D005234 Fatty Liver Valproic Acid 8.7314986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16959395 16354765
MESH:D006973 Hypertension Raloxifene 5.4515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518670907 18850075
MESH:D007249 Inflammation Flavonoids 8.9817296493
MESH:D007249 Inflammation polyphenols 8.9816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0916393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Estradiol 2.6915618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1515610895
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases polyphenols 2.8216698588
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6817203775 11408345 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008881 Migraine Disorders Valproic Acid 3.3318803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009101 Multiple Myeloma Raloxifene 3.5816497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009362 Neoplasm Metastasis irinotecan 3.2418259882
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 10.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2516359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D010024 Osteoporosis Raloxifene 3.5117882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517893378 15758505 17823083 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2915731164 16536755 16220300
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8716876388 3137016 17978042 15475178 11738929 1511512 11044598 14763951
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5717997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Estradiol 14.8019048282
MESH:D013978 Tibial Fractures Raloxifene 14.8019048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8817572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:21303 Myogenesis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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