AutismKB 2.0

Annotation Detail for FOXP3


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Basic Information Top
Gene Symbol:FOXP3 ( AIID,DIETER,IPEX,MGC141961,MGC141963,PIDX,XPID )
Gene Full Name: forkhead box P3
Band: Xp11.23
Quick LinksEntrez ID:50943; OMIM: 300292; Uniprot ID:FOXP3_HUMAN; ENSEMBL ID: ENSG00000049768; HGNC ID: 6106
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200039Calcineurin-regulated NFAT-dependent transcription in lymphocytes
200158IL2 signaling events mediated by STAT5
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Immune system diseases
Primary immunodeficiency
H00107Other well-defined immunodeficiency syndromes
No data
Desease Name
diabetes, type 1
IMMUNE
No data
Desease Name
Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked
Diabetes mellitus, type I, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of FOXP3 mRNAincreases expression 19774075
D001374 Azacitidine [Azacitidine co-treated with TGFB1 protein] results in increased expression of FOXP3 proteinaffects cotreatment|increases expression 18493985
D001374 Azacitidine [Azacitidine results in decreased methylation of FOXP3 gene] which results in increased expression of FOXP3 proteindecreases methylation|increases expression 18493985
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of FOXP3 mRNAdecreases expression 15591121
C014347 decitabine [decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 proteinaffects cotreatment|increases expression 18567616
C014347 decitabine [[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IFNG proteinaffects cotreatment|increases expression 18567616
C014347 decitabine [[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IL17A proteinaffects cotreatment|increases expression 18567616
C014347 decitabine [[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IL2 proteinaffects cotreatment|increases expression 18567616
C014347 decitabine [[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of TNF proteinaffects cotreatment|increases expression 18567616
C014347 decitabine [decitabine results in decreased methylation of FOXP3 gene] which results in increased expression of FOXP3 mRNAdecreases methylation|increases expression 18567616
C014347 decitabine [decitabine results in decreased methylation of FOXP3 gene] which results in increased expression of FOXP3 proteindecreases methylation|increases expression 18567616
C014347 decitabine [decitabine co-treated with TGFB1 protein] promotes the reaction [KLF10 protein binds to FOXP3 promoter]affects binding|affects cotreatment|increases reaction 19109157
C014347 decitabine decitabine results in decreased methylation of FOXP3 promoterdecreases methylation 19109157
C014347 decitabine decitabine results in increased expression of FOXP3 mRNAincreases expression 19109157
C014347 decitabine decitabine results in increased expression of FOXP3 proteinincreases expression 19545742
19109157
C014347 decitabine TGFB1 protein promotes the reaction [decitabine results in increased expression of FOXP3 protein]increases expression|increases reaction 19109157
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOXP3 mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant fulvestrant results in increased expression of FOXP3 mRNAincreases expression 20145137
C070081 fulvestrant TGFB1 protein promotes the reaction [fulvestrant results in increased expression of FOXP3 mRNA]increases expression|increases reaction 20145137
D006830 Hydralazine Hydralazine results in increased expression of FOXP3 proteinincreases expression 19109157
D011342 Procainamide Procainamide results in increased expression of FOXP3 proteinincreases expression 19109157
C503639 RG108 RG108 results in increased expression of FOXP3 proteinincreases expression 19109157
D013629 Tamoxifen Tamoxifen results in increased expression of FOXP3 mRNAincreases expression 20145137
D013629 Tamoxifen TGFB1 protein promotes the reaction [Tamoxifen results in increased expression of FOXP3 mRNA]increases expression|increases reaction 20145137
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FOXP3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FOXP3 proteindecreases expression 18684927
C012589 trichostatin A trichostatin A results in increased expression of FOXP3 proteinincreases expression 19545742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9018218290 18057881 20041841
MESH:D001161 Arteriosclerosis Cyclophosphamide 10.6415014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.9819698954 18651412
MESH:D001284 Atrophy fulvestrant 4.9711514358
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.4119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms marker/mechanism 17570480
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.3915136595 17388661 16978400 18234424 18323546 11325840 12006526 15093573 17020986
MESH:D001943 Breast Neoplasms decitabine 2.3918320071 19208741
MESH:D001943 Breast Neoplasms fulvestrant 2.3918984771
MESH:D001943 Breast Neoplasms Tamoxifen 2.3919011961 17242785 19084267 16202921 20135344 17440819 11161223 18425577 19115204 19066611 15668708 16873071 19142967 19103187 18855134 21152245 18629630 19289846 18351453 19244106 19155303 19059307 19189210 16273361 19221464 18821012 20544844 18997820 15565566 18984771 19288272 16818667 19189212 20390343 17893378 19410462 18815881 21138602 17261762 19200415 20005174 19487384 20859285 20065188 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.3419701751
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.3416924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.0416152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.5816201981
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6219215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9219225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2418974383
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9516919318 17681005 17333356 16105132 15861022 11677210 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.148697196 15340226 15668235 16354765 12621046
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms Azacitidine 2.9219934284
MESH:D015179 Colorectal Neoplasms decitabine 2.9218981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003556 Cystitis Cyclophosphamide 5.1615643279 18483878 18433785 11948286 15276878 18710439 12388444 16651033 18372110 12161096 10498854 17979934 12913760 10700343 16614059 18295254 16413132 17010015 18093676 16989017
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.1615331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 marker/mechanism
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2518772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 3.9515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.6219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.6219294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1116202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 4.3511006010
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Amiodarone 13.8014986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8015345470
MESH:D005234 Fatty Liver Tamoxifen 13.8019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005909 Glioblastoma trichostatin A 3.9018801729
MESH:D018316 Gliosarcoma Cyclophosphamide 5.6711389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.1716376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006467 Hemophilia A Cyclophosphamide 5.4311918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.7114986274
MESH:D006529 Hepatomegaly Amiodarone 9.0115265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.0112621046 15340226 16120746
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.8816135485 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16354765 15340226 18606429 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 3.989751232 8137927
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.6517991464 18020914
MESH:D007154 Immune System Diseases Cyclophosphamide 5.5116076520
OMIM:304790 IMMUNODYSREGULATION, POLYENDOCRINOPATHY, AND ENTEROPATHY, X-LINKED marker/mechanism
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Cyclophosphamide 16.737193160 16517039
MESH:D007248 Infertility, Male decitabine 16.7317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 16.7317937319
MESH:D007248 Infertility, Male fulvestrant 16.7311514358
MESH:D007249 Inflammation Tamoxifen 5.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1318625569
MESH:D007938 Leukemia Azacitidine 11.0219148494
MESH:D007938 Leukemia Cyclophosphamide 11.0210602166
MESH:D007938 Leukemia decitabine 11.0218980019 19235587
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5418172266 17802794 17658394 17008537 17296974 18587576
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1710373061
MESH:D007951 Leukemia, Myeloid Azacitidine 10.2719077051
MESH:D007951 Leukemia, Myeloid decitabine 10.2719117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.4918720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.4918704418 17679729 18206229 18460780 19387464 19010910
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.4918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.3119299654
MESH:D007970 Leukopenia Cyclophosphamide 5.1210052129 11830472
MESH:D008064 Lipidoses Amiodarone 8.1815342952 17567588
MESH:D008064 Lipidoses Tamoxifen 8.1817567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008113 Liver Neoplasms Tamoxifen 4.5216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.4412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6518516814
MESH:D008175 Lung Neoplasms Azacitidine 3.5621224363
MESH:D008175 Lung Neoplasms Tamoxifen 3.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 8.1212854902
MESH:D008223 Lymphoma decitabine 8.1219470736
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.7116675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.2611911406
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma decitabine 5.3416505122 17785578
MESH:D008545 Melanoma Tamoxifen 5.3419393235 12393984
MESH:D008545 Melanoma trichostatin A 5.3416505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.9416388313
MESH:D009006 Monosomy Azacitidine 6.2619299654
MESH:D009101 Multiple Myeloma Azacitidine 12.8118443271 19549372
MESH:D009101 Multiple Myeloma decitabine 12.8118172295
MESH:D009101 Multiple Myeloma trichostatin A 12.8118172295
MESH:D009181 Mycoses Amiodarone 5.0817974566 12754197
MESH:D009190 Myelodysplastic Syndromes Azacitidine 8.0217611569 19805378 17596541 18720364
MESH:D009190 Myelodysplastic Syndromes decitabine 8.0216882708 19010910 18608210 19157545
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Cyclophosphamide 5.6218854779
MESH:D009369 Neoplasms decitabine 5.6219116145 19470736 17925555
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009447 Neuroblastoma Cyclophosphamide 3.698761367 16115947 15176712
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.048761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.448291058
MESH:D009845 Oligospermia Cyclophosphamide 4.8616517039
MESH:D010051 Ovarian Neoplasms decitabine 5.3719331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 5.3719331143
MESH:D010146 Pain Cyclophosphamide 3.7118093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 9.0711332152
MESH:D010190 Pancreatic Neoplasms decitabine 9.0719294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 9.0719294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8621297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 12.9017616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.9017616702
MESH:D011471 Prostatic Neoplasms Azacitidine 2.1718324645
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1717136230
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1715067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.1719789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.1012490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 6.1016636934
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.9416636934
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2418724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.6716517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013276 Stomach Ulcer Amiodarone 3.4218087811
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2112837982
MESH:D013610 Tachycardia Amiodarone 4.4211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3219225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Amiodarone 12.6419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.6412697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4117967635
MESH:D013971 Thyrotoxicosis Amiodarone 5.0019584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.3417467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.6914692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.6917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.698653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA201094
    • No data
    Releated disease ID Related disease Name
    PA443888Diabetes Mellitus, Type 1
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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