AutismKB 2.0

Annotation Detail for ACOX1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACOX1 ( ACOX,MGC1198,PALMCOX,SCOX )
Gene Full Name: acyl-CoA oxidase 1, palmitoyl
Band: 17q25.1
Quick LinksEntrez ID:51; OMIM: 609751; Uniprot ID:ACOX1_HUMAN; ENSEMBL ID: ENSG00000161533; HGNC ID: 119
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03320PPAR signaling pathway
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
hsa01040Biosynthesis of unsaturated fatty acids
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500817Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Related Diseases/Disorders Top
Desease IDDesease Name
H00407Peroxisomal beta-oxidation enzyme deficiency
Peroxisomal diseases
Genetic disorders
No data
No data
No data
Desease Name
Peroxisomal acyl-CoA oxidase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ACOX1 mRNAdecreases expression 18281256
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ACOX1 mRNA]decreases expression|increases reaction 18281256
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACOX1 mRNAaffects expression 21346803
C487689 (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid results in decreased expression of ACOX1 mRNAdecreases expression 17261273
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in decreased expression of ACOX1 mRNAdecreases expression 15135645
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased activity of ACOX1 proteinincreases activity 16002344
D000082 Acetaminophen Acetaminophen affects the expression of ACOX1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of ACOX1 mRNAincreases expression 15265979
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACOX1 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of ACOX1 mRNAincreases expression 16648578
D001629 Bezafibrate Bezafibrate results in increased expression of ACOX1 mRNAincreases expression 17118139
15447978
D001629 Bezafibrate Bezafibrate results in increased expression of ACOX1 mRNAincreases expression 16707586
D002104 Cadmium Cadmium results in decreased expression of ACOX1 mRNAdecreases expression 17066326
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of ACOX1 mRNAdecreases expression 17066326
D002211 Capsaicin Capsaicin results in increased expression of ACOX1 mRNAincreases expression 18533110
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ACOX1 mRNAaffects expression 15963342
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ACOX1 mRNAincreases expression 16239168
C515629 chiglitazar chiglitazar results in increased expression of ACOX1 mRNAincreases expression 16751799
C019304 ciprofibrate ciprofibrate results in increased expression of ACOX1 mRNAincreases expression 12771043
D002992 Clofenapate Clofenapate results in increased expression of ACOX1 mRNAincreases expression 12971794
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of ACOX1 mRNA]affects reaction|increases expression 17585979
D002994 Clofibrate Clofibrate results in increased expression of ACOX1 mRNAincreases expression 18246545
18619722
D002995 Clofibric Acid Clofibric Acid affects the expression of ACOX1 mRNAaffects expression 17602206
D002995 Clofibric Acid Clofibric Acid results in increased activity of ACOX1 proteinincreases activity 10630566
D002995 Clofibric Acid Clofibric Acid results in increased expression of ACOX1 mRNAincreases expression 15670589
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ACOX1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of ACOX1 mRNAdecreases expression 20106945
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in increased expression of ACOX1 mRNAincreases expression 16940010
D003907 Dexamethasone Dexamethasone results in decreased expression of ACOX1 mRNAdecreases expression 12971794
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased activity of ACOX1 proteinincreases activity 16002344
C121718 dicyclanil dicyclanil results in increased expression of ACOX1 mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in increased expression of ACOX1 mRNAincreases expression 15238619
18457598
C014476 diethyl maleate diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]affects binding|decreases reaction 17134953
C014476 diethyl maleate resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]affects binding|decreases reaction 17134953
C014476 diethyl maleate resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]affects binding|decreases reaction|increases reaction 17134953
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ACOX1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACOX1 mRNAaffects cotreatment|increases expression 18775883
18253720
D015118 Eicosapentaenoic Acid Eicosapentaenoic Acid results in increased expression of ACOX1 mRNAincreases expression 18320257
C498182 ertiprotafib ertiprotafib results in increased expression of ACOX1increases expression 17178630
D004958 Estradiol Estradiol results in increased activity of ACOX1 proteinincreases activity 16002344
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased activity of ACOX1 proteinincreases activity 16002344
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in increased activity of ACOX1 proteinincreases activity 15949695
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in increased expression of ACOX1 mRNAincreases expression 15949695
D011345 Fenofibrate Fenofibrate results in increased expression of ACOX1 mRNAincreases expression 17118139
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACOX1 mRNAaffects cotreatment|increases expression 18775883
18253720
D011345 Fenofibrate Fenofibrate results in increased expression of ACOX1 mRNAincreases expression 18775883
16707586
C017690 fenvalerate fenvalerate metabolite results in increased activity of ACOX1 proteinincreases activity 10630566
D015248 Gemfibrozil Gemfibrozil results in increased expression of ACOX1 mRNAincreases expression 18619722
D005978 Glutathione Glutathione deficiency results in increased expression of ACOX1 mRNAincreases expression 15345336
C060893 L 663536 L 663536 results in increased expression of ACOX1 mRNAincreases expression 18292206
C060893 L 663536 L 663536 inhibits the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]decreases reaction|increases expression 18320257
C095104 LG 100268 LG 100268 results in increased expression of ACOX1 mRNAincreases expression 16489205
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of ACOX1 mRNAdecreases expression 18940942
D008727 Methotrexate Methotrexate results in decreased expression of ACOX1 mRNAdecreases expression 15120968
D008731 Methoxychlor Methoxychlor results in increased activity of ACOX1 proteinincreases activity 16002344
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of ACOX1 mRNAincreases expression 16966085
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ACOX1 mRNAincreases expression 12883083
D019787 Linoleic Acid Linoleic Acid results in increased expression of ACOX1 mRNAincreases expression 18320257
C033094 perfluorobutyric acid perfluorobutyric acid results in increased expression of ACOX1 mRNAincreases expression 19359353
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACOX1 mRNAincreases expression 18467677
18281256
17681415
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACOX1 mRNA]increases expression|increases reaction 18467677
18281256
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the activity of ACOX1 proteinaffects activity 15352480
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased activity of ACOX1 proteinincreases activity 14757943
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACOX1 mRNAincreases expression 8011682
C006253 pirinixic acid pirinixic acid results in decreased activity of ACOX1 proteindecreases activity 19571398
C006253 pirinixic acid pirinixic acid results in increased activity of ACOX1 proteinincreases activity 16434500
C006253 pirinixic acid pirinixic acid results in increased expression of ACOX1 mRNAincreases expression 16377806
20059764
18301758
20869979
17426115
15777286
16489205
15375163
18467677
16221962
16807375
19176532
16282640
17932310
19359353
17950772
C006253 pirinixic acid pirinixic acid results in increased expression of ACOX1 proteinincreases expression 19176532
20059764
16221962
15226431
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]affects reaction|increases expression 16489205
15777286
16807375
16221962
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]increases expression|increases reaction 18467677
20059764
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACOX1 protein]increases expression|increases reaction 20059764
C006253 pirinixic acid PPARGC1B protein inhibits the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]decreases reaction|increases expression 17932310
C006253 pirinixic acid RXRA protein promotes the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]increases expression|increases reaction 19176532
C006253 pirinixic acid RXRA protein promotes the reaction [pirinixic acid results in increased expression of ACOX1 protein]increases expression|increases reaction 19176532
C006253 pirinixic acid L 663536 inhibits the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]decreases reaction|increases expression 18320257
C006253 pirinixic acid MDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA]increases activity|increases expression|increases reaction 19103650
C006253 pirinixic acid pirinixic acid promotes the reaction [[PPARA protein binds to MDM2 protein] which binds to ACOX1 promoter]affects binding|increases reaction 19103650
C006253 pirinixic acid [pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNAincreases activity|increases expression 19103650
C006253 pirinixic acid pirinixic acid results in increased expression of ACOX1 mRNAincreases expression 16707586
16489205
18320257
16940010
18619722
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls results in increased activity of ACOX1 proteinincreases activity 16764481
C059514 resveratrol resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]affects binding|decreases reaction 17134953
C059514 resveratrol resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]affects binding|decreases reaction|increases reaction 17134953
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACOX1 mRNAincreases expression 12377990
15345368
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ACOX1 mRNA]affects reaction|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACOX1 mRNAdecreases expression 16214954
18796159
D013752 Tetracycline Tetracycline results in increased expression of ACOX1 mRNAincreases expression 16917069
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of ACOX1 mRNAdecreases expression 17217560
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 11.3018926900
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 11.3012039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.3014514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.0118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D058186 Acute Kidney Injury Capsaicin 7.4818460982
MESH:D058186 Acute Kidney Injury resveratrol 7.4816538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.3718653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.3718653653
MESH:D000230 Adenocarcinoma Estradiol 3.6611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.6614692618
MESH:D000236 Adenoma Diethylnitrosamine 5.756695378 10737359
MESH:D000236 Adenoma resveratrol 5.7515688382
MESH:D018248 Adenoma, Liver Cell dicyclanil 20.4317162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.4319061943 18056438 19052882 17162532 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.4316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.4316835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.2317302879
MESH:D000505 Alopecia Capsaicin 4.2917569567
MESH:D000544 Alzheimer Disease resveratrol 2.4416183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4711748828
MESH:D000799 Angioedema Acetaminophen 3.2910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3318057881 20041841 18218290
MESH:D001161 Arteriosclerosis Dietary Fats 8.1415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.1411256880
MESH:D001169 Arthritis, Experimental Dexamethasone 10.2717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.2715885639
MESH:D001169 Arthritis, Experimental resveratrol 10.2717115116
MESH:D001172 Arthritis, Rheumatoid Methotrexate 2.9517286800
MESH:D050197 Atherosclerosis Cadmium 5.8915687053
MESH:D050197 Atherosclerosis resveratrol 5.8917967414 16873680
MESH:D001281 Atrial Fibrillation Amiodarone 3.4918651412 19698954
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 4.4418448859
MESH:D001321 Autistic Disorder Acetaminophen 2.6118445737
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 2.6116920077
MESH:D001321 Autistic Disorder Glutathione 2.6119267885 18929414 19056591 16917939
MESH:D001321 Autistic Disorder Linoleic Acid 2.6118582451
MESH:D001778 Blood Coagulation Disorders Amiodarone 17.9719483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 17.9719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.9712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4015746008
MESH:D001919 Bradycardia Capsaicin 4.5118207255
MESH:D002545 Brain Ischemia Capsaicin 8.7519211983
MESH:D002545 Brain Ischemia resveratrol 8.7517600658
MESH:D001943 Breast Neoplasms bexarotene 4.1416344269 16818667
MESH:D001943 Breast Neoplasms Dietary Fats 4.1420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.1417474063
MESH:D001943 Breast Neoplasms Estradiol 4.1416675129 17261762 17289903 14630087 12948864 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms LG 100268 4.1416818667
MESH:D001943 Breast Neoplasms Methotrexate 4.1416978400
MESH:D001943 Breast Neoplasms resveratrol 4.1416393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.1420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2516124888 15721981 18705752 15700767 10355542 15673190 16011737 16227642 16097048 16050911 16192424 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3616835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 12771043
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.8516705839
MESH:D006528 Carcinoma, Hepatocellular (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid 14.8517261273
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.853084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.8518788625
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 14.8517162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 14.8510672840 20007298 18056438 16328049 16878318 17978847 18971187 19052882 10737359 19539802 18691550 16502159 19919837 18210153 20214788 21159647 19418558 20524982 16569478 19701751 16681979 19822196 20727157 17173139 17055752 19171122 18665156 17761372 18788625 11831363 20432363 3084413 20514400 18506893 16935385 16288022 18978308 19208518 20084675 17138121 18494052 18393292 3581430 19394651 19335982 19519916 16807293 16830150 18785209 16779866 19383236 19107877 20935162 16540662 20512989 16698587 17428255 20101231 17162532
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.8516924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 14.8516227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0516675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0216247446
MESH:D002294 Carcinoma, Squamous Cell Glutathione 4.5717015178
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.5716227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0516120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6815710769 19225199
MESH:D002318 Cardiovascular Diseases resveratrol 3.0915458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5418974383
MESH:D002386 Cataract Acetaminophen 2.2410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 21.326135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 21.3217332340
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 21.321399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.3212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.322727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.3218566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.7819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7816835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.6412912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 15.8812927374 19486331 18590720 15500046 16629650 15913567 18164287 7624871
MESH:D002779 Cholestasis Cyclosporine 15.8819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 15.8811677210 15861022 16105132 17110522 17681005 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 15.8819176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.3010220858 19407337
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8515340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis resveratrol 3.6016474422
MESH:D003110 Colonic Neoplasms Dexamethasone 3.5815824018
MESH:D003110 Colonic Neoplasms resveratrol 3.5816338953
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7815531428
MESH:D015179 Colorectal Neoplasms resveratrol 2.7816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.3816507316
MESH:D003371 Cough Capsaicin 4.6210350223
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.4917728286
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.499562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4920055451 15322242 10048152
MESH:D003456 Cryptorchidism Dibutyl Phthalate 4.9316037377
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4818551238
MESH:D003550 Cystic Fibrosis Glutathione 7.5919747007
MESH:D003550 Cystic Fibrosis Methotrexate 7.5919747007
MESH:D003704 Dementia Methylmercury Compounds 8.8616140633
MESH:D003704 Dementia Polychlorinated Biphenyls 8.8616140633
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9112438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1518249437
MESH:D003882 Dermatomyositis Methotrexate 4.6020191521
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3216873680
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.5016616286
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.6720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.4819279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.4816286809
MESH:D003967 Diarrhea Dexamethasone 3.197237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 21.9618289764 17522070 7624871 20133375
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.9621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.9616177239 11743745 19739265 12153990 11287661 18713872 16081117 14550746 12705907 19416960 17906064 11461765 16109766 12540782 14986274 11739529 18071297 16781746 15968718 14725611 19085960 19923254 10915739 12958197 19164858 17562736 16227642 10663392 17522070 16393943 15619225 16485898 10774834 11421492 11529661 12392966 11834606 2444490 12594235 19420014 19370779
MESH:D056486 Drug-Induced Liver Injury Amiodarone 21.9618218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 21.9617522070 6884620 15968718 21278145 15998439 15027814 6623471 7179309 19336974 10915739 7120509 10092053 11566570 16227642 3786805 9327722 4309450 2869522 3732212 19085960 16177239 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 21.9619107877
MESH:D056486 Drug-Induced Liver Injury perfluorobutyric acid 21.9619359353
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.9620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 21.9617522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3511462148
MESH:D004381 Duodenal Ulcer Capsaicin 4.1810671773 11535926
MESH:D050171 Dyslipidemias chiglitazar 22.8516751799
MESH:D050171 Dyslipidemias Clofibrate 22.8516707586
MESH:D050171 Dyslipidemias Dietary Fats 22.8518367378
MESH:D050171 Dyslipidemias Fenofibrate 22.8516707586
MESH:D050171 Dyslipidemias Gemfibrozil 22.8516707586
MESH:D004485 Eczema Dexamethasone 3.9412438553
MESH:D004487 Edema Dexamethasone 20.7719703484
MESH:D004487 Edema L 663536 20.777990266
MESH:D004487 Edema perfluorooctanoic acid 20.7712083418 17259670
MESH:D004487 Edema pirinixic acid 20.7712083418
MESH:D004487 Edema resveratrol 20.778985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 20.7712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.4112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 7.4117872969
MESH:D016889 Endometrial Neoplasms Estradiol 6.5318566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Fenofibrate 6.5316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5510568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.8515821434 17637181 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3117923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5616302075
MESH:D004935 Esophageal Diseases Capsaicin 5.1619566590
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6011564622
MESH:D005234 Fatty Liver Amiodarone 40.1914986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.1961145 15959796 19224547 16239168 12795759 17595544 16045604 12631006
MESH:D005234 Fatty Liver Clofibrate 40.1919224547
MESH:D005234 Fatty Liver Cyclosporine 40.1919224547
MESH:D005234 Fatty Liver Dietary Fats 40.1917967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 40.1920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.1915345470
MESH:D005234 Fatty Liver pirinixic acid 40.1920131406 19236843
MESH:D005234 Fatty Liver Tetracycline 40.1916917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9211858732
MESH:D005334 Fever Lipopolysaccharides 3.5411852909 9205823
MESH:D005355 Fibrosis Carbon Tetrachloride 16.7718705752
MESH:D005355 Fibrosis Cyclosporine 16.7712168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.7718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.7720067830
MESH:D005756 Gastritis Acetaminophen 3.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.678708960
MESH:D005909 Glioblastoma Capsaicin 3.7518405923
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0410696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.6116518429
MESH:D006356 Heartburn Capsaicin 5.1619566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.0211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.1920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.9116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 7.9418590720
MESH:D006505 Hepatitis Carbon Tetrachloride 7.9419900420 19110552
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 32.4416109766
MESH:D006529 Hepatomegaly Amiodarone 32.4415265979
MESH:D006529 Hepatomegaly fenvalerate 32.4415602828
MESH:D006529 Hepatomegaly perfluorobutyric acid 32.4419359353
MESH:D006529 Hepatomegaly perfluorooctanoic acid 32.443609246
MESH:D006529 Hepatomegaly pirinixic acid 32.4416221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 32.4416120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.867520565
MESH:D006558 Herpes Genitalis Estradiol 4.4715709030
MESH:D006561 Herpes Simplex resveratrol 3.6416876885
MESH:D019584 Hot Flashes Estradiol 3.2017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.498697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 10.7216870215
MESH:D006930 Hyperalgesia Capsaicin 10.7217434803 17043245
MESH:D006930 Hyperalgesia perfluorooctanoic acid 10.7212083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9816899240
MESH:D006937 Hypercholesterolemia Amiodarone 12.518137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 12.5121332399
MESH:D006937 Hypercholesterolemia resveratrol 12.5117188708
MESH:D006943 Hyperglycemia pirinixic acid 2.7120558911
MESH:D006949 Hyperlipidemias Dietary Fats 7.6221332399
MESH:D006949 Hyperlipidemias resveratrol 7.6216873680
MESH:D006973 Hypertension Cyclosporine 7.1910903974
MESH:D006973 Hypertension Dexamethasone 7.1917042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.1918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5515338365
MESH:D006976 Hypertension, Pulmonary L 663536 4.7714726295
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8217488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 3.9817991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8517937319
MESH:D007248 Infertility, Male Methoxychlor 5.8516467254 11955947
MESH:D007249 Inflammation Capsaicin 27.0216956363
MESH:D007249 Inflammation Dexamethasone 27.028960868 11099482
MESH:D007249 Inflammation Dietary Fats 27.0220412841
MESH:D007249 Inflammation Diethylnitrosamine 27.0218785209
MESH:D007249 Inflammation Fatty Acids, Omega-3 27.0217296493
MESH:D007249 Inflammation Lipopolysaccharides 27.029205823 12878042 17255318 17237260 17963957
MESH:D007249 Inflammation perfluorooctanoic acid 27.0212083418
MESH:D007249 Inflammation resveratrol 27.0216366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 27.0212200463 12878042
MESH:D007251 Influenza, Human resveratrol 3.9916624496
MESH:D007333 Insulin Resistance chiglitazar 14.6816751799
MESH:D007333 Insulin Resistance Dietary Fats 14.6811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 14.6816393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 14.6816306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.1217255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 15.4912587719 15629191
MESH:D007674 Kidney Diseases Cadmium 15.4916962696 16226777 16322080
MESH:D007674 Kidney Diseases Cadmium Chloride 15.4916962696
MESH:D007674 Kidney Diseases Cyclosporine 15.498314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 15.4915618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 9.7816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 9.7812371664
MESH:D007680 Kidney Neoplasms Estradiol 9.7815610895
MESH:D007805 Language Development Disorders Methotrexate 4.609562676
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid 5.5116546985
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2116087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.1515821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.688812269
MESH:D008064 Lipidoses Amiodarone 3.1115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.1211903743 21278145 17157831 17174718 16943688 16221502 16239168 17334410 11408273
MESH:D008103 Liver Cirrhosis Dietary Fats 13.1218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.1220032147 19638242 18522880 18665156 18407596
MESH:D008103 Liver Cirrhosis Methotrexate 13.1214986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.5018279442 17698563 15893842 18420326 17721639 14512876 15650968 16033810 10355542 12649538 17565644 15931870 12632512 12609069 16192424 16136751 17631135 12666154 17944888 17708605 18317297 15925388 16116963 15959796 18705752 18472332 15057751 16015684 18166357 17922224 18339082 18395095 18481824 18472094 18187930 14620537 15362042 16097048 18263696 17823541 14716833 18006644 16027843 15052691 15123356 12389079 12741479 16011737 12586293 14748882 17766677 16638106 11481614 17900296 18429990 18277467 20821823 18054572 15996030 17481882 14724832 12445418 18205269 14716496 18412020 17976157 17557913 17869086 16248980 15370692 12958196 15818738 12546737 18156304 17714472 17761835 15338365 18210741 18251166 12667390 15876570 12632514 13678700 15673190 18376398 15730626 18395914 12445421 17805973 17525996 12898905 17640975 18418968
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 9.5016718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.5014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 9.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 9.5012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.5012878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 10.6617184895
MESH:D008107 Liver Diseases Acetaminophen 10.6612969438 19460945 16611625 16610002 19784758 11587558 12587719 19014921
MESH:D008107 Liver Diseases Capsaicin 10.6616956363
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.6616246199 17285989 15720792 16964402 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 10.6617034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.8216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.8214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 37.007678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 37.0019294768
MESH:D008113 Liver Neoplasms ciprofibrate 37.0012771043
MESH:D008113 Liver Neoplasms Clofibric Acid 37.0017602206
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 37.0018709148
MESH:D008113 Liver Neoplasms dicyclanil 37.0020118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 37.002422723 20137499 19294768 12771043 19551842 19254457 20118626 15175105 18977376 19427195 18978307 19812893 20501860 20101389 19090486 20452335 19850985 12112319 15885732 18754104 20405173 16942905 20434301 19638242 10737359 19426721 20492335 21278145 19996281 19690152 21047994 18644402 19073162 18648771 19642983 19499222 19255062 21167192 21071580 19256749 9163691 20583210 19833225 2862719
MESH:D008113 Liver Neoplasms Fenofibrate 37.0018978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 37.0018709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 37.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 37.0019073162 19812893 20405173 19321006
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 37.0016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.772876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.7712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 22.778603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.779362446 18164116 17942915 18775883 17854601 19126423 3124819 18253720 21159647 18544905 18308698 18079962 18282651 17174075 18093689 16267830 16842330 2563599 19004024 19009564 19539802 19519916
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 22.7718775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 22.771423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.7712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.1617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.0012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 9.6918516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 9.6918516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.4821114838
MESH:D008175 Lung Neoplasms bexarotene 5.7017849452
MESH:D008175 Lung Neoplasms Dexamethasone 5.7015824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 5.7021163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms L 663536 5.7015899809
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.7019555203 11884234
MESH:D008223 Lymphoma Methotrexate 3.5517352296
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4214749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6111161223
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7015688416
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 14.9919196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 14.9916457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.9911807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental LG 100268 14.9912374698
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 14.9911606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 3.9219453300
MESH:D008545 Melanoma resveratrol 2.2917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0319513568
MESH:D008569 Memory Disorders Methylmercury Compounds 4.3918436314
MESH:D008659 Metabolic Diseases resveratrol 3.8917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2316801185
MESH:D009069 Movement Disorders Methylmercury Compounds 4.8218436314
MESH:D052016 Mucositis Methotrexate 4.7317488658
MESH:D009101 Multiple Myeloma Capsaicin 10.0217505005
MESH:D009101 Multiple Myeloma Dexamethasone 10.0215744524 15867202 16118317
MESH:D009101 Multiple Myeloma resveratrol 10.0217049120 16267019 14749477 17164350 16490592 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3217962980
MESH:D009135 Muscular Diseases Bezafibrate 14.9016239165
MESH:D009135 Muscular Diseases Gemfibrozil 14.9016239165
MESH:D009135 Muscular Diseases pirinixic acid 14.9016239165
MESH:D009181 Mycoses Amiodarone 4.3417974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.219809623
MESH:D009203 Myocardial Infarction pirinixic acid 4.8819151258
MESH:D009203 Myocardial Infarction resveratrol 4.8817015251 17125593 16525036 16317513 17188708 16456233
MESH:D017202 Myocardial Ischemia resveratrol 7.5517125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.5512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.8316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.8316411023
MESH:D009205 Myocarditis resveratrol 4.2117322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.327678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.339029167 3581430
MESH:D009369 Neoplasms fenvalerate 4.512895627
MESH:D009369 Neoplasms pirinixic acid 4.5117405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.478985016
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.2319196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1917289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.239884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8219348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 7.7416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.7414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.4618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.4620387270
MESH:D019636 Neurodegenerative Diseases resveratrol 11.4617652729
MESH:D020078 Neurogenic Inflammation Capsaicin 9.2817961222
MESH:D020078 Neurogenic Inflammation resveratrol 9.2817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5620387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.289802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.289802331
MESH:D009765 Obesity Capsaicin 6.5219056576
MESH:D009765 Obesity Dietary Fats 6.5217217161 21332399 18457598 19632207 16723640 18674790 20132043 11836018 20518802
MESH:D009765 Obesity pirinixic acid 6.5220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.9616049721
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 8.8216397352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.8217513867
MESH:D010051 Ovarian Neoplasms Estradiol 2.0319401270
MESH:D010146 Pain Acetaminophen 5.5416870215
MESH:D010146 Pain Capsaicin 5.5418987195 19081190 17043245 17084039 17434803 16996476
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2016540662
MESH:D010190 Pancreatic Neoplasms L 663536 5.2012384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1811578682
MESH:D010243 Paralysis fenvalerate 5.458952708
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.1716702228
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 11.9320133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 11.9312520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.8711026799
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.8315687053
MESH:C536662 Peroxisomal ACYL-COA oxidase deficiency marker/mechanism
MESH:D011014 Pneumonia Lipopolysaccharides 4.0111605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0418163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.4112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.412563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2221297632
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 18.8618436314
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 18.8617132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 18.8616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.8611222880 11118676 11399792 11896295
MESH:D017096 Prion Diseases Tetracycline 4.8610903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3920887781
MESH:D011471 Prostatic Neoplasms Cadmium 2.3117075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.3116740699
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.3115721890
MESH:D011471 Prostatic Neoplasms resveratrol 2.3117636462 17718901 17675339 16731767 17804756 15767336
MESH:D011537 Pruritus Ethinyl Estradiol 8.2916919318 15861022
MESH:D011537 Pruritus L 663536 8.2917827870
MESH:D011565 Psoriasis Cyclosporine 5.1716882103
MESH:D011565 Psoriasis Methotrexate 5.1717410198
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6212490602 11597910 12832656
MESH:D051437 Renal Insufficiency Methotrexate 4.1817352296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0216325855
MESH:D015427 Reperfusion Injury Capsaicin 9.3519211983 18460982
MESH:D015427 Reperfusion Injury pirinixic acid 9.3519058328
MESH:D015427 Reperfusion Injury resveratrol 9.3515827377 16314181 17058453 17520802 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.5218379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.1718551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5418724381
MESH:D012878 Skin Neoplasms resveratrol 4.778985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.7716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3816709447
MESH:D013272 Stomach Diseases Dexamethasone 3.7815472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 5.8718087811
MESH:D013276 Stomach Ulcer Dexamethasone 5.8715138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0016321402
MESH:D013576 Syndactyly Methotrexate 4.519562676
MESH:D013610 Tachycardia Amiodarone 3.7711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.6719225199
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.1717997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 8.4620133375
MESH:D013921 Thrombocytopenia Lipopolysaccharides 8.4615821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6915669648
MESH:D013959 Thyroid Diseases Amiodarone 10.2019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.2012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.577505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.3218020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.1319048282
MESH:D014062 Tongue Neoplasms resveratrol 3.7316227395
MESH:D016171 Torsades de Pointes Amiodarone 3.6517467628 11989578
MESH:D014202 Tremor fenvalerate 5.018952708
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.0616049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7710091137
MESH:D014581 Urticaria Acetaminophen 2.4810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.6317473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.7814692618
MESH:D014594 Uterine Neoplasms resveratrol 7.7817044934
MESH:D014605 Uveitis Cyclosporine 9.911336536
MESH:D014605 Uveitis Dexamethasone 9.911336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7717488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6915886252
MESH:D015430 Weight Gain Dietary Fats 3.2716723640
MESH:D014985 Xerophthalmia Cyclosporine 3.8817120751
Pathway ID Pathway Name
KEGG:00592 alpha-Linolenic acid metabolism
KEGG:01040 Biosynthesis of unsaturated fatty acids
KEGG:00071 Fatty acid metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA21
    • No data
    No data
    Releated drug ID Related drug Name
    PA449594fenofibrate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03147 - Flavin-Adenine Dinucleotide
    DB07930 - (3R)-3-HYDROXYDODECANOIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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