AutismKB 2.0

Annotation Detail for PCDH8


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Basic Information Top
Gene Symbol:PCDH8 ( ARCADLIN,PAPC )
Gene Full Name: protocadherin 8
Band: 13q14.3
Quick LinksEntrez ID:5100; OMIM: 603580; Uniprot ID:PCDH8_HUMAN; ENSEMBL ID: ENSG00000136099; HGNC ID: 8660
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
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Desease IDDesease Name
1934Cancer
2069Schizophrenia
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in increased expression of PCDH8 mRNAincreases expression 19901195
D000638 Amiodarone Amiodarone results in increased expression of PCDH8 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PCDH8 mRNAaffects expression 16483693
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PCDH8 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PCDH8 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PCDH8 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PCDH8 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PCDH8 mRNAincreases expression 19901195
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PCDH8 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1518057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.1619698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Estradiol 1.9012948864 18497071 19861407 17018787 17289903 16675129 17261762 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9919225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.6218974383
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.228697196 12621046 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.5119148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.5111473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Amiodarone 3.8914986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Amiodarone 10.2015265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.2016120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.668697196 18606429 16354765 15340226 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 4.258137927 9751232
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 5.0018020914 17991464
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.1816627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Estradiol 2.7615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2815610895
MESH:D008064 Lipidoses Amiodarone 3.7617567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.8511989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0918516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7711807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D009181 Mycoses Amiodarone 5.5117974566 12754197
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 10.9711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.9714600291
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11399792 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9612490602 12832656 11597910
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.6218724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013276 Stomach Ulcer Amiodarone 3.6818087811
MESH:D013610 Tachycardia Amiodarone 4.7311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.6319225199
MESH:D013959 Thyroid Diseases Amiodarone 14.1819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 14.1812697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.3418020914 19584973
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D016171 Torsades de Pointes Amiodarone 4.7317467628 11989578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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