AutismKB 2.0

Annotation Detail for PCDH9


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Basic Information Top
Gene Symbol:PCDH9 ( - )
Gene Full Name: protocadherin 9
Band: 13q21.32
Quick LinksEntrez ID:5101; OMIM: 603581; Uniprot ID:PCDH9_HUMAN; ENSEMBL ID: ENSG00000184226; HGNC ID: 8661
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015001 arsenite arsenite results in increased expression of PCDH9 mRNAincreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in increased expression of PCDH9 mRNA]affects reaction|increases expression 18929588
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of PCDH9 mRNAdecreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PCDH9 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PCDH9 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of PCDH9 mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PCDH9 mRNAincreases expression 17005392
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PCDH9 mRNAaffects binding|decreases expression|increases activity 19710929
D014415 Tunicamycin Tunicamycin results in increased expression of PCDH9 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7615469931
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.6017129689 15324884
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 2.2615948411 16924424
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 18252227
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8416002989 12952375
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6116804899 15700306
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver arsenite 14.5918296743
MESH:D005234 Fatty Liver Cyclosporine 14.5919224547
MESH:D005234 Fatty Liver pirinixic acid 14.5919236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7916534752 16513791 16611131 15751030 16002989
MESH:D005355 Fibrosis arsenite 9.9318296743
MESH:D005355 Fibrosis Cyclosporine 9.9312639820 12168785
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 18467677 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7414722030 12960047
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007021 Hypospadias Diethylstilbestrol 4.8916002989
MESH:D007246 Infertility Diethylstilbestrol 4.6415036965
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.1315003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3717184923
MESH:D008103 Liver Cirrhosis arsenite 3.5418296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.8415890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 4.8420007298 16377806 15890375
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008175 Lung Neoplasms arsenite 2.3616809336
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8916002989
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2616166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms Diethylstilbestrol 5.3915313581
MESH:D009369 Neoplasms pirinixic acid 5.3917405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.7515738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.4211399458
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9815687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.4517184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5315046698 17136230 15846301
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1015814490 17322281 17365031 17975199
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.798532709
MESH:D013088 Spermatocele Diethylstilbestrol 5.0916002989 16709447
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8517306315 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.5514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3515809267 16690809
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7416513791 16002989
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33008
    • No data
    Releated disease ID Related disease Name
    PA153906318Autism Spectrum Disorder
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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